fundamental research skills and tools - nyu langone … · fundamental research skills and tools...
TRANSCRIPT
Fundamental Research Skills and Tools MBSC-GA 4473
Course Description for Bulletin: This course will provide students with a set of skills to support their graduate work and future research careers. The course will include the following topics: literature searching, research data management, data visualization, team science, citation management, Git/GitHub, publication metrics, and publication models. Research data management topics will include rigor and reproducibility, data documentation, data preservation, and sharing of research data. Best practices in data visualization will be covered, as well as an introduction to GraphPad Prism. The team science class will include team building, collaboration, and communication skills. Information discovery and management skills taught will include database searching and citation management. The course will also explain new biosketch requirements, the use of publication metrics, and open access and other publishing models. Students will learn to manage basic coding projects and to code collaboratively using Git and GitHub, and will engage in hands-on activities in data management, data visualization, searching, and citation management to provide them with concrete skills for their research.
Aims: ● Students will be able to:
o comply with NIH rigor and reproducibility requirements o identify appropriate venues for sharing research data. o navigate current funding agency and publisher requirements for sharing data o develop documented file and variable naming conventions. o identify and create visualizations of a data-set to explore and analyze the data. o develop effective search strategies and apply them to PubMed and other relevant
databases. o develop strategies for maintaining currency with the literature. o build an EndNote Library and use EndNote’s Word plugin to generate in-text
citations and bibliography. o articulate terms to negotiate when forming a collaboration, and communication
skills to facilitate collaboration. o manage and collaborate on code using Git and GitHub o create an NIH Biosketch that best highlights the full range of their scientific
contributions. o use PubsHub to identify high impact journals for submission/publication.
Detailed course topics and readings/assignments
Week 1: Expert Searching 1: PubMed & Other Databases
● Developing a comprehensive search strategy
In class exercise:
● Searching PubMed, Embase, Google Scholar, and Web of Science
Week 1 Readings: “Johns Hopkins’ Tragedy: Could Librarians Have Prevented a Death? (2001) Information Today.
Gopnik A. The Information: How the Internet gets inside us. The New Yorker. 2011.
Google Scholar Search Tips
Pre-class assignment: Bring a topic of interest to class that you can use as the basis of your search
Week 2: Publications: Metrics, Models, and More ● Publication metrics ● Publishing models ● NIH Biosketch/SciENcv ● ORCID ● Finding where to publish using PubsHub
In-class exercise: ● Create NIH biosketch ● Identify an appropriate journal for publication
Week 2 Readings: Altmetrics.org. Altmetrics: A Manifesto. 2010.
Hicks D, Wouters P, Waltman L, de Rijcke S, Rafols I. Bibliometrics: The Leiden Manifesto for research metrics. Nature. 20
Swarz, A. Guerilla Open Access Manifesto. 2008.
Pre-class assignment: Set up JournalTOCs account
Week 3: Expert searching 2: Endnote & Advanced Searching tools ● Build Endnote Library ● Sync Library with Endnote web ● Input citations from Endnote Library into Microsoft Word ● Change citation formats in Endnote ● Save searches, create filters, and create collections in myNCBI
In-class exercise: ● Export references to Endnote ● Syncing Endnote Library with Endnote Web ● Insert in-text citations into Microsoft Word
Important: Before class: Set up MyNCBI account: http://www.ncbi.nlm.nih.gov/myncbi/
Must install Endnote on computer and set up Endnote Web login.
● Endnote Install Instructions: http://hslguides.med.nyu.edu/citationmanagement ● Endnote Web:
https://www.myendnoteweb.com/EndNoteWeb.html?SID=1FQQooSYWcwcOlATlzV&returnCode=ROUTER.Success&SrcApp=CR&Init=Yes
Week 2 Readings: NYU Health Sciences Library: Endnote Basics
Week 4: Git and GitHub
● Reviewing command line basics ● Understanding and using version control ● Using Git to manage basic projects ● Using GitHub to collaborate remotely ● Understanding and using specific functions including branching, forking, merging,
pushing, and pulling
Important: Before class: ● Download and Install GitBash: https://git-scm.com/downloads
● Create a GitHub account: https://github.com/
Week 4 Readings: If you haven’t used the command line interface before, please familiarize yourself with it using the tutorial listed below.
● Django Girls. Introduction to the command-line interface. https://tutorial.djangogirls.org/en/intro_to_command_line/
Week 5: Team Science
● Sample collaboration agreements ● Legal issues (MTA, etc) ● Communication, team structure, authorship, roles ● Resources for identifying research collaborators
Week 5 Readings: Kong HH, Segre JA. Bridging the translational research gap: A successful partnership between a
physician and a basic scientist. J Invest Dermatol. 2010;130:1478-1480.
Gadlin H, Bennett LM. Dear Doc: Advice for collaborators. Transl Behav Med. 2012;2:495-503.
Coller BS. Translational research: Forging a new cultural identity. Mount Sinai J Med.
2008;75:478-487. Collaboration form
Week 6: Approaches to Research Data Management
● Collecting research data ● Organizing research data ● Preserving research data ● Storing research data ● Sharing research data ● Rigor and reproducibility
Week 5 Readings: Collins FS, Tabak LA. NIH plans to enhance reproducibility. Nature . 2014 Jan 27; 505(7485), 612-13.
Clayton JA, Collins FS. NIH to balance sex in cell and animal studies. Nature . 2014 May 14; 509(7500), 282-283.
Ioannidis JPA. Why Most Published Research Findings Are False. PLoS Medicine . 2005;2(8):e124. doi:10.1371/journal.pmed.0020124 Watch 4 short videos on this page: https://www.nigms.nih.gov/training/pages/clearinghouse-for-training-modules-to-enhance-data-reproducibility.aspx
Week 7: Hands on Research Data Management & Open Data ● In class exercise on data organization ● FAIR principles ● Big Data to Knowledge Initiative ● Open Data and Open Science in practice
Week 7 Readings: Look at Retraction Watch
Why data management matters
Force11 FAIR Data Principles. https://www.force11.org/group/fairgroup/fairprinciples
Week 8: Concepts in data visualization and GraphPad Prism
● Why visualize? ● Best Practices/Essential Concepts (i.e. perception with regards to pre-attentive attributes
of color and shapes) ● Ways to Visualize/Common Visualization Types and When/Why to use them (i.e. heat
maps, bar charts, scatter plots) ● Creating visualizations with GraphPad Prism (conceptualizing, choosing tools, pen and
paper sketching etc)
In-Class Exercise: ● Group charting of hypothetical dataset to uncover trends in data. ● Hands on GraphPad Prism introduction
Important: Before class: Go to the MCIT software portal and install GraphPad Prism http://altwcdcpnsvm01.nyumc.org/Altiris/SoftwarePortal/UserPortal/Home.aspx
Week 8 Readings: Duke SP, Bancken F, Crowe B, Soukup M, Botsis T, Forshee R. Seeing is believing: good graphic design principles for medical research. Statistics in Medicine. 2015;34(22):3040-59.
Kelleher C, Wagener T. Ten guidelines for effective data visualization in scientific publications. Environmental Modelling & Software. 2011;26(6):822-7.
Evaluation Pass/Fail
Pass requires attendance at a minimum of 7 classes (or equivalent) and completion of all in-class and at-home activities.