from the ionization chamber to the on-line microstrip devices · from the ionization chamber to the...
TRANSCRIPT
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From the ionization chamber to the on-line microstrip devices:
the status of the art of detectors in proton therapy under the experience gained at the CATANA facility
G.A.P. Cirrone, Ph.D.Laboratori Nazionali del Sud – INFN Catania (I)
10th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD06) 1 - 5 October 2006 Siena, Italy
On behalf of
G. Cuttone, F. Di Rosa, P. Lojacono, V. Mongelli, S. Pittera, L. Raffaele, G. Russo, M.G. Sabini, L.M. Valastro
R. Cirio, F . Marchetto C. De Angelis, P. Fattibene, S. Onori
Laboratori Nazionali del Sud – INFN, Catania (I)
INFN Sezione di Torino, Torino (I)
Istituto Superiore di Sanità, Roma (I)
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TALK OUTLINE
1. CATANA: the Italian proton therapy facility
4. What future for clinical proton beam detectors?
2. Absolute and relative dosimetry in proton therapy:starting point for the dosimetric commissioning
3. Ten years of detector characterisation
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THE ITALIAN PROTON THERAPY CENTERTHE ITALIAN PROTON THERAPY CENTERTHE ITALIAN PROTON THERAPY CENTER
City of Catania
Nuclear physics Laboratory of INFN (National Institute for Nuclear Physics)
Superconductor cyclotron developed for research and now used also for the clynic
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CyclotronLocation
Treatment Room
Location
Laboratori Nazionali del Sud –INFN Catania, Italy
ProtonBeam
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THE TREATMENT BEAM LINETHE TREATMENT BEAM LINETHE TREATMENT BEAM LINE
First patient: March 12, 2001
Work started in 1996
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Patient Distribution by Origin RegionPatient Distribution by Origin RegionPatient Distribution by Origin Region
42
9
5
13
11
6
2
7
2
1
1
Total number of patients :
110
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Patient Distribution by PathologiesPatient Distribution by PathologiesPatient Distribution by Pathologies
Uveal Melanoma 99 patients (89.89 %)
Conjunctival MALT-NHL 1 patient (1.01 %)
Conjunctival Melanoma 5 patients (4.04 %)
Conjunctivalrhabdomyosarcoma
1 patient (1.01 %)
Eyelid Carcinomaand metastases
2 patient (2.02 %)
Conjunctival Papilloma 2 patient (2.02 %)
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SURVAIVAL RESULTSPatientsTotal Number
(April 2006)102
Dead patients 4
Metastatis 3
Other 1
Eye retention rate 92,68 %
TOTAL SURVIVAL 95 %
LOCAL CONTROL 97 %
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TALK OUTLINE
4. What future for clinical proton beam detectors?
2. Absolute and relative dosimetry in proton therapy:starting point for the dosimetric commissioning
3. Ten years of detector characterisation
1. CATANA: the Italian proton therapy facility
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DETECTOR DEVELOPMENT AND CHARACTERIZATIONDETECTOR DEVELOPMENT AND CHARACTERIZATIONDETECTOR DEVELOPMENT AND CHARACTERIZATION
STILL A NEED IN RADIATION THERAPY AND, IN PARTICULAR, IN A YET PIONEERING TECHNIQUE LIKE PROTON THERAPY
CONTINOUS R&D WORK
ABSOLUTE AND RELATIVE DOSIMETRY
(Dosimetric commissioning)
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Absolute Dosimetry: Energy Released in Water (Gray)
Relative Dosimetry: Three dimensional dose distributionmeasurements
⇓Considering the high gradient dose, conformation and small fields often used the detectors have to be kindlycharacterized in terms of spatial resolution, energy or
fluence dependence to be use in hadrontherapy.
