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Evert Jiménez Cotes Medicine 3 Semestre http://www.exponent.com/ toxicogenomics/

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Page 1: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

Evert Jiménez CotesMedicine

3 Semestre

http://www.exponent.com/toxicogenomics/

Page 2: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 3: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 4: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 5: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

Replacing Hydrogen in Fluorescent Dyes

Improves Detection Ability, Stability and Shelf Life

ScienceDaily (July 20, 2010)

Page 6: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

Researchers have succeeded in giving it more stability, durability and ability to detect the

fluorescent dyes through the exchange of a hydrogen atom by a deuterium.

These fluorescent probes with deuterium concentrations are able to recognize tiny R.O.S

Page 7: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

One of the great advantages of this study which showed that the fluorescent probe deuterium is oxidized by air and light by 20% in 10 days, while the standard tips are oxidized by 60%

This makes their use and marketing is broader and more accessible.

http://www.ivfpanama.com/es/pruebasgeneacuteticas2.html

Page 8: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

The fluorescent probes to detect deuterium reactive oxygen species undergoing a chemical process called oxidation of the amine.

http://images.pennnet.com/gallery/cgw/0600_cancer_cells.jpg

Page 9: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 10: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

New Measurement of Telomere DNA Could Help Identify Most Viable

Embryos for IVFScienceDaily (June 28, 2010)

 

Page 11: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

http://jnn-digital.blogspot.com/2010/04/la-encrucijada-actual-de-la-iglesia.html

Page 12: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

http://bonitofindelmundo.blogspot.com/2009/06/erosion-de-los-telomeros.html

Page 13: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

According to this study the first two days of embryonic development, telomeres are shortened and that just prior to implantation in the uterus these telomeres are lengthened in order to be able to withstand the many divisions in fetal development

http://www.queciencia.com/2008/03/23/embriones-hibridos-diputados-catolicos-podran-votar-segun-su-conciencia/

Page 14: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

In animals showed that artificial shortening of telomeres results in problems in animal embryos. It was also found that oxidative stress causes a reduction of telomeres. Therefore it is of vital importance in-depth study of these telomeres and length.

http://www.blogys.net/tags/embarazo/9

Page 15: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 16: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros
Page 17: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

Many diseases are associated with ROS in cell damage such as the coronary artery disease, lung damage, inflammatory diseases, abnormalities in embryonic development and etc.

Replacing Hydrogen in Fluorescent Dyes by deuterio

Page 18: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

I think the study of telomeres in the future will give us many answers concerning the problems of the age as well as from cancer. It would be great to study how the telomeres get longer before reaching the utero and well able to modify genetically our genome and to fight against to “age problems”.

Viable embryos for FIV due to characteristics in the DNA of the telomeros.

http://www.lashorasperdidas.com/index.php/2008/12/17/premios-de-la-sociedad-de-criticos-de-houston-2/

Page 19: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

Therefore, these studies must dig deeper to know and to detect possible abnormalities in human embryonic development.

http://www.todoesterilidad.com/causasesterilidad10.html

Viable embryos for FIV due to characteristics in the DNA of the telomeros.

Page 20: Fluorescent dye replacement with hydrogen and viable embryos for FIV due to characteristics in the DNA of the telomeros

New Measurement of Telomere DNA Could Help Identify Most Viable Embryos for IVFDisponible en: http://www.sciencedaily.com/releases/2010/06/100628075748.htm . Acceso el 26 de julio 2010.

Replacing Hydrogen in Fluorescent Dyes Improves Detection Ability, Stability and Shelf Life Disponible en: http://www.sciencedaily.com/releases/2010/07/100720123629.htm. Acceso el 26 de julio 2010.

MARTINEZ S., Lina María. Biología molecular. 5. ed. Medellín : UPB. Fac. de Medicina,  2010. 56 p.