evaluation of multiple allele probabilities at a single locus for ungenotyped members of complex...
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8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 1/20
Kvmaumteio ic Fuatepak Maakak Xri`m`eaeteks mt m
Reogak Aibus cir [ogkoitypkj Fkf`krs ic Bifpakx Xkjegrkks
Grkgir Girnmob
[oevkrsety ic Anu`anmom! @eitkbdoebma Cmbuaty! Moefma Rbekobk Jkpmrtfkot
Mppaekj RtmtestebsPe`oi! 08td Rkptkf`kr 08=8
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 2/20
Eotrijubteio
Jkvkaipfkot ic fiakbuamr gkoktebs akjti tdk m`uojmot siurbk ic gkoitypkeocirfmteio
Diwkvkr> fmssevk gkoitypeog steaa kxpkosevk sifk eojevejumas oit $ykt% gkoitypkj bioffebteog gkoitypks mfiog rkamtevks / / /
MEF> Eockr eojevejumas― gkoitypk crif gkoitypks ic rkamtevks9
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 3/20
Fitevmteog mppaebmteio & XrX $XroX% gkok eo sdkkp Gkok XrX mkbts jkvkaipfkot ic sbrmpek $fmj biw aelk jeskmsk
eo sdkkp% eo bmsk ic ‑eockbteio‖
=2td bdrifisifk! piayfirpdesfs mt skvkrma gkok piseteios
$bijios%< fist crkqukot mrk> =23td! =;:td! # =7=st>M=23P =;:P =7= ?
MPP
Fuatepak maakaks> MPP ! MD] ! MPD ! MP]! SP] ! / / /
Fmoy gkoitypks! /k/g/! ; maakaks ‒? =; gkoitypks
@rkkjkrs sdiuaj skakbt cir MPP maakak---
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 4/20
Gkoitypk eockrkobk & sefpak kxmfpak
Eockr eojevejumas― gkoitypk crif gkoitypks ic rkamtevks9
M$=%)M$0% M$0%)M$0%
M$9%)M$9%
XrM$=%)M$=%
6 8
XrM$=%)M$0%
6 =)0
XrM$0%)M$0%
6 =)0Xr
M$0%)M$0%
6 8/88
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 5/20
Gkoitypk eockrkobk & ykt moitdkr kxmfpak
Eockr eojevejumas― gkoitypk crif gkoitypks ic rkamtevks9
m= m0
m2 m:
m; m3
m7 m4 m5
m=8
g 69
--
-
-
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 6/20
Gkoitypk eockrkobk & fktdijs
=/ @rutk cirbk9 l o! 2=8 6 ;5! 8:5 >$
0/ Xkkaeog $6 vmrem`ak kaefeomteio%
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‒? etkrmtevk pkkaeog $6 aiipy `kaekc pripmgmteio%
2/ Fmrliv bdmeo Fiotk Bmrai $tkrre`ak fexeog! efprmbtebma circrkqukot usk%
:/ Mpprixefmteios wetd aeokmr fijkas ‒? maakak eockrkobk
:/= cmst cir amrgk jmtmskts:/0 mvmeam`ak sictwmrk
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 7/20
Maakak eockrkobk wetd aeokmr fktdijs
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y 6 =` , k Gkogakr kt ma/ $0887% & `msk pipuamteio $`% moj eojevejuma
jkvemteios $j% cir `emaakaeb gkoksy 6 =` , ^j , k
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 8/20
Maakak eockrkobk wetd aeokmr fktdijs
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8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 9/20
Kxtkoseio cir fuatepak maakaks‑Xdkoitypk‖
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y$0%
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8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 10/20
Fexkj fijka kqumteios
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‒? degd dkretm`eaety d0
6 =∐ ! smy 8/58&8/55
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 11/20
Mppaebmteio Zkxka sdkkp eo Raivkoemo sdkkp `rkkjeog prigrmffk
`msk ffibl efpirtkj crif Oktdkramojs eo =548― rkpkmtkj efpirts ic rmfs kvkry ckw ykmrs
`kcirk $iaj pipuamteio% moj mctkr $okw pipuamteio% streogkotskakbteio io XrX gkok eo Oktdkramojs‒? tdes pribkss wms fijkaakj wetd twi gkokteb griups! e/k/!skpmrmtk `msk pipuamteio maakak crkqukobeks
