functionalized isoflavonoids for controlled release

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Functionalized Isoflavonoids for Biomedical and Cosmetic Applications Isoflavonoid preparations 15-1 ILENE COURT, HILLSBOROUGH, NJ 08844; Tel: 908-281-7529 Email:[email protected] www.bezwadabiomedical.com

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Page 1: Functionalized Isoflavonoids for Controlled Release

Functionalized Isoflavonoids for Biomedical

and Cosmetic Applications

Isoflavonoid preparations

15-1 ILENE COURT, HILLSBOROUGH, NJ 08844; Tel: 908-281-7529 Email:[email protected]

www.bezwadabiomedical.com

Page 2: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

2

FUNCTIONALIZED ISOFLAVONOID MOLECULES

At Bezwada Biomedical , motivations to control the rate of release of theisoflavonoid molecules from few hours to months formed the basis of thedevelopment of novel absorbable oligomers of glycolide,lactice,p-dioxanone and caprolactone wherein the end group have beenfunctionalized with isoflavonoid molecules. Functionalized isoflavonoidsare expected to release isoflavonoid molecule in a controlled manner atthe site of action which will increase its efficacy over long period of time.It will also help to increase the solubility of isoflavonoid. Moreover theirhydrolysis result in release of the isoflavonoid molecules as such, thuspreserving its therapeutic activity.

Bezwada Biomedical is pleased to provide a portfolio of functionalized isoflavonoids which can

be used either as such or as monomers for preparation of absorbable therapeutic polymers which

incorporate isoflavonoid in the polymer backbone chain for extended and controlled release

applications.

Isoflavonoids are a subgroup of flavonoids that occur primarily in plants and their structural

components such as seeds, flowers and fruits. Soybeans are considered to be the richest source of

isoflavonoids. They exhibit tremendous potential to fight against number of diseases. They contain

many types of isoflavonoids, but the most beneficial are genistein and daidzein. Isoflavonoids

provides protection against a number of diseases. For example, they help prevent osteoporosis by

protecting and maintaining strong and healthy bones while improving bone mass and reducing bone

resorption. Similarly, they are known to lower the cholesterol and prevent the buildup of arterial

plaques. They also help to reduce the blood pressure by increasing vasodilatation. This reduces the

risk of coronary heart disease and associated cardiovascular complications while simultaneously

promoting cardiovascular health. In addition, isoflavonoids help reduce various forms of cancer

including breast cancer and prostate cancer by blocking the cancer causing effects of human estrogen

and hindering cell growth respectively, while reducing tumor progression and exerting anti-

inflammatory effects. Furthermore, isoflavonoids help relieve postmenopausal symptoms. Moreover,

isoflavonoids are natural antioxidants, the antioxidant powers of isoflavonoids help to counteract

damaging effects of free radicals in tissues and DNA. Genistein is the most potent antioxidant

Page 3: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

3

among the soy isoflavonoids, followed by daidzein. Finally, isoflavonoids are active ingredients of

various anti-aging creams and lotions for while protecting skin from sunburns.

OOH

O

OMeO

O

4’-Acetoxy-7-Hydroxy-6-

methoxyisoflavone

OOH

OH OOMe

Biochanin

O

OOH

OH

Daidzein

O

O

OH

OMe

OMe

3’,4’-Dimethoxy-7-

hydroxyisoflavone

O

O

OH

OMe

MeO

6,4’-Dimethoxy-7-hydroxyisoflavone

O

O

OH

OMeFormononetin

O

OOH

OH

OH

Genistein

O

OOH

OH

MeO

Glycitein

O

O

OH

7-Hydroxyisoflavone

O

O

OH

MeO

7-Hydroxy 6-

methoxyisoflavone

O

O

OH

CH3

7-Hydroxy-8-methyl isoflavone

O

OOH

OH

MeO

Prunetin

O

OOH

OH

OH

6,7,4’

Trihydroxyisoflavone

Eamples of Isoflavonoids

Controlled Release of Isoflavonoids

Widespread availability and therapeutic potential of these compounds motivated us to enhance

its native value by functionalizing it with safe and biocompatible molecules such as glycolic

acid, lactic acid, caprolactone and p-dioxanone.This functionalization enhances the native value

of Isoflavonoids and allows their controlled release at the site of action over desired time period

along with increased solubility. Furthermore, these functionalized isoflavonoids have improved

bioavailability, improved efficacy and are also anticipated to degrade into safe and

biocompatible molecules. This functionalization is expected to enhance the native value,

solubility and bioavailability of Isoflavonoid along with controlled degradation profiles.

Page 4: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

4

Potential Applications

These functionalized Isoflavonoid molecules and its absorbable oligomers and polymers with a

controlled degradation profile, have potential applications in the same or similar areas as the non-

functionalized molecules. This is attributed to the release of the isoflavonoids as such over a period

of time upon hydrolysis of the end-functionalized oligomers and polymers. Some of the key

applications of these functionalized isoflavonoid molecules include:

• Anti-osteoporotic applications

• In reducing cholesterol

• Anticancer applications

• In Relieving postmenopausal symptoms

• Anti inflammatory applications

• Anti oxidant applications

• Anti aging applications

References:

1. Rao S Bezwada. Absorbable Polymers from Soybean Isoflavonoids for Biomedical

Applications. Polymeric Materials Science & Engineering preprints 2009, 101, 1042

2. Rao S Bezwada. Absorbable Polymers from Functionalized Natural Products. Annual

Meeting of Society for Biomaterials, Chicago, April 18-21; 2007.

3. Rao S Bezwada. Synthesis and Characterization of Novel Absorbable Polymers from

functionalized Phenolic Monomers . The National Meeting of American Chemical

Society, September 10-14; 2006.

4. Bezwada, Rao S.Unsymmetrical aromatic ether diacids and absorbable polymers

therefrom. US Patent No.7, 902,319.

5. Bezwada, Rao S.Functionalized phenolic esters and amides and polymers therefrom. US

Patent No.7, 858,077.

6. Bezwada, Rao S.Unsymmetrical aromatic ether diacids and absorbable polymers

therefrom. US Patent No.7, 671,168.

7. Bezwada, Rao S. Functionalized phenolics esters and amides and polymers therefrom.US

Pub. App. No.20110130448.

8. Bezwada, Rao S. Functionalized phenolic compounds and polymers therefrom.US Pub.

App. No.20090170927.

Page 5: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

5

Contact Us

For further information on how we can help you engineer your success, please contact us at

[email protected] or visit us at www.bezwadabiomedical.com

Disclaimer: The information, statements and recommendations in this publication are to the best

of our knowledge, information and belief accurate at the date of publication. Nothing herein is to

be considered as a warranty, expressed or otherwise. In all cases, it is the responsibility of

readers and users to determine the applicability of such information for their own particular

purpose. Nothing in this publication is to be considered as recommending the infringement of

any patent or other intellectual property right. Nothing in this publication is to be viewed as a

license under any intellectual property right.

Page 6: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

6

GENERAL INFORMATION

How to order:

To place an order, please write or fax to:

Bezwada Biomedical LLC

15 Ilene Court , Suite 1

Hillsborough, NJ 08844 U.S.A.

Telephone: (908) 281-7529 Fax: (908) 359-1179

e-mail: [email protected]

Specify the chemical name, the catalog number, the quantity and your purchase order number.

Terms and conditions of sale:

Terms are F.O.B. Hillsborough, New Jersey. Net 10 days. Prices shown are in U.S. dollars and are subject

to change. All orders are insured at the buyers’ expense. Applicable taxes and shipping charges will be

added to the invoice.

Chemicals marked “with HPLC” or “with GC” are supplied with an actual analysis as determined by

high-pressure liquid chromatography or gas chromatography, respectively. These compounds have

catalog numbers with suffix letter S.

Discounting information:

Please inquire for substantial savings on bulk quantities or standing annual requirements.

Liability:

Some of the chemicals listed may be toxic or otherwise hazardous, and they should be handled by

qualified individuals trained in laboratory procedures. The information and data given in this catalog are

correct to the best of our knowledge, but their accuracy is not guaranteed. Bezwada Biomedical LLC, will

not be responsible for any loss or damage involving the use of our chemicals or products beyond the

purchase price.

No returns are accepted without prior written authorization, unless we made an error in shipment.

The listing of any products in our catalog does not imply the absence of patents, and does not constitute

license under any existing or pending patent. We are not responsible for any patent infringement resulting

from the use of our products. The information, statements and recommendations in this brochure are to

the best of our knowledge, information and belief accurate at the date of publication. Nothing herein is to

be considered as a warranty, expressed or otherwise. In all cases, it is the responsibility of readers and

users to determine the applicability of such information for their own particular purpose

All compounds listed in this catalog are for research and development purposes only. They may not be

used as drugs, food additives, cosmetics, household chemicals, or for any other non-laboratory purpose.

Delivery:

Period of delivery will be given upon receipt of an inquiry or order

Page 7: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

7

Functionalized 4’-Acetoxy-7-Hydroxy-6-methoxyisoflavone

19-1682

[3-(4-Acetoxy-phenyl)-6-methyl-4-oxo-4H-chromen

-7-yloxy]-acetic acid

C20H16O8

MW 384.35

19-1683

2-[3-(4-Acetoxy-phenyl)-6-methyl-4-oxo-4H-chromen-7-yloxy]

propionic acid

C21H18O8

MW 398.37

19-1684

{2-[3-(4-Acetoxy-phenyl)-6-methyl-4-oxo-4H-

Chromen-7-yloxy]-ethoxy}-acetic acid

C22H20O9

MW 428.40

19-1685

6-[3-(4-Acetoxy-phenyl)-6-methyl-4-oxo-4H-chromen

-7-yloxy]-hexanoic acid

C24H24O8

MW 440.45

19-1859

[4-(7-Carboxymethoxycarbonylmethoxy-6-methyl-4-oxo-4H-chromen-3-yl)

phenoxy]-acetic acid carboxymethyl ester

C24H20O12

MW 500.42

OOH

O

OMeO

O

O

O

OMeO

OOH

O

O

O

O

O

OOH

O

MeO

O

O

O

O

O

MeO

OOH

O

O

O

O

OMeO

OOH

O

O

OHO

O

O

O

OO

OH

O

O

O

OMeO

Page 8: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

8

19-1860

2-(3-{4-[1-(1-Carboxy-athoxycarbonyl)-ethoxy]-phenyl}-6-methyl-4-oxo-4H

chromen-7-yloxy)-propionic acid 1-carboxy-ethyl ester

C28H29O12

MW 557.554

19-1861

(2-{2-[2-(4-{7-[2-(2-Carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-6-methyl-4-oxo

4H-chromen-3-yl}-phenoxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C32H37O16

MW 677.64

19-1862

6-(3-{4-[5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-phenyl}-6-methyl-4-oxo-4H-

chromen-7-yloxy)-hexanoic acid 5-carboxy-pentyl ester

C40H53O12

MW 725.86

19-1686

Hydroxy-acetic acid 3-(4-acetoxy-phenyl)-6-methyl

-4-oxo-4H-chromen-7-yl ester

C20H16O8

MW 384.35

19-1687

2-Hydroxy-propionic acid 3-(4-acetoxy-phenyl)-6-

methyl-4-oxo-4H-chromen-7-yl ester

C21H18O8

MW 398.37

19-1688

(2-Hydroxy-ethoxy)-acetic acid 3- (4-acetoxy-phenyl)-6-methyl

-4-oxo-4H-chromen-7-yl ester

C22H20O9

MW 428.40

19-1689

6-Hydroxy-hexanoic acid 3-(4-acetoxy-phenyl)-6-methyl

-4-oxo-4H-chromen-7-yl ester

C24H24O8

MW 440.45

O

O

O

O

MeOO

OH

O

O

O

O

O

MeOO

OH

O

O

O

O

O

MeOO

OOH

O

O

O

O

O

MeOO

OH

O

OHO

O

O

O

OO

OH

O

O

O

OMeO

OO

OO

OH

OO

OO

OO

OH O

O

O OMeO

OO

OH

OHO

O

O

O

O

O

O

OMeO

Page 9: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

9

19-2577

[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl] 2-methoxyacetate

C21H18O8

MW 398.36

19-2578

[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl] 2-methoxypropanoate

C22H20O8

MW 412.39

19-2579

[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl] 2-(2-methoxyethoxy)acetate

C23H22O9

MW 442.42

19-2580

[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl] 6-methoxyhexanoate

C25H26O8

MW 454.47

19-2581

[2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-

methoxyacetate

C23H20O10

MW 456.40

19-2582

[2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-

methoxypropanoate

C25H24O10

MW 484.45

19-2583

2-[2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-(2-

methoxyethoxy)acetate

C27H28O12

MW 544.50

19-2584

[6-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-

methoxyhexanoate

C31H36O10

MW 568.61

OO

O

O

O

OMeO

O

OO

O

O

O

OMeO

O

OO O

O

O

O

OMeO

O

OO

O

O

O

OMeO

O

O OO

O

O

O

OMeO

O

O

O OO

O

O

O

OMeO

O

O

OO

OO O

O

O

O

OMeO

OO

OO

O

O

O

O

OMeO

O

O

Page 10: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

10

19-2585

[3-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]propanoate

C41H32O15

MW 764.7

19-2586

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]propanoate

C45H36O19

MW 880.78

19-2587

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 2-[2-

[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-

oxo-ethoxy]propanoate

C47H40O19

MW 908.83

19-2588

2-[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-

oxo-ethoxy]propanoate

C49H44O21

MW 968.88

19-2589

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-[6-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]acetyl]oxyhexanoate

