figures from the 2014 assisted reproductive technology … · 2019-02-21 · 2014 36.9 29.1 18.8...

Figures from the 2014 Assisted Reproductive Technology

National Summary Report

Locations of ART Clinics in the United States and Puerto Rico, 2014

Number of ART clinics in the United States in 2014 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 498 Number of ART clinics that submitted data in 2014 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 458 Total number of ART cycles started in 2014 at clinics reporting data . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208,604*

Number of live-birth deliveries resulting from ART cycles started in 2014 . . . . . . . . . . . . . . . . . . . . . . . . 57,323 Number of infants born as a result of ART cycles started in 2014. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70,354

* Total includes 35,406 cycles with the intent to freeze all eggs or embryos. Live-birth deliveries and infants born are based on remaining 173,198 cycles with intent to transfer at least one egg or embryo. This includes 3,596 cycles with intent to fertilize previously frozen eggs and transfer resulting embryos. This does not include 26 cycles evaluating a new treatment procedure.

Types of ART Cycles—United States,* 2014

Fresh nondonor 44.5%

(92,862 cycles)

Frozen nondonor embryo 27.0% (56,259 cycles)

Egg/embryo banking 17.0% (35,406 cycles)

Frozen donor embryo 5.7%

(11,974 cycles)

Fresh donor 4.1% (8,507 cycles)

Frozen egg 1.7% (3,596 cycles)

New treatment procedure <0.1%

(26 cycles)

* Total does not equal 100% due to rounding.

ART Use by Age Group—United States,*† 2014

Age: <35 37.6%

Age: 35–37 20.4%

Age: 38–40 19.1%

Age: 41–42 10.2%

Age: 43–44 7.0%

Age: >44 5.8%

* Based on 208,604 cycles. † Total does not equal 100% due to rounding.

Types of ART Cycles by Age Group—United States,* 2014

(58) (56) (57) (57)

(48)

(22)

(5) (8) (15)

(24)

(38) (39) (33)

(24)

(17)

(9)

(5) (10)

(20)

(44)

96%

4%

95%

5%

90%

10%

81%

18%

65%

35% 31%

68%

Perc

ent

0

20

40

60

80

100

Age (years) <35 35–37 38–40 41–42† 43–44 >44†

Fresh nondonorFrozen nondonor

Fresh donorFrozen donor

* Percentages of ART cycles that used fresh or frozen embryos from nondonor or donor eggs are in parentheses. † Totals do not equal 100% due to rounding.

Percentages of ART Cycles That Resulted in Live Births, by Type of ART and Clinic Size—United States, 2014

28 29 28 26

33 37

40 40

46 50

47 49

37 40 39 38

Perc

ent

0

10

20

30

40

50

60

<97 97–202 203–434 >434Clinic Size (number of ART cycles performed in 2014)

Fresh nondonorFresh donor

Frozen nondonorFrozen donor

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Stage, 2014

92,862 cycles

started 83,114 retrievals

67,070 transfers

30,647 pregnancies 25,016

live-birth deliveries

Num

ber

0

20,000

40,000

60,000

80,000

100,000

Reasons ART Cycles Using Fresh Nondonor Eggs or Embryos Were Canceled,*† 2014

No or not enough egg production

82.4%

Patient withdrawal for other reasons

11.6%

Over response to ovarian stimulation

medication 4.9%

Concurrent illness 1.0%

* Based on 9,748 ART cycles. † Total does not equal 100% due to rounding.

Percentages of ART Cycles and Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and

Single-Infant Live Births, 2014

33.0

26.9

20.4

45.7

37.3

28.3

Perc

ent

0

10

20

30

40

50

Pregnancies Live births Single-infant live births

Cycles Transfers

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, 2014

No pregnancy 66.4%

Ectopic pregnancy 0.6%

Single-fetus pregnancy

22.5%

Multiple- fetus

pregnancy 8.3%

Not able to determine number

of fetuses 2.2%

Clinical pregnancy 33.0%

Outcomes of Pregnancies That Resulted from ART Cycles Using Fresh Nondonor Eggs or Embryos,*† 2014

Single-infant birth 61.8%

Multiple-infant birth

19.8%

Total live births 81.6%

Stillbirth 0.6%

Miscarriage 16.2%

Induced abortion 0.9%

Unknown 0.6%

* Maternal deaths prior to birth are not displayed due to small number of cycles. † Total does not equal 100% due to rounding.