Dosimetric commissioning: absolute & relative dosimetryDosimetricDosimetric commissioningcommissioning: : absoluteabsolute & relative & relative dosimetrydosimetry
Relative and Relative and AbsoluteAbsolute DosimetryDosimetry are are fundamentalfundamental forfor::
CustomizingCustomizing of TPS of TPS Monitor Monitor UnitUnit CalculationCalculation
QualityQuality ControlControl
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Activity started in 1996 with the first test on 62 MeV protons
Gas detector (ionisation chambers)
Film detectors
Solid state detectors
Farmer
Exradin
Pin Point
Markus
Advanced Markus
Radiographic films
GAF Chromic films
(MD52, EBT, …
•Plastic scintillators
•Diamond detector
•TLD
•MOSfet
•Silicon diode
•Silicon microstrip
10 year of work
43 papers in review journals
61 conference proceeding
DETECTOR OVERVIEWDETECTOR OVERVIEWDETECTOR OVERVIEW
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FULL ENERGY BEAM
0
20
40
60
80
100
-20 -15 -10 -5 0 5 10 15 20
Distance from axis [ mm ]
Sig
nal [
% ]
Radiochromic Film
62 MeV experimental proton beam62 62 MeVMeV experimentalexperimental protonproton beambeam
0102030405060708090
100
0 5 10 15 20 25 30 35Depth in water (mm)
Dos
e
Markus Chamber
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62 MeV experimental proton beam62 62 MeVMeV experimentalexperimental protonproton beambeam
0
10
20
30
40
50
60
70
80
90
100
110
0 5 10 15 20 25 30 35
Depth in Eye Tissue (mm)
CCO Diode BPW34l
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TALK OUTLINE
1. CATANA: the Italian proton therapy facility
4. What future for clinical proton beam detectors?
2. Absolute and relative dosimetry in proton therapy:starting point for the dosimetric commissioning
3. Ten years of detector characterisation
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WHAT WE NEED FROM A DOSEMETER?WHAT WE NEED FROM A DOSEMETER?WHAT WE NEED FROM A DOSEMETER?
• Tissue equivalence (<Z> = 6, <Z/A> = 0.5 )
• Linearity vs absorbed dose
• Independence from dose rate
• Independence from energy
• Radiation hardness
• Spatial resolution (< 1 mm)
• Small size: no perturbation of the proton fluency (Bragg-Gray theory)
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MEASUREMENT CONFIGURATIONMEASUREMENT CONFIGURATIONMEASUREMENT CONFIGURATION
0102030405060708090
100
0 5 10 15 20 25 30 35Depth in water (mm)
Dos
e
Markus Chamber
0
10
20
30
40
50
60
70
80
90
100
110
0 5 10 15 20 25 30 35
Depth in Eye Tissue (mm)
CCO Diode BPW34l
Detector placed at isocenter on a special table mounted on the treatment chair
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ABSOLUTE DOSIMETRYABSOLUTE DOSIMETRYABSOLUTE DOSIMETRY
ICRU 59 AND TRS 398 IAEA ICRU 59 AND TRS 398 IAEA RECOMMENDATIONRECOMMENDATION
⇓⇓
““ FOR MEASUREMENTS OF DEPTHFOR MEASUREMENTS OF DEPTH--DOSE DOSE DISTRIBUTION IN PROTON BEAMSDISTRIBUTION IN PROTON BEAMS
THE USE OF PLANETHE USE OF PLANE--PARALLEL CHAMBERS IS PARALLEL CHAMBERS IS RECOMMENDEDRECOMMENDED””
⇓⇓
ParallelParallel plateplate MARKUS PTWMARKUS PTW isis the golden the golden standard standard forfor depthdepth dose dose measurementsmeasurements
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Dosimetric commissioning: absolute & relative dosimetryDosimetricDosimetric commissioningcommissioning: : absoluteabsolute & relative & relative dosimetrydosimetry
ADVANCED MARKUS CHAMBERADVANCED MARKUS CHAMBER
Response: 670 pC/GyDirectional dependence: smaller than 0.1% for tilting of the chamber by up to 10ºElectrode Acrylic (PMMA), graphite coated 5 mm ØLeakage current ± 4 fA
VP = 400 V V×cm-1 = 4000 kS = 1.00 (1÷100 Gy/min.).
