EVA R. CHIN

Assistant Professor

School of Public Health

University of Maryland

College Park, MD 20740

Ph (301) 405-2478

Fax (301) 405-5578

Cell (860) 405-4336

e-mail: erchin@umd.edu

EDUCATION

1989-1993 University of Waterloo Ph.D.

Faculty of Applied Health Sciences

1987-88 Queens University B.Ed.

Faculty of Education

1985-87 McMaster University M.Sc.

Adapted Human Biodynamics Exercise Physiology

Program

1981-85 University of Windsor B.H.K.

Faculty of Human Kinetics

SOCIETY MEMBERSHIPS

American Physiological Society

American College of Sports Medicine

OTHER PROFESSIONAL ACTIVITIES

Journal Review Panels

1999-2001 Editorial Review Board, Journal of Applied Physiology

1996-present Reviewer, Journal of Applied Physiology

1996-present Reviewer, Canadian Journal of Physiology and Pharmacology

1994-2000 Reviewer, Plugers Archiv

1998-present Reviewer, Journal of Physiology

2001-present Reviewer, American Journal of Physiology

2005-present Reviewer, Molecular Biology of the Cell

2009-present Reviewer, PLoS One

Grant Review Committees

1999-2000 Reviewer, Australian Research Council

2002-2006 Grant Review Committee member (Integrated Animal Biology) for Natural Science

Engineering & Research Council of Canada (NSERC)

2009-2011 Member, Vanier Canada Graduate Scholarship Selection Committee (NSERC)

2009-2012 Member, Movement and Exercise Grant Review Committee, Canadian Institutes of

Health Research (CIHR)

2013-present Member, Vanier Graduate Scholarship Selection Committee (CIHR)

RESEARCH EXPERIENCE

September 2008 – current University of Maryland, College Park: Assistant Professor

Established new research lab focused on Molecular Basis of Muscle

Function.

Research lab currently focusing on single muscle fibre contractility

and Ca2+

imaging. Model system being used to investigate

mechanisms underlying muscle dysfunction with aging, muscular

dystrophy and neurodegenerative diseases (i.e. ALS, SMA). Based

on mechanisms of the disease we are evaluating treatments (exercise,

diet and pharmacological strategies) that will attenuate these

impairments.

Research also focusing on basic cellular and molecular mechanisms

regulating fast and slow muscle fibre-type specific gene expression

using cell culture models.

Translational research with Dr. Andrew Goldberg, MD, VA Medical

Center Baltimore , investigating changes in human muscle

glycoproteins in diabetic subjects and reversal of glycoprotein

accumulation with exercise intervention.

Evaluating muscle regenerative capacity using muscle-derived

satellite cells and its application to: i) muscle tissue bioengineering

for development of a small molecule screening platform and ii)

muscle repair under disease or injury conditions.

April 2006 – August 2008 Pfizer Global Research & Development (Groton labs): Associate Director

Global Project Management: Cardiovascular & Metabolic Disease

support Research Candidate Management Teams in planning, conducting

and reviewing data from clinical trails for novel proprietary compounds in

obesity, osteoporosis and frailty

April 2004 – April 2006 Pfizer Global Research & Development (La Jolla labs): Principal Scientist

Research Pharmacology (Diabetes & Obesity)

Lead a small group of scientists conducting in vitro and in vivo

pharmacological studies aimed at identifying small molecule and

antibody-based therapies that are efficacious at lowering blood glucose

Focus on mechanisms for overcoming fatty acid-induced insulin

resistance in muscle, adipose and liver through targeting MAPK

signalling pathways and for increasing muscle mass by targeting

myostatin signalling

In vitro assay development includes Cellomics nuclear translocation

assays, Meso Scale Discovery phosphoprotein assays (include multi-spot

arrays) and 3H 2-deoxyglucose uptake assays in myocytes and 3T3-L1

adipocytes

In vivo studies include use of ob/ob, db/db and KKAy/a models of

diabetes for efficacy and biomarker outcomes

December 1999 – April 2004 Pfizer Global Research & Development (Groton labs): Senior Research

Scientist (Frailty Biology)

Focused on identifying novel targets for drug discovery in new area of

age-related muscle wasting (sarcopenia)

Utilized micro-array and proteomics technologies, adenovirus and siRNA

approaches as well as transgenic and knockout mouse models for target

identification and validation

Developed cell-based assays for moderate throughput screens of

proprietary compounds including Cellomics-based nuclear translocation

assays

Developed in vivo models for assessing motor performance to establish

pre-clinical efficacy of clinical candidates; included use of genetically

modified mice, ob/ob, and mdx mice

Established fluorescence microscopy technique for assessing myocyte

intracellular Ca2+

levels in aged and atrophied muscle

Focused on myostatin and IGF-1 signaling pathways

Managed external grants to academics including Dr. Karyn Esser

(University of Illinois at Chicago; now at University of Kentucky), Dr.

