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Expectant Parents’ Guide to Cord Blood and Cord Lining Banking

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Page 1: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Expectant Parents’ Guide to Cord Blood and Cord Lining Banking

Page 2: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Saving Precious Stem Cells for your Family

Who We Are

Umbilical Cord Stem Cells

Difference between Umbilical Cord Blood & Umbilical Cord Lining Banking

Umbilical Cord Blood (UCB) Stem Cells

Diseases Treated with Stem Cells & Other Potential Applications

Umbilical Cord Lining (UCL) Stem Cells

Mesenchymal Stem Cells Application Reports

Epithelial Stem Cells Applications

UCB and UCL Collection Process

12 Good Reason to Bank with Cordlife

Cordlife’s Success Stories

Cordlife Parents

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04

06

07

08

09

11

13

15

17

21

25

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TABLE OF CONTENTS

Page 3: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

As you prepare for the arrival of your baby, one of the first and most important decisions you may need to make is choosing to save your baby’s cord blood.

Today, diseases including certain cancers and blood disorders may be treated with hematopoietic stem cells that can be found in cord blood. A recent study reported that as many as 1 in 217 individuals may need a stem cell transplant in their lifetime.*

That is why saving your baby’s cord blood could be a lifesaving decision for your little one and your family. Find out more about cord blood banking with Cordlife today.

SAVING PRECIOUS STEM CELLS FOR YOUR FAMILY

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* Nietfeld JJ, Pasquini MC, Logan BR, et. al. 2008 Biology of Blood and Marrow Transplantation. 14:316-322.

Page 4: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• A subsidiary of Cordlife Group Limited, a company listed on the Singapore Exchange.

• Officially launched in February 2010 as Philippines’ first and only private cord blood processing and cryopreservation facility.

• First and the only ISO 9001:2008 and DOH-registered facility in the country.• Facility was built in accordance to global gold standards such as AABB to give

local families peace of mind.• The 365-day facility is equipped with the world’s most advanced fully automated

cord blood processing system, SEPAX, and has a storage capacity for 30,000 cord blood units.

CORDLIFEMEDICAL PHILS. INC.

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Page 5: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• Listed on the Main Board of the Singapore Exchange ("SGX"), Cordlife Group

Limited ("Cordlife", and together with its subsidiaries, the "Group") is presently

a service provider of umbilical cord blood and cord lining banking.

• The first cord blood bank to be set up in Singapore (May 2001) and amongst

the first in Asia, Cordlife Group Limited has more than 16 years of cord blood

banking experience as well as a published track record of cord blood

transplants.

• The Group currently owns and operates full processing and cryopreservation

storage facilities across Asia (Singapore, Hong Kong, India, Indonesia,

Malaysia and the Philippines). The Group also extends its products and

services to families in the region through its associates, sub-licensing

partners and marketing agents in China, Thailand and Myanmar.

CHINA

THAILAND

MYANMARHONG KONG

PHILIPPINES

MALAYSIA

SINGAPORE

INDONESIA

INDIA

Cordlife’s Headquarters

Cordlife’s Subsidiaries

Cordlife’s Associates & Sub-licensing Partner

Cordlife’s Marketing Agent

Cordlife’s Associate

CORDLIFE GROUP LIMITED

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Page 6: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• Umbilical Cord is a tube-like structure that connects the fetus to placenta, providing nutrients and removing waste.

• The umbilical cord contains cord blood, Wharton’s Jelly, umbilical arteries and an umbilical vein. The components are protected by a sheet-like membrane known as the cord lining.

Three main types of stem cells can be found in the umbilical cord:

• Hematopoietic Stem Cells (HSCs)• Mesenchymal Stem Cells (MSCs) • Epithelial Stem Cells (EpSCs)

The stem cells in the umbilical cord are the youngest and inherently valuable cells that have the potential to keep your baby protected for the years to come.

THE UMBILICAL CORD AND UMBILICAL CORD STEM CELLS

Umbilical Vein

Wharton’s Jelly

Cord Lining

UmbilicalArteries

PlacentaUmbilical

cord

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Page 7: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

By storing HSCs, EpSCs and MSCs from umbilical cord blood and umbilical cord lining- the youngest and most potent adult stem cells-your child may have access to more medical options in the future.