Pressure equilibrium ≤ 10 sec
Temperature equilibrium = 2-3 min./K
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Proton beam
Ionisation, free air monitor chamber calibrated against the Markus:
Sensibility: 5 pC
Reprucibility: 0.5 %
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DETECTOR FOR RELATIVE DOSIMETRYDETECTOR FOR RELATIVE DOSIMETRYDETECTOR FOR RELATIVE DOSIMETRY
1 2 3
5 64
1) Film Kodak: XV and EDR2 2) TLD 3) Radiochromic Film
4) Scanditronix Diode 5) PTW Natural Diamond 6) Mosfet
• In collaboration with ISS (S. Onori..) and DFC Florence (M. Bucciolini…)
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RELATIVE DOSIMETRY: FILM DETECTORSRELATIVE DOSIMETRY: FILM DETECTORSRELATIVE DOSIMETRY: FILM DETECTORS
GAFCHROMICGAFCHROMIC®® EBT ConfigurationEBT Configuration
CLEAR POLYESTER - 97 microns
CLEAR POLYESTER - 97 microns
ACTIVE LAYER - 17 microns
ACTIVE LAYER - 17 micronsSURFACE LAYER - 6 microns
1) Transmission densitometer2) Colour scanner
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SPECTRA OF NEW AND OLD RADIOCHROMIC FILMSSPECTRA OF NEW AND OLD RADIOCHROMIC FILMSSPECTRA OF NEW AND OLD RADIOCHROMIC FILMS
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
450 500 550 600 650 700 750
Wavelength, nm
Abs
orba
nce
GAFCHROMIC EBT
GAFCHROMIC HS
EPSON flatbedcolor scanner
OLD: HS ISPOLD: HS ISPNEW: EBT ISPNEW: EBT ISP
RESPONSE ENHANCED RESPONSE ENHANCED BY MEASUREMENT BY MEASUREMENT
WITH RED LIGHTWITH RED LIGHT
EBT
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ENERGY INDEPENDENCE HS GAF ENERGY INDEPENDENCE HS GAF ENERGY INDEPENDENCE HS GAF
0,0
0,5
1,0
1,5
2,0
2,5
3,0
0 5 10 15 20 25 30 35
DOSE (Gy)
N.O
.D
Full energy (62MeV), Rres.=28.9 mm
Modulated Beam (Rres.= 12 mm)
y = 0.0801x R2 = 0.9966
y = 0.0791x R2 = 0.9976
0,0
0,5
1,0
1,5
2,0
2,5
3,0
0 5 10 15 20 25 30 35
DOSE (Gy)
N.O
.D
Full energy (62MeV), Rres.=28.9 mm
Modulated Beam (Rres.= 12 mm)
y = 0.0801x R2 = 0.9966
y = 0.0791x R2 = 0.9976
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EBT GAFEBT GAF
Calibrazione Protoni 62 MeV
00,10,20,30,40,50,60,70,80,9
0 200 400 600 800 1000
Dose (cGy)
N.O
.DCalibrazione Protoni 62 MeV
00,10,20,30,40,50,60,70,80,9
0 200 400 600 800 1000
Dose (cGy)
N.O
.D
EPSON flatbedcolor scannerRED CHANNELRED CHANNEL
DOSE CALIBRATION DOSE CALIBRATION DOSE CALIBRATION
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RELATIVE DOSIMETRY: plastic scintilatorsRELATIVE DOSIMETRY: plastic RELATIVE DOSIMETRY: plastic scintilatorsscintilators
Plastic scintillatorBC 400
Alumina (Al2O3) Caesium Iodide (CsI)
• Alumina: poor in light efficiency;
• Caesium Iodide: excellent light efficiency, but scarce homogeneity;
• BC 400: good brightness and homogeneity;
BC 400 has been chosen for our experimental purposes.
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DETECTOR ARRANGEMENTDETECTOR ARRANGEMENTDETECTOR ARRANGEMENT
Mirror forming45° with the beam direction.
