fast imaging fast - clinicauniversitariaradiologia.pt
TRANSCRIPT
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FastImagingS. I. Gonçalves, PhD
Radiology DepartmentUniversity Hospital CoimbraAutumn Semester, 2011
Fast Im
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“MRI: Principles and Applications”, Friday, 8.30‐9.20 am
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Overview
• The necessity for fast imaging
• Segmented k‐Space: Fast Spin Echo and Fast Gradient Echo
• Conventional Echo Planar Imaging
• Fast Imaging in Steady‐State
Fast Im
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Reducingscantimes
• In traditional scanning methods, only one k‐space line is acquired after each RF pulse;
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RF
RF
-kmax kmax
0 RF
Spin‐echo
RF
-kmax kmax
0 RF
Gradient‐echo
TR
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Reducingscantimes
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kx
ky
Acquired in one TR
Ny – Number of phase encode linesNz – Number of partition encode lines (3D acquisitions)Nacq – Number of averages
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Totalscantime
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TT = NacqNzNyTR
• Example: Time to acquire one SE image
Acquisition matrix = 256256TR = 2000 ms
TT = 2562000 ms = 8.53 min
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Reducingtotalscantime
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• There are obviously two ways to reduce scan times:
Decrease the number of RF excitations Segmented k‐space and Echo‐Planar Imaging (EPI);
Short TRRapid Imaging in Steady‐State
SSFP (Steady‐State Free Precession) sequences
TT = NacqNzNyTR
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Segmentedk‐space
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• Decrease the number of RF pulses associated with phase encode and partition encoding steps;
• Encode more than one k‐space line per RF pulse – Multi‐Shot acquisition
• FSE and Ultra Fast GE
TSE, FSE, TurboFLASH, Fast SPGR, T1‐TFE
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1st k‐line 2nd k‐line 3rd k‐line 4th k‐line
Segmentedk‐space
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Fast Spin‐EchoNumber of k‐lines per TR is controlled by the Turbo Factor or Echo Train Length (ETL) (2‐32);SAR intensive;Blurring;Robust to susceptibility artifacts;
Q. Chen et al., EJR, 1999
N
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• The contrast in FSE is modified in relation to a standard SE sequence; Echoes are received at different echo times;
• The echoes corresponding to the central k‐space lines are the ones that will determine image contrast;
• The moment at which theses echoes are acquired is called effective TE;
• In T1‐weighted FSE sequences, the need to choose a short TR limits ETL;
• Fat has a higher T2 signal in FSE than in standard SE;
• This is due to a lengthening of T2 relaxation time in FSE;k=0
TEeff
FSE
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FSE‐ Examples
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A) SE image with TR=650 ms, TE=8 msB) FSE image with TR=650 ms, TEeff=14 ms, ETL=8
T1 weighting
A) FSE image with TR=5.1 s, TEeff=58 msB) FSE image with TR=5.4 s, TEeff=84 ms
T2 weighting
Hendrick, “Breast MRI”, Springer‐Verlag, 2008
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• Category of GRE sequences with short TR, small flip‐angle and optimized k‐space filling;
• Due to the small flip‐angle and short TR, these sequences have typically poor T1‐weigthing;
• Therefore it is common to prepare de magnetization with an 180 RF pulse to increase T1‐weigthing;
• The lines in k‐space can be acquired after a single inversion pulse (single‐shot) or can be distributed amongst several inversion pulses (multi‐shot or segmented acquisition);
• Effective inversion time will correspond to the delay between the inversion pulse and acquisition of the central k‐space lines;
• T2‐weigthing can be obtained with a 90‐180‐180‐90 (T2‐Prep);
Ultra‐FastGRE
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Findingyourwayinbetweenvendoracronyms…
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Sequence Type Siemens GE Philips
Ultrafast GRE TurboFLASH Fast GRE, Fast SPGR
TFE
Ultrafast GRE 3D MPRAGE 3D Fast GRE, 3D Fast SPGR
3D TFE
Volume Interpolated GRE VIBE FAME, LAVA‐XV THRIVE
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SequencediagramforUltrafastGRE
1st k-line
TR
RF
Signal2nd k-line 3rd k-line
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Ultrafast GRE sequences have a short TR, TE, a low flip‐angle ;
TR is so short that image acquisition lasts less than 1 sec and typically less than 500 ms;
Typical values: TR= 3‐5 msec, TE= 2 msec, and flip angle 5;
ShotN k‐lines per shot
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SequencediagramforUltrafastGRE
TR
RF
1st k-line
SignalK=0 3rd k-line
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TIeff can be adjusted to null the signal from a given tissue, similar to STIR;
Multi‐shot approach especially useful for cadiac imaging where images have to be acquired consistently within different heart phases and adequate temporal resolution has to be used;
The speed of these GRE sequences is particularly suited to monitoring Gadolinium bolus arrival while imaging at arterial phase and in T1 high‐resolution 3D imaging;
TIeff
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Ultra‐FastGRE‐ Examples
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VIBE post‐contrastTR=3 ms, TE=1.1 msVoxel size = 1.561.56 1.70 mm104 imagesTotal scan time: 21 s
3D FLASHTR=1.9 ms, TE=0.8 msVoxel size = 1.561.56 5.00 mm8 imagesTotal scan time: 5.01 s
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ConventionalEchoPlanarImaging(EPI)
