Figure 8.1 The Biology of Cancer (© Garland Science 2007)

Figure 8.3b The Biology of Cancer (© Garland Science 2007)

Figure 8.8 The Biology of Cancer (© Garland Science 2007)

Kinetics of Cyclin D1 after mitogenic stimulus

Many Growth Factor-Stimulated Pathways Upregulate Cyclin D

Figure 8.12 The Biology of Cancer (© Garland Science 2007)

Waxing & Waning of Cyclin-CDK Complexes

Families of Cyclin-CDK Inhibitors

Figure 8.14a The Biology of Cancer (© Garland Science 2007)

Figure 8.15a The Biology of Cancer (© Garland Science 2007)

Figure 16.44a The Biology of Cancer (© Garland Science 2007)

Recall the AKT/PKB – mTOR Axis

Figure 8.16b The Biology of Cancer (© Garland Science 2007)

AKT Directs Growth-Sparing Compartmentation of p27Kip1 (and

p21Cip1 too)

Figure 8.17a The Biology of Cancer (© Garland Science 2007)

Paradoxical Effects of p21 and p27 on Cyclin D-CDK4/6 VS other Cyclin-CDKs

Rb’s Actions are Regulated by its State of Phosphorylation

Figure 8.22 The Biology of Cancer (© Garland Science 2007)

Phosphorylation Determines Rb-E2F Interaction

Figure 8.25b The Biology of Cancer (© Garland Science 2007)

Cyclin E transcription

+ Feedback loop

Cyc E-CDK2 Promotes Destruction of p27

Figure 8.21a The Biology of Cancer (© Garland Science 2007)

The Rb Family of Pocket Proteins p105 (Rb); p107

& p130

(Associated with Hypophosphosphorylated Rb family members)

(Free E2F-DP complexes)

E2F/DP and Transcription

Figure 8.26 The Biology of Cancer (© Garland Science 2007)

During G1Cooperation Among Pathways (mostly) Favors D1

Accumulation

Figure 8.27 The Biology of Cancer (© Garland Science 2007)

Myc, Max & Mad-Max

Figure 8.28 The Biology of Cancer (© Garland Science 2007)

Myc & Its Collaborators Promote D/CDK & Decrease Rb Inhibition of R Point Transit

Figure 8.31 The Biology of Cancer (© Garland Science 2007)

TGFβ can Trump Myc

Figure 8.34 The Biology of Cancer (© Garland Science 2007)

Myc can Influence Differentiation

Figure 8.35 The Biology of Cancer (© Garland Science 2007)

A Web of Interactions & Pathways Influence R Point Transition