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Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Gaetano Guglielmi MD, PHD
) Director Office IRCCS-
Helthcare ad Research Excellence Center
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Health Research Network of the Ministry of Health
Istituto Superiore di Sanità (National Health Institute)
INAIL (National Institute for Environmental and Work Related Diseases)
Agenzia per i Servizi Sanitari Regionali (National Healthcare Agency)
45 IRCCS Institutes for Healthcare and Scientific Research
10 IZS – Veterinary Institutes
21 Regions (National Health System)
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
• 40 Schools of Medicine and Biology
•30 Schools of Pharmacy
• No. Depts and PhD courses on translational medicine
•23 Centres of Excellence in the biotechnology and biomedicine sectors
• 34 technological districts
• 31 S&T parks REGIONS
NATIONAL HEALTH SERVICE
HOSPITALS
IRCCS 43
AIFA MIUR
ISS
UNIVERSITIES NATIONAL RESEARCH COUNCIL
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
IRCCS’ Network 2014
48 Research Comprensive
Center -Institutes for
Healthcare and Scientific
Research
(*) Data are referred to 2012 Activities solely to the
expertise areas of recognition of the different Institutes
IRCCS - Researchers 9.575
IRCCS - Scientific Publications (*)
10.834
IRCCS - Total Normalised Impact Factor (*)
43.229
IRCCS - Total Hospital Beds
17.849
2013
2 New Institutes
•Pharmacologu Mario Negri
•Oncological Institutes Candiolo
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Funds for Health Research of the
Ministry of Health
Global trend in the last 11 years
E
U
R
O
Ordinary Research (Ricerca Corrente) aimed at the 48
IRCCS Basic scientific research, leaded by the IRCCS in the areas of recognition,
according to a three-years plan agreed with the Ministry of Health.
Aimed Research (Ricerca Finalizzata) Aimed to all the Participants belonging to the NHS Research Network
To implement the main biomedical and health objectives of the National
Health Plan, through grants that reward the best research projects
In Addition € 1 Billion for Salary Costs Permanent Staff for up 10.000 Researchers
0
20
40
60
80
100
120
140
160
180
200
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
175 180
185 180
155 150
190 192 200
161 163 159
174
151
47 52 56
52
20 25
45
70
50
100
86 84
51
78
Ricerca Corrente
Ricerca Finalizzata
* Nella RF 20 milioni riservati agli IRCCS
Bandi Altri Fondi
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
MoH funding of Health Research
2007-2009 = 1.014 MEuro
Translational Medicine (75%)
MIUR funding of Translational Medicine
2007-2009 = 585 MEuro
Public + Public-Industry Industrial
Research
ITALIAN GOVERNMENTAL
FUNDING FOR TRASLATIONAL RESEARCH
2013
EVERY 5 EUROS INVESTED IN BIOMEDICAL RESEARCH
CALL
UP TO 3,5 EUROS FROM MOH – 1,5 EUROS FROM MIUR
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
2013 - Quality and Quantity of the Italian Research in Biomedical Sector
Ru
ssia
n
Fed
erat
ion
Medicine – Rank Research Quality on H index and Citation Index
Medicine – Rank on Research Activities Number of Publications
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Researcher
Programme Committee
National Contact Points - NCP
Member /Associated States
Permanent Representatives
Min. of Research
Min. of Health
European Commission
European Council European Parliament
Research Institutes / Academias
Scientific Societies
Umbrella Organisations
Federations of Scientific Societies Industry
National Federations of Industries
International Federations of Industries
Patient
International Patients Groups
Patients Groups of Interest
Min. of Foreign Affairs
POLICY and STRATEGIC AGENDA
POLICY IMPLEMENTATION
Min. of Industry
Government
Specific DGs
European Institutions
Exec Agencies
Advisory Board
National Patients Groups Stakeholders
EU – CONSULTATION PROCESS
Regions
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
EU CONSULTATION PROCESS
Workshops Conferences
Inputs from
scientific societies,
etc… Consultation with Commission (non compulsory)
Workprogramme proposal Consultation with Commission (compulsory)
Advisory
Group
Workprogramme
Definitive text
Programme
Committee
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Ricerca Biomedica
DG Ricerca e Innovazione
(RTD)
DG Informazione e Società
(INFSO)
Public Health
Bioengineering / e-health
19/34
education
cancer
cardiovascular
neurosciences
biotech
Systems
medicine
Legislation /
regulation policy
psychology
Society &
Culture
access to
cure and
continuity
ICT
public
health
JTIs, JPIs, JPs, Agenzie
JTIs, JPIs, JPs, Agenzie
DG Salute e Consumatori
(SANCO) Agenzia
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