George Ordway (University of Texas Southwestern Medical Center at

Dallas), Dr. Richard Harvey (Victor Chang Cardiac Research Institute,

Sydney Australia) and Professor David Allen (University of Sydney)

July-December 1999 University of Queensland: Lecturer

Set up research lab to investigate the molecular basis for skeletal muscle

adaptation to exercise training.

Established cell culture model for investigating Ca2+

-dependent pathways

of gene expression using quantitative rt-pcr

Held three internal grants funded through the Australian Research

Council (~ $60,000 per yr)

October 1996-June 1999 University of Texas Southwestern Medical Center: Research Fellow

Investigated the molecular basis for fibre-type specificity of gene

expression in skeletal muscle

Developed expertise in techniques of molecular biology which can be

applied to understanding the molecular basis of muscle plasticity,

including: DNA cloning, tissue culture work, gene transfection,

generation of transgenic mice, genotyping using southern blot and PCR

screening and gene expression analysis using RT-PCR, northern blot and

western blot techniques

Established expertise in Ca2+

-dependent pathways of regulating muscle

gene expression including use of cell-based and transgenic mouse models

August 1993-October 1996 University of Sydney, NH&MRC Research Officer

Investigated the regulation of intracellular Ca2+

in isolated single fibres

during muscle fatigue

Trained in techniques of micro-dissection, micro-injection and the use of

fluorescent dyes and caged compounds for single cell analysis

Developed expertise in the role of intracellular Ca2+

in both acute and

prolonged muscle fatigue

Sept. 1989-July 1993 University of Waterloo, Ph.D. Candidate

Modified and implemented several techniques for assessing skeletal

muscle membrane function

Co-ordinated research into sarcoplasmic reticulum Ca2+

regulation during

muscle fatigue

September 1985- McMaster University, M.Sc. Candidate

September 1987 Supervisors: Dr. J.D. MacDougall and Dr. G.J.F. Heigenhauser

Design and completion of thesis research investigating ionic and

metabolic regulation in inactive skeletal muscle

May 1983- University of Windsor, Summer Research Assistant

September 1983

Assistance with experiments investigating myosin ATPase plasticity

during compensatory hypertrophy in rat skeletal muscle

TEACHING & SUPERVISORY EXPERIENCE

January 2009 – current University of Maryland, College Park

Teaching courses in Exercise Physiology cluster

Undergraduate courses (3): KNES497 Senior Thesis Research,

KNES497-0104 Adaptations of Skeletal Muscle with Disease and

Exercise Training; KNES498I Advanced Applied Physiology and

KNES498N Skeletal Muscle Physiology in Exercise and Disease

Graduate course: KNES691 Muscular Aspects of Exercise Physiology

Undergraduate on-line and hybrid course KNES498N and KNES498N-

WB Skeletal Muscle Physiology in Exercise and Disease

January - May 2007

& January-May 2008 Connecticut College

Adjunct Professor for Human Physiology undergraduate course.

Course designed as a studio class with mini-lectures, lab activities, group

discussion and presentation.

Focus is problem-based learning.

December 1999- Pfizer Global Research & Development

August 2008

Supervise research associates involved in developing high throughput

screening assays, cell-based signalling assays, analysis of tissues ex vivo for

signalling proteins and gene expression and in vivo drug screening

Trained and supervised undergraduate students during summer research

internships

July - December 1999 University of Queensland

Lectured undergraduate and graduate students in exercise physiology course

Co-ordinated undergraduate and graduate level exercise physiology laboratory

course

November 1997- UT Southwestern Medical Center

June 1999

Lead team project investigating the role of calcineurin in the regulation of gene

expression and hypertrophic growth in skeletal muscle

Supervised 2 full-time and 1 part-time technical staff and 1 graduate student

June-July 1998 UT Southwestern Medical Center

Training and supervision of rotating medical student during summer research

experience

August 1994 - University of Sydney

October 1995

Casual lecturer in graduate course in Applied Physiology - Exercise Sports

Science/Sports Physiology

lecturer for topics of metabolic regulation and muscle fatigue

December 1992- University of Waterloo

July 1993

Lectured in undergraduate and graduate courses in exercise and muscle

physiology

Representative of Graduate Student Association on committee set up by the

University President to evaluate the use and needs of the students physical activity

complex

Academic Supervisory Experience

Graduate Students

Current: 1. Dapeng Chen (PhD)

