from the trenches: a clinician’s perspective gogi kumar,md assistant professor wsubsom medical...

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From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s Hospital

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Page 1: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

From the trenches: A clinician’s perspective

Gogi Kumar,MDAssistant Professor

WSUBSOMMedical Director

Department of Child NeurologyDayton Children’s Hospital

Page 2: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

My Trench

Page 3: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

General Cope’s Trench

Page 4: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Case

• 13 year old with first unprovoked seizure• Mom hears a thud in the morning , finds her in

the shower having a generalized tonic- clonic seizure

• Seizure lasts for 2 minutes • Sleep deprived

Page 5: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

• CT scan, urine pregnancy and drug screen is negative

• EEG:

Page 6: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

• I diagnose her with new onset primary generalized epilepsy

• Suggest starting on Lamictal

Page 7: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

First Question

What is Epilepsy?

Page 8: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Definition of Epilepsy

• 2005 ILAE definition: 2 unprovoked seizures >24 hours apart

• Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures

Page 9: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

A practical clinical definition of epilepsyFisher et al Epilepsia,55(4):475-482,2014

ILAE Task force

Epilepsy is a disease of the brain defined by any one of the following:1.Atleast 2 unprovoked (reflex seizures) occurring >24 hour apart2.One unprovoked seizure(or reflex)seizure and a probability of further seizures similar to the general recurrence rate (at least 60%) after two unprovoked seizures occurring over the next 10 years3.Diagnosis of an epilepsy syndrome

Page 10: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

2nd Question

• Can you do any other test to be sure?• Blood test? MRI?• Does epilepsy get better?• How will I know when epilepsy has resolved?

Page 11: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Epilepsy BiomarkersEngel et al Epilepsia 2013 August;54(04)61-69

Biomarker is an objectively measured characteristic of a normal or pathological process.Uses in epilepsy include Predict the development of epilepsy Confirm the presence of epilepsy Measure progression Predict pharmaco-resistance Confirm that the condition is resolved Used to create animal models Reduce the cost of the clinical trial

Page 12: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Epilepsy BiomarkersElectrophysiology Imaging

Ictal patterns and interictal spikesFrequencies, duration, source localization, morphology, field size

Routine MRI Measures Enhancement (BBB)Functional (FMRI) Spectroscopy (MRS)Diffusion Tensor (DTI) Susceptibility (SWI)

High frequency oscillationsActivation proceduresPhotic Stimulation Hyperventilation Sleep Deprivation Drug Induction

PET (Positron Emission Tomography)FDG (Deoxyglucose) FMZ (Flumazanil)AMT (alphamethyltryptophane) PK (Inflammation)

Excitability TMS(Transcranial Magnetic Stimulation)Direct Electrical Stimulation(Part of Surgical Workup)

SPECT (Single Photon Emission Computed Tomography)

Engel et al Epilepsia 2013 August;54(04)61-69

Page 13: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

3rd Question

• What kind of epilepsy does my child have?• I was reading about seizures while waiting for

you to come and see us and read about focal and generalized seizures. Can you tell me more about this?

Page 14: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

The Organization of the Epilepsies: Report of the ILAE Commission on Classification and Terminology Ingrid E Scheffer et al

• For each patient, we should aim to diagnose seizure type(s), electroclinical syndrome and etiology where possible.

Page 15: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Organization of epilepsies

Electro clinical syndrome: age of onset, seizure types, EEG patterns, imaging features and co-morbidities such as intellectual impairment

Benign is replaced by ‘Self limited’

She has ‘Genetic generalized epilepsy’

Page 16: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Organization of epilepsies

Etiological(1) Genetic (2) Structural (3)Metabolic (4) Immune (5) Infectious (6) Unknown

Page 17: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Organization of epilepsiesDescriptors of focal seizures according to degree of impairment during seizure* Without impairment of consciousness or awareness • With observable motor or autonomic components – “Focal motor” and “autonomic” can be used • Involving subjective sensory or psychic phenomena only – “aura” can also be used • Replaces term “simple partial seizure”

With impairment of consciousness or awareness • “Dyscognitive” can also be used. It is understood that dyscognitive may not always mean altered awareness but it is used here to denote altered consciousness or awareness which may be response tested • Replaces term “complex partial seizure”

Evolving to a bilateral convulsive seizure • May include tonic, clonic or tonic and clonic components in any order • Replaces term “secondarily generalized seizure”

Page 18: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Question no 4

• Are you sure it is generalized and not focal?

Page 19: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Focal abnormalities in idiopathic generalized epilepsy

Seneviratne et al Epilepsia,55(8);1157-1169,2014

• Aura:25% to 54%, visual/epigastric/preictal prodromal symptoms

• Focal semiology:35%to 46% include head version/eye version/focal myoclonic jerks

• Absence seizures: Automatisms are common during hyperventilation

• EEG: Focal interictal abnormalities found in 1/3rd

Page 20: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Focal abnormalities in idiopathic generalized epilepsy

Seneviratne et al Epilepsia,55(8);1157-1169,2014

Cortical focus theory :Cortical focus within the perioral regions of somatosensory cortex led the thalamus by a mean of 8.1 m sec during the first 500ms of an absence seizure.Important to differentiate Idiopathic generalized epilepsy from focal frontal lobe epilepsy with secondary bilateral synchrony.