C53H52O19

MW 992.97

O

O

OOO

OO

O

OO O

O O

OMe MeO

O

O

OOO

OO

OO

O

OO

O O

OOMe MeO

O O

O

O

OOO

OO

OO

O

OO

O O

OOMe MeO

O O

O

O

OO

OO

OO

OO

O

OO O O O

O

OMe MeO

O O

O

O

OOO

OO

OO

O

OO

O O

OOMe MeO

O O

Page 11: Functionalized Isoflavonoids for Controlled Release

Think Absorbable. Think Bezwada Biomedical

Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

11

19-2590

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]hexanoate

C44H38O15

MW 806.78

19-2591

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]hexanoate

C48H42O19

MW 922.86

19-2592

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-

[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-

oxo-ethoxy]hexanoate

C50H46O19

MW 950.91

19-2593

2-[2-[3-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-

oxo-ethoxy]hexanoate

C52H50O21

MW 1010

19-2594 [6-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]hexanoate

C56H58O19

MW 1035.08

O

O

OO

OO

O

OO O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

MeOOMe

O O

O

O

OO

OO

OO

O

OO

O O

O

O

MeOOMe

O O

O

O

OO

OO

OO

OO

O

OO O O O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

O O

OMe MeO

Page 12: Functionalized Isoflavonoids for Controlled Release

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Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

12

19-2595

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]hexanoate

C45H40O15

MW 820.81

19-2596

[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C49H44O19

MW 936.89

19-2597

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-

[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-1-

methyl-2-oxo-ethoxy]hexanoate

C51H48O19

MW 964.94

19-2598

2-[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-1-

methyl-2-oxo-ethoxy]hexanoate

C53H52O21

MW 1024.99

19-2599

[6-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C57H60O19

MW 1049.10

O

O

OO

OO

O

OO O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

OO

O

OO O O O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

Page 13: Functionalized Isoflavonoids for Controlled Release

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Copyright©2018 Bezwada Biomedical LLC

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13

19-2600

[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl] 6-[2-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]hexanoate

C46H42O16

MW 850.84

19-2601

[2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-[2-

(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C50H46O20

MW 966.91

19-2871 [2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-

[2-[2-[3-(4-acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-

2-oxo-ethoxy]ethoxy]hexanoate

C52H50O20

MW 994.94

19-2602

2-[2-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-

2-oxo-ethoxy]ethoxy]hexanoate

C54H54O22

1055.02

O

O

O

OO

OO

O

O

O

O

O

OOMe

MeO

O

O

O

OOO

OO

OOO

O

OO

O

O

O

O

OMe

MeO

O

O

O

OOO

OO

OOO

O

OO

O

O

O

O

OMe

MeO

O

O

O

OOO

OO

OO

OOO

O

OO O

O O

O

OMe

MeO

O

Page 14: Functionalized Isoflavonoids for Controlled Release

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Hillsborough, New Jersey 08844

14

19-2603

[6-[3-(4-Acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[2-[6-[2-

(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C58H62O20

MW 1079.13

19-2604

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]acetate

C40H30O15

MW 750.68

19-2605

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]acetate

C44H34O19

MW 866.75

19-2606

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]acetyl]oxypropanoate

C46H38O19

MW 894.80

19-2607

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]acetyl]oxyethoxy]acetate

C48H42O21

MW 954.86

O

O

OOO

OO

OOO

O

O

O

O

O

O

O

OMe

MeO

O

O

O

OOO

OO

O

OO O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

OO

O

OO O O O

O

OMe MeO

O O

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15

19-2608

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-[6-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]acetyl]oxyhexanoate

C52H50O19

MW 978.97

19-2609

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[3-(4-acetoxyphenyl)-6-

methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]acetate

C42H34O16

MW 794.73

19-2610

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[3-

(4-acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]acetate

C46H38O20

MW 910.80

19-2611

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[3-(4-

acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]acetyl]oxypropanoate

C48H42O20

MW 938.86

19-2612

2-[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[2-[3-(4-acetoxyphenyl)-6-methoxy-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-

2-oxo-ethoxy]ethoxy]acetate

C50H46O22

MW 998.91

O

O

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OOO

OOO

O

OO

O

O

OMe

MeO

O

O

O

OOO

OO

OOO

O

OO

O

O

O

O

OMe

MeO

O

O

O

OOO

OO

OOO

O

OO

O

O

O

O

OMe

MeO

O

O

O

O

OO

OO

OO

OO

O

O

O

O

OO

OOOMe

MeO

O

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16

19-2613

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-[2-[6-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]acetyl]oxyhexanoate

C54H54O20

MW 1023.02

19-2816

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-(4-acetoxyphenyl)-7-

methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C44H38O17

MW 838.76

19-2817

[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[2-

[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C48H42O21

MW 954.83

19-2818

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C50H46O21

MW 982.89

19-2819 2-[2-[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[2-[2-[2-(4-acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-

ethoxy]ethoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C52H50O23

MW 1042.94

OOO

OO

OO

O

O OO

O

O

O

O

O

OMe

MeOO

O

O

O

OO

OO

OO

O

OO O

O

OMe MeO

O O

O

O

OO

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

O

O

OO

OO

OO

OO

OO

O

OO O O O

O

OMe MeO

O O

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17

19-2820 [2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[2-[2-[2-[6-[2-(4-

acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C56H58O21

MW 1067.05

O

O

OO

OO

OO

OO

O

OO

O O

O

O

OMe MeO

O O

Page 18: Functionalized Isoflavonoids for Controlled Release

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18

Functionalized Biochanin

19-1690

(5-Carboxymethoxy-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)

Acetic acid

C20H16O9

MW 400.35

19-1691

2-[5-(1-Carboxy-ethoxy)-4-oxo-3-p-tolyl-4H-chromen

-7-yloxy]-propionic acid

C22H20O9

MW 428.40

19-1692

2-[7-(2-Carboxymethoxy-ethoxy)-4-oxo-3-p-tolyl-

4H-chromen-5yloxy]-ethoxy}-acetic acid

C24H24O11

MW 488.45

19-1693

6-[7-(5-Carboxy-pentyloxy)-4-oxo-3-p-tolyl-4H-chromen-5-yloxy]-

hexanoic acid

C28H32O9

MW 512.56

19-1863

(7-Carboxymethoxycarbonylmethoxy-4-oxo-3-p-tolyl-4H-chromen-5-

yloxy)-acetic acid carboxymethyl ester

C24H20O13

MW 516.42

19-1864

2-{7-[1-(1-Carboxy-ethoxycarbonyl)-ethoxy]-4-oxo-3-p-tolyl-4H-chromen

-5-yloxy}-propionic acid 1-carboxy-ethyl ester

C28H29O12

MW 557.54

OOH

OH OOMe

O

O OOMe

OOH

O

OH

O

O

O OOMe

OOH

O

OH

O

O

O OOMe

O

OOH

OOH

O

O

OOH

OOH

O

O

O

O

OMe

OHO

OHO

O O

OMeO

O

O

O

O

O

OHO

OHO

O O

OMeO

O

O

O

O

O

Page 19: Functionalized Isoflavonoids for Controlled Release

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19

19-1865

2-[2-(2-{7-[2-(2-Carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-

-4-oxo-3-p-tolyl-4H-chromen-5-yloxy}-ethoxy)-acetoxy]-ethoxy}-acetic acid

C32H36O17

MW 692.63

19-1866

6-{7-[5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-4-oxo-3-p-tolyl-

4-H-chromen-5-yloxy}-hexanoic acid 5-carboxy-pentyl ester

C40H53O12

MW 725.86

19-1694

Hydroxy-acetic acid 5-(2-hydroxy-acetoxy)-4-oxo-3

p-tolyl-4H-chromen-7-ester

C20H16O9

MW 400.35

19-1695

2-Hydroxy-propionic acid 5-(2-hydroxy-propionyl)-4-oxo-3-p

-tolyl-4H-chromen-7-yl ester

C22H20O9

MW 428.40

19-1696

(2-Hydroxy-ethoxy)-acetic acid 5-[2-(2-Hydroxy-ethoxy)-acetoxy]-4-

Oxo-3p-tolyl-4H-chromen-7-yl ester

C24H24O11

MW 488.45

19-1697

6-Hydroxy-hexanoic acid 5-hydroxy-hexanoyloxy)-4-oxo-3p-tolyl

4H –chromen-7-yl ester

C28H32O9

MW 512.56

OH OO

OO

OO

OO O

OMeO

OO

OO

OH

OHO

O

OO

OH

O

OMeO

O

O

O

O

O

OOMe

OOH

OOH

O

O

O

OOMe

O

O

O

O

OOH

OOH

O

OOMe

O

O

O

O

OH

OH

O

OOMe

OOH

OOH

O

O

Page 20: Functionalized Isoflavonoids for Controlled Release

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20

19-2614

[5-(2-Methoxyacetyl)oxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxyacetate

C22H20O9

MW 428.39

19-2615

[3-(4-Methoxyphenyl)-5-(2-methoxypropanoyloxy)-4-oxo-chromen-7-yl] 2-

methoxypropanoate

C24H24O9

MW 456.44

19-2616

[5-[2-(2-Methoxyethoxy)acetyl]oxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-(2-

methoxyethoxy)acetate

C26H28O11

MW 516.49

19-2617

[5-(6-Methoxyhexanoyloxy)-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 6-

methoxyhexanoate

C30H36O9

MW 540.60

19-2618

[2-[5-[2-(2-Methoxyacetyl)oxyacetyl]oxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-

2-oxo-ethyl] 2-methoxyacetate

C26H24O13

MW 544.46

19-2619

[2-[3-(4-Methoxyphenyl)-5-[2-(2-methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-

7-yl]oxy-1-methyl-2-oxo-ethyl] 2-methoxypropanoate

C30H32O13

MW 600.57

OO

OO

O

O

OOMe

O

OO

OO

O

O

OOMe

O

O

OO

O

OO

O

O

OOMe

O

O

O

O

O

O

O

OOMe

O

O

OO

O

OO

O

O

OOMe

O

O

O

O

OO

O

OO

O

O

OOMe

O

O

O

Page 21: Functionalized Isoflavonoids for Controlled Release

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21

19-2620

2-[2-[5-[2-[2-[2-(2-Methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy-3-(4-methoxyphenyl)-4-

oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C34H40O17

MW 720.67

19-2621

[6-[5-[6-(6-Methoxyhexanoyloxy)hexanoyloxy]-3-(4-methoxyphenyl)-4-oxo-chromen-7-

yl]oxy-6-oxo-hexyl] 6-methoxyhexanoate

C42H56O13

MW 768.89

OO

OO

O

OO

O

OO

O

O

OOMe

O

O

O

O

O

O

O

O

O

O

O

OOMe

O

O

O

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22

Functionalized Daidzein

19-1698

[3-(4-Carboxymethoxy-phenyl)-4-oxo-4H

Chromen-7-yloxy]-acetic acid

C19H14O8

MW 370.32

19-1699

2-{3-[4-(1-Carboxy-ethoxy)-phenyl]-4-oxo-4H

Chromen-7-yloxy}-propionic acid

C21H18O8

MW 398.37

19-1700

(2-{3-{4-(2-Carboxy-methoxy-ethoxy)-phenyl]-4-oxo-4H-

Chromen-7-yloxy}-ethoxy)-acetic acid

C23H22O10

MW 458.43

19-1701

6-{3-[4-(5-Carboxy-pentyloxy)-phenyl]-4-oxo-4H-chromen-7-yloxy}-

hexanoic acid

C27H30O8

MW 482.54

19-1867

[4-(7-Carboxymethoxycarbonylmethoxy-4-oxo-4H-chromen-3-yl)-phenoxy]-acetic acid

carboxymethyl ester

C23H18O12

MW 486.39

19-1868

2-(3-{4-[1-(1-Carboxy-ethoxycarbonyl)-sthoxy]-phenyl}-4-oxo-4H-chromen-7-yloxy)-

Propionic acid 1-carboxy-ethyl ester

C27H26O12

MW 542.50

O

OOH

OH

O

OO

OOH

OH

O

O

O

OO

OOH

OH

O

O

O

OO

OO

OH

OOH

OO

OOH

O

O

O

OOH

O

OHO

O

O

O

OO

OH

O

O

O

O

OHO

O

O

O

OO

OH

O

O

O

O

Page 23: Functionalized Isoflavonoids for Controlled Release

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23

19-1869

(2-{2-[2-(4-{7-[2-(2-Carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-4-oxo-4H-

chromen-3-yl}-phenoxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C31H34O16

MW 662.61

19-1870

6-(3-{4-{5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-phenyl}-4-oxo-4H-chromen-7-

yloxy)-hexanoic acid 5-carboxy-pentyl ester

C39H50O12

MW 710.83

19-1702

Hydroxy-acetic acid 3-{4-(2-hydroxy-acetoxy)-phenyl]-

4-oxo-4H-chromen-7-yl ester

C19H14O8

MW 370.32

19-1703

2-Hydroxy-propionic acid 3-[4-(2-hydroxy-propionyloxy)-

Phenyl]-4-oxo-4H-chromen-7-yl ester

C21H18O8

MW 398.37

19-1704

(2-Hydroxy-ethoxy)-acetic acid 3-{4-[2-(2-hydroxy-ethoxy)-acetoxy]

