SummingSumming--upup

George F. George F. GaoGao (China)(China)Ann Reid (USA)Ann Reid (USA)

Workshop on the Genomics Revolution: New Tools for Combating Infectious Diseases

China-US Dialogue on Emerging Science and Technology

What we are facing What we are facing in the 21st century:in the 21st century:

EmergingEmerging and Reand Re--emerging emerging Infectious DiseasesInfectious Diseases

We are living in a changing world, what should we do? ? ? …

China-US Dialogue on Emerging Science and Technology

?“…Profound and powerful forces are shaking and remaking our world,and the urgent question of our time is whether we can make change our friend and not our enemy…” -----First Inaugural Address of William J. Clinton

We start to work together!

China-US Dialogue on Emerging Science and Technology

Genomics & Pathogens

Huanming Yang Ph.D.Beijing Genomics Institute (BGI), Beijing

James D. Watson Institute of Genome Sciences, Hangzhou

What does DNA tell us？

“Life is of sequence”“Life is Digital”

Two Pillars of Genomis

Origin of SARS-CoV

Tracing the H5N1 AIV

Genomics does make a difference for ID research and practice

IndonesiaJune 2004

Thailand July 2004

China QinghaiMay 2005

MongoliaAug.2005

Russia July 2005

KazakhstanJuly 2005

Europe?

AIV

AIV？

H5N1 transmission through migratory birds??

What we have learnt from this workshop?

• Genomics has revolutionized/is revolutionizing our understanding of the pathogens …

• Interrelationships among the pathogens, hosts, environments, …

Keynote Lectures: good appetizers

• Prof. Depei Liu: Population and health in China

• Prof. Paul Ahlquist: Enormous burdens and threats of infectious disease demands vigorous genomics and international cooperation

Surveillance and Detection

• Maria Elena Panaranda: A good model for the developing countries where the EIDs are still in epidemic

• Ruifu Yang: Microarray for tracing the Yersinia pestis

• Charles Chiu:ViroChip to detect viruses esp. for discovery of new viruses

• Biao Kan: Pulse-Net China, a good start to link China and US (the world) for IDs

Predicting Pathogenesis and Adaptations to Humans

• Prof. Eric Eisenstadt: Pathogen-related genomics in TIGR, USA

• Prof. Huanming Yang: Pathogen-related genomics in BGI, China

• Prof. Gary Anderson: Biomarkers, microarray and microflora

• Prof. Zhenghong Yuan: HBV, genomics and beyond

Diagnostics—US and China Perspectives

• Dr. Stephen Popper: Microarray, hospital blood test and so on

• Prof. Wenhan Wu: HEV, AIV and beyond

• Dr. Patrick R. Murray: Genomics and the clinical diagnoses

• Prof. George F Gao: Updates of two emerging pathogen outbreaks in China

Vaccine Development

• Prof. Dexin Li: Overview of vaccine development in China

• Prof. Xiaoyan Zhan: Reverse genetics and vaccine development,

• Prof. Youchun Wang: HIV vaccines, preventive vs therapeutic

• Prof. Arnold Monto: Origin of influenza

Drug Discovery

• Dr. Bruce Taillon: 454 Life Sciences, life is getting easier!

• Prof. Junzhi Wang: Vaccine and drug development in China

• Prof. Paul Ahlquist: Host and pathogens, the usefulness of the genomics

• Prof. Hualiang Jiang: Genomics-guided drug discovery, SARS-CoV as an example

Case Studies—Prevention and Treatment

• Prof. Lai Wei: HBV, genotypes and the diseases• Prof. Steve O’Brien: Aju-CoV, HIV and the

host genetics• Prof. Taisheng Li: HIV treatment in China• Dr. Lance Gable: Preparedness of a potential

influenza pandemic, beyond the science!

The dialogue does not END, but just STARTED:

(Dessert)• Young Scientist Dialogue: Looking

toward the Future of the Genomics Revolution

• Prof. Jiang Gu

• … …(The legacy is being continued by a new generation …)

Let’s work together to tackle the emerging or re-emerging INFECTIOUS DISEASES!

We are the winners!

Never give up!

We ought to work together!

Where are we going and what are we going to do?

• The legacy will be continued• Dr. Ann Reid …

GDEST Objectives

• To understand rapidly advancing global capabilities in science and engineering

• To provide all participants with an opportunity to become more familiar with research priorities, potential colleagues, and facilities

Goals for this meeting

• To provide leading U.S. and Chinese science and engineering researchers in genomics and related fields an opportunity to explore research directions and challenges with their counterparts having outstanding capacity

• To provide U.S. researchers with exposure to a broad cross-cutting sample of Chinese scientists, including the most promising junior investigators, in order to facilitate future international collaborations

• To identify common interests between current and future U.S. and Chinese research leaders ingenomics and related areas

Why are we concerned?

• Infectious diseases remain a significant challenge for humanity– Ancient scourges continue to cause immense

suffering and loss (tuberculosis and malaria) – New diseases will continue to emerge (AIDS,

SARS, and West Nile virus) – Many diseases that are not considered

“infectious” may have a microbial component (cancer and heart disease)

What are the challenges?

• It is a global challenge: infectious diseases do not respect national boundaries

• It is a long-term challenge: we must inspire and educate the next generation of scientists to work on these problems

• It is a shared challenge: scientists must work together and share knowledge in order to make progress as quickly as possible

What about genomics?

• Genomics can contribute in many ways– Detecting infectious agents– Predicting pathogenicity– Making accurate diagnoses– Predicting response to treatment – Developing effective vaccines and therapeutics

What did we learn from each other?

• Life is digital!– Genomics information is especially well-suited

to international cooperation– Researchers all over the world can work with

the same data– “ACTG” is a common language

What do we hope for the future?

• To create opportunities for dialogue between Chinese and U.S. researchers– Hold global conferences– Increase cooperative programs– Facilitate student exchanges

• To encourage more collaborative projects between Chinese and U.S. genomics researchers

• To build global communication networks– Make results available more quickly– Broaden use of new techniques and technologies

• To inspire more bright, young researchers in the U.S. and China to choose genomics as an exciting career path

What do US and Chinese researchers have in common?

• Passionate commitment to using genomicsto lift the burden of infectious disease

• Dedication to doing research at the cutting edge of knowledge using the very highest scientific standards

• Desire to meet again soon!

Let’s work together to tackle the emerging or re-emerging INFECTIOUS DISEASES!

We are the winners!

Never give up!

We ought to work together!

研究所简介研究所简介

Thank YouThank You

for your attention for your attention

China-US Dialogue on Emerging Science and Technology