2. Davi A.G. Mazala (PhD)

3. Alicia DeRusso (MA)

Previous: 4. Davi A.G. Mazala (MA, May 2011)

Thesis: The role of excitation-contraction coupling failure in muscle fatigue

and weakness of dystrophic mice

5. Sam A. English (MA, June 2012)

Thesis: Alterations in the myogenic capacity of satellite cells in a mouse

model of ALS

Undergraduate Students

Current: 1. Jessica Moy (Kinesiology Honor’s Program)

2. Joshua Schimmel (Kinesiology Honor’s Program)

3. David Amici (Kinesiology Honor’s Program)

4. Matthew Liu (Physiology & Neurobiology)

Previous: 1. Pai Han Cheng (Physiology & Neurobiology); currently a Research Assistant

2. Brad Antlitz (Kinesiology); currently Physiotherapy Assistant

3. Daphney Clermont (Microbiology May 2012; currently Research Associate at NIH)

Undergraduate Thesis: Evaluation of the effects of gingerol on skeletal muscle

satellite cell function in vitro

4. Spencer Bonar (BSc Physiology & Neuroscience May 2012; medical school

applicant)

5. Sumeet Gupta (BSc Neuroscience & Business May 2011; currently Medical

Student, University of Virginia)

Undergraduate Thesis: Impaired regenerative capacity of muscle satellite cells

from a mouse model of Amyotrophic Lateral Sclerosis

6. Avi Blumenthal (B.Sc. Kinesiology); MCUR student.

7. Brittany Jacobs (BSc. Kinesiology May 2010; currently PhD candidate,

University of Wisconsin, Madison)

Undergraduate Thesis: Role of Ca2+ signaling pathways in the regulation of

fast versus slow twitch muscle gene expression

8. Andrew Bauder (BSc U. Penn 2010; UG Intern Summer 2009); currently in

Medical School University of Pennsylvania

9. Cathy Saenz (B.Sc. Kinesiology 2009; M.Sc. U Connecticut; currently Ph.D.

student at U of Connecticut)

10. Shannon Brown (B.Sc. Kinesiology 2009; Currently in Veterinary Medicine,

Virginia Tech)

Thesis/Dissertation Examination Committees

2000 Thomas J. Hawke, University of Guelph

Ph.D. Dissertation: Intracellular calcium’s role in methylxanthine-induced changes in

potassium uptake in mammalian skeletal muscle

Oral and written thesis examination

2001 Francois M. Viau, Laurentian University

M.Sc. Thesis: The role of Ca2+

and calcineurin in regulating the myofibrillar and

metabolic properties of individual skeletal muscle fibres

Written thesis examination

2005 Nicole Stupka, University of Melbourne

Ph.D. Dissertation: The calcineurin signal transduction pathway in muscular

dystrophy and skeletal muscle regeneration.

Written thesis examination

2007 Joseph Eibl, Laurentian University

M.Sc. Thesis: Deciphering the calcineurin/NFAT pathway in the hypertrophy and

fiber type conversions of skeletal muscle

Oral and written thesis examination

2009 Ryan Sheppard, University of Maryland

Ph.D. Dissertation: Effects of androgen receptor polyglutamine repeat on

C2C12 cell cycle and gene expression Thesis Committee Member; Oral and written thesis examination

2010 Mallory Marshall, University of Maryland

M.A. Thesis: The effects of diet and physical activity on telomere length and

telomere-related genes in mice bred for high voluntary wheel running Thesis Committee Member; Oral and written thesis examination

