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figure 15.2 a model signal transduction pathway

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Figure 15.2 A Model Signal Transduction Pathway Signal Solutes enter the space between the two membranes through large pores in the outer membrane of E. coli. EnvZ Receptor The EnvZ membrane protein changes shape in response to the high solute concentration, catalyzing the addition of a phosphate from ATP. Transduction The phosphate from EnvZ is transferred to the OmpR protein… …and the phosphorylated OmpR changes shape, enabling it to bind to DNA and stimulate transcription of the ompC gene. OmpC protein inserts into the outer membrane, preventing solute entry and keeping the cell’s exterior osmotically balanced. Outer membrane of bacterium Cell wall Intermembrane space Plasma membrane Pores Environment Solute OmpR ompC DNA mRNA OmpC protein

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Figure 15.2 A Model Signal Transduction Pathway. Outer membrane of bacterium. Cell wall. Intermembrane space. Plasma membrane. Pores. Environment. Solute. EnvZ. Receptor The EnvZ membrane protein changes shape in response to the high solute concentration, - PowerPoint PPT Presentation

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Page 1: Figure 15.2 A Model Signal Transduction Pathway

Figure 15.2 A Model Signal Transduction Pathway

SignalSolutes enter the space betweenthe two membranes throughlarge pores in the outer membraneof E. coli.

EnvZ

ReceptorThe EnvZ membrane proteinchanges shape in response to thehigh solute concentration,catalyzing the addition of aphosphate from ATP.

TransductionThe phosphate from EnvZ istransferred to the OmpR protein…

…and the phosphorylatedOmpR changes shape,

enabling it to bind to DNAand stimulate transcriptionof the ompC gene.

OmpC protein inserts into theouter membrane, preventingsolute entry and keeping thecell’s exterior osmoticallybalanced.

Outermembraneof bacterium

Cellwall

Intermembranespace

Plasmamembrane

Pores

EnvironmentSolute

OmpR

ompCDNA

mRNA

OmpCprotein

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