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The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National Institutes of Health Senate Appropriations L/HHS Subcommittee Hearing October 7, 2015

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The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D.

Director, National Institutes of Health

Senate Appropriations L/HHS Subcommittee Hearing

October 7, 2015

Page 2: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

NIH’s Impact on U.S. Health and Medicine

Cardiovascular disease death rates have fallen more than 70% in

the last 60 years

Cancer death rates now falling more than 1% per year; each 1%

drop saves ~$500 billion

HIV therapies enable people in their 20s to live to age 70+

U.S. Life Expectancy

Page 3: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Landscape of Medical Opportunities

Page 4: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Emily’s Story

Page 5: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Origins of Cancer Immunotherapy

Page 6: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Early Cancer Immunotherapy

Page 7: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Recombinant DNA Technology

Plasmid

Recombinant

Plasmid

Splice at a

specific site

Foreign

DNA

Join free

ends

Page 8: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Monoclonal Antibodies for Cancer

Immunotherapy

James P. Allison

Page 9: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Current Immunotherapy

Page 10: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Cytotoxic T-Cells

Page 11: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Monoclonal Antibodies for Cancer

Immunotherapy

James P. Allison

Page 12: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Emily Today

Page 13: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

Many Success Stories & More to Come

Page 14: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

NIH…

Turning Discovery Into Health

directorsblog.nih.gov @NIHDirector

Page 15: Francis S. Collins, M.D., Ph.D. Director, National Institutes of … · 2015-10-14 · The NIH: Investing in a Healthier Future Francis S. Collins, M.D., Ph.D. Director, National

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