Camera forming90° with the beam axis, framing the image reflected by the mirror.
Scintillating screen lodged on a support,
perpendicularly to the beam axis.
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LabView EnvironmentLabViewLabView EnvironmentEnvironment
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CHARACTERIZATIONCHARACTERIZATIONCHARACTERIZATION
LINEARITY SIGNAL TO NOISE RATIO
0 2 4 6 80
50
100
150
200
250
300
Experimental data linear FIT
Equazion: y = A*x + B
A = 30.03107 ± 0.63571B = 10.58847 ± 2.77585
R2 = 0.99421
SNR
sqrt (frames)
SNR vs sqrt(frames)
Castleman says: SNR (N)= N^0.5*SNR(1)Linearity in the treatment range(10 ÷ 20 Gy/min) Experimental results
are in good agreementwith theoretical considerations
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RELATIVE DOSIMETRY: diamond detectors(synthetic and natural)RELATIVE DOSIMETRY: RELATIVE DOSIMETRY: diamonddiamond detectorsdetectors((syntheticsynthetic and and naturalnatural))
PROPRIETA’ DIAMANTE SILICIO Gap [eV] 5.5 1.12
Campo di rottura [V/cm] 107 3·105
Hole mobility [cm2/Vs] 1200 450 Velocità di saturazione [cm/s] 2.2·107 0.8·107
Mobilità elettronica [cm2/Vs] 1800 1450 Vita media dei portatori minoritari [s] 10-9 2.5·10-3
Costante dielettrica εr 5.7 11.9
Numero atomico effettivo Zeff 6 14 Energia per creare un coppia elettrone-lacuna [eV] 13 3.6
Energia di Wigner [eV] 43 13-20
Low dark current
Fast responce
time
Tissueequivalence
Radiationhardness
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ON-LINE CONFIGURATION (CVD diamond)ONON--LINE CONFIGURATION (CVD LINE CONFIGURATION (CVD diamonddiamond))
De Beer’s diamond sample with two bonding solution
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ON LINE CONFIGURATION: CVD vs NATURALON LINE CONFIGURATION: CVD ON LINE CONFIGURATION: CVD vsvs NATURALNATURAL
-200.0
-150.0
-100.0
-50.0
0.0
50.0
100.0
150.0
200.0
-500 -400 -300 -200 -100 0 100 200 300 400 500
Bias [V]
Cur
rent
[nA
]
CVD
-0.5
0.0
0.5
1.0
1.5
2.0
2.5
3.0
-150 -100 -50 0 50 100 1
Bias [V]
Cur
rent
[nA
]
Diamante Naturale
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RESPONCE vs ABSORBED DOSE (CVD diamond)RESPONCE RESPONCE vsvs ABSORBED DOSE (CVD ABSORBED DOSE (CVD diamonddiamond))
0
5
10
15
20
25
30
0 5 10 15 20 25Absorbed Dose [Gy]
Cha
rge(µC
)
Protons 62 MeVPhotons 6 MVElectrons 15 MeV
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PTW NATURAL DIAMONDPTW NATURAL DIAMONDPTW NATURAL DIAMOND
TWO PTW DIFFERENT DETECTORS HAVE BEEN STUDIEDTWO PTW DIFFERENT DETECTORS HAVE BEEN STUDIED
20 mm20 mm
7.3mm7.3mm
•Sensitive area: 4.3/4.5 mm2
•Sensitive volume: 1.3/1.4 mm3
•Thickness of sensitive volume: 0.30/0.31 mm
•Operating bias: 100 V
In photon and electron beams the relative differences have been studied and already published (see De Angelis C et al. Med. Phys. 2002; 29(2): 248-254.)