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• Fastest imaging modality in MRI (100 ms/slice), but with limited resolution (i.e. 128128 ); Extensively used for perfusion, diffusion and functional MRI;
• Collection of all data necessary to build an image after a single RF pulse (single‐shot);
• Continuous signal acquisition of all k‐space in the form of an gradient‐echo train;
• In EPI, there is water‐fat shift (WFS) in the phase encoding direction due to phase errors and because of the low BW in the PE direction. Fat‐suppression should be selected;
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ConventionalEchoPlanarImaging(EPI)
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• GE‐EPI: single RF excitation pulse, with no preparation, followed by an echo train; T2* weighting
• SE‐EPI: 90‐180 pulses followed by an echo train; T2 weighting
• IR‐EPI: 180 inversion pulse to prepare magnetization followed by an RF excitation pulse and echo train; T1 weighting
• DW‐EPI: preparatory pattern for diffusion weighting
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ConventionalEchoPlanarImaging(EPI)
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GE‐EPI
T2*
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ConventionalEchoPlanarImaging(EPI)
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SE‐EPI
T2 T2
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ConventionalEchoPlanarImaging(EPI)
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DW SE‐EPI
T2T2
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ConventionalEchoPlanarImaging(EPI)
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k‐space trajectory
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AlternativeEchoPlanarImaging(EPI)
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Segment of k‐lines per excitation
Segmented EPI – shorter echo trains
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AlternativeEchoPlanarImaging(EPI)
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Spiral EPI – non‐uniform sampling
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AlternativeEchoPlanarImaging(EPI)
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Angled k‐Space EPI– constant phase encoding gradient
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EPI– Examples
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BOLD response
TR= 3 s6464
fMRI‐BOLD with GRE EPI
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EPI– Examples
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DWI with SE EPI
DW SE‐EPI for b=0
TR=3271 ms, TE=62 msPixel size = 2.572.57 mmSlice Thickness = 10 mmPACE
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DWI with SE EPI
DW SE‐EPI for b=0
TR=5584 ms, TE=96 msPixel size = 3.13.1 mmSlice Thickness = 10 mmPACE
What went wrong here?
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FastImaginginSteady‐State
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• When TRT2, magnetization does not completly relax until the next RF pulse;
• Transverse and longitudinal co‐exist in one TR;
• The type of steady state depends on the flip angle , TR and gradient pattern that is applied;
• In order for steady state to be established, time and amplitude patterns of gradients must be exactly reproduced between RF pulses;
• TR<10 ms, <60
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FastImaginginSteady‐State
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• In steady‐ state gradient echo sequences, residual transverse magnetization will participate in the signal and the contrast will vary according to the type of sequence;
• By maintaining residual transverse magnetization, excitation pulses will produce new echoes (Hahn echos, stimulated echos) in addition to the gradient‐echo;
• There are several variants in the family of steady‐state gradient echo sequences, according to the type of echo recorded (which determines contrast) and how the gradients are adjusted:
FLASH, SPGR, FFE, FISP, PSIF, TrueFisp, N-FFE, T2-FFE, b-FFE, SSFP, FIESTA, GRASS
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FastImaginginSteady‐State
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• Breath‐hold scans;
• Fast 3D scans;
• Less SAR deposition when compared to SE;
• High‐resolution imaging;
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Steady‐statefreeprecession(SSFP)mechanism
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TR
+ + +
Rotation DephasingMT
T2 relaxation MZ
T1 relaxation
nth RF pulse (n+1)th RF pulse
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SSFPmechanism
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…… ……
TR(n‐1)th RF nth RF
1n M
1n M
nM
nM
nn MM
1
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Different types of SSFP sequences
RF
Slice
PhaseEncode
Read
Signal
Sampling
SSFP-FID(N-FFE, FAST, GRASS, FISP, MPGR)
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Different types of SSFP sequences
RF
Slice
PhaseEncode
Read
SSFP-ECHO(T2-FFE, CE-FAST,PSIF, SSFP)
Signal
Sampling
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Low SNR
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Different types of SSFP sequences
RF
Slice
PhaseEncode
Read
Sampling
DESS – Double echoe steady-state
Signal
FID ECHO
t0 tp
(tp-t0)
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RF
Read
Signal
TR
Balanced (b)-SSFP, signal contrast
1
20
21
21
21
11cos
TTMSignal
TTTT
opt
β=
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(TrueFISP, FIESTA, b-FFE)
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SSFPsequences– Examples
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1.5 T
2D TrueFisp
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SSFPsequences– Examples
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FLASH FISP DESS