2011 Erik Hanson, University of Maryland

Ph.D. Dissertation: Can strength training improve musculoskeletal health and

body composition in black men with prostate cancer on androgen deprivation

therapy? Thesis Committee Member; Oral and written thesis examination

2011 Andrew T. Ludlow, University of Maryland

Ph.D. Dissertation: Telomere dynamics and regulation: Effects of chronic exercise,

acute exercise and oxidative stress

Thesis Committee Member; Oral and written thesis examination

2011 Davi A.G. Mazala

M.A. Thesis: The role of excitation-contraction coupling failure in muscle fatigue and

weakness of dystrophic mice

Thesis Committee Chair; Oral and written thesis examination

2012 Lindsay Wohlers

Ph.D. Dissertation: Reductions in estrogenic function lead to metabolic dysfunction

in adipose tissue and skeletal muscle Thesis Committee Member; Oral and written thesis examination

2012 Sam A. English

M.A. Thesis: Alterations in the myogenic capacity of satellite cells in a mouse

model of ALS Thesis Committee Chair; Oral and written thesis examination

2012 Michael P. Morini

M.A. Thesis: Effects of chronic exercise on global DNA methylation and

epigenetic factors in sperm and testes of mice. Thesis Committee Member; Oral and written thesis examination

2013 Katherine Jackson

Ph.D. Dissertation: Breast cancer type 1 susceptibility protein is a critical regulator of

skeletal muscle lipid metabolism.

Thesis Committee Member; Oral and written thesis examination

2014 Lisa Guth Ph.D. Dissertation: The effects of exercise ancestry on health-related traits in two

generations of mouse offspring

Thesis Committee Member; Oral and written thesis examination

PUBLICATIONS

Refereed Publications

1. Chin, E.R., M.I. Lindinger and G.J.F. Heigenhauser. (1991). Lactate metabolism in inactive skeletal

muscle during lactacidosis. American Journal of Physiology 261 (Regulatory Integrative Comp. Physiol.

30): R98-R105.

2. Green, H.J., M. Ball-Burnett, E.R. Chin and D. Pette. (1993). Time dependent increases in Na+/K+

ATPase content of chronically stimulated rabbit muscle. FEBS, 310(2): 129-131).

3. Green, H.J., E.R. Chin, M. Ball-Burnett and D. Ranney. (1993). Increases in human skeletal muscle Na+-

K+ ATPase pump concentration with short term training. American Journal of Physiology, 264 (Cell

Physiol. 33): C1538-C1541.

4. Chin, E.R. and H.J. Green. (1993). Fibre type differences in Na+ -K+ ATPase concentration of rat skeletal

muscle are related to oxidative potential. Canadian Journal of Physiology and Pharmacology, 71(8): 615-

618.

5. Dossett-Mercer, J., H.J. Green, E. Chin and F. Grange. (1994). Preservation of sarcoplasmic reticulum

Ca2+

sequestering function in homogenates of different fibre type composition following sprint activity.

Canadian Journal of Physiology and Pharmacology, 72: 1231-1237.

6. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer and P.J. O'Brien. (1994). Technical considerations for

assessing alterations in sarcoplasmic reticulum Ca2+

sequestration function in vitro. Molecular and Cellular

Biochemistry, 139: 41-52.

7. Dossett-Mercer, J., H.J. Green, E.R. Chin and F. Grange. (1995). Failure of short term stimulation to

reduce sarcoplasmic reticulum Ca2+

ATPase function in homogenates of rat gastrocnemius. Molecular and

Cellular Biochemistry, 146(1): 23-33.

8. Chin, E.R., H.J. Green, F. Grange, J. Dossett-Mercer and P.J. O'Brien. (1995). Effects of prolonged low

frequency stimulation on skeletal muscle sarcoplasmic reticulum. Canadian Journal of Physiology and

Pharmacology, 73: 1154-1164.

9. Chin, E.R. and H.J. Green. (1996). Effects of tissue fractionation on exercise-induced alterations in

sarcoplasmic reticulum function in rat gastrocnemius muscle. Journal of Applied Physiology, 80(3): 940-

948.

10. Chin, E.R. and D.G. Allen. (1996). The role of elevations in intracellular [Ca2+

] in the development of

low frequency fatigue in mouse single muscle fibres. Journal of Physiology, 491.3: 813-824.

11. Allen, D.G., C.D. Balnave and E.R. Chin (1996). Intracellular calcium release and muscle fatigue.

[Review]. Today’s Life Sciences. Vol. 8 (9): 12-17.