The Last Strategies in Research
Biomedical Sector
THE NATIONAL PILLARS
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
IT MOH Biomedical Research Strategies :
Principal Milestones
• Setup and Support Network for Biomedical
Research
• Support the Italian Researchers involved in
Projects at EU or International Level
• Grant Call: Award the Best Projects
• REMOVE All Programme for Specific Areas
• Support Network between Italian Institutions
and Italian Researchers Abroad
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
STRESS Quality and Competitiveness’ Italian
Research in Biomedical Sector
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
The Framework for a EU Research
The It-MOH Point of View
NATIONAL
CALL
National
Rules and
Strategies
EU H2020
Common
Rules and
Strategies at
European
Level
JOINT
INITIATIVE
Eranet and JPI
Common Tools to
Harmonized the
Different National
Startegies in a EU
Level
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
50,00%
60,00%
70,00%
80,00%
2008Oncology Programme
2009NEURON
2012TRANSCAN+NEURON
0,00%
10,00%
20,00%
30,00%
40,00%
50,00%
60,00%
70,00%
80,00%
1 2 3 4
Neurology
Oncology
2008Oncology Programme
2009NEURON
2012TRANSCAN+NEURON
EFFECT OF ERANET STRATEGY
Success Rate National Calls
NEUROLOGY VS ONCOLOGY
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Joint EU Projects Supported Directly by
the Italian MOH in the Last Three Years EUROPEAN PROJECTS:
Support in Joint Call (JTC) with other European Countries
• JTC ERANET TRANSCAN (Oncology) Coordinator IT-MOH
• JTC ERANET NEURON (Neurology)
• JTC ERANET E-RARE (Rare Diseases)
• JTC ERANET EURONANOMED (Nano Medicine)
• JTC ERANET SYSTEM MEDICINE (starting on 2014)
• JTC ERANET CARDIOVASCULAR (starting on 2015)
• Joint Programming Initiative Neurodegenerative Diseases (JPND)
• Joint Programming Initiative More Year Better Life (Ageing and
Demography Change)
• Coordination and Support Action Personalized Medicine (future JTC)
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
LAST
FUNDED
CALL
NATIONAL CALL – Principal Pillar
OPEN TO ALL BIOMEDICAL EXPERT AREAS
Free participation to all NHS Researchers
140 million Funding Grant
• Up to 60 million for young researchers
• Feasibility of co-financing with participation of Regions, Private
Company and Stakeholders
• 50% Funding to biomedical research (Early Translational) and
• 50 % to clinical-healthcare research (Later Translational)
• classification of projects according to rankings derived from NIH-
CSR in order to facilitate the Automatic and Blind Link Referee – Project
• Ratings by Referee reported by the NIH-CSR and living outside Italy
Introduction
Dec-March 2013
Final Rank
31 Jan 2014
Projects Submitted 4.158
Projects Evaluated
3.158
Funded Projects 294
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
The list of projects for funding is pursuant only to the scientific quality independently from the Expertise Area This is the call of the Italian National Health System
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
LAST FUNDED CALL RF2011-2012
3.158 PROPOSED APPLICATION EXPERTISE AREAS DISTRIBUTION
21,3%
12,6%
11,3%
6,2% 5,4% 5,1%
3,9%
3,4%
3,1%
3,0%
3,0%
2,7%
2,5%
2,5% 2,2%
1,8% 1,7%
1,7%
1,5%
1,3% 1,0%
1,0% 1,0%
0,6% 0,1%
0,1%
Brain Disorders and Clinical Neuroscience Oncology 2 - Translational Clinical
Oncology 1 - Basic Translational Genes, Genomes and Genetics
Cardiovascular and Respiratory Sciences Immunology
Musculoskeletal, Oral and Skin Sciences Infectious Diseases and Microbiology
Biobehavioral and Behavioral Processes Endocrinology, Metabolism, Nutrition and Reproductive Sciences
Molecular, Cellular, and Developmental Neuroscience Bioengineering Sciences and Technologies
Healthcare Delivery and Methodologies Surgical Sciences, Biomedical Imaging, and Bioengineering
Vascular and Hematology Integrative, Functional, and Cognitive Neuroscience
Cell Biology Digestive, Kidney and Urological Systems
AIDS and Related Research Risk, Prevention and Health Behavior
Emerging Technologies and Training in Neurosciences Population Sciences and Epidemiology
Biology of Development and Aging Biological Chemistry and Macromolecular Biophysics
Veterinary Interdisciplinary Molecular Sciences and Training
391 Projects Funded
REAL NHS
CONTRIBUTION – DIRECT
AND INDIRECT COSTS-
TOTAL VALUE FUNDED
PROJECTS
800 Million euros
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
New CALL: start 18 June 2014
Budget 74 Milion
New Diagnostic, Therapeutic and Healthcare Strategies in :
1‐ Dis-metabolism and Cardiovascular Dieseases
2‐ Neurology Diseases
3‐ Oncology
4‐ Immunologic and Infectious Diseases
5‐ New Biotechnology
6‐ Food Safety and Veterinary Health
7‐ Environmental and Work Related Diseases