Standard treatment:blood, immune and meta-bolic disorders

Potentially unneces-sary for certain allogenic uses

Required for standard treatment

Potential treatment:cerebral palsy, autism, spinal cord injury

Potential treatment:heart disease, stroke, diabetes type 1, bone or cartilage disorder, liver disease, lung disease

Mesenchymal Stem Cells (MSCs) and Epithelial Stem Cells (EpSCs)

Hematopoietic Stem Cells (HSCs)

Cord Blood Banking Cord Lining Banking

Type ofStem Cells

Treatment type

Number of uses

HLA match

One or two uses Multiple uses

DIFFERENCES BETWEEN UMBILICAL CORD BLOOD & UMBILICAL CORD LINING BANKING

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Page 8: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Cord blood is a rich source of Hematopoietic Stem Cells (HSCs), which are responsible for replenishing blood and regenerating the immune system. HSCs are known as ‘precursor cells’, as they have the unique ability to differentiate into the different types of cells found in the body, namely:

• Red Blood Cells - transport oxygen• White Blood Cells - produce antibodies and fight infections• Platelets - assist in blood clotting

What are cord blood stem cells?

differentiates into all other blood cells including these illustrated here:

The hematopoietic stem cell

carry oxygen to the organs and tissues

Red blood cells

fight infectionsWhite blood cells

Plateletshelp blood to clot

UMBILICAL CORD BLOOD (UCB) STEM CELLS

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Page 9: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

* Reference:• Diseases treated page. Parent’s Guide to Cord Blood Foundation. http://parentsguidecordblood.org/diseases.php. Accessed March

20, 2015.• Stem cell treatment page. Cord Blood Registry Website.

http://www.cordblood.com/benefits-cord-blood/umbilical-cord-stem-cells/stem-cell-treatments. Accessed March 20, 2015.• Clinical trial registry page. ClinicalTrials.gov. http://clinicaltrials.gov. Accessed April 27, 2015.

• Acute Myelogenous Leukaemia• Acute Lymphoblastic Leukaemia• Chronic Myelogenous Leukaemia• Histiocytic Neoplasms• Other Myeloproliferative Neoplasms

• Hodgkin Lymphoma• Non-Hodgkin Lymphoma• Langerhans' Cell Histiocytosis

• Aplastic Anaemia• Chediak-Higashi Syndrome• Congenital Dyserythropoietic

Anaemia• Diamond-Blackfan Syndrome• DiGeorge Syndrome• Evans Syndrome• Fanconi's Anaemia• Glanzmann'sThrombasthenia• Gunther’s Disease (erythropoietic

BLOOD CANCERSStandard Treatment

SOLID TUMORS

NON-MALIGNANT BLOOD DISORDERS

• Chronic Granulomatous Disease• Common Variable Immunodeficiency• Cartilage-Hair Hypoplasia• Reticular Dysgenesis

IMMUNODEFICIENCY DISORDERS

• Myelodysplastic syndrome• Multiple Myeloma• Plasma Cell Leukaemia• Systemic Mastocytosis• Waldenstrom’s Macroglobulinemia

• Neuroblastoma• Retinoblastoma

porphyria)• Hereditary BM failure syndromes• Hemophagocytic Lymphohistiocytosis• Leukocyte Adhesion Deficiency• Paroxysmal Nocturnal

Hemoglobinuria• Pure Red Cell Aplasia• Sickle Cell Anaemia• Thalassemia Major

• Severe Combined Immune Deficiency (SCID)

• Shwachman-Diamond Syndrome• Wiskott-Aldrich Syndrome

DISEASES TREATED WITH STEM CELLS & OTHER POTENTIAL APPLICATIONS*

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Page 10: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

* Reference:• Diseases treated page. Parent’s Guide to Cord Blood Foundation. http://parentsguidecordblood.org/diseases.php. Accessed March

20, 2015.• Stem cell treatment page. Cord Blood Registry Website.

http://www.cordblood.com/benefits-cord-blood/umbilical-cord-stem-cells/stem-cell-treatments. Accessed March 20, 2015.• Clinical trial registry page. ClinicalTrials.gov. http://clinicaltrials.gov. Accessed April 27, 2015.

