genx exposure study pfas blood sample results
TRANSCRIPT
![Page 1: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/1.jpg)
GenX Exposure Study
PFAS blood sample results
1
Wilmington, November 13, 2018
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 2: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/2.jpg)
2
PFAS stands for per- and polyfluoroalkyl substances
1. Group of chemicals (for example: GenX)
2. Used in consumer products (for example:
non-stick pans)
3. Can be released to environment by PFAS
manufacturers
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 3: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/3.jpg)
Wilmington, NC
Chemours Plant, Fayetteville, NC
upper
lower
GenX
Newly identified PFAS in Wilmington drinking water
3Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 4: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/4.jpg)
Wilmington, NC
Chemours Plant, Fayetteville, NC
upper
lower
GenX and other poorly-understood PFAS
It’s not just GenX
4Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 5: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/5.jpg)
Wilmington, NC
Chemours Plant, Fayetteville, NC
upper
lower
GenX and other poorly-understood PFAS
It’s not just GenX
5Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 6: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/6.jpg)
Assess exposure to GenX and related PFAS in
people living in the Lower Cape Fear River
Basin.
Look for GenX and other PFAS in drinking
water, blood and urine.
The GenX Exposure Study
6Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 7: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/7.jpg)
345 participants (56 children)
310 enrolled in November 2017
35 enrolled in May 2018
Collected tap water, blood and urine
44 participants gave two blood samples
The GenX Exposure Study
7Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 8: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/8.jpg)
8
GenX Exposure Study Timeline
Report blood results: letters and community meeting
Collected tap water, blood and urine
Report water results: letters and community meeting
Blood method development; Update advisory board
Blood sample analysis
Blood sample analysis; Data processing
Share results with study team
Review blood letters
Blood sample analysis; Update advisory board
Analyzed tap water from 198 homes
Study funded by NIEHS
Review water lettersMar 2018
Report water resultsApr 2018
Nov 2017
Nov-Feb, 2017
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 9: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/9.jpg)
Most tap water with Cape Fear River source had:
1. GenXMedian: 50 parts per trillion GenX
2. Nafion byproduct 2, PFMOAA, PFO2HxA, and PFO4DA
Wilmington tap water in Nov 2017
9Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 10: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/10.jpg)
10
GenX Exposure Study Timeline
Report blood results
Blood method development; Update advisory board
Begin analysis of 388 blood samples
Blood sample analysis; Quality controls
Review blood letters
Blood sample analysis; Update advisory board
Nov 2018
May 2018
Jun 2018
July 2018
Aug-Sept 2018
Oct 2018
Collected tap water, blood and urine
Analyzed tap water from 198 homes
Study funded
Review water lettersMar 2018
Report water resultsApr 2018
Nov 2017
Nov-Feb, 2017
Oct 2017
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 11: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/11.jpg)
11
PFAS blood results: Key findings
1. GenX was NOT detected
2. Found new PFAS: Nafion byproduct 2, PFO4DA, PFO5DoDA and Hydro-EVE
3. Levels of historically-used PFAS were higher in Wilmington than United States
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 12: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/12.jpg)
Newly identified in lower Cape Fear RiverGenXNafion byproduct 2PFO3OAPFO4DAPFO2HxA
Nafion byproduct 1Nafion byproduct 4PFO5DoDAPEPAPMPANVHOSHydro-EVE
Monitored for 23 PFAS in blood
12Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 13: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/13.jpg)
Newly identified in lower Cape Fear RiverGenXNafion byproduct 2PFO3OAPFO4DAPFO2HxA
Nafion byproduct 1Nafion byproduct 4PFO5DoDAPEPAPMPANVHOSHydro-EVE
Monitored for 23 PFAS in blood
13Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 14: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/14.jpg)
Historically-used
PFBAPFPeAPFHxAPFHpAPFOAPFNAPFDAPFBSPFHxSPFOS6:2 FTS
Monitored for 23 PFAS in blood
14
Newly identified in lower Cape Fear RiverGenXNafion byproduct 2PFO3OAPFO4DAPFO2HxA
Nafion byproduct 1Nafion byproduct 4PFO5DoDAPEPAPMPANVHOSHydro-EVEPreliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 15: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/15.jpg)
Historically-used
PFBAPFPeAPFHxAPFHpAPFOAPFNAPFDAPFBSPFHxSPFOS6:2 FTS
Results for 15 PFAS
15
Newly identified in lower Cape Fear RiverGenXNafion byproduct 2PFO3OAPFO4DAPFO2HxA
Nafion byproduct 1Nafion byproduct 4PFO5DoDAPEPAPMPANVHOSHydro-EVEPreliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 16: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/16.jpg)
What are the results?
16Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 17: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/17.jpg)
Did we find GenX in blood?
No, we did NOT find GenX in blood samples
Method reporting limit: 2 parts per billion GenX
17Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 18: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/18.jpg)
Did we find GenX in blood?
No, we did NOT find GenX in blood samples
Method reporting limit: 2 parts per billion GenX
GenX was NOT found in blood even though 50 parts per trillion in tap water
18Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 19: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/19.jpg)
Did we find GenX in blood?
No, we did NOT find GenX in blood samples
Method reporting limit: 2 parts per billion GenX
GenX was NOT found in blood even though 50 parts per trillion in tap water
GenX was NOT found in blood from 30 people living near the Chemours plant
19Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 20: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/20.jpg)
Blood did NOT have
Newly identifiedGenXNafion byproduct 1PMPA PEPA
20
Historically-usedPFHxA6:2 FTS
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 21: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/21.jpg)
Four newly-identified PFAS in blood
1. Nafion byproduct 2 (99% of samples)
2. PFO4DA (98%)
3. PFO5DoDA (87%)
4. Hydro-EVE (76%)
21Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 22: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/22.jpg)
Median blood concentration (parts per billion)
Nafionbyproduct 2
PFO4DA
PFO5DoDA
0.0
How much was found?
22Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 23: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/23.jpg)
Median blood concentration (parts per billion)
Nafionbyproduct 2
PFO4DA
PFO5DoDA
0.0
How much was found?
23Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 24: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/24.jpg)
Median blood concentration (parts per billion)
Nafionbyproduct 2
PFO4DA
PFO5DoDA
0.0
How much was found?
24
Hydro-EVE
?
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 25: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/25.jpg)
Median blood concentration (parts per billion)
Nafionbyproduct 2
PFO4DA
PFO5DoDA
0.0
How much was found?
25
Hydro-EVE
?
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 26: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/26.jpg)
Median blood concentration (parts per billion)
Nafionbyproduct 2
PFO4DA
PFO5DoDA
0.0
How much was found?
26
No published health or toxicology data
Hydro-EVE
?
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 27: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/27.jpg)
27
Yes.
Are these findings unique to Wilmington?
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 28: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/28.jpg)
28
Yes.
We did not find Nafion byproduct 2, PFO4DA, PFO5DoDA or Hydro-EVE in blood from two other groups.
20 samples. Women, 30-44 years old, in Raleigh, Durham, Chapel Hill, 2008-2009.
24 samples. People in Dayton, OH, with high PFOS exposure, 1992-2014.
Are these findings unique to Wilmington?
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 29: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/29.jpg)
PFO4DA PFO5DoDA
Blood concentrations decrease after six months
November 2017May 2018 (six months later)
29
Nafionbyproduct 2
No
vem
be
r 2
01
7
May
20
18
Median blood concentration for 44 participants (parts per billion)
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 30: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/30.jpg)
Blood concentrations decrease after six months
Nafionbyproduct 2
PFO4DA
PFO5DoDA
Median blood concentration for 44 participants (parts per billion)
30
No
vem
be
r 2
01
7
May
20
18
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 31: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/31.jpg)
31
PFAS blood results: Key findings
1. GenX was NOT detected
2. Found four new PFAS: Nafion byproduct 2, PFO4DA, PFO5DoDA and Hydro-EVE
The levels decreased after six months
3. Levels of historically-used PFAS were higher in Wilmington than United States
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 32: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/32.jpg)
32
PFAS blood results: Key findings
1. GenX was NOT detected
2. Found new PFAS: Nafion byproduct 2, PFO4DA, PFO5DoDA and Hydro-EVE
Their levels decreased after six months
3. Levels of historically-used PFAS were higher in Wilmington than United States
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 33: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/33.jpg)
33
How do we know about other people in United States?