12. Chin, E.R., M.I. Lindinger, and G.J.F. Heigenhauser. (1997). Distribution of lactate and other ions in

inactive skeletal muscle: Influence of hyperkalemic lactacidosis. Canadian Journal of Physiology and

Pharmacology, 75: 1375-1386.

13. Chin, E.R., C.D. Balnave and D.G. Allen. (1997). The role of intracellular calcium and metabolites in low

frequency fatigue of mouse skeletal muscle. American Journal of Physiology. 272 (Cell Physiology 41):

C550-C559.

14. Chin, E.R. and D.G. Allen. (1997). The effects of reduced muscle glycogen concentration on force, Ca2+

release and contractile protein function in intact mouse skeletal muscle. Journal of Physiology. 498: 587-

600.

15. Chin, E.R. and D.G. Allen. (1998). The contributions of pH-dependent mechanisms to fatigue at different

workloads in mammalian single muscle fibres. Journal of Physiology. 512: 831-840.

16. Chin, E.R., E.N. Olson, J.A. Richardson, Q. Yang, C. Humphries. J.M Shelton, H. Wu, W. Zhu, R.

Bassel-Duby and R.S. Williams. (1998). A calcineurin-dependent transcriptional pathway controls

skeletal muscle fiber type. Genes & Development 12: 2499-2509.

17. Garry, D.J., G.A. Ordway, J.N. Lorenz, N.B. Radford, E.R. Chin, R.W. Grange, R. Bassel-Duby and R.S.

Williams. (1998). Mice without myoglobin. Nature. 395: 905-908.

18. Ordway, G.A., P. D. Neufer, E. R. Chin, and G. N. DeMartino. (2000). Chronic contractile activity

upregulates the proteasome system in rabbit skeletal muscle. J. Appl. Physiol. 88: 1134-1141.

19. Wu, H., F.J. Naya, T.A. McKinsey, B. Mercer, J.M. Shelton, E.R. Chin, A.R. Simard, R.N. Michel, R.

Bassel-Duby, E.N. Olson and R.S. Williams. (2000). MEF2 responds to multiple calcium-regulated signals

in the control of skeletal muscle fiber type. Embo J. 19(9): 1-11.

20. Dunn, S.E., E.R. Chin & R.N. Michel. (2000). Matching of calcineurin activity to upstream effectors is

critical for skeletal muscle fiber growth. J. Cell. Biol. 151(3): 1-10.

21. Grange, R.W., A. Meeson, E.R. Chin, K.S. Lau, J.T. Stull, J.M. Shelton, R.S. Williams & D.J. Garry.

(2001). Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. Am. J.

Physiol. 281(5): C1487-C1494.

22. Chin, E.R., R.W. Grange, R.F. Viau, R.S. Bassel-Duby, R.N. Michel and R.S. Williams. (2003a).

Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+

buffering protein

parvalbumin. J. Physiol. 547: 649-663.

23. Chakkalakal, J.V., M.A. Stocksley, M.A. Harrison, L.M. Angus, J. Deschenes-Furry, S. St.Pierre, L.A.

Megheny, E.R. Chin, R.N. Michel and B.J. Jasmin. (2003). Expression of utrophin A mRNA correlates

with the oxidative capacity of skeletal muscle fibre types and is regulated by calcineurin. PNAS 100:

7791-7796.

24. Chakkalakal, J.V., M.A. Harrison, E.R. Chin, R.N. Michel and B.J. Jasmin. (2004). Stimulation of

calcineurin signalling attenuates the dystrophic pathology in mdx mice. Human Molecular Genetics 13(4):

379-388.

25. Chin, E.R. (2004). The role of Ca2+

and the Ca2+

/calmodulin-dependent kinases in skeletal muscle

plasticity and mitochondrial biogenesis. Proceedings of the Nutrition Society. 63: 279-286.

26. Michel, R.N., S.E. Dunn and E.R. Chin. (2004). Calcineurin and muscle growth. Proceedings of the

Nutrition Society. 63: 341-349.

27. Hornberger, T.A., R. Stuppard, K.E. Conley, M. Fedele, M.L. Fiorotto, E.R. Chin and K.A. Esser.

(2004). Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide-3-kinase,

protein kinase B and growth factor independent mechanism. Biochemical Journal. 380: 795-804.

28. Hornberger, T.A., R.D. Mateja, E.R. Chin, J.L. Andrews and K.A. Esser (2005). Aging does not alter the

mechanosensitivity of the p38, p70S6k

and JNK2 signaling pathways in skeletal muscle. J. Appl. Physiol.