8 – Public Health Organisation
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
New CALL: June 2014
74 Million Euros
• 10 Million for Great Network Projects
• 10 Million for Collaboration Projects with Italian
Researchers Abroad
• 5 Million for Industry Collaboration Projects
• 27,5 Million in for Italian Young Researchers
• Other Fund is allocate to the Best Projects
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
National Contact Point (APRE)
17/34
Unità di Coordinamento misto MdS-IRCCS / CNRS
Coordinamento scientifico
Integrazione con le Regioni
Network degli IRCCS
ISTITUZIONI EUROPEE
REGIONI / Conferenza S-R
Territorio
(Servizi, Attività
Produttive)
Consultazione
obbligatoria
Consu
ltazione n
on
-obblig
atoria (lo
bby)
Contributo
coordinato
MIUR - ISS
Comitati di Programma /
Advisory Boards
Researchers Relationship Management
Policy Support
Administrative & Management
Support
Networking
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
21
Struttura DTS
NEUROLOGY – HEATHY AGEING
GENETICS-BIOTECHNOLOGIES-RARE DISEASE
HEALTH-DEMOGRAPHICCHANGE-WELLBEING
ONCOLOGY
IRCCS INTERNATIONAL ACTIVITIES NETWORK
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
22
Direzione Tecnico-Scientifica
componenti del Board
Rappresentanti degli IRCCS:
Claudio Bordignon, Ospedale San Raffaele
Bruno Dellapiccola, Ospedale Pediatrico Bambin Gesù
Giovanni De Girolamo, Centro san Giovanni di Dio Fatebenefratelli
Giuseppe Ippolito, Istituto per le Malattie Infettive Lazzaro Spallanzani
Antonio Moschetta, Istituto Tumori Giovanni Paolo II
Pier Giuseppe Pelicci, Istituto europeo di Oncologia
Angelo Luigi Vescovi, Ospedale Casa Sollievo della Sofferenza
Rappresentanti degli altri Destinatari Istituzionali:
Stefano Cinotti, IZS Lombardia ed ER
Roberto Grilli, Regione Emilia Romagna,
Sergio Iavicoli, INAIL
Giada Li Calzi, Regione Sicilia,
Massimo Mirandola, MATTONE Internazionale,
Fabrizio Oleari, ISS
Gabriella Paoli, Regione Liguria,
Alberto Zanobini, MATTONE Internazionale
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
23
Direzione Tecnico-Scientifica
Esperti d’Area
Genetics, Biotechnologies, Rare Diseases
Del Mistro Annarosa, Istituto Oncologico Veneto
Gasparini Paolo, Ospedale infantile Burlo Garofolo
Martini Alberto, Istituto Giannina Gaslini
Nicoletti Ferdinando, Istituto Neurologico Mediterraneo Neuromed
Peyvandi Flora, Fondazione Ca'Granda – Ospedale Maggiore Policlinico
Picardo Mauro, Istituti fisioterapici ospitalieri - Istituto Dermatologico Santa Maria e San Gallicano
Russo Giandomenico, Istituto Dermopatico dell'Immacolata (IDI)
Sangiorgi Luca, Istituto Ortopedico Rizzoli
Information and Communication Technologies
Andrich Renzo, Fondazione Don Carlo Gnocchi
Annicchiarico Roberta, Fondazione Santa Lucia
Moretti Matteo, Istituto Ortopedico Galeazzi
Benfenati Emilio, Istituto Mario Negri
Epidemiology
Baiardi Paola, Fondazione Salvatore Maugeri
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
24
Neurology, Healthy Ageing
Antonini Angelo, Ospedale San Camillo
Blandini Fabio, Fondazione Istituto Neurologico Casimiro Mondino
Marino Silvia, Centro Neurolesi Bonino Pulejo
Martinuzzi Andrea, Istituto Eugenio Medea
Tagliavini Fabrizio, Fondazione Istituto Neurologico Carlo Besta
Health, Demographic Change, Wellbeing
Klersy Catherine, Fondazione Policlinico San Matteo
Oncology
Allavena Paola, Istituto Clinico Humanitas
Colombatti Alfonso, Centro di riferimento oncologico di Aviano
Piaggio Giulia, Istituto Nazionale Tumori Regina Elena
Krogh Vittorio, Fondazione Istituto Nazionale per lo studio e la cura dei tumori
Bruzzi Paolo, Azienda ospedaliera universitaria San Martino - IST
Paganelli Giovanni, IRST Meldola
Buonaguro Luigi, Istituto nazionale tumori Fondazione Giovanni Pascale
Direzione Tecnico-Scientifica
Esperti d’Area
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
“We must assure to the citizens that we can choose the best
projects, which, for their quality, should be the more functional to
the growth of the country; essentially we have to guarantee that
the taxpayers' money is well spent.
Thus the satisfaction of the scientific world is only a consequence of
the serious work done, but primarily we have to respond to the
citizen on the proper use of resources”.
A PHILOSOPHY OF TRANSPARENCY
At the end of the assessment process the Principal Investigator has
access to all the information related to the evaluation of his project
and all the Ranking List and Official Document of the Evaluation
Procedure are published on Ministerial Official Web Site.
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti
Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti
Direzione Generale Ricerca Sanitaria e
Biomedica e della Vigilanza sugli Enti