Phenyl}-4-oxo-4H-chromen-7-yl ester

C23H22O10

MW 458.43

19-1705

6-Hydroxy-hexanoic acid 3-[4-(6-hydroxy-hexanoyloxy)-phenyl]-

4-oxo-4H-chromen-7-yl ester

C27H30O8

MW 482.54

O

OO

O

O

OH

O

OH

O

OO

O

O

OH

O

OH

O

OO

O

OO

OOH

OOH

OO

OO

OH

OO

OO

OO

OH O

O

O O

OO

OH

OHO

O

O

O

O

O

O

O

O

OO

O

OO

OH

OH

Page 24: Functionalized Isoflavonoids for Controlled Release

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24

19-2622

[4-[7-(2-Methoxyacetyl)oxy-4-oxo-chromen-3-yl]phenyl] 2-methoxyacetate

C21H18O8

MW 398.36

19-2623

[4-[7-(2-Methoxypropanoyloxy)-4-oxo-chromen-3-yl]phenyl] 2-methoxypropanoate

C23H22O8

MW 426.42

19-2624

[4-[7-[2-(2-Methoxyethoxy)acetyl]oxy-4-oxo-chromen-3-yl]phenyl] 2-(2-

methoxyethoxy)acetate

C25H26O10

MW 486.47

19-2625

[4-[7-(6-Methoxyhexanoyloxy)-4-oxo-chromen-3-yl]phenyl] 6-methoxyhexanoate

C29H34O8

MW 510.58

19-2626

[2-[4-[7-[2-(2-Methoxyacetyl)oxyacetyl]oxy-4-oxo-chromen-3-yl]phenoxy]-2-oxo-ethyl]

2-methoxyacetate

C25H22O12

MW 514.43

19-2627

[2-[4-[7-[2-(2-Methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-1-

methyl-2-oxo-ethyl] 2-methoxypropanoate

C29H30O12

MW 570.54

OO

O

O OO

O

O

O

O

O

O

OO

O

O OO

O

O

O

O

O

O

OO

OO

O

O

O

O

OO

OO

O

O

O

O

OO

O

OO

O O

O

O

O

OO

OO

O

O

O

O

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25

19-2628

2-[2-[4-[7-[2-[2-[2-(2-Methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy-4-oxo-chromen-3-

yl]phenoxy]-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C33H38O16

MW 690.64

19-2629

[6-[4-[7-[6-(6-Methoxyhexanoyloxy)hexanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-6-oxo-

hexyl] 6-methoxyhexanoate

C41H54O12

738.86

OO

OOO

OO

OO

O O

O

O

OO

O

OOO

OO

O

O

O

O

O

O

O

Page 26: Functionalized Isoflavonoids for Controlled Release

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26

Functionalized 3’,4’-Dimethoxy-7-hydroxyisoflavone

19-1714

[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-

Acetic acid

C19H16O7

MW 356.34

19-1715

2-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-

7-yloxy]-propionic acid

C20H18O7

MW 370.36

19-1716

{2-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-ethoxy}-

Acetic acid

C21H20O8

MW 400.39

19-1717

6-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-

hexanoic acid

C23H24O7

MW 412.44

19-1871

[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-acetic acid carboxy methyl ester

C21H20O7

MW 384.39

O

O

OH

OMe

OMe

O

O

OOH

O

OMe

OMe

O

O

OOH

O

OMe

OMe

O

O

OO

OH

O OMe

OMe

OOH

O

O

OMe

OMe

O

OHO

O

O

O

O

O

OMe

OMe

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27

19-1872

2-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-propionic acid 1-

carboxy-ethyl ester

C23H24O7

MW 412.44

19-1873

[2-(2-{2-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-ethoxy}-acetoxy)-ethoxy]-

acetic acid

C25H28O9

MW 472.50

19-1874

6-[3-(3,4-Dimethyl-phenyl)-4-oxo-4H-chromen-7-yloxy]-hexanoic acid 5-carbpxy-pentyl

ester

C29H36O7

MW 496.61

19-1718

Hydroxy-acetic acid 3-(3,4-dimethyl-phenyl)-4-oxo-4H

Chromen-7-yl ester

C19H16O7

MW 356.34

19-1719

2-Hydroxy-propionic acid 3-(3,4-dimethyl-phenyl)-4-oxo

4H-chromen-7-yl ester

C20H18O7

MW 370.36

19-1720

(2-Hydroxy-ethoxy)-acetic acid 3-(3,4 dimethyl-phenyl)

-4-oxo-4H-chromen-7-yl ester

C21H20O8

MW 400.39

19-1721

6-Hydroxy-hexanoic acid 3-(3,4-dimethyl-phenyl)-4-oxo-4H

Chromen-7-yl ester

C23H24O7

MW 412.44

O

O

O

O

OH

OMe

OMe

O

O

O

O

OH

OMe

OMe

O

O

O

O

O

OMe

OMe

OH

O

O

O

O

OH

OMe

OMe

OHO

O

O

O

O

O

OMe

OMe

OO

OO

OO

OH O

O

OMe

OMe

OHO

O

O

O

O

O

OMe

OMe

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28

19-2630

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxyacetate

C20H18O7

MW 370.35

19-2631

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxypropanoate

C21H20O7

MW 384.38

19-2632

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 2-(2-methoxyethoxy)acetate

C22H22O8

MW 414.40

19-2633

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 6-methoxyhexanoate

C24H26O7

MW 426.46

19-2634

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-methoxyacetate

C22H20O9

MW 428.39

19-2635

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-

methoxypropanoate

C24H24O9

MW 456.44

19-2636

2-[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-(2-

methoxyethoxy)acetate

C26H28O11

MW 516.49

OO

O

O

O

OMe

OMe

OO

O

O

O

OMe

OMe

OO

O O

O

OOMe

OMe

OO

O

O

O

OMe

OMe

O OO

O

O

O

O

OMe

OMe

O OO

O

O

O

O

OMe

OMe

OO

OO

O O

O

OO OMe

OMe

Page 29: Functionalized Isoflavonoids for Controlled Release

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Hillsborough, New Jersey 08844

29

19-2637

[6-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-methoxyhexanoate

C30H36O9

MW 540.60

19-2638

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 2-[2-[3-(3,4-dimethoxyphenyl)-4-oxo-

chromen-7-yl]oxy-2-oxo-ethoxy]propanoate

C39H32O13

MW 708.68

19-2639

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-[2-[2-[3-(3,4-

dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]propanoate

C43H36O17

MW 824.76

19-2640

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-[2-[2-[3-

(3,4-dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]propanoate

C45H40O17

MW 852.81

19-2641

2-[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[3-

(3,4-dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]propanoate

C47H44O19

MW 912.86

O OO

O

O

O

OMe

OMe

O

O

OOMe

OMe

OO

OO

O

MeO

MeO

O O

O

OOMe

OMe

OO

OO

OO

O

MeO

MeO

O

O O

O

O

OOMe

OMe

OO

OO

OO

O

MeO

MeO

O

O O

O

O

OOMe

OMe

OO

OO

OO

OO

O

MeO

MeO

O O O O

Page 30: Functionalized Isoflavonoids for Controlled Release

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Hillsborough, New Jersey 08844

30

19-2642

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[6-[3-(3,4-dimethoxyphenyl)-4-

oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-ethoxy]acetyl]oxyhexanoate

C51H52O17

MW 936.97

19-2643

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-(3,4-dimethoxyphenyl)-4-oxo-

chromen-6-yl]oxy-2-oxo-ethoxy]hexanoate

C42H38O13

MW 750.76

19-2644

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]hexanoate

C46H42O17

MW 866.84

19-2645

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-

(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]hexanoate

C48H46O17

MW 894.89

19-2646

2-[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-

(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]hexanoate

C50H50O19

MW 954.94

O

OOMe

OMe

OO

OO

OO

O

MeO

MeO

O

O O

O

OO

OO

O O

O

OO

O

O

O

OMe

OMe

O

MeO

MeO

OO

OO

O O

O

OO

O

O

O

OMe

OMe

O

MeO

MeO

OO

OO

OO

O O

OOOO

O

OOMe

OMe

O

MeO

MeO

OO

O O

OO

O

O

OMe

OMeO

MeO

MeO

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Hillsborough, New Jersey 08844

31

19-2647

[6-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]hexanoate

C54H58O17

MW 979.05

19-2648

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-(3,4-dimethoxyphenyl)-4-oxo-

chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]hexanoate

C43H40O13

MW 764.79

19-2649

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C47H44O17

MW 880.86

19-2650

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-

(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C49H48O17

MW 908.92

19-2651

2-[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-

(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C51H52O19

MW 968.97

O

O

OO

OO

O

O

O

O

O O

O

OMe

OMe

OMe

MeO

O

O

OO

OO

O O

OMe

OMe

OMe

OMe

O

O

O

OO

OO

OO

O

O O

O

OMe

OMe

OMe

OMe

O

O

O

OO

OO

OO

O

O O

O

OMe

OMe

OMe

OMe

O

OO

OO

OO

O O

OOOO

O

O

OMe

OMeO

MeO

MeO

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Hillsborough, New Jersey 08844

32

19-2652

[6-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C55H60O17

MW 993.08

19-2653

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[2-(3,4-dimethoxyphenyl)-4-oxo-

chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]hexanoate

C44H42O14

MW 794.82

19-2654

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C48H46O18

MW 910.8

19-2655

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-

[2-(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C50H50O18

MW 938.95

19-2656

2-[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-

[2-(3,4-dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C52H54O20

MW 999

OO

OO

O O

O

OO

O

O

O

OMe

OMe

MeO

MeOO

OOO

O

OO

O

O

O

OMe

OMe

OMe

OMe

O

O OO

OO

OO O

O

O

O

O

O

OMe

OMe

OMe

OMe

O

O OO

OO

OO O

O

O

O

O

O

OMe

OMe

OMe

OMe

O

OOO

OO

OO

OOO

O O

O O

OOMe

OMe

OMe

OMe

O

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Hillsborough, New Jersey 08844

33

19-2657

[6-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[2-[6-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C56H62O18

MW 1023.11

19-2658

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-(3,4-dimethoxyphenyl)-4-oxo-

chromen-6-yl]oxy-2-oxo-ethoxy]acetate

C38H30O13

MW 694.66

19-2659

[2-[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]acetate

C42H34O17

MW 810.73

19-2660

[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-(3,4-dimethoxyphenyl)-4-

oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-ethoxy]acetyl]oxypropanoate

C44H38O17

MW 838.78

19-2661

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]acetyl]oxyethoxy]acetate

C46H42O19

MW 898.84

OOO

OO

OOO

O

O

O

O

O

OMe

OMe

OMe

OMe

O

OO

OO

O O

O

OMe

OMe OMe

OMe

O O

OO

OO

OO

O

O O

O

O

OMe

OMeOMe

OMeO O

OO

OO

OO

O

O O

O

O

OMe

OMeOMe

OMeO O

OO

OO

OO

OO

O O O O

O

OMe

OMe OMe

OMe

O O

Page 34: Functionalized Isoflavonoids for Controlled Release

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34

19-2662

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[6-[2-(3,4-dimethoxyphenyl)-4-

oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]acetyl]oxyhexanoate

C50H50O17

MW 922.95

19-2663

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[3-(3,4-dimethoxyphenyl)-4-oxo-

chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]acetate

C40H34O14

MW 738.71

19-2664

[2-[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[3-(3,4-

dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]acetate

C44H38O18

MW 854.78

19-2665

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[3-(3,4-dimethoxyphenyl)-

4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]acetyl]oxypropanoate

C46H42O18

MW 882.84

19-2666

2-[2-[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-

[3-(3,4-dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]acetate

C48H46O20

MW 942.87

OO

OO

OO

O

O O

O

O

OMe

OMe OMe

OMe

O O

OOO

OOO

O

O

OOMe

OMe

OMe

OMe

O

OOO

OO

OOO

O

O

O

O

O

OMe

OMe

OMe

OMe

O

OOO

OO

OOO

O

O

O

O

O

OMe

OMe

OMe

OMe

O

O OO

OO

OO

OO O

O

OO

OO

OMe

OMe

OMe

OMe

O

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35

19-2667

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[6-[3-(3,4-dimethoxyphenyl)-

4-oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxyhexanoate

C52H54O18

MW 966.97

19-2668

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[3-(3,4-dimethoxyphenyl)-4-

oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C42H38O15

MW 782.74

19-2670

[2-[3-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[2-[2-(3,4-

dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C46H42O19

MW 898.81

19-2671

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[3-(3,4-

dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C48H46O19

MW 926.87

19-2672

2-[2-[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-

[2-[3-(3,4-dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C50H50O21

MW 986.92

O

O

OO

OO

OOO

O

O

O

O

OMe

OMe

OMe

OMe

O

O

O

OO

OO

OO

O O

OMe OMe

OMe OMeO

O

O

OO

OO

OO

OO

O

O O

O

OMeOMe

OMe OMeO

O

O

OO

OO

OO

OO

O

O O

O

OMeOMe

OMe OMeO

O

O

OO

OO

OO

OO

OO

O O O O

OMeOMe

OMe OMeO

Page 36: Functionalized Isoflavonoids for Controlled Release

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Hillsborough, New Jersey 08844