Distribution of Multiple-Fetus Pregnancies and Multiple-Infant Live Births Among ART Cycles Using Fresh Nondonor Eggs or Embryos, 2014

A. 30,647 pregnancies

Single fetuses 68.1%

Twins 23.7%

Triplets or more 1.5%

Not able to determine number of

fetuses 6.7%

B. 25,016 live births*

Single infants 75.7%

Twins 23.3%

Triplets or more 0.9%


Percentages of Preterm Infants or Infants with Low Birth Weight from ART Cycles Using Fresh Nondonor Eggs or Embryos, by Number of Infants Born, 2014

10.9 16.8

56.8

98.7

9.0 14.9

55.4

93.7

Perc

ent

0

20

40

60

80

100

Single infantsfrom single-fetus

pregnancies

Single infantsfrom multiple-fetus

pregnancies

Twins Triplets or more

Number of Infants Born

Preterm infants Low birth weight infants

Age Distribution of Women Who Had ART Cycles Using Fresh Nondonor Eggs or Embryos, 2014

Perc

ent

0

1

2

3

4

5

6

7

8

9

10

Age (years) <24 24 26 28 30 32 34 36 38 40 42 44 46 48 >48

Mean Median

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births,

by Age of Woman,* 2014

Perc

ent

0

10

20

30

40

50

Age (years) <24 24 26 28 30 32 34 36 38 40 42 44 >44


* For consistency, all percentages are based on cycles started.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births

Among Women Aged 40 or Older,* 2014

23

18

15

10

6

3

16

11

8

5

2 1

13

9 7

4 2 1

Perc

ent

0

10

20

30

Age (years) 40 41 42 43 44 >44


* For consistency, all percentages are based on cycles started.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Miscarriage, by Age of Woman, 2014

Perc

ent

0

10

20

30

40

50

60

70

Age (years) <24 24 26 28 30 32 34 36 38 40 42 44 >44

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Stage and Age Group, 2014

94 90

87 83 81

75 78 76 70

62 55

40 43 36

27

16 9

3

37 30

19

10 4 1

Perc

ent

0

20

40

60

80

100

Age (years) <35 35–37 38–40 41–42 43–44 >44

Retrieval Transfer Pregnancy Live birth

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Type of Infertility Diagnosis,* 2014

14.2 13.7

30.8

9.3 5.5

35.1

12.4 14.1 11.2

17.9

Perc

ent

0

10

20

30

40

Diagnosis

* Total percentages are greater than 100% because more than one diagnosis can be reported for each cycle.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Type of Infertility Diagnosis, 2014

27.1

32.9

14.6

29.0

20.6

30.5

21.8

32.3

18.7

24.9

Perc

ent

0

10

20

30

40

Diagnosis

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group and

Number of Previous Live Births, 2014

36

29

18

9

3 1

40

32

22

11

4 2

39

33

23

9 5

1

Perc

ent

0

10

20

30

40

50

Age (years) <35 35–37 38–40 41–42 43–44 >44

No previous live births 1 previous live birth 2 or more previous live births

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group and History of Miscarriage,

Among Women with No Previous Births,* 2014

36.9

29.1

18.8

9.2

3.1 1.1

34.7

28.3

17.6

9.5

3.5 1.0

Perc

ent

0

10

20

30

40

50

Age (years) <35 35–37 38–40 41–42 43–44 >44

No previous pregnancies 1 or more previous miscarriages

* Women reporting only previous ectopic pregnancies or pregnancies that ended in induced abortion are not included.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group and Number of Previous ART Cycles,

