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Page 1: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but
Page 2: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Gastric CancerRemains the most common malignancy in Japan and China . It was the first-ranked malignancyin the United States in the 1930s to1940s, but it has rapidly declined in more recent decades

Page 3: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Gastric neoplasms are predominantlyMalignant , and nearly 90 to 95 % of cases are adenocarcinomas.Less frequently observed malignanciesInclude lymphomas, especially non-Hodgkin’s lymphoma, as well assarcomas, such as leiomyosarcoma.

Page 4: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

ADENOCARCINOMA OF THE STOMACHADENOCARCINOMA OF THE STOMACH

Epidemiology:

There is great geographic variation inthe incidence of gastric cancer worldwide,strongly indicating that environmentalfactors influence the pathogenesis of gastric carcinogenesis

Page 5: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Gastric adenocarcinoma localized tothe distal stomach has declined,the incidence rate of proximal gastric,gastro- esophageal adenocarcinomashas been steadily increasing in the United States

Page 6: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Th

The incidence of gastric cancer is variable in different parts of the word .

In japan 75 to 100 new cases per 100,000 per year. other areas of high prevalence include chile and Scandinavia.

Page 7: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Epidemiologic studies of high-risk populations have also suggested that genotoxic agents such as N-nitroso compounds may play a role in gastrictumorigenesis. N-nitroso compoundscan be formed in the human stomachby nitrosation of ingested nitrates,which are common constituents of the diet.

Page 8: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Etiology:

Risk factors for the development of gastric adenocarcinoma can bedivided into environmental andgenetic factors as well as precursorconditions

Page 9: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

اتيولوژي كانسر معده

عوامل -1محيطي

عامل -2ژنيتيك

عوامل -3مستعد كننده

Page 10: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Typically, gastric cancer occurs between ages 50 to 70 years andis uncommon before age 30 years.The rates are higher in males thanfemales by 2 to 1.

Page 11: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

The achlorhydria associated with gastritis related toH. pylori,pernicious anemia, or other causes favors the growthof bacteria capable of convertingnitrates to nitrites.

Page 12: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

In united states is 7 cases per 100,000 per yr . It is the 10 th most common cause of cancer in USA .

Increase in incidence of adnocarcinoma of the distal esophagus and cardia of the stomach.

Page 13: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Patients with familial adenomatous polyposis also have a risk approximately three time higher than that of the general population of developing gastric cancer.

( كننده مستعد (عوامل

Page 14: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Blood group antigens have also been associated with gastric cancer .

With the incidence highest in persons with blood type A and lowest in persons with blood type O.

مستعد ) عوامل(كننده

Page 15: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Etiology :

Dietary factor: Salted Smoked fish Pickled vegetables Well-cooked meats

Fruit and fiber have been found to be protective.Vit C is thought to protect against some of the mutagens present especially in smoked foods

Page 16: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but
Page 17: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but
Page 18: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Atrophic gastritis and gastriccancer share a number of commonenvironmental risk factors.It is likely that atrophic gastritis and intestinal metaplasia representintermediary steps to gastric cancer.

( كننده مستعد (عوامل

Page 19: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

.

Pernicious anemia

Peptic ulcer disease

Iron deficiency

N-nitroso compounds

H2 antagonists

مستعد ) عوامل(كننده

Page 20: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

Aspirin Nonsteroidal anti-inflamatory Drugs

have been associated with

a decreased risk of gastric cancer.

( كننده مستعد (عوامل

Page 21: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

بررسي توزيع فراواني در متغيرهاي دموگرافيك

بيماران مبتال به سرطان

)در 1374-1369 سال ( 5در استان اصفهان

شماره پژوهشي طرح1010

Page 22: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

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Stomach

Lymphoma

bladder

blood

Colon

esophagus

prostst

rectum

lung

Cancer in Men

Page 23: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

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skin

Breast

Stomach

Lymphoma

Blood

Colon

esophagus

rectum

Lung

Othrers

در سرطان وفور نسبتزنان

Page 24: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but
Page 25: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but
Page 26: Gastric Cancer Remains the most common malignancy in Japan and China. It was the first-ranked malignancy in the United States in the 1930s to 1940s, but

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