exhibition 2018: national center for patent and ... · 3 total global market, 2016 60,000 tonnes...
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Exhibition 2018: National Center for Patent and Information of the republic of Tajikistan (NCPI RT)
Chemistry Institute of Tajikistan Academy of Sciences (Институи кимиёи ба номи В.И. Никитини Академияи илмҳои Ҷумҳурии Тоҷикистон) 299/2 Ainy str., 734063 Dushanbe, Tajikistan tel/fax: 992 372258095, mobil: 992 934884843 E-mail: [email protected]; web: www.ikai.tj
New Technological Process include flash
Hydrolysis & Extraction (A) of pectin from
fruits pulps and dynamics mode for sunflower
head residues (B). Technological line include
dia-ultrafiltration method for purification and
concentrate of pectin solution (C).
Advantage over traditional methods– low
acid pH and contact time during extraction 5-
10 min instead of 60-120 min. Highly quality
of extracted pectin. Process exclude vacuum
evaporation and use of large quantity of
alcohol
The technology is protected by 2 patents in
Tajikistan, 1 Eurasian and 2 Industrial Model
in Ukraine
The advantage of C technique over typical
process and other patents (DE 3041096 A1,
EP 0426431 A1) was proved in the
experimental pectin workshop of PAPO
“Shahrinav”, Tajikistan
The technological line of A & C and B & C
were tested in the Pilot Plan using different
local raw materials (Appendix 1).
New Process
Low energy consumption
Easy retrofitting and low
maintenance
Low cost product
Ecological friendly, reliability
and productivity of process
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Advantages of Technique of A,B, C:
Low Pectin Price;
Flexible technology;
Easy retrofitting and low maintenance ;
Low energy consumption;
Ecological friendly, reagent less,
reliability and productivity of process.
Citrus pectin-CP Kelco, Denmark,
Apple pectin-Herbstreith & Fox KG, Germany
Fruit Pectin-Technological line combining
process A &C
Sunflower pectin-Technological line
combining process B &C
Competitive advantageous over Traditionally technology for
Pectin production :
Shortcomings of competitors:
High price;
Time consumption;
Large quantities of expensive and
inflammable settling alcohol;
High consumption of electric power for
evaporation and spirit regeneration;
Ecological problem- explosive spirit and
vacuum installation.
Citrus pectin-Danisco Ingredients USA Inc.
Exhibition 2018, NCPI RT
HM Pectin –
Jams and Jelly
68%
Characteristics of Commercial Pectin
Food additive (code # 440 & E440)
DE>50 - high methoxy (HM)
• rapid, medium or slow set (RS, MS, SS)
DE<50 - low methoxy
• conventional (LMC)
• low methoxy amidated(LMA)
Several grades marketed for
different applications
2003
2013
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Total global market, 2016 60,000 tonnes CIC countries market 4,500 tonnes LM pectin (~15%) ~5,000 tonnes Overall growth rate 7,1% LM pectin 10-20% Current price (US$) HM: 11.00/kg LM: 12.90/kg
Application Growth Rate
Fruit preparations 15 –20% Fruit spreads (low sugar jams) 10% + Yoghurt and dairy 15 –20% Acidified milk drinks, high-sugar jams
2 –5%
Fruit juices & high calcium drinks 10 –15% Baked goods, confectionary 5% Fat replacers 20% +
The global pectin market [http://www.grandviewresearch.com/industry-analysis/pectin-market ]is expected to reach USD 1.9 billion by 2025, according to a new report by Grand View Research, Inc.
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Production of LM Pectin: Traditional R-COOMe+ H2O →R-COOH + MeOH
aq. acid or aq. acid/org. solvent
aq. alkali (other than amidation)
enzymic
Main natural sources Sunflower (pectin-20-25%,
GA>65%)
Pumpkin (10-15%, GA >60%)
Peach (15-20%, GA >65%)
Some special applications
Reduced/low sugar jams & jellies
Heat reversible jams, jellies &
fillings
Baking stable fruit preparations
Cold setting milk jellies
Fruit preparations for yoghurt
Control of fruit separation: HM +
LM.
Peach Pectin (Prunus persica) Powder, 10 kg (22 lbs): RF--$522
Пектин превращает еду в наслаждение
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Food Prophylactic
products ( Functional &
diet)
BioActive Additives
OTC
Non-prescription medication
Drug form
Pharmaceuticals
• Colon-specific drug delivery systems
(are more effective and reproducible
in comparison with other delivery
systems).
• utilized in a number of liquid
pharmaceutical preparations.
• Anti-diarrhea suspensions,
• Pectin is extensively used as a
component in the adhesive part of
ostomy rings,
• Pectin composites as cartilage
replacers
Medicine • Pectin, excret lipids, cholesterol and bile
acids, and reduce serum cholesterol levels.
• Pectin has anti-diarrhea effect.