36

19-2673

[2-(3,4-Dimethoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[2-[6-[3-(3,4

dimethoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C54H58O19

MW 1011.03

O

O

OO

OO

OO

OO

O

O O

O

OMe

OMeOMe

OMeO

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37

Functionalized 6,4’-Dimethoxy-7-hydroxyisoflavone

19-1722

(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-

acetic acid

C19H16O7

MW 356.34

19-1723

2-(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-propionic acid

C20H18O7

MW 370.36

19-1724

[2-(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-ethoxy]

acetic acid

C21H20O8

MW 400.39

19-1725

6-(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-hexanoic acid

C23H24O7

MW 412.44

19-1875

(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-acetic acid

Carboxymethyl ester

C21H20O7

MW 384.39

O

O

OH

OMe

MeO

O

O

OOH

O

OMe

MeO

O

O

OOH

O

OMe

MeO

O

O

OO

OH

O

OMe

MeO

OOH

O

OOMe

O

MeO

OHO

O

O

O

O

OOMe

MeO

Page 38: Functionalized Isoflavonoids for Controlled Release

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38

19-1876

2-(6-Methyl-4-oxo-p-tolyl-4H-chromen-7-yloxy)-propionic acid 1-

carboxy-ethyl ester

C23H24O7

MW 412.44

19-1877

(2-{2-[2-(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-ethoxy]-acetoxy}-ethoxy)-

acetic acid

C25H28O9

MW 472.50

19-1878

6-(6-Methyl-4-oxo-3-p-tolyl-4H-chromen-7-yloxy)-hexanoic acid 5-carboxy-pentyl ester

C29H34O9

MW 526.59

19-1726

Hydroxy-acetic acid 6-methyl-4-oxo-3-p-tolyl-4H

chromen-7-yl ester

C19H16O7

MW 365.34

19-1727

2-Hydroxy-propionic acid 6-methyl 4-oxo-3-p-tolyl

4H-chromen-7-yl ester

C20H18O7

MW 370.36

19-1728

(2-Hydroxy-ethoxy)-acetic acid 6-methyl 4-oxo-3-p-tolyl-4H

Chromen-7-yl ester

C21H20O8

MW 400.39

19-1729

6-Hydroxy-hexanoic acid 6-methyl-4-oxo-3-p-tolyl-

4H chromen-7-yl ester

C23H24O7

MW 412.44

O

O

O

O

OH

OMe

MeO

O

O

O

O

OH

OMe

MeO

O

O

O

O

O

OMe

OH

MeO

O

O

O

O

OH

OMe

MeO

OHO

O

O

O

O

OOMe

MeO

OO

OO

OO

OH O

O

MeO

OMe

OHO

O

O

O

O

OOMe

MeO

Page 39: Functionalized Isoflavonoids for Controlled Release

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39

19-2674

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxyacetate

C20H18O7

MW 370.35

19-2675

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxypropanoate

C21H20O7

MW 384.38

19-2676

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-(2-methoxyethoxy)acetate

C22H22O8

MW 414.40

19-2677

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 6-methoxyhexanoate

C24H26O7

MW 426.46

19-2678

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-

methoxyacetate

C22H20O9

MW 428.39

19-2679

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-

methoxypropanoate

C24H24O9

MW 456.44

19-2680

2-[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-(2-

methoxyethoxy)acetate

C26H28O11

MW 516.49

OO

O

O

OOMe

MeO

OO

O

O

OOMe

MeO

OO

O O

O

O

OMe

MeO

OO O

O

O

OMe

MeO

O OO

O

O

OOMe

O

MeO

O OO

O

O

OOMe

O

MeO

OO

O O O

O

O

OMe

MeO

O

O

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40

19-2681

[6-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-

methoxyhexanoate

C30H36O9

MW 540.60

19-2682

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 2-[2-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]propanoate

C39H32O13

MW 708.66

19-2683

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-[2-[2-[6-

methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]propanoate

C43H36O17

MW 824.74

19-2684

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-

[2-[2-[6-methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-

2-oxo-ethoxy]propanoate

C45H40O17

MW 852.79

19-2685

2-[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[6-methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-

oxo-ethoxy]propanoate

C47H44O19

MW 912.84

19-2686

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[6-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]acetyl]oxyhexanoate

C51H52O17

MW 936.95

O OO

O

O

OOMe

O

MeO

OOO

OO

OO

O

O

O O

O

OOMe OMe

MeOOMe

OOO

OO

OO

O

O

O O

O

OOMe OMe

OMe MeO

OOO

OO

OO

OO

O

O O O O

OOMe OMe

OMe MeO

OOO

OO

OO

O

O

O O

O

OOMe OMe

OMe MeO

OOO

OO

O

O O

O

OMe

OMeMeO

MeO

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41

19-2687

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]hexanoate

C42H38O13

MW 750.74

19-2688

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]hexanoate

C46H42O17

MW 866.82

19-2689

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-

[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-

2-oxo-ethoxy]hexanoate

C48H46O17

MW 894.87

19-2690

2-[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-

oxo-ethoxy]hexanoate

C50H50O19

MW 954.92

19-2691

[6-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexyl] 6-[2-[6-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]hexanoate

C54H58O17

MW 979.0

OO

OO

OO

O

O O

O

O

OMe

OMeOO

MeO

MeO

OO

OO

OO

O O

O

OOOO

O

OOMe

OMe

MeO

MeO

OO

O O

O

OO

O

OOMe

OMe

MeO

MeO

OO

OO

O O

O

O

OO

O

O

O

OMe

OMe

MeO

MeO

OO

OO

O O

O

O

OO

O

O

O

OMe

OMe

MeO

MeO

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42

19-2692

[2-(4-Acetoxyphenyl)-7-methoxy-4-oxo-chromen-6-yl] 6-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]hexanoate

C43H40O13

MW 764.77

19-2693

[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(4-

hydroxyphenyl)-7-methoxy-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C47H44O17

MW 880.84

19-2694

[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 6-

[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-

1-methyl-2-oxo-ethoxy]hexanoate

C49H48O17

MW 908.90

19-2695

2-[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-1-

methyl-2-oxo-ethoxy]hexanoate

C51H52O19

MW 968.95

19-2696

[6-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[6-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C55H60O17

MW 993.05

OO

OO

O

O O

O

OOMe

OMe

MeO

MeO

OO

OO

OO

O

O

O O

O

O

O

OMe

OMeMeO

MeO

OO

OO

OO

O

O

O O

O

O

O

OMe

OMeMeO

MeO

OO

OO

OO

O O

OOOO

O

O

OMe

OMeMeO

MeO

O

OO

OO

O O

O

OO

O

O

O

OMe

OMe

MeO

MeOO

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43

19-2697

[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]hexanoate

C44H42O14

MW 794.80

19-2698

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C48H46O18

MW 910.87

19-2699

[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-

[2-[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-

ethoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C50H50O18

MW 938.92

19-2700

2-[2-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-

[2-[2-[2-[7-methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-

ethoxy]ethoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C52H54O20

MW 998.97

O

O

O

OO

O

OO

OO

O

O

O

OOO

OMe

OMe

MeO

MeO

O OO

OO

OO O

O

O

O

O

O

OMe

OMe

O

MeO

MeO

O

O

OO

O

OO

O

O

O

OMe

OMe

MeO

MeO

O OO

OO

OO O

O

O

O

O

O

OMe

OMe

O

MeO

MeO

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44

19-2701

[6-[6-Methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[2-[6-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C56H62O18

MW 1023.08

19-2702

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]acetate

C38H30O13

MW 694.64

19-2703

[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[7-

methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]acetate

C42H34O17

MW 810.71

19-2704

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]acetyl]oxypropanoate

C44H38O17

MW 838.76

19-2705

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[7-methoxy-2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]acetyl]oxyethoxy]acetate

C46H42O19

MW898.81

OOO

OO

OO

O

O

O

O

O

O

O

OMe

OMe

MeO

MeO

OO

OO

O O

O

OMe

OMe

MeO

MeO

O O

OO

OO

OO

O

O O

O

O

OMe

OMe

MeO

MeO

O O

OO

OO

OO

O

O O

O

O

OMe

OMe

MeO

MeO

O O

OO

OO

OO

OO

O O O O

O

OMe

OMe

MeO

MeO

O O

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45

19-2706

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[6-[7-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]acetyl]oxyhexanoate

C50H50O17

MW 922.92

19-2707

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]acetate

C40H34O14

MW 738.69

19-2708

[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[6-

methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]acetate

C44H38O18

MW 854.76

19-2709

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]acetyl]oxypropanoate

C46H42O18

MW 882.81

19-2710

2-[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[2-[6-methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-

ethoxy]ethoxy]-2-oxo-ethoxy]ethoxy]acetate

C48H46O20

MW 942.87

OOO

OO

OOO

O

O

O

O

O

OMe

OMe

MeO

MeO

O

OOO

OO

OOO

O

O

O

O

O

OMe

OMe

MeO

MeO

O

O OO

OO

OO

OO O

O

OO

OOOMe

OMe

OMeO

MeO

OO

OO

OO

O

O O

O

O

OMe

OMe

MeO

MeO

O O

OOO

OOO

O

O

OOMe

OMe

MeO

MeO

O

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46

19-2711

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[6-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]acetyl]oxyhexanoate

C52H54O18

MW 966.97

19-2712

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C42H38O15

MW 782.74

19-2713

[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[2-

[6-methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C46H42O19

MW 898.81

19-2714

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C48H46O19

926.87

19-2715

2-[2-[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-

[2-[2-[2-[2-[6-methoxy-3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-

ethoxy]ethoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C50H50O21

MW 986.92

O

O

OO

OO

OOO

O

O

O

O

OMe

OMe

OMeO

MeO

O

O

OO

OO

OO

O O

OMe

OMe

OMeO

MeO

O

O

OO

OO

OO

OO

O

O O

OOMe

OMeO

MeO

MeO

O

O

OO

OO

OO

OO

O

O O

OOMe

OMeO

MeO

MeO

O

O

OO

OO

OO

OO

OO

O O O OOMe

OMeMeO

MeO

O

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47

19-2716

[7-Methoxy-2-(4-methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[2-[6-[6-methoxy-3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C54H58O19

MW 1101.03

O

O

OO

OO

OO

OO

O

O O

O

OMe

OMeMeO

MeO

O

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48

Functionalized Formononetin

19-1730

(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-acetic acid

C18H14O6

MW 326.31

19-1731

2-(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-propionic acid

C19H16O6

MW 340.34

19-1732

[2-(4-Oxo-3-p-tolyl-4H-chromen-7-yl oxy)-ethoxy]-

acetic acid

C20H18O7

MW 370.36

19-1733

6-(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy) hexanoic acid

C22H22O6

MW 382.42

19-1879

(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-acetic acid carboxymethyl ester

C20H16O7

MW 368.35

O

O

OH

OMe

O

O

OOH

O

OMe

O

O

OOH

O

OMe

O

O

OO

OH

O

OMe

OOH

O

OOMe

O

OHO

O

O

O

O

OOMe

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49

19-1880

2-(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-propionic acid 1-carboxy-ethyl ester

C22H21O7

MW 397.41

19-1881

(2-{2-[2-(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C24H25O9

MW 457.46

19-1882

6-(4-Oxo-3-p-tolyl-4H-chromen-7-yloxy)-hexanoic acid 5-carboxy-pentyl ester

C28H33O7

MW 481.57

19-1734

Hydroxy-acetic acid-4-oxo-3-p-tolyl-4H-chromen-

7-yl ester

C18H14O6

MW 326.31

19-1735

2-Hydroxy-propionic acid 4-oxo-3-p-tolyl-4H-

chromen-7-yl ester

C19H16O6

MW 340.34

19-1736

(2-Hydroxy-ethoxy)-acetic acid 4-oxo-3-p-tolyl-4H-chromen-7-yl ester

C20H18O7

MW 370.36

19-1737

6-Hydroxy-hexanoic acid 4-oxo-3-p-tolyl-4H-chromen

-7-yl ester

C22H22O6

MW 382.42

O

O

O

O

OH

OMe

O

O

O

O

OH

OMe

O

O

O

O

O

OMe

OH

O

O

O

O

OH

OMe

OHO

O

O

O

O

OOMe

OO

OO

OO

OH O

OOMe

OHO

O

O

O

O

OOMe

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50

19-2717

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxyacetate

C19H16O6

MW 340.33

19-2718

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 2-methoxypropanoate

C20H18O6

MW 354.35

19-2719

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 2-(2-methoxyethoxy)acetate

C21H20O7

MW 384.38

19-2720

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 6-methoxyhexanoate

C23H24O6

MW 396.43

19-2721

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-methoxyacetate

C21H18O8

MW 398.36

19-2722

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-

methoxypropanoate

C23H22O8

MW 426.42

19-2723

2-[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-(2-

methoxyethoxy)acetate

C25H26O10

MW 486.47

OO

O

O

OOMe

OO

O

O

OOMe

OO

O

O

OOMe

O O O

O

O

OMe

O

O OO

O

O

OOMe

O

O OO

O

O

OOMe

O

OO

O O O

O

O

OMe

O

O

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51

19-2724

[6-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-methoxyhexanoate

C29H34O8

MW 510.58

19-2725

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 2-[2-[3-(4-methoxyphenyl)-4-oxo-chromen-

7-yl]oxy-2-oxo-ethoxy]propanoate

C37H28O11

MW 648.61

19-2726

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 2-[2-[2-[3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]propanoate

C41H32O15

MW 764.68

19-2727

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 2-[2-[2-[3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]propanoate

