functions of the urinary system rinaldiseas=09i8d nitrogenous wastes toxins drugs
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Functions of the Urinary SystemFunctions of the Urinary System
Rinal diseas =09i8d Nitrogenous wastes
Toxins
Drugs
Blood Flow in the KidneysBlood Flow in the Kidneys
Figure 15.2c
The structural and functional units of the kidneys
Responsible for forming urine
Main structures of the nephrons
A specialized capillary bed
Attached to arterioles on both sides (maintains high pressure) Large afferent
arteriole
Narrow efferent arteriole Figure 15.3c
GlomerulusGlomerulus
Capillaries are covered with podocytes from the renal tubule
The glomerulus sits within a glomerular (Bowman’s) capsule (the first part of the renal tubule) Figure 15.3c
Renal TubuleRenal Tubule
Figure 15.3b
Types of NephronsTypes of Nephrons
Located entirely in the cortex
Includes most nephrons
Figure 15.3a
Types of NephronsTypes of Nephrons
Found at the boundary of the cortex and
medulla (loop of Henle dips into medulla)
Figure 15.3a
Glomerular CapillariesGlomerular Capillaries Afferent arteriole feeds glomerular capillary bed
Efferent arteriole drains glomerular capillary bed
Arterioles are high resistance vessels
Afferent diameter is greater than Efferent diameter, so blood pressure in glomerulus is extremely high
The high BP forces fluids and solutes out of the blood and into the glomerular capsule that drains into the collecting tubule
Peritubular CapillariesPeritubular Capillaries
Arise from efferent arteriole of the glomerulus
Normal, low pressure capillaries
Attached to a venule
Cling close to the renal tubule
Reabsorb (reclaim) some substances from collecting tubes
Urine Formation ProcessesUrine Formation Processes
Figure 15.4
FiltrationFiltration
Water and solutes smaller than proteins are forced through capillary walls
Blood cells cannot pass out to the capillaries
Filtrate is collected in the glomerular capsule and leaves via the renal tubule
ReabsorptionReabsorption
Some water
Glucose
Amino acids
Ions
Some reabsorption is passive, most is active
Most reabsorption occurs in the proximal convoluted tubule (PCT)
Materials Not ReabsorbedMaterials Not Reabsorbed
Nitrogenous waste products Urea
Uric acid
Creatinine
Excess water
Secretion – Reabsorption in Secretion – Reabsorption in ReverseReverse
Some materials move from the peritubular capillaries into the renal tubules
Hydrogen and potassium ions
Creatinine
Materials left in the renal tubule move toward the ureter
Formation of UrineFormation of Urine
Figure 15.5
Characteristics of Urine Used for Characteristics of Urine Used for Medical DiagnosisMedical Diagnosis
Colored somewhat yellow (straw) due to the pigment urochrome (from the destruction of hemoglobin) and solutes
Sterile
Slightly aromatic
Normal pH of around 6
Specific gravity of 1.001 to 1.035
Characteristics of Urine Used for Characteristics of Urine Used for Medical Diagnosis (Dip Stick)Medical Diagnosis (Dip Stick)
= excessive sugar intake, diabetes mellitus
= physical activity, pregnancy, glomerulonephritis, hypertension
= urinary tract infection
= bleeding (kidney stone, infection)
= transfusion reaction, hemolytic anemia
= hepatitis
UretersUreters
Continuous with the renal pelvis
Enter the posterior aspect of the bladder
Runs behind the peritoneum
Peristalsis aids gravity in urine transport
Urinary BladderUrinary Bladder Smooth, collapsible, muscular sac
Temporarily stores urine
Retroperitoneal, behind pubic symphysis
Figure 15.6
Urinary BladderUrinary Bladder
– three openings
Two from the ureters
One to the urethrea
Figure 15.6
Urinary Bladder WallUrinary Bladder Wall Three layers of smooth muscle (
)
Mucosa made of transitional epithelium
Walls are thick and folded in an empty bladder
In males the prostate gland surrounds the neck of the bladder where it empties into urethra
UrethraUrethra
Thin-walled tube that carries urine from the bladder to the outside of the body by peristalsis
Release of urine is controlled by two sphincters
Urethra Gender DifferencesUrethra Gender Differences
Length
Females – 3–4 cm (1.5 inches)
Males – 20 cm (8 inches)
Location
Females – along wall of the vagina, opening anterior to vaginal opening
Males – through the prostate and penis
Urethra Gender DifferencesUrethra Gender Differences
Function
Females –
Males –
3 parts of urethra in males
– through prostate
– through membraneous tissue between prostatic and penile
– through penis
Both sphincter muscles must open to
allow voiding
The internal urethral sphincter is relaxed after stretching of the bladder
Activation is from an impulse sent to the spinal cord and then back to bladder via the pelvic splanchnic nerves causing contractions
This sends urine past internal sphincter, and causes the sensation of having to void
The external urethral sphincter must be voluntarily relaxed
Fluid, Elecrolyte, & Acid-Base BalanceFluid, Elecrolyte, & Acid-Base Balance Blood composition depends on:
Diet, cellular metabolism, & urine output
In 24 hours the kidneys filter 150 – 180 liters of blood plasma, but only 1 – 1.8 liters of urine is produced
Filtrate is same as blood plasma, and as it moves along CD the kidney reabsorbs the good stuff (water, nutrients, ions), and secretes more of the bad stuff (nitrogenous wastes, and unneeded substances)
The left over filtrate is Urine
Fluid, Elecrolyte, & Acid-Base BalanceFluid, Elecrolyte, & Acid-Base Balance
Kidney’s role in blood composition:
1)
2)
3)
4)
Maintaining Water BalanceMaintaining Water Balance
Normal amount of water in the human body
Young adult females – 50% (F>fat, F<musles)
Young adult males – 60%
Babies – 75% (low fat, low bone mass)
Old age – 45%
Water is necessary for many body functions and levels must be maintained
Distribution of Body Fluid (Fluid Distribution of Body Fluid (Fluid Compartments)Compartments)
Interstitial fluid
Blood plasma
CSF, lymph, serous, eye humors, etc.