98: 1562-1566.

29. Chin, E.R. (2005). The role of Ca2+

/calmodulin-dependent kinases in skeletal muscle plasticity. J. Appl.

Physiol. 99(2): 414-23.

30. Angus, L.M., J.V. Chakkalakal, A. Mejat, J.K. Eibl, G. Belanger, L.A. Megheny, E.R. Chin, L. Schaeffer,

R.N. Michel and B.J. Jasmin. (2005). Calcineurin/NFAT signaling, together with GABP and PGC-1,

drives utrophin gene expression at the neuromuscular junction. Am. J. Physiol. Cell Physiol. 289: C908-

C917.

31. Chakkalakal, J.V., S.A. Michel, E.R. Chin, R.N. Michel and B.J. Jasmin. (2006). Targeted inhibition of

Ca+2

/calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle. Hum. Mol. Gen.

15: 1423-1435.

32. Michel, R.N., E.R. Chin, J.V. Chakkalakal, J.K. Eibl and B.J. Jasmin. (2007). Ca2+

/Calmodulin-based

signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of

utrophin A and myostatin expression. Appl. Physiol. Nutr. Metab. 32: 921-929.

33. Cairns, S., E.R. Chin and J.M. Renaud. (2007). Stimulation pulse characteristics and electrode

configuration determine site of excitation in isolated mammalian skeletal muscle: Implications for fatigue.

J. Appl. Physiol. 103: 359-368.

34. Chin, E.R. (2010). Intracellular Ca2+

signaling in skeletal muscle: Decoding a complex message. Exerc.

Sport Sci. Rev. 38(2): 76-85.

35. Sheppard, R.L., E.E. Spangenburg, E.R. Chin, S.M. Roth. (2011). Androgen receptor

polyglutamine repeat length affects receptor activity and C2C12 cell development. Physiol. Gen.

43: 1135-1143.

36. Wohlers, L.M., Powers, B.L., Chin, E.R. and E.E. Spangenburg. (2013). Using a novel co-

culture model to dissect the role of intramuscular lipid load on skeletal muscle insulin

responsiveness under reduced estrogen conditions. Am J Physiol Endocrinol Metab. 304(11):

E1199-212.

37. Ludow, A.T., Spangenburg, E.E., Chin, E.R., Cheng, W-H and S.M. Roth. (2014). Telomeres

shorten in response to oxidative stress in mouse skeletal muscle fibers. Gerontol A Biol Sci Med

Sci. 69(7):821-30.

38. Bamman, M.M., F.W. Booth, E.R. Chin, P.D. Neufer, S. Trappe, J.T. Lightfoot, D.M. Cooper,

W.E. Kraus and M.J. Joyner. (2014). Exercise biology and medicine: innovative research to

improve global health. Mayo Clin Proc. 89(2):148-53.

39. Chin, E.R., D.A.G. Mazala, K. Bobyk and D. Chen. Perturbations in Intracellular Ca2+

Handling

in Skeletal Muscle of a Mouse Model of Amyotrophic Lateral Sclerosis. (2014) Am J Physiol

Cell Physiol. 307(11): C1031-C1038.

40. Mazala DA, Grange RW, Chin ER. (2015). The role of proteases in excitation-contraction

coupling failure in muscular dystrophy. Am J Physiol Cell Physiol. 308(1): C33-C40.

Published Abstracts/Conference presentation 1. Galea, V., E.R. Freisinger, M.I. Lindinger and G.F.J. Heigenhauser. (1987). Effects of lactacidosis

on skeletal muscle ion regulation. Medicine and Science in Sports and Exercise. Suppl. 19(2): S35.

2. Freisinger, E.R., M.I. Lindinger, V. Galea and G.J.F. Heigenhauser. (1987). Effects of lactacidosis

on resting skeletal muscle metabolism in isolated perfused rat hindlimb. Medicine and Science in

Sports and Exercise. Suppl. 19(2): S54.

3. Freisinger, E.R., M.I. Lindinger, V. Galea, J.D. MacDougall and G.J.F. Heigenhauser. (1987).

Effects of arterial lactacidosis on fat and carbohydrate metabolism in inactive skeletal muscle.

Canadian Journal of Sport Sciences. 12(3): 7P.