C43H36O15

MW 792.74

19-2728

2-[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]propanoate

C45H40O17

MW 852.79

O OO

O

O

OOMe

O

OOO

OO

O

O O

OOMeMeO

OOO

OO

OO

O

O

O O

O

OOMeMeO

OOO

OO

OO

O

O

O O

O

OOMeMeO

OOO

OO

OO

OO

O

O O O O

OOMeMeO

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52

19-2729

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[6-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-ethoxy]acetyl]oxyhexanoate

C49H48O15

MW 876.90

19-2730

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-(4-methoxyphenyl)-4-oxo-chromen-

6-yl]oxy-2-oxo-ethoxy]hexanoate

C40H34O11

MW 690.69

19-2731

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]hexanoate

C44H38O15

MW 806.76

19-2732

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]hexanoate

C46H42O15

MW 834.82

19-2733

2-[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-ethoxy]hexanoate

C48H46O17

MW 894.87

OOO

OO

OO

O

O

O O

O

OOMeMeO

OO

O O

OO

O

OOMeMeO

O

OO

OO

O

O

OO

O

O

O

OMeMeOO

OO

OO

O

O

OO

O

O

O

OMeMeOO

OO

OO

OO

O O

OOOO

O

OOMeMeO

O

Page 53: Functionalized Isoflavonoids for Controlled Release

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53

19-2734

[6-[3-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]hexanoate

C52H54O15

MW 918.98

19-2735

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-(4-methoxyphenyl)-4-oxo-chromen-

6-yl]oxy-1-methyl-2-oxo-ethoxy]hexanoate

C41H36O11

MW 704.72

19-2736

[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C45H40O15

MW 820.79

19-2737

[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C47H46O14

MW834.86

19-2738

2-[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C49H48O17

MW 908.90

OO

OO

OO

O

O O

O

O

OMeO O

MeO

OO

OO

O O

O

OMeO O

MeO

OO

OO

OO

O

O O

O

O

OMeMeOO O

OO

OO

OO

O

O O

O

O

OMeMeOO O

OO

OO

OO

O O

OOOO

O

OOMe

OMeO

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54

19-2739

[6-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[6-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-1-methyl-2-oxo-

ethoxy]hexanoate

C53H56O15

MW 933

19-2740

[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl] 6-[2-[2-[2-(4-methoxyphenyl)-4-oxo-

chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]hexanoate

C42H38O12

MW 732.74

19-2741

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethyl] 6-[2-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C46H42O16

MW 850.82

19-2742

[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-1-methyl-2-oxo-ethyl] 6-[2-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C48H46O16

MW 878.87

19-2743

2-[2-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-[2-

(4-methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C50H50O18

MW 938.92

OO

OO

O O

O

OO

O

O

OOMe

OMeO

OOO

O

OO

O

O

O

OMe

MeO

O

O OO

OO

OO O

O

O

O

O

O

OMe

MeO

O

O OO

OO

OO O

O

O

O

O

O

OMe

MeO

O

OOO

OO

OO

OOO

O O

O O

OOMe

MeOO

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55

19-2744

[6-[3-(4-Methoxyphenyl)-4-oxo-chromen-7-yl]oxy-6-oxo-hexyl] 6-[2-[2-[6-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C54H58O16

MW 963.03

19-2745

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-(4-methoxyphenyl)-4-oxo-chromen-

6-yl]oxy-2-oxo-ethoxy]acetate

C36H26O11

MW 634.58

19-2746

[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-(4-

methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]acetate

C40H30O15

MW 750.66

19-2747

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-(4-methoxyphenyl)-4-oxo-

chromen-6-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-ethoxy]acetyl]oxypropanoate

C42H34O15

MW 778.71

19-2748

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[2-(4-methoxyphenyl)-4-oxo-

chromen-6-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-ethoxy]acetyl]oxyethoxy]acetate

C44H38O17

MW 838.76

OOO

OO

OOO

O

O

O

O

OOMe

MeOO

OO

OO

O O

O

OMeO O

MeO

OO

OO

OO

O

O O

O

O

OMeO O

MeO

OO

OO

OO

O

O O

O

O

OMeO O

MeO

OO

OO

OO

OO

O O O O

O

OMeO O

MeO

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56

19-2749

[3-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[6-[2-(4-methoxyphenyl)-4-oxo-

chromen-6-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]acetyl]oxyhexanoate

C48H46O15

MW 862.87

19-2750

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]acetate

C38H30O12

MW 678.64

19-2751

[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]acetate

C42H34O16

MW 794.71

19-2752

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxypropanoate

C44H38O16

MW 822.76

19-2753

2-[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-[3-

(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]acetate

C46H42O18

MW 882.81

OO

OO

OO

O

O O

O

O

OMeO O

MeO

OOO

OOO

O

O

OOMe

OMeO

OOO

OO

OOO

O

O

O

O

OOMe

OMeO

OOO

OO

OOO

O

O

O

O

OOMe

OMeO

O OO

OO

OO

OO O

O

OO

OO

OMe

OMeO

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57

19-2754

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[6-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxyhexanoate

C50H50O16

MW 906.92

19-2755

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C40H34O13

MW 722.69

19-2756

[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethyl] 2-[2-[2-[2-[2-[3-(4-

methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C44H38O17

MW 838.76

19-2757

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 2-[2-[2-[2-[2-[2-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-1-methyl-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C46H42O17

MW 866.82

19-2758

2-[2-[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl]oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-[2-

[3-(4-methoxyphenyl)-4-oxo-chromen-7-yl]oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C48H46O19

MW 926.87

O

O

OO

OO

OOO

O

O

O

O

OMe

MeOO

O

O

OO

OO

OO

O O

OMeMeOO

O

O

OO

OO

OO

OO

O

O O

O

OMeO

MeO

O

O

OO

OO

OO

OO

O

O O

O

OMeO

MeO

O

O

OO

OO

OO

OO

OO

O O O O

OMeO

MeO

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58

19-2759

[2-(4-Methoxyphenyl)-4-oxo-chromen-6-yl] 6-[2-[2-[2-[2-[6-[3-(4-methoxyphenyl)-4-oxo-

chromen-7-yl]oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C52H54O17

MW 950.97

O

O

OO

OO

OO

OO

O

O O

O

OMeO

MeO

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59

Functionalized Genistein

19-1738

[5-Carboxymethoxy-3-(4-carboxymethoxy-phenyl)-4-oxo

-4-H-chromen-7-yloxy]-acetic acid

C21H16O11

MW 444.36

19-1739

2-{5-(1-Carboxy-ethoxy)-3-[4-(1-carboxy-ethoxy)-phenyl]

-4-oxo-4H-chromen-7-yloxy}-propionic acid

C24H22O11

MW 486.44

19-1740

(2-{5-(2-Carboxymethoxy-ethoxy)-3-[4-(2-carboxymethoxy-ethoxy)-phenyl]-4-oxo-4H-

chromen-7-yloxy}-ethoxy)-acetic acid

C27H28O14

MW 576.52

19-1741

6-{7-(4-Carboxy-butoxy)-3-[4-(4-carboxy-butoxy)-pheny;]-4-oxo-4H

Chromen-5-yloxy}-hexanoic acid

C31H36O11

MW 584.63

19-1883

[7-Carboxymethoxycarbonylmethoxy-3-(4-carboxymethoxycarbonylmethoxy-phenyl)-4-

oxo-4H-chromen-5-yloxy]-acetic acid carboxymethyl ester

C27H22O17

MW 618.47

O

OOH

OH

OH

O

OO

OOH

OH

O

O

OOH

O

O

OO

OOH

OH

O

O

OOH

O

O

OO

OO

OH

OOH

OO

OO

OH

O

O

OO

OOH

OH

OO

OOH

O

OO

OH

O

O

OHO

OHO

O O

O

O

O

O

O

O

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60

19-1884

2-(4-{5,7-Bis-[1-(1-carboxy-ethoxycarbonyl)-ethoxy]-4-oxo-4H-chromen-3-yl}phenoxy)-

propionic acid 1 carboxy-ethyl ester

C33H34O17

MW 702.63

19-1885

(2-{2-[2-(4-{5,7-Bis-[2-(2-carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-4-oxo-4H-

chromen-3-yl}-phenoxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C39H46O23

MW 882.79

19-1886

6-(5-[5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-3-{4-[5-(5

carboxypentyloxycarbonyl)-pentyloxy]-phenyl}-4-oxo-4H-chromen-7-yloxy)-hexanoic

acid 5-carboxy-pentyl ester

C51H70O17

MW 955.12

19-1742

Hydroxy-acetic acid 5-(2-hydroxy-acetoxy)-3-[4-(2-hydroxy-acetoxy)-

Phenyl]-4-oxo-4H-chromen-7-yl ester

C21H16O11

MW 444.36

19-1743

2-Hydroxy-propionic acid 5-(2-hydroxy-propionyloxy)-3-[4-(2-hydroxy-propionyloxy)-

phenyl]-4-oxo-4H-chromen-7-yl ester

C24H22O11

MW 486.44

19-1744

(2-Hydroxy-ethoxy)-acetic acid 5-[2-(2-hydroxy-ethoxy)-acetoxy]-3-{4-[2-(2-hydroxy-

ethoxy)-acetoxy]-phenyl}-4-oxo-4H-chromen-7-yl ester

C27H28O14

MW 576.52

O

OO

O

O

OH

O

OHOOH

O

O

OO

O

O

OH

O

OHOOH

O

O

OO

O

OO

OOH

OOH

OO

OH

O

OO

OH

O

O

OHO

OHO

O O

O

O

O

O

O

O

OO

OO

OH

O O

OH OO

OO

OO

OO O

O

OO

OO

OH

OO

OH

O

O

OHO

O

OO

OH

O

O

O

O

O

O

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61

19-1745

6-Hydroxy-hexanoic acid 5-(6-hydroxy-hexanoyloxy)-3-[4-(6-hydroxy-hexanoyloxy)-

phenyl]-4-oxo-4H-chromen-7-yl ester

C33H40O11

MW 612.68

19-2760

[4-[5,7-Bis[(2-Methoxyacetyl)oxy]-4-oxo-chromen-3-yl]phenyl] 2-methoxyacetate

C24H22O11

MW 486.42

19-2761

[4-[5,7-Bis(2-Methoxypropanoyloxy)-4-oxo-chromen-3-yl]phenyl] 2-methoxypropanoate

C27H28O11

MW 528.50

19-2762

[4-[5,7-Bis[[2-(2-methoxyethoxy)acetyl]oxy]-4-oxo-chromen-3-yl]phenyl] 2-(2-

methoxyethoxy)acetate

C30H34O14

MW 618.58

19-2763

[4-[5,7-Bis(6-methoxyhexanoyloxy)-4-oxo-chromen-3-yl]phenyl] 6-methoxyhexanoate

C36H46O11

MW 654.74

19-2764

[2-[4-[5,7-Bis[[2-(2-methoxyacetyl)oxyacetyl]oxy]-4-oxo-chromen-3-yl]phenoxy]-2-oxo-

ethyl] 2-methoxyacetate

C30H28O17

MW 660.53

O

OO

O

OO

OH

OH

OOH

O

OO

OO

O

OOO

O

O

O

OO

OO

O

OOO

O

O

O

OO

OO

OO

OO

O

O

O

O

O

O

OO

OO

OO

O

O

O

O

O

O

OOO

OO

O

O

OOO

O

O

O O

O

O

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62

19-2765

[2-[4-[5,7-Bis[2-(2-methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-

1-methyl-2-oxo-ethyl] 2-methoxypropanoate

C36H40O17

MW 744.69

19-2766

2-[2-[4-[5,7-Bis[[2-[2-[2-(2-methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy]-4-oxo-chromen-

3-yl]phenoxy]-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C42H52O23

MW 924.85

19-2767

[6-[4-[5,7-Bis[6-(6-methoxyhexanoyloxy)hexanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-6-

oxo-hexyl] 6-methoxyhexanoate

C54H76O17

MW 997.17

O

OOO

OO

O

O

OOO

O

O

O O

O

O

OO

OO

OO

OO

OO

OO

OO

O

OO

O

O

OO

O O

OO

OO

OO

OO

O

O

O

O

O

O

O O

O

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63

Functionalized Glycitein

19-1754

[3-(4-Carboxymethoxy-phenyl)-6-methyl-4-oxo-4H

Chromen-7-yloxy]-acetic acid

C20H16O9

MW 400.35

19-1755

2-{3-[4-(1-Carboxy-ethoxy)-phenyl]-6-methyl-4-oxo-4H

Chromen-7-yloxy}-propionic acid

C22H20O9

MW 428.40

19-1756

(2-{3-[4-(2-Carboxymethoxy-ethoxy)-phenyl]-6-methyl-4-oxo-4H-chromen-7-yloxy}-

ethoxy)-acetic acid

C24H24O11

MW 488.45

19-1757

6-{4-[7-(5-Carboxy-pentyloxy)-6-methyl-4-oxo-4H-

chromen-3-yl ]-phenoxy}hexanoic acid

C28H32O9

MW 512.56

19-1887

[4-(7-Carboxymethoxycarbonylmethoxy-6-methyl-4-oxo-4H-chromen-3-yl)-phenoxy]-

acetic acid carboxymethyl ester

C24H20O13

MW 516.42

O

OOH

OH

MeO

O

OO

OOH

OH

O

O

MeO

O

OO

OOH

OH

O

O

MeO

O

OO

OO

OH

OOH

OOMeO

OOH

OOH

O

O

O

O

MeO

OHO

O

O

O

OO

OH

O

O

O

OMeO

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64

19-1888

2-(3-{4-[1-(1-Carboxy-ethoxycarbonyl)-ethoxy]-phenyl}-6-methyl-4-oxo-4H-chromen-7-

yloxy)-propionic acid 1-carboxyethyl ester

C28H28O13

MW 572.53

19-1889

(2-{2-[2-(4-{7-[2-(2-Carboxymethoxyethoxycarbonylmethoxy)-ethoxy]-6-methyl-4-oxo-