;;; moefmas eo tdk pkjegrkk 52 moefmas crif rkbkot gkokrmteios gkoitypkj cir XrX gkok
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 12/20
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 13/20
@msk pipuamteio maakak crkqukoby
kstefmtks
MaakakFktdij MPP MD] MPD MP] SP]
Biuoteog 8!;07 8!8:4 8!=0: 8!032 8!824
@A[K= 8!;:: 8!8;2 8!8;4 8!28; 8!8:8
@A[K0 ‑iaj‖ 8!2;: 8!87= 8!848 8!:23 8!8;5
@A[K0 ‑okw‖ 8!558 8!885 8!884 &8!880 &8!883
=fijka wetdiut gkokteb griups0
fijka wetd gkokteb griups $‑iaj‖ moj ‑okw‖ pipuamteio%
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 14/20
Zrkojs cir MPP maakak `y fktdij
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=54; =558 =55; 0888 088;
8 / 8
8 / 0
8 / :
8 / 3
8 / 4
= / 8
Ukmr ic `ertd
M P P
m a a k a k c r k q u k o b y
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=54; =558 =55; 0888 088;
8 / 8
8 / 0
8 / :
8 / 3
8 / 4
= / 8
Ukmr ic `ertd
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=54; =558 =55; 0888 088;
8 / 8
8 / 0
8 / :
8 / 3
8 / 4
= / 8
Ukmr ic `ertd
Xkkaeog AF AF,GG
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 15/20
Biobauseios
Aeokmr fijkas kom`ak nieot $mpprixefmtevk-% eockrkobk ic
eojevejuma maakak pri`m`eaeteks moj `msk pipuamteio maakak crkqukobeks
eo bmsk ic
amrgk pipuamteios! fuatepak maakas! jekrkot iregeos moj gkoitypk moj)ir pkjegrkk krrirs/
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 16/20
Moy quksteios-
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 17/20
M`strmbt
Jkvkaipfkot ic fiakbuamr gkoktebs akj ti tdk m`uojmot siurbk ic gkoitypk eocirfmteio/ Diwkvkr! tdkrk mrk ictko sifk eojevejumastdmt mrk oit $ykt% gkoitypkj ir tdker gkoitypk es eo bioffebt wetd tdkgkoitypk ic rkamtevks/ Eo subd bmsks tdk kvmaumteio ic gkoitypkpri`m`eaeteks `mskj io tdk gkoitypks ic rkamtevks bmo `k pkrcirfkj
useog tdk si bmaakj pkkaeog fktdijs/ Diwkvkr! stmojmrj pkkaeogfktdijs bmo ioay `k uskj wetd rkamtevkay sefpak pkjegrkks/ Cirbifpakx pkjegrkks tdk mpprixefmtk fktdijs bmo `k uskj/ Dkrk subdm fktdij es prkskotkj tdmt kfpaiys m aeokmr fexkj fijka wdebd
biosejkrs fuatepak maakak aibe! gkoitypk moj)ir pkjegrkk krrirs!uoloiwo maakak crkqukoby eo m ciuojeog pipuamteio! moj pkjegrkks ic prmbtebmaay uoaefetkj sezk/ Mo mppaebmteio ic tdes fktdij es sdiwo cirtdk XrX gkok eo sdkkp eo Raivkoem/
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 18/20
Kteiaigy ic sbrmpek eo sdkkp
=/ 0/
2/ :/
$ %
8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 19/20
Gkoitypk eockrkobk & fijka $gkoktebs%
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`
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p
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p $ge |`% 6
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` $0%` $=% ` $0%` $0%
//// / /
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8/8/2019 Evaluation of Multiple Allele Probabilities at a Single Locus for Ungenotyped Members of Complex Pedigrees - Talk
http://slidepdf.com/reader/full/evaluation-of-multiple-allele-probabilities-at-a-single-locus-for-ungenotyped 20/20
/ / / , krrirs)pkoktrmobk
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p $ge |ye ! `! % ∖p $ye |ge ! % p $ge |`%p $ye |ge ! % p
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" p d k o i t y p k "
∐ k r r i r r m t k
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