ex vivo gene therapy using patient ipsc-derived nscs reverses pathology in the brain of a homologous...

9
Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson, John H. Wolfe Stem Cell Reports Volume 4, Issue 5, Pages 835-846 (May 2015) DOI: 10.1016/j.stemcr.2015.02.022 Copyright © 2015 The Authors Terms and Conditions

Upload: bethany-morton

Post on 18-Jan-2016

214 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model 

Tagan A. Griffin, Hayley C. Anderson, John H. Wolfe 

Stem Cell Reports Volume 4, Issue 5, Pages 835-846 (May 2015)

DOI: 10.1016/j.stemcr.2015.02.022

Copyright © 2015 The Authors Terms and Conditions

Page 2: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 1

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 3: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 2

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 4: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 3

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 5: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 4

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 6: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 5

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 7: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 6

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 8: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Figure 7

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions

Page 9: Ex Vivo Gene Therapy Using Patient iPSC-Derived NSCs Reverses Pathology in the Brain of a Homologous Mouse Model Tagan A. Griffin, Hayley C. Anderson,

Stem Cell Reports 2015 4, 835-846DOI: (10.1016/j.stemcr.2015.02.022) Copyright © 2015 The Authors Terms and Conditions