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Figure 1. A PPLIC A TIO N S Basic Biology C ancer Biology G enom ics D rug D iscovery C ellTherapy SOURCE Bone M arrow A dipose Tissue U m bilicalCord C ord Blood Placenta & O thers ESC /iPSC M ulti-lineage A dult Stem Cells (i.e.M APC,M PLC,M IAM I,etc.) M ESO D ERM D IFFEREN TIATIO N EXPA N SIO N ISO LATIO N C hondrocyte (cartilage) O steocyte (bone) A dipocyte (fat) Tenocyte (tendon) M yoblast (m uscle) TR A N SD IFFEREN TIA TIO N N eural H epatic Endothelial C haracterization:M inim alD efining C riteria (1) A dherence to tissue culture plastic under standard culture conditions (i.e.10% FBS-containing m edium ) (2) C ellSurface C haracterization: Positive N egative CD73 CD 11b or CD 14 CD90 CD34 CD105 CD45 CD79 or C D 19 H LA-D R (3) In vitro tri-lineage m esoderm differentiation (osteoblasts,chondrocytes and adipocytes)

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Page 1: Figure 1

Figure 1.

APPLICATIONSBasic Biology

Cancer BiologyGenomics

Drug DiscoveryCell Therapy

SOURCE

Bone MarrowAdipose TissueUmbilical Cord

Cord BloodPlacenta& Others

ESC/ iPSC

Multi-lineage Adult Stem Cells (i.e. MAPC, MPLC, MIAMI, etc.)

MESODERM DIFFERENTIATION

EXPANSIONISOLATION

Chondrocyte (cartilage)

Osteocyte (bone)

Adipocyte (fat)

Tenocyte(tendon)

Myoblast(muscle)

TRANSDIFFERENTIATIONNeuralHepatic

Endothelial

Characterization: Minimal Defining Criteria

(1) Adherence to tissue culture plastic under standard culture conditions (i.e. 10% FBS-containing medium)

(2) Cell Surface Characterization:Positive NegativeCD73 CD11b or CD14CD90 CD34 CD105 CD45

CD79 or CD19HLA-DR

(3) In vitro tri-lineage mesoderm differentiation (osteoblasts, chondrocytes and adipocytes)

（9）APO...IT Capital Contribution Share in the Asian Tigers, China, and India Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11

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