Centers for Disease Control and Prevention’s National Health and Nutrition Examination Survey (NHANES)
PFOA, PFOS, PFHxS, PFNA, PFDA results are publicly-available
1999-2000 survey2015-2016 survey
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 34: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/34.jpg)
34
PFOA concentration (parts per billion)
PFOA
one sample
Non-detect
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 35: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/35.jpg)
35
1.5
US,
20
15
5.2
US,
19
99
PFOA blood levels in United States have decreased
PFOA concentration (parts per billion)
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 36: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/36.jpg)
36
4.4
Wilm
ingt
on
, 20
17
Wilmington PFOA levels similar to US levels 20 years ago
PFOA concentration (parts per billion)
1.5 5.2
US,
20
15
US,
19
99
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 37: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/37.jpg)
37
Wilm
ingt
on
US,
20
15
US,
19
99
Half of Wilmington samples above levels for 95% US population in 2015
95% of USat or below 4.1 in 2015
4.41.5 5.2
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 38: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/38.jpg)
38
Were other historically-used PFAS levels higher in Wilmington than United States?
Yes.
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 39: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/39.jpg)
39
Were other historically-used PFAS levels higher in Wilmington than United States?
Yes.PFOS
PFHxS
PFNAPFDA
0
1
2
3
4
5
6
7
8
9
10
PFOA
Median blood concentration (parts per billion)
Wilm
ingt
on
US
PFOS
PFHxS
PFNAPFDA
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 40: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/40.jpg)
40
What does this mean for Wilmington?
Unusually high exposure to historically-used PFAS compared with United States
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 41: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/41.jpg)
41
What does this mean for Wilmington?
Unusually high exposure to historically-used PFAS compared with United States
Exposure to historically-used PFAS may result in health effects
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 42: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/42.jpg)
42
What does this mean for Wilmington?
Unusually high exposure to historically-used PFAS compared with United States
Exposure to historically-used PFAS may result in health effects
Do not know what your individual blood level means for your health
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 43: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/43.jpg)
Historically-used PFAS levels didn’t change much
Median blood concentration for 44 participants (parts per billion)
43
PFOS
PFOA
PFHxS
PFNA
PFDANo
vem
be
r 2
01
7
May
20
18
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 44: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/44.jpg)
Historically-used PFAS levels didn’t change much
Median blood concentration for 44 participants (parts per billion)
44
PFOS
PFOA
PFHxS
PFNA
PFDANo
vem
be
r 2
01
7
May
20
18
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 45: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/45.jpg)
45
PFAS blood results: Key findings
1. GenX was not foundEven though it was present in tap water
2. Found four new PFAS: Nafion byproduct 2, PFO4DA, PFO5DoDA and Hydro-EVE
Levels decreased after six months
3. Levels of historically-used PFAS were higher in Wilmington than United States
Levels didn’t change much after six monthsPreliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 46: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/46.jpg)
Next steps
Test urine samples for PFAS
Identify predictors of PFAS in blood and urine
Analyze PFAS associations with health measures
46Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 47: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/47.jpg)
NCSU
Jane Hoppin, PI
Rob Smart
Katy May
Detlef Knappe
Nadine Kotlarz
ECU
David Collier
Jamie DeWitt
Suzanne Lea
EPA
Mark Strynar
James McCord
Andrew Lindstrom
New Hanover County Health Department
Phillip Tarte
Katelyn Matney
Cape Fear River Watch
Kemp Burdette
Madi Polera
Amanda Boomershine
Larry Cahoon
GenX Exposure Study Team
47Grant # 1R21ES029353
Grant # P30ES025128
Preliminary Information Subject to Revision. Not for Citation or Distribution.
![Page 48: GenX Exposure Study PFAS blood sample results](https://reader031.vdocuments.site/reader031/viewer/2022022820/621c14bdf2e0786fb4343d99/html5/thumbnails/48.jpg)
48
Thank you to GenX Exposure Study participants
Preliminary Information Subject to Revision. Not for Citation or Distribution.