Among Women with No Previous Live Births, 2014

39

32

20

10

3 2

31

26

17

10

5

0

30

26

16

8

2 1

26 22

14

7

3 1

Perc

ent

0

10

20

30

40

50

Age (years) <35 35–37 38–40 41–42 43–44 >44

No previous cycles 1 previous cycle2 previous cycles 3 or more previous cycles

Percentages of Retrievals Using Fresh Nondonor Eggs or Embryos That Used ICSI, 2014

94.9 93.5 93.2 92.5 90.2 88.8

66.8 67.5 69.0 70.9 73.9 77.6

Perc

ent

0

20

40

60

80

100

Age (years) <35 35–37 38–40 41–42 43–44 >44

ICSI, with male factor ICSI, no male factor

Percentages of Fresh Nondonor Retrievals That Resulted in Live Births Among Patients with or Without Diagnosed Male Factor Infertility,

by Age Group and Use of ICSI,* 2014

41

34

24

14

6

1

41

36

24

11

5 1

38

32

21

12

4 1

Perc

ent

0

10

20

30

40

50

Age (years) <35 35–37 38–40 41–42 43–44 >44

ICSI, with male factor No ICSI, no male factor ICSI, no male factor

* Cycles using donor sperm and cycles using GIFT or ZIFT are excluded.

Numbers of Embryos Transferred Among All Transfers Using Fresh Nondonor Eggs or Embryos,* 2014

One 28.8%

Two 54.1%

Three 12.4%

Four 3.2%

Five 1.1%

Six 0.2%

Seven or more 0.1% Zero or unknown

<0.1%


Percentages of Embryos Transferred That Implanted Using Fresh Nondonor Eggs or Embryos, by Age Group, 2014

41.1

32.3

21.1

10.8

5.0 2.3

Perc

ent

0

10

20

30

40

50

Age (years) <35 35–37 38–40 41–42 43–44 >44

Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births of Single, Term, and Normal Birth Weight Infants,

by Number of Embryos Transferred, 2014

30.5

23.1

16.0

11.7

Perc

ent

0

10

20

30

40

Number of Embryos Transferred 1 2 3 4+

Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births and Distribution of Number of Infants Born,

by Number of Embryos Transferred,* 2014

(98.4) (65.6)

(73.8) (77.6)

(1.6) (33.4)

(22.6)

(20.8)

(<0.1)

(0.9)

(3.6)

(1.6)

36.1%

42.1%

26.2%

18.2% Perc

ent

0

10

20

30

40

50

Number of Embryos Transferred 1† 2† 3 4+

Single infants Twins Triplets or more

* Percentages of transfers resulting in live births are shown on top of each bar graph. Percentages of live births that were single infants, twins, and triplets or more are in parentheses.

† Totals do not equal 100% due to rounding.

Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births and Distribution of Number of Infants Born

Among Good-Prognosis Women, by Number of Embryos Transferred,* 2014

(98.3)

(57.1) (58.2)

(42.9)

(1.7) (41.6)

(35.5) (57.1)

(<0.1) (1.3)

(6.4)

52.2% 56.6%

39.7% 36.8%

Perc

ent

0

10

20

30

40

50

60

70

Number of Embryos Transferred 1† 2 3† 4+


* Percentages of transfers resulting in live births are shown on top of each bar graph. Percentages of live births that were single infants, twins, and triplets or more are in parentheses.


Day of Embryo Transfer* Among All ART Transfers Using Fresh Nondonor Eggs or Embryos,† 2014

Day 1 0.1% Day 2

3.6%

Day 3 35.8%

Day 4 1.5%

Day 5 54.3%

Day 6 4.7%

* Number of days following egg retrieval. † Cycles using GIFT or ZIFT are excluded. Missing or implausible values for day of embryo transfer

(that is, 0 or greater than 6) are not included.