Potential Applications

• Autism• Brain Tumor• Cartilage Repair• Cleft Palate Repair (Alveolar)• Cerebral palsy• Crohn’s disease• Critical Limb Ischemia• Diabetes Type 1• Epidermolysis Bullosa• Ewing Sarcoma• Graft-versus-Host Disease

(GvHD)• Hypoxic Ischemic

Encephalopathy (HIE)

• Alzheimer's Disease• Amyotrophic lateral sclerosis• Congenital hydrocephalus• Huntington's Disease

• Adrenoleukodystrophy• Gaucher's Disease• Hurler Syndrome• Hunter’s Syndrome• Krabbe Disease• Lesch-Nyhan Syndrome

METABOLIC DISORDERS

Clinical Trials

Experimental Treatments

• Hearing Loss• HIV• Ischemic Stroke• Lupus• Multiple Sclerosis• Myocardial

Infarction• Ovarian Cancer• Rheumatoid

Arthritis• Spinal cord injury• Scleroderma• Testicular Tumour

• Liver cirrhosis• Parkinson's Disease• Traumatic Brain Injury

• Maroteaux-Lamy Syndrome• Metachromatic leukodystrophy• Osteopetrosis• Sly Syndrome, Beta-Glucuronidase

Deficiency• Wolman Disease

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Page 11: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Mesenchymal Stem Cells (MSCs) are multipotent stem cells which can differentiate into various types of specialized cells (i.e. bone, cartilage, fat, muscle, etc.).

Mesenchymal Stem Cells (MSCs) • Assist in repair• Reduce inflammation• Divide into other tissues, such as neural tissue, under induction

Mesenchymal Stem Cells (MSCs) also possess immunomodulatory properties. They can be used to promote engraftment for cord blood transplants and hence increase the success rate of blood (hematopoietic) stem cell transplants.

UMBILICAL CORD LINING (UCL) STEM CELLS

Bone Cells

Fat Cells

FibrousTissue Cells

MuscleCells

CartilageCells

MesenchymalStem Cells

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Page 12: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Expanded potential therapeutic applications of Mesenchymal Stem Cells

Mesenchymal Stem Cells (MSCs) have immense potential to be used as therapeutic cells for tissue or organ regeneration due to physical injury or biological damage caused by degenerative disease progression or aging (e.g. heart disease, stroke, diabetes type 1, bone or cartilage disorder, liver disease, lung disease, etc.)

MESENCHYMAL STEM CELLS

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Skeletal tissues – bone & cartilage Cardiac muscle

Nervous system – brain & spinal cord Pancreatic cell

Page 13: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Honmou O et al. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain 2011 134(6): 1790-1807.

• 12 patients with various brain lesions due to ischemic stroke

• Treated with intravenous injection of ex-vivo expanded patients’

own MSC harvested from marrow

• Safe: no tumors, neurologic deterioration, infection from

treatment

• More than 20% reduction of lesions after MSC treatment

MSCs and stroke

Source: Chen SL et al. Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction. Chinese Medical Journal 2004 117(0): 1443-1448.

• 69 heart attack patients were treated;

• Following angioplasty, doctor directly injected patients’ damaged

heart site with MSC harvested from patients’ own bone marrow;

• Results showed significant improvements in patients’ left

ventricular function.

MSC and Heart AttackPlaque build up in the coronary artery blocking

flow and oxygen to the

heart

Damage and death to heart

tissue shown in purple

University of Minnesota , Paediatric Blood and Marrow Transplant Center

• In 2002, Sydney Scott at 13 weeks, was diagnosed with

Acute Myeloid Leukemia (AML)

• Treated with chemotherapy followed by umbilical cord blood

and MSC co-transplantation – world’s first

• MSC thought to enable faster blood stem cell engraftment

• Sydney is relapse and medication free

MSC-HSC co-transplantation

MESENCHYMAL STEM CELLS (MSCs) APPLICATION REPORTS

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Page 14: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• 1 yo male, non-healing wound on left ankle 90 days post hemangioma radiotherapy

• Treatment with cord Tissue MSC in conjunction with Tegaderm™ wound dressing

• Wound healing and closure at 20 days post MSC treatment

• 82 yo male, with non-healing diabetic wound after 15 weeks, chronic leg wound

• Treatment with cord lining MSC in conjunction with Tegaderm™ wound dressing

• Wound healing and closure at 45 days post MSC treatment

• 30 yo male, chemical burn on left foot• Treated with cord lining MSC• Would closure and healing by 21 days

post MSC treatment

Since 2006, 1500+ patients treated with cord tissue MSC therapy for difficult to heal wounds. Cord Tissue MSC heal 80% of these

wounds, improve wound beds for skin graft success.Source: National Institute of Burns, Hanoi Vietnam

