from yu et al. ’s website: vet.purdue/cristal/oci-info

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From Yu From Yu et al. et al. ’s ’s website: website: www.vet.purdue.edu www.vet.purdue.edu /cristal/oci-info /cristal/oci-info An experimental An experimental model for model for in vivo in vivo tumors tumors

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An experimental model for in vivo tumors. From Yu et al. ’s website: www.vet.purdue.edu/cristal/oci-info. From Yu et al. ’s website: www.vet.purdue.edu/cristal/oci-info. V. N. V. From Yu et al. ’s website: www.vet.purdue.edu/cristal/oci-info. Nutrient distribution. - PowerPoint PPT Presentation

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Page 1: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

From Yu From Yu et al.et al.’s website: ’s website: www.vet.purdue.edu/cristalwww.vet.purdue.edu/cristal

/oci-info/oci-info

An experimental An experimental model for model for in vivoin vivo

tumorstumors

Page 2: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

From Yu From Yu et al.et al.’s website: ’s website: www.vet.purdue.edu/cristalwww.vet.purdue.edu/cristal

/oci-info/oci-info VV

VV

NN

Page 3: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

From Yu From Yu et al.et al.’s website: ’s website: www.vet.purdue.edu/cristal/oci-www.vet.purdue.edu/cristal/oci-

infoinfo

Page 4: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

Nutrient distributionNutrient distribution

Inverse of OInverse of O22 distribution distribution

From Walerta From Walerta et al.et al. (2000) J. Histochem. (2000) J. Histochem. Cytochem. 48:509-522.Cytochem. 48:509-522.

Page 5: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

Published by AAAS

J. Holash et al., Science 284, 1994 -1998 (1999)

Angiogenesis in Implanted Rat C6 GliomasAngiogenesis in Implanted Rat C6 Gliomas

Page 6: From Yu  et al. ’s website: vet.purdue/cristal/oci-info

Published by AAAS

J. Holash et al., Science 284, 1994 -1998 (1999)

Cells Sense Hypoxia, Respond by Secreting VEGF and ang-2Cells Sense Hypoxia, Respond by Secreting VEGF and ang-2