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New RNA Repair Technology and

Therapeutic Strategies for Controlling Gene

ExpressionAnny Carolina Sarria MenaMedicine Student, 3rd

semesterTeacher: Lina María Martinez

SánchezMolecular Biology

UPB - 2012

INTRODUCTION

The proper use of the tools offered by molecular biology would be of great benefit to modern medicine, as with so many technological advances, to the heart of mutations and would reduce the pathologies that they can be repaired.Interestingly travésde as identifyingRNA sequences and errors in the maturation of the same drugs can create and repair mechanisms such as RNA.

Scientists Create Novel RNA Repair Technology

  

Scientists Create Novel RNA Repair Technology

Identification a compound that can help repair a specific type of defect in RNA, a type of genetic material.

Methods in the new study could accelerate the development of therapeutics to treat a variety of incurable diseases such as Huntington's disease, Spinocerebellar ataxia, and Kennedy disease.

Scientists Create Novel RNA Repair Technology

Describe a method to find compounds that target defective RNAs, specifically RNA that carries a structural motif known as an "expanded triplet repeat.

The triplet repeat, a series of three nucleotides repeated many more times than normal in the genetic code of affected individuals, has been associated with a variety of neurological and neuromuscular disorders.

It has been shown recently that both the protein and the RNA are toxic. The toxic RNA defect actually sucks up other proteins that play critical roles in RNA processing, and that is what contributes to these various diseases.

Also opens up new avenues for therapeutic development because we have clearly demonstrated that small molecules can reverse this type of defect.

Scientists Create Novel RNA Repair Technology

COMMENT

New RNA-Based Therapeutic Strategies

for Controlling Gene Expression

 

New RNA-Based Therapeutic Strategies

for Controlling Gene Expression Small RNA-based nucleic acid drugs represent a

promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes.

Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them attractive drug candidates.

New RNA-Based Therapeutic Strategies

for Controlling Gene Expression

  Researchers have discovered new

mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances.

New RNA-Based Therapeutic Strategies

for Controlling Gene Expression Review common features shared by RNAi

pathways for controlling gene expression and focus in detail on the potential for Argonaute-RNA complexes in gene regulation and other exciting new options for targeting emerging forms of non-coding RNAs and pre-mRNAs in the article "Argonaute and the Nuclear RNAs: New Pathways for RNA Mediated Control of Gene Expression."

COMMENT

Medical Utility

Medical UtilityThe RNA may represent one of the great advances in medicine, if

used properly and that the viruses that plague humanity are

involved in transcription and maturation of the same.

And with the proper identification of the processing and

maturation of these viruses can find a solution by

using drugs that can attack in its genome.

Medical Utility

If accurately elucidate the general maturation

and processing of RNA from this may create drugs that can "manipulate" the RNA and fix all the

mutations that can occur.

Medical Utility

Through the years and with the expertise of researchers

have made significant progress in the field of medicine have been

established treatments and therapies, drugs and

instruments which act on the genome

and polymorphisms reduce all thanks to Molecular Biology.

BIBLIOGRAPHY• “Scientists Create Novel RNA Repair

Technology”, Science Daily Journal, internet edition, January 2012, http://www.sciencedaily.com/releases/2012/01/120117191544.htm

• “New RNA-Based Therapeutic Strategies for Controlling Gene Expression”, Science Daily Journal, internet edition, February 2012, http://www.sciencedaily.com/releases/2012/02/120202164825.htm