CORD LINING MSC – CELLRESEARCH CORP TRIALS

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Page 15: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• Sep 1998 – Feb 1999, 8 patients with 10 skin wounds treated in SGH Burn Centre

• Autologous and allogeneic skin epithelium (keratinocytes) cultured and transplanted with polymer dressing aid

• Rapid re-epithelialization, closure and healing of wounds

• In 2003, 7 patients in Singapore with various ocular surface disorders

• Autologous harvesting and cultivation of conjunctival epithelial stem cells

• Transplantation of cultured stem cells on human amniotic membrane

• All 7 patients fully recovered: disease resolution and complication free

Source: Tay AG et al. Cultured subconfluent keratinocytes on wound polymer dressings in the treatment of burns and chronic wounds. Wounds 2000 12(5):127-133.

Tan DT et al. Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent. Transplantation 2004 77(11): 1729-1734.

EPITHELIAL STEM CELLS (EpSCs) APPLICATION: SINGAPORE

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Page 16: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• Cord lining EpSC transplant in 31 eyes with persistent epithelial defect (PED) – Jan 2011 to Dec 2012

• 29 out of 31 eyes (93.5%) healed with a single EpSC transplant• Normal corneal healing found in all 29 cases with 3-27 months follow up

Source: Department of Cornea and External Diseases , National Eye Institute, Hanoi, Vietnam

CORD LINING (EpSCs) –CELLRESEARCH CORP TRIALS

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Page 17: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Enrollment & Collection:Overview & Reminders

Cord BloodCollection Kit

Umbilical CordCollection Kit

A personalized collection kit will be provided to you.Bring collection kit to hospital on the day of delivery.Trained hospital staff (doctor or nurse) will perform maternal blood and cord blood collection.Call Cordlife immediately after birth of your baby.Cord blood unit will be picked up by Cordlife or its representative within 24 hours, for processing and storage within 48 hours of collection.Cord blood unit can be maintained at room temperature prior to storage, and must not be subjected to x-ray. * Refer to Cordlife Service Agreement for details.

CORD BLOOD AND CORD LINING COLLECTION PROCESS

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Page 18: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Infectious diseasesscreening doneon maternal blood:

• Human immunodeficiency virus (HIV 1 / 2)

• Syphilis (Treponema pallidum)• Cytomegalovirus (CMV)• Hepatitis B (HBV)• Hepatitis C (HCV)• HTLV-I/II (Human T-lymphotrophic

virus)

For HCV/HIV/HTLVreactive samples:• Consent for discard is required• If client insists on storage, a

waiver is required• Need to consult MD for advice

For Hepa Breactive samples :• May be limited to autologous

use

MATERNAL BLOOD COLLECTION AND TESTING

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Maternal Blood Draw/Collection before delivery

4 tubes of maternal blood are collected for a panel of infectious disease testing

Blood samples are sent to 3rd party Laboratory via Cordlife Lab for infectious

diseases testing

Page 19: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

The process of collecting yourbaby's cord blood & cord lining

The baby issafely delivered.

The umbilical cordis clamped

4 tubes ofmaternal bloodare collected for a panel ofinfectious diseases testing.

The cord bloodis collected

Picked-up and Deliveredto Cordlife laboratory

A segment ofumbilical cord

is collected

If cord lining isbeing stored

CordlifeLaboratory

UmbilicalCord

The OB-GYNE is the designated Healthcare

Profesional for collectionInform your OB that you will be banking your baby’s cord blood

Cord blood collection is a safe, painless and risk-free procedure. It is easily collected within a few minutes.

for processing and storage in a cryogenic environment

Cord

Blood

CORD BLOOD ANDCORD LINING COLLECTION

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Page 20: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

CRYO-PRESERVATION

HSCs SEPARATION

PLACEMENTIN CRYO BAG

Sepax machine

Dual compartmentcryo bag with HSCs

Collectedcord bloodin collection

bag

Cord bloodcollection kit

Collectedumbilical cord

in a sterilecontainer

PLACEMENT IN INDIVIDUALCRYO VIALS

CLEANING ANDSEGMENTATION

OF THE CORD

Cord liningcollection kit

Liquid nitrogencryogenic tank

CORD BLOOD AND CORD LINING PROCESSING &LONG TERM STORAGE

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UmbilicalCord

Page 21: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Listed on the Singapore Exchange, Cordlife Group Limited is well established as the largest network of private stem cell banks across Asia with state-of-the-art umbilical cord blood and cord tissue processing and cryopreservation facilities in Singapore, Hong Kong, India, Indonesia, Malaysia, and the Philippines as well as a network that extends through its associates and sub-licensing partners and marketing agents in China, Thailand, and Myanmar.