4. Chin, E.R., M.I. Lindinger and G.J.F. Heigenhauser. (1990). Effects of lactacidosis on ionic flux

across inactive skeletal muscle. Canadian Journal of Sport Sciences. 15(4): 7S.

5. Chin, E.R. and H.J. Green. (1991). Fibre type differences in Na+ -K+ ATPase concentration of rat

skeletal muscle are related to oxidative potential. Medicine and Science in Sports and Exercise. Suppl.

23(4): S23.

6. Chin, E.R., H.J. Green, M. Ball-Burnett and D. Ranney. (1992). Training induced changes in

sarcolemmal Na+ -K+ pump concentration in human skeletal muscle. Medicine and Science in Sports

and Exercise. Suppl. 24(5): S106.

7. Green, H.J., F. Grange, E.R. Chin, C. Goreham, D. Ranney and R.J. Xiu. (1992). Alterations in

sarcoplasmic reticulum Ca2+

ATPase activity in human skeletal muscle with prolonged exercise. The

Physiologist. 35(4): 215.

8. Chin, E.R., F. Grange, J.D. Mercer and P.J. O'Brien. (1992). Technical considerations for assessing

skeletal muscle sarcoplasmic reticulum function following exercise. The Physiologist. 35(4): 215.

9. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer, P.J. O'Brien. (1993). Functional impairment of

sarcoplasmic reticulum Ca2+

-Mg2+

ATPase in vitro is related to altered membrane yield following

prolonged running. The FASEB Journal. 7(3): A226.

10. Dossett-Mercer, H.J. Green, E.R. Chin, F. Grange and P.J. O'Brien. (1993). Lack of an effect of short

term stimulation on sarcoplasmic reticulum Ca2+

uptake and Ca2+

ATPase activity in homogenates of

rat red and white gastrocnemius. Medicine and Science in Sports and Exercise. Suppl. 25(5): S177.

11. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer, P.J. O'Brien. (1993). Muscle fatigue in situ is

independent of altered sarcoplasmic reticulum function in vitro following prolonged electrical

stimulation. Medicine and Science in Sports and Exercise. Suppl. 25(5): S19

12. Chin, E.R. and H.J. Green. (1994). Skeletal muscle Ca2+

ATPase activity in heavy and light

sarcoplasmic reticulum fractions following treadmill running. Proceedings of the Australian

Physiological and Pharmacological Society. 25(1): 25P.

13. Chin, E.R., F. Grange and H.J. Green. (1994). Calcium uptake in heavy and light sarcoplasmic

reticulum of skeletal muscle following treadmill running. Proceedings of the Australian Physiological

and Pharmacological Society. 25(2): 114P.

14. Chin, E.R. and D.G. Allen. (1995). Effects of caffeine and tetanic stimulation on the force-frequency

relationship in isolated single muscle fibres. Proceedings of the Australian Physiological and

Pharmacological Society. 26(1): 27P.

15. Chin, E.R. and D.G. Allen. (1995). Raised intracellular calcium can cause subsequent failure of

calcium release in mammalian skeletal muscle. Proceedings of the Physiological Society Oxford

Meetings. 41P.

16. Chin, E.R. and D.G. Allen. (1995). The role of substrate supply and Ca2+

release in fatigue

resistance of mouse single skeletal mouse single skeletal muscle fibres. Proceedings of the Australian

Physiological and Pharmacological Society. 26(2): 124P.

17. Chin, E.R. and D.G. Allen. (1996). Alterations in myofibrillar protein function associated with

glycogen depletion in mouse skeletal muscle. Proceedings of the Australian Physiological and

Pharmacological Society. 27(1): 59P.

18. Chin, E.R. and D.G. Allen. (1996). The effects of muscle glycogen depletion on Ca2+

release in single

skeletal muscle fibres. Medicine and Science in Sports and Exercise. Suppl. 28(5): S122.

19. Allen, D.G. and E.R. Chin. (1996). Fatigue in mouse muscle fibres at different work intensities.

Proceedings of the Australian Physiological and Pharmacological Society. 27(2).

20. Allen, D.G., E.R. Chin, and C.D. Balnave. (1996). Modulation of tetanic calcium concentrations in

skeletal muscle during and after exercise. The Physiologist. 39(5): A-62.

21. Chin, E.R. and D.G. Allen. (1996). Changes in intracellular free Ca2+

concentration during

constant 10 Hz stimulation of mouse single skeletal muscle fibres. The Physiologist. 39(5): A-74.