Figure 15.7
The Link Between Water and SaltThe Link Between Water and Salt
Changes in electrolyte balance (solute concentrations in/between compartments) causes water to move from one compartment to another
Alters blood volume and blood pressure
Can impair the activity of cells
Maintaining Water BalanceMaintaining Water Balance Sources for water intake
Ingested foods and fluids
Water produced from metabolic processes
Cellular metabolism (small amount)
Sources for water output Vaporization out of the lungs Lost in perspiration Leaves the body in the feces Urine production (will vary w/ kidney control)
Maintaining Water BalanceMaintaining Water Balance
Dilute urine is produced if water intake is excessive
Less urine (concentrated) is produced if large amounts of water are lost
Likewise, proper concentrations of various electrolytes must be present
Regulation of Water and Electrolyte Regulation of Water and Electrolyte ReabsorptionReabsorption
Regulation is primarily by hormones prevents
excessive water loss in urine
regulates sodium ion content of extracellular fluid
Triggered by the rennin-angiotensin mechanism
Cells in the kidneys and hypothalamus are active monitors
Maintaining Water and Electrolyte Maintaining Water and Electrolyte BalanceBalance
Figure 15.9
Maintaining Acid-Base Balance in Maintaining Acid-Base Balance in BloodBlood
Blood pH must remain between 7.35 and 7.45 to maintain homeostasis
Most (hydrogen) ions originate as byproducts of cellular metabolism
Maintaining Acid-Base Balance in Maintaining Acid-Base Balance in BloodBlood
Most acid-base balance is maintained by the kidneys
Other acid-base controlling systems
Blood buffers
Respiration (blow of CO2, Carbonic Acid)
Blood BuffersBlood Buffers 1st line of defense, because quick to act
Molecules react to prevent dramatic changes in hydrogen ion (H+) concentrations Bind to H+ when pH drops
Release H+ when pH rises
Three major chemical buffer systems
Acid-Base ReveiwAcid-Base Reveiw Acid – proton (H+) donor, decreases pH
Strong Acid – dissociate completely and give up a lot of H+, decreases pH significantly
Weak Acid – dissociate partially and gives up a few H+, lowering pH only slightly (ex: carbonic acid)
Weak acids get stronger (release more H+) as pH rises
Buffer system
Acid-Base ReveiwAcid-Base Reveiw Base – proton (H+) acceptor, increases
pH Strong Base – dissociate completely and
tie up a lot of H+, raising pH significantly
Weak Base – dissociate partially and tie up a few H+, raising pH only slightly (ex: bicarbonate ion, ammonia)
Weak bases get stronger (tie up more H+) as pH decreases
Buffer system
The Bicarbonate Buffer SystemThe Bicarbonate Buffer System Mixture of carbonic acid (H2CO3, weak acid)
and sodium bicarbonate (NaHCO3, weak base)
Bicarbonate ions (HCO3–) react with strong
acids (HCl) to change them to weak acids and salt
Carbonic acid dissociates in the presence of a strong base to form a weak base and water
Weak bases/acids do not cause fluctuations in pH, thus allowing us to maintain a narrow range of 7.35-7.45
Respiratory System Controls of Respiratory System Controls of Acid-Base BalanceAcid-Base Balance
Carbon dioxide in the blood is converted to bicarbonate ion and transported in the plasma
Increases in hydrogen ion concentration produces more carbonic acid
Excess hydrogen ion can be blown off with the release of carbon dioxide from the lungs
Respiratory rate can rise and fall depending on changing blood pH (stim. Chemoreceptors in respiratory centers in brain)
Renal Mechanisms of Acid-Base Renal Mechanisms of Acid-Base BalanceBalance
Slow processes, takes hours to days
1)
2)
Urine pH varies from 4.5 to 8.0
Developmental Aspects of the Developmental Aspects of the Urinary SystemUrinary System
Functional kidneys are developed by the third month
Urinary system of a newborn
Bladder is small
Urine cannot be concentrated
Developmental Aspects of the Developmental Aspects of the Urinary SystemUrinary System
Control of the voluntary urethral sphincter does not start until age 18 months
Urinary infections are the only common problems before old age
Aging and the Urinary SystemAging and the Urinary System
There is a progressive decline in urinary function
The bladder shrinks with aging
Urinary retention is common in males