Located in UP-AyalaLand Technohub, our ISO 9001:2008 certified local stem cell processing and storage facility is the first and only in the Philippines with a storage capacity of over 30,000 units. Cordlife prides itself as the widest network of cord blood bank in Asia, and is trusted by over 300,000 parents worldwide. Cordlife’s facilities are managed by highly qualified laboratory biotechnologists. Built using stringent criteria set by AABB, our facilities are closely monitored and equipped with multiple back-up systems.

1. Publicly Listed, Transparent Credibility

2. The Only Private Cord Blood Bankwith Local Facility in the Philippines

12 GOOD REASONS TO BANK WITH CORDLIFE

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BIGGEST NETWORK OFCORD BLOOD BANKS IN ASIA

Page 22: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

The Company's in-depth knowledge of stem cell banking practices and standards is well recognized by numerous world class quality standard organizations as well as country regulators in the Asia Pacific region. In 2007, Cordlife was bestowed the prestigious ' Technology Pioneer ' title by the World Economic Forum, which further validated the Company's outstanding performance in the industry.

• Started in 2001, Cordlife is highly regarded as the largest and most experienced network of cord blood banks with more processing and storage facilities across Asia than any other cord blood banks in the region.

• As a Group, Cordlife has released a total of 35 cord blood units* to our clients for treatment. Our proven track record for release is the ultimate validation of our processing and storage methods.

• Passed through stringent tests by external medical professionals before infusion.

• Ultimate validation of Cordlife’s processing and long-term storage capability.

3. Quality You Can Trust

4. Most Experienced

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AABB AccreditedSingapore, Hong Kong,

India

ISO CertifiedPhilippines, Hong Kong,

Indonesia & India

Technology Pioneer AwardWinner from WorldEconomic Forum

FACT AccreditationSingapore

Ministry of HealthCertification

Singapore

ISO 9001:2008Philippines

DOH RegistrationUmbilical Cord

Philippines

DOH RegistrationUmbilical Cord Blood

Philippines

* For details, visit www.Cordlife.ph/en/release-track-record

Page 23: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

• Full Refund for No Blood Collection, Low Blood Collection and Unprocessed Samples

• Partial Refund for samples unsuitable for storage• Guaranteed Continuity of Storage to comparable

facilities at no cost

5. Client Protection

7. Highest Quality Service at Reasonable Prices

Cordlife is the only stem cell bank in the Philippines that provides Total Stem Cell Banking Solution for your family’s complete protection against potential diseases.

Unlike conventional technology, Cordlife’s Cell Optima™ technology can harvest two other potentially useful stem cells from the umbilical cord lining: mesenchymal and epithelial stem cells. This patented technology is exclusively available at Cordlife.

Cordlife is a world-recognized healthcare company that can provide you with the highest quality services. At the same time, our services are priced affordably so that every family can benefit from private cord blood banking to safeguard their family’s health.

6. Total Stem Cell Banking Solution

When it comes to stem cell banking for your family, we go all out for quality. We always insist on the best so our clients can receive better transplant and cellular therapy outcomes. Unlike other processing and storage technologies, our technology has never been recalled by manufacturers.

• Eliminates cross-contamination.• Trusted by the majority of private cord

blood banks worldwide.• Lowest sample temperature at -190 C.

• Precision technology made in Switzerland.

• The world's only fully automated cord blood processing technology approved by U.S. FDA.

• Able to recover up to 99% of stem cells (TNC) from cord blood.

8. Best Solution for Cord Blood Banking

MVE Anti-contamination Vapor-PhaseLiquid Nitrogen Storage System

Sepax2™

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300,000 *

* As of July 2016, based on consolidated figures of Cordlife Group Limited and its associates.

Page 24: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Your baby’s cord blood could turn out to be the most precious gift to your child. That is why we have it doubly protected by the Cordlife Quality Guarantee* to assure you of a cord blood unit of suitable match or SGD 50,000 if the cord blood stem cells lost its viability at the point of transplant to safeguard you and your family.

