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GENReports:,Market,&,Tech,Analysis,!Produced!by!Enal!Razvi,!Ph.D.!©!2014,GENengnews.com,

> Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. [email protected]!

GENReports: Market & Tech Analysis


•  The, focus, of, this, GEN, Market, &, Tech, Analysis, Report, is, to, provide, an,update,on,the,pointBofBcare,diagnosCcs, (POC),marketplace,based,upon,a,boJomBup,publicaCons,analysis,we,have,conducted,of,the,enCre,field,

•  We,analyzed,12,298,publicaCons,in,the,broader,POC,space,as,a,means,to,capture,the,enCre,space,–,the,argument,for,this,analysis,is,that,the,en#bloc,set, of, publicaCons, can, be, uClized, as, a, proxy, for, the, enCre, field, and, an,understanding,of,the,segments,and,dynamics,therein,

•  We’ve, defined, the, POC, space, broadly, including, “PointBofBCare,Systems”,,“PointBofBCare,TesCng”,,and,“Bedside,TesCng”,

•  The,publicaCons,data,are,truly,global,in,terms,of,their,origin,signifying,the,worldwide,global,nature,of,the,POC,field,

•  The,data,and,our,analysis,seek,to,frame,the,POC,marketplace,,circa,2014,

Topic Introduction and Scope


Point-of-Care Diagnostics Publications Activity

0!

500!

1000!

1500!

2000!

1950! 1960! 1970! 1980! 1990! 2000! 2010!

PublicaC

ons,in,the,Given,Ye

ar,

The,POC,DiagnosCcs,Field,is,Clearly,on,an,Upward,Growth,Trajectory,


Point-of-Care Diagnostics Publications Activity: A Truly Global Representation

!@!!!! !500!! !1,000!! !1,500!! !2,000!! !2,500!! !3,000!! !3,500!! !4,000!! !4,500!! !5,000!!

AFRICA!

ASIA!

AUSTRALIA!

EUROPE!

Canada!

United!States!

!197!!

!1,178!!

!395!!

!3,091!!

!536!!

!4,789!!

Number,of,PublicaCons,ContribuCng,to,the,Data,Set,


Point-of-Care Diagnostics Publications Activity: Representation broken-out by Country

0!

500!

1000!

1500!

2000!

2500!

3000!

3500!

4000!

4500!

5000!

ARGE

NTINA!

AUSTRIA!

BARB

ADOS!

BOLIVIA!

BRAZ

IL!

BURK

INA!FA

SO!

CAMER

OON!

CHAD

!CH

INA!

CONGO

!CU

BA!

CZEC

H!RE

PUBLIC!

DOMINICA!

ESTO

NIA!

FINLAND!

FREN

CH!POLYNESIA!

GAMBIA!

GERM

ANY!

GREECE

!HA

ITI!

HUNGA

RY!

INDO

NESIA!

IRELAN

D!ITALY!

JAPA

N!

KENYA

!KO

SOVO

!LEBA

NON!

LUXEMBO

URG

!MAD

AGAS

CAR!

MALAY

SIA!

MALTA

!MONTSER

RAT!

NETHE

RLAN

DS!

NEW

!ZEA

LAND!

NORW

AY!

PAKISTAN

!PH

ILIPPINES!

PORT

UGA

L!QAT

AR!

RUSSIA!

SAUDI!ARA

BIA!

SERB

IA!

SLOVE

NIA!

SPAIN!

SUDA

N!

SWITZERLAN

D!TA

IWAN

!TH

AILAND!

TUNISIA!

UGA

NDA

!UNITED

!KINGD

OM!

URU

GUAY

!VIETNAM

!ZA

MBIA!

United!States!

1.  This!breakout!suggests!a!fragmented!global!distribu^on!of!the!POC!field!

2.  Although!technology!development!and!cuang@edge!science!performed!in!specific!countries,!however,!the!contribu^on!of!many!global!regions!cannot!be!ignored!

3.  Therefore!we!suggest!that!POC!diagnos^cs!development!is!a!global!endeavor!


!  Total,PublicaCons,Analyzed,in,POC,Space:,12,298,

!  PublicaCons,from,this,Set,Focusing,on,Microfluidics/LabBonBaBChip:,2,059,

!  Represents,17%,of,total,!  Suggests,that,there,is,an,intersecCon,of,POC,DiagnosCcs,with,LOAC/Microfluidics,approaches,–,perhaps,for,rapid/lowBsample,volume,analyses,of,analytes,

Point-of-Care Diagnostics Publications Activity: Intersection with Microfluidics/Lab-on-a-Chip (LOAC)


Point-of-Care Diagnostics Publications in the Oncology Space

1.  Definite!Convergence!of!POC!with!Cancer!Space!2.  Less!Clear!is!the!Correlaôn!with!Specific!Cancer!Classes!–!Breast!and!Prostate!have!

Small!Correlaôns!3.  Immunoassays!rather!than!PCR!Shows!Correlaôns!4.  Also,!No!Significant!Penetrance!of!POC!into!Clinical!Trials!Space!


Point-of-Care Diagnostics Publications in Cardiovascular Disease and Infectious Diseases

1.  Deep!Correlaôns!between!POC!and!Cardiovascular!Disease!Classes!2.  Deep!Correlaôns!between!POC!and!Infecôus!Disease!Classes!3.  Unlike!Cancer,!where!Immunoassays!more!Penetrant,!neither!Cardiovascular!Disease!nor!Infecôus!Disease!Show!

Strong!Correlaôn!with!Immunoassays,!rather!PCR!Penetrant!into!Viral!Disease!Spaces!


Point-of-Care Diagnostics Publications in CNS Disease, Pregnancy, Neonatal Testing Spaces

1.  Pregnancy,!Neonatal!Tes^ng!and!Transplants!show!Correla^on!with!POC!Tes^ng!2.  CNS!Diseases!for!the!Most!Part!Don’t!Demonstrate!Correla^on!with!POC!Tes^ng!


!  In,this,report,,we’ve,sought,to,map,the,landscape,of,the,POC,field,by,an,en#masse,analysis,of,academic,publicaCons, that,consCtute, the, literature,in,the,field,

!  Analysis, of, the, literature, can, provide, clues, as, of, penetrance, of,technologies,and,approaches,in,a,parCcular,field,as,well,as,disease,classes,addressed,

!  Here, we, show, that, the, POC, field, is, global, in, nature, with, a, broad,geographic, base, of, contribuCons, into, the, academic, literature, which,consCtute,the,field,

!  We,also,examine,the,penetrance,of,POC,into,specific,disease,classes:,!  Oncology!!  Cardiovascular!Disease!!  Infec^ous!Disease!(including!various!viral!diseases)!!  CNS!Disease!!  Pregnancy,!Neonatal!Tes^ng!

!  The,Data,show,striking,correlaCons,of,POC,into,specific,disease,classes,!  Taken,together,,we,believe,that,this,en#bloc#analysis,of,POC,provides,an,

understanding,of,the,broader,POC,space,

In Summary

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