4H-chromen-3-yl}-phenoxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C32H37O16

MW 677.64

19-1890

6-(3-{4-[5-(5-Carboxypentyloxycarbonyl)-pentyloxy]-phenyl}-6-methyl-4-oxo-4H-

chromen-7-yloxy)-hexanoic acid 5-carboxypentyl ester

C40H53O12

MW 725.86

19-1758

Hydroxy-acetic acid 3-[4-(2-hydroxy-acetoxy)-pheny;]-

-6-methyl-4-oxo-4H-chromen-7-yl ester

C20H16O9

MW 400.35

19-1759

2-Hydroxy-propionic acid 3-[4-(2-hydroxy-propionyloxy)-

phenyl]-6-methyl-4-oxo-4H-chromen-7-yl ester

C22H20O9

MW 428.40

19-1760

(2-Hydroxy-ethoxy)-acetic acid3-{4-[2-(2-hydroxy-ethoxy)-acetoxy]-

Phenyl}-6-methyl-4-oxo-4H-chromen-7-yl ester

C24H24O11

MW 488.45

O

OO

O

O

OH

O

OH

MeO

O

OO

O

O

OH

O

OH

MeO

O

OO

O

OO

OOH

OOH

MeO

OHO

O

O

O

OO

OH

O

O

O

OMeO

OO

OO

OH

O O

OO

OO O

O

OO

OH

MeO

OO

OH

O

O

OHO

O O

O

O

O

OMe

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65

19-1761

6-Hydroxy-hexanoic acid 3-[4-(6-hydroxy-hexanoyloxy)-phenyl]-6-methyl-4-oxo-4H-

chromen-7-yl ester

C28H32O9

MW 512.56

19-2768

[4-[6-Methoxy-7-(2-methoxyacetyl)oxy-4-oxo-chromen-3-yl]phenyl] 2-methoxyacetate

C22H20O9

MW 428.39

19-2769

[4-[6-Methoxy-7-(2-methoxypropanoyloxy)-4-oxo-chromen-3-yl]phenyl] 2-

methoxypropanoate

C24H24O9

MW 456.4

19-2770

[4-[6-Methoxy-7-[2-(2-methoxyethoxy)acetyl]oxy-4-oxo-chromen-3-yl]phenyl] 2-(2-

methoxyethoxy)acetate

C26H28O11

MW 516.49

19-2771

[4-[6-Methoxy-7-(6-methoxyhexanoyloxy)-4-oxo-chromen-3-yl]phenyl] 6-

methoxyhexanoate

C30H36O9

MW 540.6

19-2772

[2-[4-[6-Methoxy-7-[2-(2-methoxyacetyl)oxyacetyl]oxy-4-oxo-chromen-3-yl]phenoxy]-2-

oxo-ethyl] 2-methoxyacetate

C26H24O13

MW 544.46

O

OO

O

OO

OH

OH

MeO

OO

O

OOO

O

O

MeO

OO

O

OOO

O

O

MeO

OO

O

OO

O

O

O

O

OMeO

OO

OO

O

O

O

OMeO

O

OOO

O

OOO

O

O

O

O

MeO

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66

19-2773

[2-[4-[6-Methoxy-7-[2-(2-methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-3-

yl]phenoxy]-1-methyl-2-oxo-ethyl] 2-methoxypropanoate

C30H32O13

MW 600.57

19-2774

2-[2-[4-[6-Methoxy-7-[2-[2-[2-(2-methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy-4-oxo-

chromen-3-yl]phenoxy]-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C34H40O17

MW 720.67

19-2775

[6-[4-[6-Methoxy-7-[6-(6-methoxyhexanoyloxy)hexanoyloxy]-4-oxo-chromen-3-

yl]phenoxy]-6-oxo-hexyl] 6-methoxyhexanoate

C42H56O13

MW 768.89

O

OOO

O

OOO

O

O

O

O

MeO

OO

OOO

OO

OO

O

O

O

O

OMeOO

O

O

O

OO

OO

O

O

O

OMeO

O

O

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67

Functionalized 7-Hydroxyisoflavone

19-1762

(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid

C17H12O5

MW 296.28

19-1763

2-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-propionic acid

C18H14O5

MW 310.31

19-1764

[2-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-ethoxy]-acetic acid

C19H16O6

MW 340.34

19-1765

6-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-hexanoic acid

C21H20O5

MW 352.39

19-1891

(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid carboxymethyl

ester

C19H14O7

MW 354.32

19-1892

2-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-propionic acid 1-carboxy-ethyl ester

C21H18O7

MW 382.37

O

O

OH

O

O

OOH

O

O

O

OOH

O

O

O

OO

OH

O

OOH

O

O

O

OHO

O

O

O

O

O

OHO

O

O

O

O

O

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68

19-1893

(2-{2-[2-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C23H22O9

MW 442.43

19-1894

6-(4-Oxo-3-phenyl-4H-chromen-7-yloxy)-hexanoic acid 5-carboxypentyl ester

C27H30O7

MW 466.54

19-1766

Hydroxy- acetic acid 4-oxo-3-phenyl-4H-chromen-7-yl ester

C17H12O5

MW 296.28

19-1767

2-Hydroxy-propionic acid 4-oxo-3-phenyl-4H-chromen-7-yl ester

C18H14O5

MW 310.31

19-1768

(2-Hydroxy-ethoxy)-acetic acid 4-oxo-3-phenyl-4H-chromen

7-yl ester

C19H16O6

MW 340.34

19-1769

6-Hydroxy-hexanoic acid 4-oxo-3-phenyl-4H-chromen-7-

yl ester

C21H20O5

MW 352.39

19-2776

(4-Oxo-3-phenyl-chromen-7-yl) 2-methoxyacetate

C18H14O5

MW 310.30

O

O

O

O

OH

O

O

O

O

OH

O

O

O

O

OOH

O

O

O

O

OH

OO

OO O

O

OO

OH

OHO

O O

O

O

O

OOO

O

O

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69

19-2777

(4-Oxo-3-phenyl-chromen-7-yl) 2-methoxypropanoate

C19H16O5

MW 324.33

19-2778

(4-Oxo-3-phenyl-chromen-7-yl) 2-(2-methoxyethoxy)acetate

C20H18O6

MW354.35

19-2779

(4-Oxo-3-phenyl-chromen-7-yl) 6-methoxyhexanoate

C22H22O5

MW 366.41

19-2780

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-methoxyacetate

C20H16O7

MW 368.34

19-2781

[1-Methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-methoxypropanoate

C22H20O7

MW 396.39

19-2782

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C24H24O9

MW 456.44

19-2783

[6-Oxo-6-(4-oxo-3-phenyl-chromen-7-yl)oxy-hexyl] 6-methoxyhexanoate

C28H32O7

MW 480.55

OOO

O

O

OO

O

O

O

O

OO

O

O

O

O OOO

O

O

O

O OOO

O

O

O

OO O

OO

O

O

O

O

O OO

O

O

O

O

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70

19-2836

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]propanoate

C35H24O9

MW 620.60

19-2837

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-[2-oxo-2-[2-oxo-2-(4-oxo-3-phenyl-

chromen-7-yl)oxy-ethoxy]ethoxy]propanoate

C39H28O13

MW 736.67

19-2838

[1-Methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-[2-[1-methyl-2-oxo-2-(4-

oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]-2-oxo-ethoxy]propanoate

C41H32O13

MW 764.73

19-2839

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 2-[2-oxo-2-[2-[2-oxo-2-(4-

oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]propanoate

C43H36O15

MW 824.78

19-2840

(4-Oxo-3-phenyl-chromen-7-yl) 6-[2-[1-methyl-2-oxo-2-[6-oxo-6-(4-oxo-3-phenyl-

chromen-7-yl)oxy-hexoxy]ethoxy]acetyl]oxyhexanoate

C47H44O13

MW 848.89

19-2841

(4-Oxo-3-phenyl-chromen-7-yl) 6-[2-oxo-2-(4-oxo-2-phenyl-chromen-6-yl)oxy-

ethoxy]hexanoate

C38H30O9

MW 662.68

OOO

OO

O

O O

O

OOO

OO

OO

O

O

O O

O

O

OOO

OO

OO

O

O

O O

O

O

OOO

OO

OO

OO

O

O O O O

O

OOO

OO

OO

O

O

O O

O

O

OO

O O

OO

O

O O

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71

19-2842

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 6-[2-oxo-2-[2-oxo-2-(4-oxo-2-phenyl-

chromen-6-yl)oxy-ethoxy]ethoxy]hexanoate

C42H34O13

MW 778.75

19-2843

[1-Methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 6-[2-[1-methyl-2-oxo-2-(4-

oxo-2-phenyl-chromen-6-yl)oxy-ethoxy]-2-oxo-ethoxy]hexanoate

C44H38O13

MW 806.81

19-2844

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 6-[2-oxo-2-[2-[2-oxo-2-(4-

oxo-2-phenyl-chromen-6-yl)oxy-ethoxy]ethoxy]ethoxy]hexanoate

C46H42O15

MW 866.86

19-2845

[6-Oxo-6-(4-oxo-2-phenyl-chromen-6-yl)oxy-hexyl] 6-[2-oxo-2-[6-oxo-6-(4-oxo-2-phenyl-

chromen-6-yl)oxy-hexoxy]ethoxy]hexanoate

C50H50O13

MW 890.97

19-2846

(4-Oxo-2-phenyl-chromen-7-yl) 6-[1-methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]hexanoate

C39H32O9

MW 676.71

OO

OO

O O

O

OO

O

O

O O

OO

OO

O O

O

OO

O

O

O O

OO

OO

OO

O O

OOOO

O

O O

OO

OO

O

O

O

O

O O

O

O

O

O

OO

OO

O

O O

O

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72

19-2847

[2-Oxo-2-(4-oxo-2-phenyl-chromen-7-yl)oxy-ethyl] 6-[1-methyl-2-oxo-2-[2-oxo-2-(4-oxo-

3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]hexanoate

C43H36O13

MW 792.78

19-2848

[1-Methyl-2-oxo-2-(4-oxo-2-phenyl-chromen-7-yl)oxy-ethyl] 6-[1-methyl-2-[1-methyl-2-

oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]-2-oxo-ethoxy]hexanoate

C45H40O13

MW 820.83

19-2849

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 6-[1-methyl-2-oxo-2-[2-[2-

oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]hexanoate

C47H44O15

MW 880.88

19-2850

[6-Oxo-6-(4-oxo-3-phenyl-chromen-7-yl)oxy-hexyl] 6-[1-methyl-2-oxo-2-[6-oxo-6-(4-oxo-

3-phenyl-chromen-7-yl)oxy-hexoxy]ethoxy]hexanoate

C51H52O13

MW 904.99

19-2851

(4-Oxo-2-phenyl-chromen-6-yl) 6-[2-[2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]ethoxy]hexanoate

C40H34O10

MW 706.73

OO

OO

OO

O O

O

OOOO

O

O

OO

OO

O O

O

O

OO

O

O

O

O

OO

OO

OO

O

O

O O

O

O

O

OO

OO

OO

O

O

O O

O

O

O

O

OO

O

OO

O

O

O

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73

19-2852

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 6-[2-[2-oxo-2-[2-oxo-2-(4-oxo-2-

phenyl-chromen-6-yl)oxy-ethoxy]ethoxy]ethoxy]hexanoate

C44H38O14

MW 822.80

19-2853

[1-Methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 6-[2-[2-[1-methyl-2-oxo-2-

(4-oxo-2-phenyl-chromen-6-yl)oxy-ethoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C46H42O14

MW 850.86

19-2854

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 6-[2-[2-oxo-2-[2-[2-oxo-2-(4-

oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]ethoxy]hexanoate

C48H46O16

MW 910.91

19-2855

[6-Oxo-6-(4-oxo-3-phenyl-chromen-7-yl)oxy-hexyl] 6-[2-[2-oxo-2-[6-oxo-6-(4-oxo-3-

phenyl-chromen-7-yl)oxy-hexoxy]ethoxy]ethoxy]hexanoate

C52H54O14

MW 935.02

19-2856

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]acetate

C34H22O9

MW 606.57

O

O

OO

O

OO

OO

O

O

O

OO

O

O

OOO

OO

OOO

O

O

O

O

O

O

OO

OO

O

O O

O

O

O OO

OO

OO O

O

O

O

O

O

O

O OO

OO

OO O

O

O

O

O

O

O

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19-2857

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-[2-oxo-2-[2-oxo-2-(4-oxo-3-phenyl-

chromen-7-yl)oxy-ethoxy]ethoxy]acetate

C38H26O13

MW 722.65

19-2858

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[1-methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-7-

yl)oxy-ethoxy]-2-oxo-ethoxy]acetyl]oxypropanoate

C40H30O13

MW 750.70

19-2859

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-oxo-2-[2-[2-oxo-2-(4-oxo-3-phenyl-chromen-