Page 21: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Question no 5

• When will she grow out of this?• How will I know?

Page 22: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Resolution of epilepsyFisher et al Epilepsia,55(4):475-482,2014

ILAE Task force

• Epilepsy is resolved for individuals who have an age dependent epilepsy syndrome and are now past the age

• Seizure free for the last 10 years with no seizure medication for the last 5 years.

Page 23: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Long-Term Outcome in Epilepsy with Grand Mal on Awakening: Forty Years ofFollow-up

Holtkamp et al, Annals of Neurology Volume 75,Issue 2 February 2014

42 patients with Epilepsy with Grandmal on Awakening (EGMA)

Follow up of 40.1 +/- 12.6 years(range=20-62).26 of 42 patients with EGMA (61.9%) were in 5 year terminal remission.

Out of the 26 patients 21 were still taking AEDs and 5 had been completely off medications.

Age at the time of investigation was the only independent predictor for seizure freedom. 35.7% in patients younger than 55 years,66.7% in patients between 56 and 65 years and 81.3% in patients older than 65 years.

AED withdrawal was done in 45.2% patients and 63.2% of them had a relapse

47.6% had an university degree and 88.1% were regularly employed.

Page 24: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Natural course and predictors of spontaneous seizure remission in idiopathic generalized epilepsy :7-27 years of follow up

Podewelis et al Epilepsy Research (2014)108,1221-1227

• 15 IGE patients who refused treatment• Mean duration of follow up was 15.3 years• 5 patients had CAE,5 patients had EGCTS,4 patients had JAE (absence

+GTCS), 1 patient had CAE• Mean age of onset of epilepsy was 15.3 years, mean duration of epilepsy

was 18.3 years and mean duration of follow up was 15.3 years• Remission rate was 80% in CAE,60% EGTCS and 20% with IGE with

ABS/GTCS.• Photoparoxysmal response was found in 20% of the patients and it was a

poor prognostic factor

Page 25: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Juvenile myoclonic epilepsy 25 years after seizure onset : A population based study

Camfield et al Neurology 2009,73;1041-1045

• 23 patients• Age at first seizure 10.4+/-4.3 years• Mean follow up of 25.8 years• Average age at follow up was 36 years• 11 (48%) no longer received AEDs, 6 of these were

seizure free,3 had myoclonus only and 2 had rare seizures

• 12 received AED treatment at the end of follow up• 1/3 rd grew out of their troublesome seizures.17% free

of all seizures.

Page 26: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Question no 6

• Will she have a normal life?

Page 27: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Psychosocial complications in Adult Life Epidemiologic aspects: Lost in transition Camfield et al

Epilepsia,55(Suppl.3):3-7,2014

Nova scotia cohort IGE• Psychiatric diagnosis (27%)• High school graduation (40%)• Pregnancy outside stable relationships (38%)• Living alone (23%)• Unemployment(33%)• Criminal conviction (7%)

Page 28: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Behavioral changes in Pediatric epilepsy syndrome

JME• Impaired abstract reasoning, cognitive speed

and planning• Janz noted ‘an engaging but emotionally

unstable, fairly immature personality, wavering between camaraderie and mistrust, which may lead to difficulties in social adaptation’

Page 29: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Death in children with epilepsy

• Children with an underlying neurological disorder sufficient to interfere with daily activities have a death rate of 25% (Nova scotia study)

• Risk of SUDEP in children without neurological disorders is same as general reference population (Nova scotia study)

Page 30: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Long-Term Mortality in Childhood-Onset EpilepsyMatti Sillanpää, M.D., Ph.D., and Shlomo Shinnar, M.D., Ph.D.

N Engl J Med 2010; 363:2522-2529 December23,2010

• 245 Finnish children with epilepsy, after 40 years of follow-up, 60 subjects had died (24%), a rate three times as high as the expected age- and sex-adjusted mortality in the general population.

• A total of 33 of 60 deaths (55%) were related to epilepsy

• A remote symptomatic cause of epilepsy associated with an increased risk of death as compared with an idiopathic or cryptogenic cause (37% vs. 12%, P<0.001).

• Risk for SUDEP was 7% at 40 years overall and 12% not in long-term remission and not receiving medication.

Page 31: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Cumulative Risk of All Epilepsy-Related Deaths and Sudden, Unexplained Deaths in Subjects with Epilepsy.

Sillanpää M, Shinnar S. N Engl J Med 2010;363:2522-2529

Page 32: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Cumulative Rate of Death According to Cause of Epilepsy.

Sillanpää M, Shinnar S. N Engl J Med 2010;363:2522-2529

Page 33: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s

Conclusions

• Childhood-onset epilepsy was associated with a substantial risk of epilepsy-related death, including sudden, unexplained death.

• The risk was especially high among children who were not in remission.

Page 34: From the trenches: A clinician’s perspective Gogi Kumar,MD Assistant Professor WSUBSOM Medical Director Department of Child Neurology Dayton Children’s