Percentages of Day 3 and Day 5 Embryo Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group,* 2014

36.1 31.4

22.5

12.6

5.5 1.7

52.6

45.5

34.1

20.2

9.3 6.2

Perc

ent

0

10

20

30

40

50

60

Age (years) <35 35–37 38–40 41–42 43–44 >44

Day 3 Day 5

* Cycles using GIFT or ZIFT are excluded. Embryo transfers performed on days 1, 2, 4, and 6 are not included because each of these accounted for a small proportion of procedures.

Numbers of Embryos Transferred on Day 3 and Day 5 Among All Transfers Using Fresh Nondonor Eggs or Embryos,* 2014

Day 3

One 18.5%

Two 50.5%

Three 21.4%

Four or more 9.6%

Day 5

One 33.6%

Two 58.3%

Three 6.9%

Four or more 1.2%


Distribution of Number of Infants Born Among Day 3 and Day 5 Embryo Transfers Using Fresh Nondonor Eggs or Embryos

That Resulted in Live Births,* 2014 Day 3

A. 6,242 live births


Twins 21.1%

Triplets or more

1.1%

Day 5

B. 16,531 live births


Twins 24.7%

Triplets or more

0.9%


Percentages of Day 5 Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births and Distribution of Number of Infants Born Among

Good-Prognosis Women, by Number of Embryos Transferred,* 2014

(98.3)

(54.6) (58.9)

(1.6) (43.9)

(35.7)

(<0.1) (1.4)

(5.4)

53.3% 59.0%

49.1%

Perc

ent

0

10

20

30

40

50

60

70

Number of Embryos Transferred 1† 2† 3+


* Percentages of transfers resulting in live births are shown on top for each bar graph. Percentages of live births that were single infants, twins, and triplets or more are in parentheses. Cycles using GIFT or ZIFT are excluded.


Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births Among ART Cycles That Used Gestational Carriers and

Those That Did Not, by Age Group,* 2014

54.7

46.5

32.3

26.4

7.1

47.5

39.6

28.0

15.6

7.0 3.0

Perc

ent

0

10

20

30

40

50

60

Age (years) <35 35–37 38–40 41–42 43–44† >44

Used a gestational carrier Did not use a gestational carrier

* Age groups reflect the age of the ART patient, not the age of the gestational carrier. † There were no transfers resulting in live births among patients aged 43–44 who used gestational carriers.

Percentages of Embryos Transferred That Implanted Using Frozen Nondonor Embryos, by Age Group, 2014

43.7 40.8

35.2

28.4

19.9

12.9

Perc

ent

0

10

20

30

40

50

Age (years)

<35 35–37 38–40 41–42 43–44 >44

Percentages of Transfers Using Frozen or Fresh Nondonor Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births, 2014

52.8

42.4

34.4

45.7

37.3

28.3

Perc

ent

0

10

20

30

40

50

60


Frozen nondonor Fresh nondonor

Distribution of Multiple-Fetus Pregnancies and Multiple-Infant Live Births Among ART Cycles Using Frozen Nondonor Embryos, 2014

A. 27,757 pregnancies


Twins 18.5%

Triplets or more

0.9% Not able to determine number of

fetuses 8.4%

B. 22,267 live births


Twins 18.4%

Triplets or more

0.5%

Percentages of ART Cycles Using Donor Eggs, by Age of Woman, 2014 Pe

rcen

t

0

10

20

30

40

50

60

70

80

90

100

Age (years) <24 24 26 28 30 32 34 36 38 40 42 44 46 48 >48

Percentages of Transfers Using Fresh Embryos from Donor or Nondonor Eggs That Resulted in Live Births, by Age of Woman, 2014

Perc

ent

0

10

20

30

40

50

60

70

80

90

100

Age (years) <30 30 32 34 36 38 40 42 44 46 >47

Donor eggs Nondonor eggs

Distribution of Multiple-Fetus Pregnancies and Multiple-Infant Live Births Among ART Cycles Using Fresh Embryos from Donor Eggs, 2014

A. 4,849 pregnancies*


Twins 30.3%

Triplets or more

0.8% Not able to determine number of

fetuses 5.5%

B. 4,125 live births*


Twins 30.1%

Triplets or more

0.4%

* Totals do not equal 100% due to rounding.