9. Double Protection Guarantee

11. Cordlife Shield*

for Legal Parents and Grand Parents of Cordlife Child, tapping Asia’s largest network of public cord blood banks

• Protection for 3 generations of your family• Child whose cord blood is stored with Cordlife• Legal parents• Legal grandparents• Assistance in the search for a matching cord blood

unit should the need arise

12. Cord Blood Network*

Cordlife will provide a one-time subsidy of SGD 50,000 to partially cover medical costs of transplantation for the child whose cord blood unit is stored (autologous use), applicable for use in standard treatment at any accredited hospital in the Philippines.

10. Cordlife Transplant Care*

Cordlife Shield

Cordlife Shield provides coverage for a pregnant mom who has availed of Cord Blood Banking from 7 types of pregnancy complications, 16 types of congenital illnesses and maternal or child death. Cordlife will provide a subsidy of SGD2,000 for pregnancy complications and congenital illnesses. For maternal or child death, coverage is SGD5,000. Cordlife Shield may only be availed once and is subject to Terms and Conditions and Provisions of the Insurance Policy.

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CordlifeChild

LegalParent

Legal GrandParent

CordBlood NetworkAssisted Search for Matching Cord Blood

* Details are discussed in the Cordlife Service Agreement.

Page 25: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Justin (alias) was diagnosed with a common childhood cancer, neuroblastoma, at a tender age of one and half years old. Over the course of 1 year, the child had to endure numerous rounds of high-dose chemotherapy to treat his condition. Chemotherapy destroyed cancer cells, but at the same time also killed normal cells.

Fortunately, Justin’s parents had his cord blood stored at birth with Cordlife. The cord blood stem cells were infused back to his body after a course of chemotherapy in January 2011 at Queen Mary Hospital and he was discharged from hospital after 3 months. The cord blood unit used had been cryopreserved in Cordlife Hong Kong facility for 29 months. Cordlife is very proud to achieve this milestone in the cord blood banking industry in Hong Kong.

Moinam was diagnosed with Thalassemia when he was barely one year old. If left untreated, most of the children inflicted with this disorder do not live beyond the age of 10. Fortuitously, his newborn sister was free from Thalassemia and her cord blood stem cells were a perfect match for Moinam, with small amount of bone marrow to supplement

the transplant, Moinam is now in his recovery phase and the results from his blood is very heartening.

Justin

Moinam

CORDLIFE’S SUCCESS STORIES

25

"We decided to use a mixture of bone marrow and cord blood cells as it has a better and faster chance of success than only bone marrow cells. Bone marrow stem cells, on the other hand, could lead to Graft Versus Host Disease, triggered by the body's defense mechanism while the transfusion is being done. Not only increase the stem cell count, but also reduce the chance of any complications. It is the treatment of choice in such cases and leads to a complete cure," explained Dr Mukherjee, Medical Director of NetajiSubhash Chandra Bose Cancer Research Institut.

Page 26: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Moinam was diagnosed with Thalassemia when he was barely one year old. If left untreated, most of the children inflicted with this disorder do not live beyond the age of 10. Fortuitously, his newborn sister was free from Thalassemia and her cord blood stem cells were a perfect match for Moinam, with small amount of bone marrow to supplement

the transplant, Moinam is now in his recovery phase and the results from his blood is very heartening.

Source: The Telegraph, 7 May 2011

Georgia

Source: The Sun, 3 December 2009

An accident at birth 2.5 years ago deprived Baby Georgia of oxygen to her brain, resulted in cerebral palsy. The damage to the toddler's brain caused her to move involuntarily, suffer from muscle spasms and have up to 50 seizures a day. It was only after Cordlife put the family in touch with a renowned neurosurgeon that enable Georgia to be

infused with her own cord blood, also stored by Cordlife. Her conditions have improved since then.

"Georgia has made good progress since her stem cell infusion. She has better visual focus and eye contact with adults during play. She has more vocalization and tries to 'sing-a-song' by making different sounds to nursery rhymes. Georgia has improved postural and head control and is observed to be reaching more with her arms," said Ms. Jaclyn Tan, Consultant Occupational Therapist at OzWorks Therapy.

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"We decided to use a mixture of bone marrow and cord blood cells as it has a better and faster chance of success than only bone marrow cells. Bone marrow stem cells, on the other hand, could lead to Graft Versus Host Disease, triggered by the body's defense mechanism while the transfusion is being done. Not only increase the stem cell count, but also reduce the chance of any complications. It is the treatment of choice in such cases and leads to a complete cure," explained Dr Mukherjee, Medical Director of NetajiSubhash Chandra Bose Cancer Research Institut.