• Pectin acts as an antioxidant against the
damaging portion of cholesterol in the blood
stream.
• Prevent colon cancer.
• Pectin increase acidity (pH) in the large
intestines, suffering from ulcer or colitis, and
regulating blood pressure.
• Pectin prevent gallstones.
• Regular use of Pectin may lessen the
severity of diabetes.
Fibersol Caps -(200 Capsules),Twinlab- $19 MCP (Modified Citrus Pectin) 360 grams -
Vital Nutrients - $132 Allergy Research Group Modified Citrus Pectin
Pwd 16oz -$115
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A new drug delivery system (DDS) based on pectin/protein in form of hydrogels and microcapsules in emulsion are developed.
The hydrogel drug delivery form based on the pectin and corn zein
The microcapsules tailored on different pectin & Whey Lg concentrate.
Both therapeutic systems may withstand high temperature and pH, to protect active drug, aroma and flavor.
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Drug Delivery Technology Market worth 1,669.40 Billion USD by 2021
Global Forecast to 2021", Drug delivery technology market is projected to reach USD
1,669.40 Billion by 2021 from USD 1,179.20 Billion in 2016, at a CAGR of 7.2% during
the forecast period.
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1. Jonmurodov, A., Bobokalonov, J., Usmanova, S.,
Muhidionоv Z.K., and Liu, L.S. Agricultural Sciences,
2017, vol.8, p.857-867.
2. Shamsara O., Jafari S. M., Muhidinov Z.K. Journal of
Biological Macromolecules, 103(2017), p. 1285-1293.
3. DjonmurodovA.S., Muhidinov Z.K., Strahan G.D., Kholov
S.E., Teshaev Kh.I., Fishman M.L., Liu LS. In Gums and
Stabilisers for Food Industry 16. / Ed. by Peter A. Williams
and Glyn O. Philips.-RSC Publishing 2016. P. 23-36.
4. Muhidinov Z.K., Teshaev Kh.I, Kasimova G. F.,
Nasriddinov A.S., Liu LS. Pectin-Zein Hydrogels for
delivery of Drugs and Nutrients. In Gum and Stabilisers for
the Food Industry 16, RSC publishing, Cambridge UK.
2012, p. 401-406.Shamsara O., Jafari S.M.,
5. Muhidionv Z.K. Development of double layered emulsion
droplets with pectin/ β-lactoglobulin complex for bioactive
delivery purposes. Journal of Molecular Liquid, 2017, 243,
6. Shamsara O., Muhidinov Z.K., Jafari S.M., Bobokalonov
J., et al. International Journal of Biological
Macromolecules, 81(2015), p. 1019-1025.
7. Z.K. Muhidinov, J.D. Bobokalonov, L.S. Liu, and R.
Fassihi. A Kinetic Study of Poor Water Soluble Drug
Released from Pectin Microcapsules Using
Diffusion/Dissolution Model ACS Symposium series 2008,
No. 992 s, Chapter 11, p. 193-208.
8. Z.K. Muhydinov, D.Kh. Khalikov, T. Speaker and R.
Fassihi. Development and characterization of different low
methoxy pectin microcapsules by an emulsion – interface
reaction technique. Journal of Microencapsulation. 2004
vol. 21 (7), p. 729-741.
Piroxicam release kinetics from
the Zein/pectin hydrogel
microspheres at ex vivo
experiments.
Ex Vivo Piroxicam fraction
released cures for
microcapsules prepared with
the LM APSh pectins:
LgC/Pectin ratio 18; volume
of emulsion containing
cecum content in dialysis
Piroxicam plasma concentration
released from microcapsules of
LgC/LM Apple pectin. In vivo
experiments; mean SD, n= 6.
0.0
0.1
0.2
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0.8
0.9
0 5 10 15 20 25 30 35t, hours
Mt/
Mo
0
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0 10 20 30 40 50 60t, h
Mt/
Mo
Z/APSH 1,0 Z/CPK L/200 1,0
PX plasma
concentration
0,
00
0,
20
0,
40
0,
60
0,
80
1,
00
1,
20
1,
40
1,
60
0 5 1
0
1
5
2
0
2
5
3
0
t,ho
urs
um/
ml
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• Nasal drug delivery (транспорт ЛВ через органов дыхания)
• Oral drug delivery (пероральная) • Cancer-targeted drug delivery (транспорт в
раковых клеток) • Pectin polyplexes for gene delivery
(Polyplex-Биаксиально ориентированной пленки ПЭТ (BOPET) успешно используется в различных областях, благодаря отличной комбинации оптических, физических, механических, термических и химических свойств.
• Ocular drug delivery (носителей для глазных каплей)
• Pectin gels for tissue engineering (пектиновые гели для тканевых инженерии)
Pectin gels as wound healing
patches (гели для заживление ран)
• Функциональная пища
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