In proton beams the measured repeatibility is 0.1%
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PTW NATURAL DIAMONDPTW NATURAL DIAMONDPTW NATURAL DIAMOND
PTW Diamond Linearity (protons, photons, electrons)
0
200
400
600
800
1000
1200
1400
0 200 400 600 800 1000 1200 1400 1600Dose (Gy)
Cha
rge[
nC
ProtoniFotoni 6MVElettroni, 25 MeV
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PTW NATURAL DIAMONDPTW NATURAL DIAMONDPTW NATURAL DIAMOND
0
0,5
1
1,5
2
2,5
3
3,5
4
4,5
5
0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0 40,0
Depth in water (mm)
Ioni
zatio
n [a
.
Markus chamber
PTW Diamond
Bragg Peak Measurements
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RELATIVE DOSIMETRY: surface TLD detectorRELATIVE DOSIMETRY: RELATIVE DOSIMETRY: surfacesurface TLD detectorTLD detector
PHANTOM & DETECTORS• 0.27mm mean thickness,
• 7 detectors in each set,
• 10 detector sets.
6 setsirradiated!
in dose range4.5 – 18Gy
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READOUTS
READOUTS
(visible photo and heated)
NOISE SUBTRACTION
HOT PIXELS & ZERO BACKGROUND SETTINGS
THICKNESS CORRECTIONING FACTORS (RELATIVE TO
CALIBRATION DETECTORS)
CALIBRATION
(Co60 SOURCE UP TO 20Gy)
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RELATIVE DOSIMETRY: silicon diode and MOSFET RELATIVE DOSIMETRY: RELATIVE DOSIMETRY: siliconsilicon diodediode and MOSFET and MOSFET
MOSFET e MicroMOSFET
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SILICON DIODE SILICON DIODE SILICON DIODE SCANDITRONIX Silicon Diode
Two different p-type Scanditronix detectors having the followingfeatures have been studied:
•Thickness: 0.06 mm•Sensitive Area: 0.28 mm2
•Sensitive Volume: 0.017 mm3
•Materials tickness in front of the detectors: 0.42/0.54 mm•Center Distance from Detector Surface: 0.546/0.684
Both samples were preirradiated in proton beams, beforeshipping.
Measured repeatibility (10 meas. at 4 Gy): 0.2%Sensitivity change after 300 Gy irradiation 0.7%
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SILICON DIODE SILICON DIODE SILICON DIODE
Silicon Diode Linearity with 62 MeV Proton Beam
0
2
4
6
8
10
12
14
16
18
0 200 400 600 800 1000 1200 1400 1600 1800
Dose (cGy)
Car
ica
(nC
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0
20
40
60
80
100
120
0 10 20 30 40
Depth in w ater (mm)
Rela
tive
resp
onse
(%)
diodo LNS
Markus
0
100
200
300
400
500
600
0 10 20 30 40Depth in water (mm)
Rel
ativ
e re
spon
se (%
) Markus
Diodo ISS
The two detectors givedifferent positions of the peak.
An overestimation of the peak has beennoted (up to 6%).
SILICON DIODE: full energy Bragg peak SILICON DIODE: full SILICON DIODE: full energyenergy BraggBragg peak peak
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SILICON DIODE: Spread Out Bragg PeakSILICON DIODE: SILICON DIODE: SpreadSpread Out Out BraggBragg PeakPeak
0,0
0,2
0,4
0,6
0,8
1,0
1,2
1,4
1,6
0,0 5,0 10,0 15,0 20,0 25,0 30,0 35,0
Depth in water [mm]
Ioni
zatio
n [a
.u.]
