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TRIGGER MECHANISM PROVIDES QUALITY CONTROL IN CELL DIVISION

AND UNNATURAL GENES USED TO REPLACE MISSIND DNA KEEP CELLS

ALIVE

MARIA MONICA JARAMILLO S.

MEDICINE STUDENT

FOLDING

INTRODUCTION

The genetical material can be modified in cell cycle and replicas wrong. For that this cycle has be

controlled by some factors to ensure a correct cell

division

Some cells doesn't has some genes, the science is looking a way to save cell introducing a new

DNA sequence.


January 2011

Nuclear Pore complex (NPC), a cellular structure that is embedded in membranes that enclose the nucleus. NPCs serve as gateways for material moving between the nucleus and

the rest of the cell, and they are also important to nuclear organization.



In some cases, elements of CNP doesn't work well and this affect

some factors in other steps of cell division.


NPC components are emerging in cell division

a component of the NPC called Nup153 is important in cell division

Aurora B, stopping the cell cycle from proceeding When activated, it conveys signals beginning and ending many steps of cell division.

Aurora B and Nup 153 works together


This trigger mechanism monitors whether the cell's nucleus, where the DNA resides, has the proper

structure and delays cell division if the structure is not correct.

OBSERVATION

That experiments are fundamental to

know how the human life is

affected begging in the littlest process

that define the whole life

UNNATURAL GENES USED TO REPLACE MISSIND DNA KEEP CELLS ALIVE

January 17, 2011

UNNATURAL GENES USED TO REPLACE MISSIND DNA KEEP CELLS

ALIVE

DNA sequences designed in a laboratory

-No random.

-A specific code for amino acid arrangements.

-Different from any natural protein.

UNNATURAL GENES USED TO REPLACE MISSIND DNA KEEP

CELLS ALIVE

The new ADN sequence where introduce in a cell

with out a gen.


CELLS ALIVE

EXPERIMENT – E. coli

The cell with out DNA sequence after incubation

died

The cell with artificial DNA sequence after

incubation survive


CELLS ALIVE

The cell with artificial DNA

sequence after incubation

survive

The E. coli DNA where modified and purified. The gene that was

deleted now is right.

OBSERVATION

I think that this is an important step in the science, because this

would be the beginning of the

treatment of many pathologies

Understanding the genetic

material allows find the

answers for many medical

riddles

MEDICAL UTILITY

This particular trigger could be

one of the contributing

factors to the initiation of

cancer. It's not going to be the

only one, but it will help us ask additional important

questions about how cancer

forms."

MEDICAL UTILITY

MEDICAL UTILITY

The unnatural genes can be used to rescue cells

and fix mutations of some genes and ensure a correct phenotype

expression and a correct genotype conformation.

This is important beacuse this mechanism can fix genetical patologies.

BIBLIOGRAPHY

• http://www.sciencedaily.com : 22092530

• http://www.scientificamerican.com/article. synthetic-genes-proteins

• MARTINEZ SANCHEZ, LINA MARIA. VARGAS GRISALES NATALIA. TORO MONTOYA, ANDRES EDUARTO, ET ALL. Biología Molecular, libro de clase. Sexta Edición. Universidad Pontificia Bolivariana. Medellín 2011

http://www.sciencedaily.com/

THANK YOU…

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