Experimental genomics of fitness in yeast

by Graham Bell

Proceedings BVolume 277(1687):1459-1467

May 22, 2010

©2010 by The Royal Society

Distribution of standard yield among deletion strains in complete (YPD) medium.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Distribution of maximum growth rate among deletion strains in complete (YPD) medium.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Distribution of selection coefficients among deletion strains in complete (YPD) medium.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Relative growth of heterozygote and homozygote deletion strains in a competition pool assay.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Epistasis in crosses between deletion strains with low growth rates.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Distribution of genetic correlation over environments for the deletion strains.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

‘Shellburst’ plot of variance on mean for the Parsons dataset (82 media).

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

The cumulative frequency of conditional sublethal loci when the deletion set is tested over a large number of substrates. ‘Subvital’ is defined as lying 2 s.d. units or more below average in

pool competition experiments.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society

Frequency of deletions among natural isolates in relation to geometric mean fitness in culture.

Graham Bell Proc. R. Soc. B 2010;277:1459-1467

©2010 by The Royal Society