Diode
Markus
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MOSFET (Metal Oxide Semiconductor Field Effect Transistor)MOSFET (Metal MOSFET (Metal OxideOxide Semiconductor Semiconductor FieldField EffectEffect Transistor)Transistor)
Why a MOSFET:stable, reproduciblelinear vs absorbed dosedose-rate independenceon-line readingtemperature indipendenceno fluence perturbationsmall size
It is OK for in-vivo dosimetry
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INSTRMENTATIONINSTRMENTATIONINSTRMENTATION
•Autosense™ reader• “Dual Sensitivity Bias Supply” (up to 5 MOSFETs)
2 sensibility modality: High e Standard• MOSFET TN-502RD
AutoSense™ PCSoftware V. 1.1
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Linearità MOSFETs vs MicroMOSFETs
y = 2,0309x + 12,708R2 = 0,9999
y = 2,1485x + 7,9625R2 = 1
y = 0,743x + 3,8749R2 = 0,9998
0
500
1000
1500
2000
2500
3000
3500
0 200 400 600 800 1000 1200 1400 1600
Dose assorbita in acqua [cGy]
Lettu
ra M
OSF
ET
[m
V]
MOSFET 3301 - High Sensitivity
MicroMOSFET 0132 - High Sensitivity
MOSFET 3051 - Standard Sensitivity
RESPONCE vs ABSORBED DOSERESPONCE RESPONCE vsvs ABSORBED DOSEABSORBED DOSE
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A STUDY OF THE OUTPUT FACTORSA STUDY OF THE OUTPUT FACTORSA STUDY OF THE OUTPUT FACTORS
Output Factor All dosimeters
80
85
90
95
100
105
110
0 5 10 15 20 25 30
Collimator diameter [mm]
Out
put F
acto
r
MOSFETTLDDiode ScanditronixGAFchromic FilmMicroMOSFET
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TALK OUTLINE
1. CATANA: the Italian proton therapy facility
4. What future for clinical proton beam detectors?
2. Absolute and relative dosimetry in proton therapy:starting point for the dosimetric commissioning
3. Ten years of detector characterisation
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WHY proton Computed Tomography (pCT) ? WHY WHY protonproton ComputedComputed TomographyTomography ((pCTpCT) ? ) ?
TOMOGRAPHIC IMAGE RECONSTRUCTION USING HIGH ENERGY PROTON BEAMS
MAIN IUSSUES IN PROTON THERAPY QUALITY
Patient positioning
Actually TPS are based on the xCTimages as input and this bring a sensible
amount of imprecisionDose planning
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EXPERIMENTAL SOLUTION FOR SINGLE TRAKINGEXPERIMENTAL SOLUTION FOR SINGLE TRAKINGEXPERIMENTAL SOLUTION FOR SINGLE TRAKING
All the studies and prototypes developed in the last years are based on the
principle of follow each single proton traversing the medium to investigate
( ) ( )∫∫ =in
out
E
ELe ES
dEKrdrηThe “single tracking” approach should permit toimprove the spatial risolution up to 1 mm or less
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THE PRIMA (PRoton IMAging DETECTORTHE PRIMA (THE PRIMA (PRotonPRoton IMAgingIMAging DETECTORDETECTOR
CALORIMETRO
DATA OUT USB
USB
TRIGGER
DAQ CALORIMETRO
MODULO STRIP
Single tracking
Acquisition rate up to 1 MHz
Detector: 2 orthogonal microstrip; 200 um picth x 256 strips; about 5x5 cm of active area
Trigger from the calorimeter
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THE ROLE OF MONTE CARLOTHE ROLE OF MONTE CARLOTHE ROLE OF MONTE CARLO
•Study of the proton paths inside objects
•Study of the algorithms for image reconstructions
GEANT4 tomographic image
3.3 l/cm
200 MeV, 179 projections at 1°, 5M Histories, 20 cm circular phantom
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THE ROLE OF MONTE CARLOTHE ROLE OF MONTE CARLOTHE ROLE OF MONTE CARLO
Experiment: 250 MeVproton beams (LLUMC)
Our Geant4 application and results on detector
study
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THE MOPI ONLINE MONITOR:TEST SET-UPTHE MOPI ONLINE MONITOR:TEST SETTHE MOPI ONLINE MONITOR:TEST SET--UPUP
p beam
x-y ion. strip chambersMOPI
ionization chambers
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THE MOPI ONLINE MONITORTHE MOPI ONLINE MONITORTHE MOPI ONLINE MONITOR
Three different currents of the beam steering magnetThree different currents of the beam steering magnet
a .u .
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Thank you
for your attention