Page 27: Expectant Parents’ Guide to Cord Blood and Cord Lining Banking€¦ · 10 skin wounds treated in SGH Burn Centre • Autologous and allogeneic skin epithelium (keratinocytes) cultured

Chito MirandaSongwriter, Lead Singer for Parokya ni Edgar,

Proud Dad to Miggy and Husband to Neri

Isabel Oli PratsModel, Television Host, Movie Actressand Mom to Feather and Wife to John

Iya Villania-ArellanoTV Personality, Proud Mom of Primo and Wife to Drew

CORDLIFE PARENTS

“This is my family.

I will do everything in my power para maalagaan sila ng maayos, to provide for them, to spoil them, and to give them an advantage sa future.

I will save and invest all my money for them. I will take care of myself better para mabantayan ko sila hanggang sa pagtanda ko. I will behave and not do anything stupid, I will work harder, and spend as much time with them as possible.

Kumuha din ako ng cordlife para sa anak ko. Mga 8k a year lang yun, chong. Google nyo. Sobrang solid yun. Para kahit paano mas kampante ako sa health ng anak ko sa future.

Parang spare tire lang yan eh. Ayaw mo syempre na ma-flatan ka, pero at least kampante ka na may reserba ka...just in case. Hindi yung maghahanap ka lang ng reserba kung kelan flat na yung gulong mo.

Anyway, tulog ngayon ang mag-ina ko. Sarap ng tulog nila pareho. Both of them, safe and healthy.”

“As a mother, I strongly recommend cord blood banking to other parents. It is a health insurance that is safe, painless, and non-disruptive to your birth plan.”

“Banking Primo's cord blood and lining was a no brainer! Who knows who might need his stem cells! He just might end up being his Lola's hero or maybe even mine one day”

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Luzelle Atienza-ZataMother of three & Cordlife Cares recipient

Leanne Joy Marie Co PachecoCordlife Mom since 2012

Tammy BanateCordlife Parent

“My heart was broken in a million pieces when I found out that my first born was stricken with Leukemia at 2 years old. When almost all hope is gone, his pedia-oncologist recommended stem cells to help treat his illness. I recently gave birth to a healthy baby girl and through the help of Cordlife Cares Program, we were able to store the stem cells from her umbilical cord blood. Now we have a ready source of stem cells for her older brother! In the midst of all our worries and fears, Cordlife gave us hope that we can conquer the big C. I consider it as the wisest decision a parent could ever have, like getting a life security blanket to keep the family safe and warm in time of need.”

“Wala kaming medical history ng leukemia—just diabetes in the family, but alam naman namin na along the way madami pang mga research and findings, so kumuha kami ng Cordlife tapos ayun, na-lessen yung worry ko for my kids’ health kasi may hope if ever may mangyari.”

“I’m a first-time mom to six-month old triplets. I asked my OB-Gyne about cord blood banking even before I got pregnant to ensure that we are on the same page. I believe having a doctor who is very knowledgeable about cord blood banking plays a vital role in making the journey to motherhood smooth and worry-free. I can say that I’m in good hands, have peace of mind and am now a proud Cordlife mom.”

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A Singapore Exchange mainboard-listed mother and child healthcare company.Trusted by 300,000* parents in Asia since 2001.

Cordlife Medical Phils., Inc.

A consumer healthcare company continuingto serve the needs of mother and child

Cordlife Medical Philippines Inc.Corporate Office and Storage Facility

Unit 104, Building H, UP-AyalaLand TechnohubCommonwealth Avenue, Brgy. UP Campus, Diliman

Quezon City 1101, Philippines

Cordlife Cebu OfficeUnit B204, Cluster B 2nd Floor,

Axis Entertainment Avenue, Vibo Place N. Escario Street, Cebu City 6000, Philippines

(032) 415 3083

Satellite OfficeRoom 216, Medical Arts Building

St. Luke’s Medical Center279 E. Rodriguez Sr. Bldg., Quezon City 1112

(02) 470 1735 / (02) 332 18880998-8486063 / 0998-8486064

LIKE US ON FACEBOOK:facebook.com/CordlifePhilippines

[email protected]

* As of July 2016, based on consolidated figures of Cordlife Group Limited and its associates.

All information accurate at time of printing. DCR No. 1864