familial breast cancer in southern finland · 2019. 8. 1. · disease markers 15 (1999) 105 ios...

Disease Markers 15 (1999) 105 IOS Press 0278-0240/99/$8.00 © 1999 – IOS Press. All rights reserved 105 Hannaleena Eerola, Carl Blomqvist, Seppo Pyrhönen and Heli Nevanlinna Departments of Oncology, Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland We evaluate here the prevalence of hereditary and familial breast cancer in Southern Finland and the accuracy of patient reports of family history. Breast cancer patients from three different cohorts: young (170), bilateral (118), and unselected (1282) patients, were interviewed for family history. Families fulfilling one uniform selection criterion (at least three first- or second- degree relatives with breast or ovarian cancer) were considered hereditary. The genealogy of these families was confirmed through church parish registries and Population Register Center and cancer diagnoses through Finnish Cancer Registry. Altogether, any family history was reported by about 30% of the patients. 100 families fulfilled the selection criterion: 9.4% of the young, 8.5% of the bilateral, and 6.9% of the unselected patients. 20% of these families also included ovarian cancer cases. Index patients reported 86% of all confirmed cancer diagnoses (99.5% among first- and second-degree relatives) and primary site was correctly identified in 95% of the reported cases. However, only 61% of cancer diagnoses of more distant relatives (3rd degree, e.g. cousins) were reported by the patients — these may be important also when considering criteria for diagnostic testing. Although the reported family history is quite accurate, the level of error should be considered in epidemiological studies and verification of the cancer diagnoses is important when deciding clinical management. Abstract Familial Breast Cancer in Southern Finland

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Disease Markers 15 (1999) 105IOS Press

0278-0240/99/$8.00 © 1999 – IOS Press. All rights reserved

105

Hannaleena Eerola, Carl Blomqvist,Seppo Pyrhönen and Heli Nevanlinna

Departments of Oncology, Obstetrics andGynecology, Helsinki University CentralHospital, Helsinki, Finland

We evaluate here the prevalence of hereditaryand familial breast cancer in Southern Finlandand the accuracy of patient reports of familyhistory.

Breast cancer patients from three differentcohorts: young (170), bilateral (118), andunselected (1282) patients, were interviewed forfamily history. Families fulfilling one uniformselection criterion (at least three first- or second-degree relatives with breast or ovarian cancer)were considered hereditary. The genealogy ofthese families was confirmed through churchparish registries and Population Register Center

and cancer diagnoses through Finnish CancerRegistry.

Altogether, any family history was reported byabout 30% of the patients. 100 families fulfilledthe selection criterion: 9.4% of the young, 8.5%of the bilateral, and 6.9% of the unselectedpatients. 20% of these families also includedovarian cancer cases. Index patients reported86% of all confirmed cancer diagnoses (99.5%among first- and second-degree relatives) andprimary site was correctly identified in 95% ofthe reported cases. However, only 61% of cancerdiagnoses of more distant relatives (3rd degree,e.g. cousins) were reported by the patients —these may be important also when consideringcriteria for diagnostic testing.

Although the reported family history is quiteaccurate, the level of error should be consideredin epidemiological studies and verification of thecancer diagnoses is important when decidingclinical management.

Abstract

Familial Breast Cancer in Southern Finland
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