322

EBV latent gene expression similar to that of HD is

nasopharyngeal carcinoma, biopsy samples of which havebeen shown to express EBNA 1 and, in up to 65% of cases,LMP.20,27 Expression of LMP in an epithelial cellenvironment is also associated with morphologicaltransformation28 and with inhibition of differentiation.19These effects of LMP may be important in the oncogenesisof HD.

Since LMP can serve as a target for cytotoxic Tlymphocyte-mediated rejection,3o protein expression mightfacilitate host control of the disease process. However, if theycannot be rejected by the individual, LMP-positive RS cellsmay acquire a growth-advantage over LMP-negative RScells through the enhanced proliferative capacity induced byLMP. These opposing effects may lead to differences in theclinical course of LMP-positive and LMP-negative HD;this may have implications not only in diagnosis andtreatment of HD, but also possibly in the primaryprevention of this malignant disorder by vaccination.31

This work was supported by grants from the Danish Medical ResearchCouncil, the Danish Cancer Society, and the Cancer Research Campaign,London. M. R. is a Wellcome Senior Research Fellow.

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From The Lancet

Tippling in the CityThe City Press of Jan 3 says that the pernicious habit of tippling

seems on the increase in the City. Our contemporary says that at allhours of the day, at frequent intervals, young and middle-aged menof splendid physique, strong mental capacity, and sound judgmenton all points but one-viz, the habit engendered by falsely calledhospitality of drinking at odd hours-are to be observed passing inand out of the City public-houses and wine stores. This is a mostdisappointing and distressing statement. We should have hesitatedto repeat it, or aid its circulation, had it appeared in any journal lesslikely to be correctly informed of what goes on in the City. Ratherwe should have said that City men were alive to the advance ofscience and common sense, which alike dictate that tippling isdisastrous to both health and business. We were aware, of course,that there were soakers in the City-men saturated with alcohol,and even young men-but that such should be on the increase

surprises us. Can there not be some City movement, apart from theausterities of teetotalism, to remedy this great evil, and to discouragedrinking "whenever a stroke of business" is attempted or done?Such drinking is a veritable delusion, as our contemporary suggests,and all sane men should discountenance it. It is thought that somewho would not think of such practices for themselves connive atthem in their agents on business grounds. There is little distinctionin morals between a drinker and one who allows another to drink forthe good of his business.

(Jan 17, 1891)