EVOLUTIONARY GENOMICS OF ORGANISMAL DIVERSITY

Steve Moss

My PhD

• Introduction

• Summer work

• First year

• Second year

• Third year

• In a Nutshell

Introduction

• Deliberately broad title

• Comparative Genomics

• Genome evolution

• Organismal adaptation

• Bioinformatics and Computational Biology

• Cross-discipline

“Evolutionary Genomics of Organismal Diversity”

Summer work

• Previous PhD work

• Teleost fish

• Genome architecture

• Introns and exons

• EnsEMBL

• Comparative genomics

Summer Work

Corroboration

• Retrieve original data

• Developed novel scripts

• EnsEMBL release 46

• EnsEMBL release 58

• Unable to reproduce

The PhD

First Year• Phylogenetic comparative

method?• Genome size• Intron number and size• Transposable elements

• Orthologous loci?• Do orthologous introns

evolve in a clock-like manner?

• Gene families?• Significance of gene family

size changes?• Social insect data

The PhD

First Year

• Data

• Computational evolutionary comparative genomics

• Develop software toolkit

• Implement basic pipeline

• Genomic components

• Include orthology

• Expand across taxa

The PhD

Second Year

• Patterns of heterozygosity

• Expansion of transposable element families

• Polyploidy• Decay of alleles• Regain of diploidy

• Nematode genomics• Blaxter Lab• Meiosis• Sequence pair• 3 nematode genomes

The PhD

Third Year

• Follow up interesting ideas and discoveries

• Analyze any new genomes

• GOLD

• Make updates to toolkit

In a nutshell…

• Answer important biological questions

• Evolution of genome architecture

• Evolutionary Comparative Genomics

• Bioinformatics and Computational Biology

• Development of software and tools

Thank you!

Any questions?

Steve MossEmail: S.P.Moss@2007.hull.ac.uk

Web: http://stevemoss.ath.cx/Twitter: @gawbul