7-yl)oxy-ethoxy]ethoxy]ethoxy]acetyl]oxyethoxy]acetate

C42H34O15

MW 810.75

19-2860

(4-Oxo-3-phenyl-chromen-7-yl) 6-[2-[2-oxo-2-[6-oxo-6-(4-oxo-3-phenyl-chromen-7-

yl)oxy-hexoxy]ethoxy]acetyl]oxyhexanoate

C46H42O13

MW 834.86

19-2861

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]ethoxy]acetate

C36H26O10

MW 650.63

OO

OO

OO

O

O

O O

O

O

O

OO

OO

OO

O

O

O O

O

O

O

OO

OO

OO

OO

O

O O O O

O

O

OO

OO

OO

O

O

O O

O

O

O

OOO

OOO

O

O

O

O

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19-2862

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-[2-[2-oxo-2-[2-oxo-2-(4-oxo-3-

phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]acetate

C40H30O14

MW 766.70

19-2863

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-[1-methyl-2-oxo-2-(4-oxo-3-phenyl-chromen-

7-yl)oxy-ethoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxypropanoate

C42H34O14

MW 794.75

19-2864

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 2-[2-[2-oxo-2-[2-[2-oxo-2-(4-

oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]ethoxy]acetate

C44H38O16

MW 854.80

19-2865

(4-Oxo-3-phenyl-chromen-7-yl) 6-[2-[2-[2-oxo-2-[6-oxo-6-(4-oxo-3-phenyl-chromen-7-

yl)oxy-hexoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C48H46O14

MW 878.91

19-2866

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-

ethoxy]ethoxy]ethoxy]acetate

C38H30O11

MW 694.68

OOO

OO

OOO

O

O

O

O

O

O

OOO

OO

OOO

O

O

O

O

O

O

O

O

OO

OO

OO

OO O

O

OO

OO

O

O

OO

OO

OOO

O

O

O

O

O

O

O

OO

OO

OO

O

O O

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19-2867

[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethyl] 2-[2-[2-[2-oxo-2-[2-oxo-2-(4-oxo-3-

phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]ethoxy]acetate

C42H34O15

MW 810.75

19-2868

(4-Oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-[2-[1-methyl-2-oxo-2-(4-oxo-3-phenyl-

chromen-7-yl)oxy-ethoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C44H38O15

MW 838.80

19-2869

2-[2-Oxo-2-(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethyl 2-[2-[2-[2-oxo-2-[2-[2-oxo-2-

(4-oxo-3-phenyl-chromen-7-yl)oxy-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate

C46H42O17

MW 898.86

19-2870

(4-Oxo-3-phenyl-chromen-7-yl) 6-[2-[2-[2-[2-oxo-2-[6-oxo-6-(4-oxo-3-phenyl-chromen-

7-yl)oxy-hexoxy]ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C50H50O15

MW 922.96

O

O

OO

OO

OO

OO

O

O

O O

O

O

O

OO

OO

OO

OO

O

O

O O

O

O

O

OO

OO

OO

OO

OO

O

O O O O

O

O

OO

OO

OO

OO

O

O

O O

O

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77

Functionalized 7-Hydroxy-8-methyl isoflavone

19-1778

(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid

C18H14O5

MW 310.31

19-1779

2-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-propionic acid

C19H16O5

MW 324.34

19-1780

[2-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-ethoxy]-

acetic acid

C20H18O6

MW 354.36

19-1781

6-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-hexanoic acid

C22H22O5

MW 366.42

19-1899

(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid carboxymethyl

ester

C20H16O7

MW 368.35

19-1900

2-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-propionic acid 1-carboxy

ethyl ester

C22H20O7

MW 396.40

O

O

OH

CH3

O

O

OOH

O CH3

O

O

OOH

O CH3

O

O

OO

OH

O

CH3

OOH

O

O

O CH3

OHO

O

O

O

O

O

CH3

OHO

O

O

O

O

O

CH3

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19-1901

(2-{2-[2-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-ethoxy]-acetoxy}

ethoxy)-acetic acid

C24H24O9

MW 456.45

19-1902

6-(8-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-hexanoic acid5-carboxy

pentyl ester

C28H32O7

MW 480.56

19-1782

Hydroxy-acetic acid 8-methyl-4-oxo-3-phenyl-4H-chromen-7-yl ester

C18H14O5

MW 310.31

19-1783

2-Hydroxy-propionic acid 8-methyl-4-oxo-3-phenyl-4H

chromen-7-yl ester

C19H16O5

MW 324.34

19-1784

(2-Hydroxy-ethoxy)-acetic acid 8-methyl-4-oxo-3-phenyl-4H

chromen-7-yl ester

C20H18O6

MW 354.36

19-1785

6-Hydroxy-hexanoic acid 8-methyl-4-oxo-3-pheny;-4H-chromen

-7-yl ester

C22H22O5

MW 366.42

19-2792

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-methoxyacetate

C19H16O5

MW 324.33

O

O

O

O

OH

CH3

O

O

O

O

OH

CH3

O

O

O

O

OOH

CH3

O

O

O

O

OH

CH3

OO

OO O

O

OO

OH

CH3

OHO

O O

O

O

O

CH3

OO O

O

O

CH3

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79

19-2793

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-methoxypropanoate

C20H18O5

MW 338.35

19-2794

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-(2-methoxyethoxy)acetate

C21H20O6

MW 368.38

19-2795

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-methoxyhexanoate

C23H24O5

MW 380.43

19-2796

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-methoxyacetate

C21H18O7

MW 382.36

19-2797

[1-Methyl-2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-

methoxypropanoate

C23H22O7

MW 410.42

19-2798

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 2-(2-

methoxyethoxy)acetate

C25H26O9

MW 470.47

19-2799

[6-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-6-oxo-hexyl] 6-methoxyhexanoate

C29H34O7

MW 494.58

OO O

O

O

CH3

OO

O O

O

O

CH3

OO O

O

O

CH3

OO

O O

O

O

O CH3

OO

O O

O

O

O CH3

OO O

OO O

O

OO

CH3

OO

O O

O

O

O CH3

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80

19-1770

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-(8-methyl-4-oxo-3-phenyl-chromen-7-

yl)oxy-2-oxo-ethoxy]propanoate

C37H28O9

MW 616.61

19-1771

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-[2-[2-(8-methyl-4-oxo-3-

phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]propanoate

C41H32O13

MW 732.68

19-1772

[1-Methyl-2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-[2-[1-methyl-2-

(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]propanoate

C43H36O13

MW 760.74

19-1773

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-(8-

methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]propanoate

C45H40O15

MW 820.79

19-1774

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-[2-[1-methyl-2-[6-(8-methyl-4-oxo-3-phenyl-

chromen-7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]acetyl]oxyhexanoate

C49H48O13

MW 844.90

OOO

OO

O

O O

O

CH3

CH3

OOO

OO

OO

O

O

O O

O

O

CH3

CH3

OOO

OO

OO

O

O

O O

O

O

CH3

CH3

OOO

OO

OO

OO

O

O O O O

O

CH3

CH3

OOO

OO

OO

O

O

O O

O

O

CH3

CH3

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81

19-1775

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-[2-(5-methyl-4-oxo-2-phenyl-chromen-6-

yl)oxy-2-oxo-ethoxy]hexanoate

C40H34O9

MW 658.69

19-1776

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[2-[2-(5-methyl-4-oxo-2-

phenyl-chromen-6-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]hexanoate

C44H38O14

MW 774.76

19-1777

[1-Methyl-2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[2-[1-methyl-2-

(5-methyl-4-oxo-2-phenyl-chromen-6-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]hexanoate

C46H42O13

MW 802.82

19-1895

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-(5-

methyl-4-oxo-2-phenyl-chromen-6-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-ethoxy]hexanoate

C48H46O15

MW 862.87

19-1896

[6-(7-methyl-4-oxo-2-phenyl-chromen-6-yl)oxy-6-oxo-hexyl] 6-[2-[6-(7-methyl-4-oxo-2-

phenyl-chromen-6-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]hexanoate

C52H54O13

MW 886.98

OO

O O

CH3

OO

CH3

O

O O

OO

OO

O O

CH3

O

OO

O

CH3

O

O O

OO

OO

O O

CH3

O

OO

O

CH3

O

O O

CH3

OO

OO

OO

CH3O

O O

O

O

O O

OO

OO

OO

O O

CH3

OOOO

CH3

O

O O

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82

19-1897

(5-Methyl-4-oxo-3-phenyl-chromen-6-yl) 6-[1-methyl-2-(5-methyl-4-oxo-2-phenyl-

chromen-6-yl)oxy-2-oxo-ethoxy]hexanoate

C41H36O9

MW 672.72

19-1898

[2-(8-Methyl-4-oxo-2-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[1-methyl-2-[2-(8-methyl-

4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]hexanoate

C45H40O13

MW 788.79

19-2784

[1-Methyl-2-(8-methyl-4-oxo-2-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[1-methyl-2-[1-

methyl-2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]hexanoate

C47H44O13

MW 816.84

19-2785

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 6-[1-methyl-2-[2-

[2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]hexanoate

C49H48O15

MW 876.90

19-2786

[6-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-6-oxo-hexyl] 6-[1-methyl-2-[6-(8-methyl-

4-oxo-3-phenyl-chromen-7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]hexanoate

C53H56O13

MW 901

OO

OO

OO

O O

OOOO

O

O O

CH3

CH3

OO

OO

O O

O

OO

O

O

O O

CH3

CH3

O

CH3

OO

OO

O

CH3

O O

O

O

O

CH3

OO

OO

OO

O

CH3

O

O O

O

O

O

CH3

OO

OO

OO

O

CH3

O

O O

O

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83

19-2787 (8-Methyl-4-oxo-2-phenyl-chromen-6-yl) 6-[2-[2-(8-methyl-4-oxo-3-phenyl-chromen-7-

yl)oxy-2-oxo-ethoxy]ethoxy]hexanoate

C42H38O10

MW 702.77

19-2788

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[2-[2-[2-(8-methyl-4-oxo-

2-phenyl-chromen-6-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C46H42O14

MW 818.82

19-2789

[1-Methyl-2-(8-methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 6-[2-[2-[1-methyl-

2-(8-methyl-4-oxo-2-phenyl-chromen-6-yl)oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C48H46O14

MW 846.87

19-2790

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 6-[2-[2-[2-[2-(8-

methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]hexanoate

C50H50O16

MW 938.96

19-2791

[6-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-6-oxo-hexyl] 6-[2-[2-[6-(8-methyl-4-oxo-

3-phenyl-chromen-7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]hexanoate

C54H58O14

MW 963.03

O

O

OO

O

OO

OO

O

O

O

OO

O

O

CH3

CH3

OOO

OO

OOO

O

O

O

O

O

CH3

CH3

O

O

O

OO

O

OO

O

O

OCH

3

CH3

O OO

OO

OO O

O

O

O

O

CH3

O

CH3

O

O OO

OO

OO O

O

O

O

O

CH3

O

CH3

O

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84

19-2821

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-(8-methyl-4-oxo-3-phenyl-chromen-7-

yl)oxy-2-oxo-ethoxy]acetate

C38H26O9

MW 634.63

19-2822

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-[2-[2-(8-methyl-4-oxo-3-

phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]acetate

C40H30O13

MW 750.70

19-2823

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[1-methyl-2-(8-methyl-4-oxo-3-phenyl-

chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]acetyl]oxypropanoate

C42H34O13

MW 778.75

19-2824

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-[2-[2-(8-methyl-4-oxo-3-phenyl-

chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-ethoxy]acetyl]oxyethoxy]acetate

C44H38O15

MW 838.80

19-2825

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-[2-[2-[6-(8-methyl-4-oxo-3-phenyl-chromen-

7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]acetyl]oxyhexanoate

C48H46O13

MW 862.91

19-2826

(8-methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-(8-methyl-4-oxo-3-phenyl-chromen-7-

yl)oxy-2-oxo-ethoxy]ethoxy]acetate

C38H30O10

MW 678.68

OO

OO

O O

O

O O

CH3

CH3

OO

OO

OO

O

O O

O

O

O O

CH3

CH3

OO

OO

OO

O

CH3

O

O O

O

CH3

O

O

OO

OO

OO

OO

O O O O

O

O O

CH3

CH3

OO

OO

OO

O

O O

O

O

O O

CH3

CH3

OOO

OOO

O

O

O

O

CH3

CH3

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85

19-2827

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-[2-[2-[2-(8-methyl-4-oxo-

3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]acetate

C42H34O14

MW 794.75

19-2828

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-[1-methyl-2-(8-methyl-4-oxo-3-

phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxypropanoate

C44H38O14

MW 822.80

19-2829

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-(8-

methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]acetate

C46H42O16

MW 882.86

19-2830

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-[2-[2-[2-[6-(8-methyl-4-oxo-3-phenyl-

chromen-7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]acetyl]oxyhexanoate

C50H50O15

MW 906.96

19-2831

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-(8-methyl-4-oxo-3-phenyl-chromen-