Percentages of Transfers Using Frozen or Fresh Donor Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births, 2014

51.7

41.5

32.9

66.8

56.9

39.5

Perc

ent

0

10

20

30

40

50

60

70


Frozen donor Fresh donor

Numbers of ART Cycles Performed, Live-Birth Deliveries, and Infants Born Using ART, 2005–2014

Num

ber

0

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

180,000

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Art cycles Live-birth deliveries Infants born

Numbers of ART Cycles Performed for Banking All Fresh Nondonor Eggs or Embryos, 2005–2014

Num

ber

0

5,000

10,000

15,000

20,000

25,000

30,000

35,000

40,000

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Numbers of ART Cycles Using Donor Eggs or Embryo, 2005–2014 N

umbe

r

0

2,000

4,000

6,000

8,000

10,000

12,000

14,000

16,000

18,000

20,000

22,000

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Numbers and Percentages of Transfers Using Gestational Carriers, 2005–2014 N

umbe

r

0

500

1,000

1,500

2,000

2,500

3,000

3,500

4,000

4,500

Perc

ent

0

0.5

1.0

1.5

2.0

2.5

3.0

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Number Percent

Percentages of Retrievals Using Fresh Nondonor or Donor Eggs or Embryos That Used ICSI, 2005–2014

Perc

ent

0

10

20

30

40

50

60

70

80

90

100

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Overall Male factor No male factor

Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Single-Infant Live Births, by Age Group, 2005–2014

Perc

ent

0

10

20

30

40

Year 2005 2006* 2007* 2008 2009 2010 2011 2012 2013 2014

Age Group: <35 35–37 38–40 41–42 >42 43–44 >44

* Through 2006, data for women older than age 42 were combined. Starting in 2007, data for women older than age 42 were reported as women aged 43–44 and women older than age 44.

Percentages of Fresh Nondonor Transfers of One, Two, Three, or Four or More Embryos, 2005–2014

9.3 10.7 11.6 11.9 13.5 15.5 16.6 19.5 23.6

28.8

43.4 46.0 48.1 49.8 51.5 52.8 53.9

55.0 55.7 54.2 29.5 27.6 26.0 24.8 23.4 21.3 20.1 17.7 14.6 12.4

17.9 15.8 14.4 13.5 11.6 10.4 9.4 7.8 6.0 4.6

Perc

ent

Year 2005* 2006* 2007* 2008 2009 2010 2011 2012 2013* 2014

Number of Embryos Transferred One Two Three Four or more


Percentages of Elective Single Embryo Transfer (eSET) Among All Transfers Using Fresh Nondonor Eggs or Embryos, by Age Group,* 2005–2014

Perc

ent

0

5

10

15

20

25

30

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Age Group: <35 35–37 38–40 >40

* All ages older than 40 years are reported together due to the small number of transfers performed with eSET.

Percentages of Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Number of Embryos Transferred, 2005–2014

Perc

ent

0

10

20

30

40

50

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Number of Embryos Transferred One Two Three Four or more

Percentages of Live Births Using Fresh Nondonor Eggs or Embryos That Resulted in Multiple Infants Born, by Age Group, 2005–2014

Perc

ent

0

10

20

30

40

50

Year 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Age Group: <35 35–37 38–40 41–42 >42

Percentages of Single Infants, Twins, and Triplets or More Among ART Transfers Using Fresh Nondonor Eggs or Embryos That

Resulted in Live Births, 2005–2014

68.0 69.3 68.8 68.4 69.5 69.7 71.3 72.6 73.4 75.7

29.6 28.8 29.4 29.8 28.9 28.8 27.5 26.4 25.7 23.3

2.4 1.9 1.8 1.8 1.6 1.5 1.3 1.0 0.9 0.9

Perc

ent

Year 2005 2006 2007 2008 2009 2010 2011* 2012 2013 2014*



figures from the 2014 assisted reproductive technology … · 2019-02-21 · 2014 36.9 29.1 18.8...

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