7-yl)oxy-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C40H34O11

MW 722.73

19-2832

[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethyl] 2-[2-[2-[2-[2-(8-methyl-4-

oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetate

C44H38O15

MW 838.8

OOO

OO

OOO

O

O

O

O

O

O

CH3

CH3

OOO

OO

OOO

O

O

O

O

O

O

CH3

CH3

O OO

OO

OO

OO O

O

OO

OO

O

CH3

CH3

O

O

OO

OO

OOO

O

O

O

OCH3

CH3

O

O

O

OO

OO

OO

O O

O

CH3

CH3

O

O

OO

OO

OO

OO

O

O O

O

O

CH3

CH3

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86

19-2833

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 2-[2-[2-[2-[2-[1-methyl-2-(8-methyl-4-oxo-3-

phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetyl]oxypropanoate

C46H42O15

MW 866.86

19-2834

2-[2-(8-Methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethyl 2-[2-[2-[2-[2-[2-(8-

methyl-4-oxo-3-phenyl-chromen-7-yl)oxy-2-oxo-ethoxy]ethoxy]-2-oxo-

ethoxy]ethoxy]ethoxy]acetate

C48H46O17

MW 926.91

19-2835

(8-Methyl-4-oxo-3-phenyl-chromen-7-yl) 6-[2-[2-[2-[2-[6-(8-methyl-4-oxo-3-phenyl-

chromen-7-yl)oxy-6-oxo-hexoxy]-2-oxo-ethoxy]ethoxy]ethoxy]acetyl]oxyhexanoate

C52H54O15

MW 951.02

O

O

OO

OO

OO

OO

O

O O

O

O

CH3

CH3

O

O

OO

OO

OO

OO

OO

O O O O

O

CH3

CH3

O

O

OO

OO

OO

OO

O

O O

O

O

CH3

CH3

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Functionalized Prunetin

19-1786

[4-(5-Carboxymethoxy-7-methyl-4-oxo-4H-chromen-3-yl)-phenoxy]-

acetic acid

C20H16O9

MW 400.35

19-1787

2-{4-[5-(1-Carboxy-ethoxy)-7-methyl-4-oxo-4H-chromen-3-yl]-

phenoxy]-propionic acid

C22H20O9

MW 428.40

19-1788

(2-{4-[5-(2-Carboxymethoxy-ethoxy)-7-methyl-4-oxo-4H-chromen-3-yl]-

phenoxy}-ethoxy)-acetic acid

C24H24O11

MW 488.45

19-1789

6-{3-[4-(4-Carboxy-butoxy)-phenyl]-7-methyl-4-oxo-4H-

chromen-5-yloxy}-hexanoic acid

C27H30O9

MW 498.53

19-1903

[3-(4-Carboxymethoxycarbonylmethoxy-phenyl)-7-methyl-4-oxo-4H-chromen-5-yloxy]-

acetic acid carboxymethyl ester

C24H21O12

MW 501.43

O

OOH

OH

MeO

O

OO

OH

O

OOH

O

MeO

O

OO

OH

O

OOH

O

MeO

O

OO

OOH

O

OO

OH

O

MeO

O

OO OH

O

OOH

O

MeO

OO

OH

O

O

OHO

O

O

O

O

O

MeO

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19-1904

2-(4-{5-[1-(1-Carboxy-ethoxycarbonyl)-ethoxy]-7-methyl-4-oxo-4H-chromen-3-yl}-

phenoxy)-propionic acid 1-carboxy-ethyl ester

C28H29O12

MW 557.54

19-1905

(2-{2-[2-(4-{5-[2-(2-Carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-7-methyl-4-oxo-

4H-chromen-3-yl}-phenoxy)-ethoxy]-acetoxy}-ethoxy)-acetic

acid

C32H37O16

MW 677.64

19-1906

6-(4-{5-[5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-7-methyl-4-oxo-4H-chromen-3-

yl}-phenoxy)-hexanoic acid-5-carboxy –pentyl ester

C40H53O12

MW 725.86

19-1790

Hydroxy-acetic acid 4-[5-(2-hydroxy-acetoxy)-7-methyl-4-

Oxo-4H-chromen-3-yl]-phenyl ester

C20H16O9

MW 400.35

19-1791

2-Hydroxy-propionic acid 4-[5-(2-hydroxy-propionyloxy)-7-methyl-4-

oxo-4H-chromen-3-yl]-phenyl ester

C22H22O9

MW 428.40

19-1792

(2-Hydroxy-ethoxy)-acetic acid 4-{5-[2-(2-hydroxy-ethoxy)-acetoxy]-

7-methyl-4-oxo-4H-chromen-3-yl}-phenyl ester

C24H24O11

MW 488.45

19-1793

6-Hydroxy-hexanoic acid 4-[5-(6-hydroxy-hexanoyloxy)-7-methyl-4-oxo-4H-chromen-3-

yl]-phenyl ester

C28H32O9

MW 512.56

O

OO

O

OHOOH

O

MeO

O

OO

O

OHOOH

O

MeO

O

OO

O

OOH

OO

OH

O

MeO

O

OO

O

OHOOH

O

MeO

OO

OH

O

O

OHO

O

O

O

O

O

MeO

OO

OO

OH

O O

OH OO

OO

O

O

OO

MeO

OO

OH

O

O

OO

OH

O

O

O

O

MeO

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19-2800

[4-[7-Methoxy-5-(2-methoxyacetyl)oxy-4-oxo-chromen-3-yl]phenyl] 2-methoxyacetate

C22H20O9

MW 428.39

19-2801

[4-[7-Methoxy-5-(2-methoxypropanoyloxy)-4-oxo-chromen-3-yl]phenyl] 2-

methoxypropanoate

C24H24O9

MW 456.44

19-2802

[4-[7-Methoxy-5-[2-(2-methoxyethoxy)acetyl]oxy-4-oxo-chromen-3-yl]phenyl] 2-(2-

methoxyethoxy)acetate

C26H28O11

MW 516.49

19-2803

[4-[7-Methoxy-5-(6-methoxyhexanoyloxy)-4-oxo-chromen-3-yl]phenyl] 6-

methoxyhexanoate

C30H36O9

MW 540.60

19-2804

[2-[4-[7-Methoxy-5-[2-(2-methoxyacetyl)oxyacetyl]oxy-4-oxo-chromen-3-yl]phenoxy]-2-

oxo-ethyl] 2-methoxyacetate

C26H24O13

MW 544.46

19-2805

[2-[4-[7-Methoxy-5-[2-(2-methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-3-

yl]phenoxy]-1-methyl-2-oxo-ethyl] 2-methoxypropanoate

C30H32O13

MW 600.57

OO

O

OO

O

O

O

MeO

OO

O

O

OO

O

O

O

O

MeO

OO

O

OO

O

O

O

MeO

O

OO

O

O

O

OOO

O

O

O

MeO

O

OO

O

O

O

OOO

O

O

O

MeO

OO

O

OO

O

O

O

MeO

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19-2806

2-[2-[4-[7-Methoxy-5-[2-[2-[2-(2-methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy-4-oxo-

chromen-3-yl]phenoxy]-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C34H40O17

MW 720.67

19-2807

[6-[4-[7-Methoxy-5-[6-(6-methoxyhexoxy)hexanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-6-

oxo-hexyl] 6-methoxyhexanoate

C42H58O12

MW 754.9

OOO

OO

OO

OO

OO

O

O O

O

O

MeO

OO

O

O

O

OO

O

O

O

O

MeO

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91

Functionalized 6,7,4’ Trihydroxyisoflavone

19-1794

[6-Carboxymethoxy-3-(4-carboxymethoxy-phenyl)-4-oxo-4H –chromen-7-yloxy]-acetic

acid

C21H16O11

MW 444.36

19-1795

2-[6-(1-Carboxy-ethoxy)-3-(4-carboxymethoxy-phenyl)-4-oxo-4H-chromen-7yloxy]-

propionic acid

C23H20O11

MW 472.41

19-1796

(2-{7-(2-Carboxymethoxy-ethoxy)-3-[4-(2-carboxymethoxy-ethoxy)-phenyl]-4-oxo-4H-

chromen-6-yloxy}-ethoxy)-acetic acid

C27H28O14

MW 576.52

19-1797

6-{4-{6,7-Bis-(5-carboxy-pentyloxy)-4-oxo-4H-chromen-3-yl]-phenoxy}-hexanoic acid

C33H40O11

MW 612.68

19-1907

[4-(6,7-Bis-carboxymethoxycarbonylmethoxy-4-oxo-4H-chromen-3-yl)-phenoxy]-acetic

acid carboxy methyl ester

C27H22O17

MW 618.47

O

OO

OOH

OH

O

O

O

OH

O

O

OO

OOH

OH

O

O

O

OH

O

OO

OH

O

O

OH

O

O

OO

OOH

OO

O

OOH

OH

OH

OOH

OH

O

OH

O O

O

O

O

O

OHO

O

O

O OO

OH

O

O

OHO

O O

O

O

O

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19-1908

2-(7-[1-(1-Carboxy-ethoxycarbonyl)-ethoxy]-3-{4-[1-(1-carboxy-ethoxy

carbonyl)-ethoxy]-phenyl}-4-oxo-4H-chromen-6-yloxy)-propionic acid 1-

carboxy-ethyl ester

C33H34O17

MW 702.63

19-1909

(2-{2-[2-(7-[2-(2-Carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-3-{4-

[2-(2-carboxymethoxy-ethoxycarbonylmethoxy)-ethoxy]-phenyl}-4-oxo-4H-chromen-6-

yloxy)-ethoxy]-acetoxy}-ethoxy)-acetic acid

C39H46O23

MW 882.79

19-1910

6-(6-[5-(5-Carboxy-pentyloxycarbonyl)-pentyloxy]-3-{4-[5-carboxy-penty

loxycarbonyl)-pentyloxy]-phenyl l}-4-oxo-4H-chromen-7-yloxy)-hexanoic acid 5

carboxy-pentyl ester

C51H70O17

MW 955.12

19-1798

Hydroxy-acetic acid 6-(2-hydroxy-acetoxy)-3-[4-(2-hydroxy-acetoxy)-

Phenyl]-4-oxo-4H-chromen-7-yl ester

C21H16O11

MW 444.36

19-1799

2-Hydroxy-propionic acid 6-(2-hydroxy-propionyloxy)-3-[4-(2-hydroxy

Propionyloxy)-phenyl]-4-oxo-4H-chromen-7-yl ester

C24H22O11

MW 486.44

O

OH

OOH

O

O

OO

O

O

OH

O

OH

OOH

O

O

OO

O

O

OH

OHO

O

O

O OO

OH

O

O

OHO

O O

O

O

O

OH OO

OO

OO OO

OO

OH

O O

OO

OO O

O

OO

OH

OO

OH

O

O OO

OH

O

O

OHO

O O

O

O

O

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19-1800

(2-Hydroxy-ethoxy)-acetic acid 7-[2-(2-hydroxy-ethoxy)-acetoxy]-3-{4-[2-(2-hydroxy-

ethoxy)-acetoxy]-phenyl}-4-oxo-4H-chromen-6-yl ester

C27H28O14

MW 576.52

19-1801

6-Hydroxy-hexanoic acid 6-(6-hydroxy-hexanoyloxy)-3-[4-(6-hydroxy-

hexanoyloxy)-phenyl]-4-oxo-4H-chromen-7-yl ester

C33H40O11

MW 612.68

19-2808

[4-[6,7-Bis[(2-methoxyacetyl)oxy]-4-oxo-chromen-3-yl]phenyl] 2-methoxyacetate

C24H22O11

MW 486.42

19-2809

[4-[6,7-Bis(2-methoxypropanoyloxy)-4-oxo-chromen-3-yl]phenyl] 2-methoxypropanoate

C27H28O11

MW 528.50

19-2810

[4-[6,7-Bis[[2-(2-methoxyethoxy)acetyl]oxy]-4-oxo-chromen-3-yl]phenyl] 2-(2-

methoxyethoxy)acetate

C30H34O14

MW 618.58

19-2811

[4-[6,7-Bis(6-methoxyhexanoyloxy)-4-oxo-chromen-3-yl]phenyl] 6-methoxyhexanoate

C36H46O11

MW 654.74

O

OH

O

OHO

OH

O

O

O

O

O

O

O

OH

OO

O

OH

O

OO

O

OOH

O

OO

O

O

OO

O

O

OO

O

OO

O

O

OO

O

O

OO

O

OO

O

O OO

O

O

OO

O

O

O

O

OO

O OO

O

OO

O

O

O

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Copyright©2018 Bezwada Biomedical LLC

Hillsborough, New Jersey 08844

94

19-2812

[2-[4-[6,7-Bis[[2-(2-methoxyacetyl)oxyacetyl]oxy]-4-oxo-chromen-3-yl]phenoxy]-2-oxo-

ethyl] 2-methoxyacetate

C30H28O17

MW 660.53

19-2813

[2-[4-[6,7-Bis[2-(2-methoxypropanoyloxy)propanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-

1-methyl-2-oxo-ethyl] 2-methoxypropanoate

C36H40O17

MW 744.69

19-2814

2-[2-[4-[6,7-Bis[[2-[2-[2-(2-methoxyethoxy)acetyl]oxyethoxy]acetyl]oxy]-4-oxo-chromen-

3-yl]phenoxy]-2-oxo-ethoxy]ethyl 2-(2-methoxyethoxy)acetate

C42H52O23

MW 924.85

19-2815

[6-[4-[6,7-Bis[6-(6-methoxyhexanoyloxy)hexanoyloxy]-4-oxo-chromen-3-yl]phenoxy]-6-

oxo-hexyl] 6-methoxyhexanoate

C54H76O17

MW 997.17

OO

O

O

O

OO

O O

OO

O

O

O

O

O

O

OO

O

O

O

OO

O O

OO

O

O

O

O

O

O

OO

OO

O

O O OO

OO

O

OO

OO

OO

O

OO

O

O

OO

O

O

O OO

O

O

O

OO

O

O

O

O

O