22. Chin, E.R. and D.G. Allen. (1997). Effects of epinepherine-stimulated glycogenolysis on force and

Ca2+

release in mouse single skeletal muscle fibres. Medicine and Science in Sports and Exercise.

Suppl. 29(5): S272.

23. Chin, E.R. and R.S. Williams. (1998). An RT-PCR-based assay system for examining fiber-type

specific gene expression in skeletal muscle. FASEB Journal. 12(4): A472.

24. Chin, E.R., E.N. Olson, C. G. Humphries., H. Wu, R.S. Bassel-Duby and R.S. Williams. (1998).

Regulation of skeletal muscle fiber-type diversity by a calcineurin-dependent transcriptional pathway.

American Heart Association Meetings.

25. Chin, E.R., R.W. Grange, M.Maier, R.S. Bassel-Duby and R.S. Williams. (1999). Altered contractile

function in slow-twitch muscle from transgenic mice overexpressing parvalbumin. Medicine and

Science in Sports and Exercise. Vol. 31:5 Suppl.

26. Dunn, S.E., A.R. Simard, E.R. Chin and R.N. Michel. (2001). Calcineurin and its upstream activity-

dependent effectors signal via NFAT and MEF2 to induce skeletal muscle hypertrophy. FASEB

Journal. 15(4): A421.

27. Viau, F., E.R. Chin, R.S. Williams and R.N. Michel. (2001). Alterations in skeletal muscle gene

expression in transgenic mice overexpressing the Ca2+

buffering protein parvalbumin. FASEB Journal.

15(4): A420.

28. Chin, E.R., S.E. Dunn, R.N. Michel and R.S. Williams. (2001). Alterations in muscle phenotype in

transgenic mice overexpressing a calmodulin inhibitory peptide regulated by the troponin I slow

promoter. FASEB Journal. 15(4): A421.

29. Chakkalakal, J.V., M.A. Stocksley, J. Deschenes-Furry, E.R. Chin, M.-A. Harrison, R.N. Michel and

B. J. Jasmin. (2003). Expression of Utrophin A mRNA correlates with the metabolic efficiency of

muscle and involves calcineurin. FASEB. J. 17(5): A956.

30. Chin, E.R., F.-W. Bangerter and J.M. Renaud. (2003b). Alterations in intracellular Ca2+

transients in

single muscle fibers from old compared to young rats. FASEB J. 17(5): A1277.

31. Renaud, J.M., J.P. O’Malley and E.R. Chin. (2003). Effect of time in culture on intracellular Ca2+

levels and unloaded shortening velocity. FASEB. J. 17(5): A1275.

32. Hill, R.J., D.B. Rouillard, E.R. Chin, C. Ibebunjo, X.N. Wang, R. Layfield and J.J. Oleynek. (2004).

Age-related muscle atrophy is associated with both an increase in poly ubiquitination and expression

of the muscle-specific E3 ligase MAFbx. FASEB J. 18(4): A346.

33. Genido, J., J.F. Schaefer and E.R. Chin. (2004). Down-regulation of both fast and slow fibre-type

specific genes by myostatin and TGF. The Physiologist. 47 (4): 342.

34. Chin, E.R. and J.F. Schaefer. (2005). Inhibition of Caseine Kinase I increases nuclear NFAT in

C2C12 cells. FASEB J. 19(4): A116.

35. Petras, C.F. and E.R. Chin. (2005). Motor activity in mdx mice is increasingly impaired with age.

FASEB J. 19(4): A573.

36. Muthuri, S.K., E.R. Chin and R.N. Michel. (2007). Myostatin as a putative downstream gene target

of calcineurin signaling associated with muscle growth remodelling. FASEB J. 21: 895.14.

37. Chin, E. R. and J. F. Schaefer. (2008). Inhibition of caseine kinase I increases nuclear NFAT in

C2C12 cells. Meeting Program for the Integrative Biology of Exercise V Meeting. p. 69.

38. Chin, E.R., C. Ibebunjo and M. T McDowell. (2009). A proteomics-based approach to changes in

skeletal muscle gene expression with age-related sarcopenia. FASEB J. 2009 23:954.4.

39. Sheppard, R., E.E. Spangenburg, E.R. Chin and S.M. Roth. (2010). Androgen Receptor CAG repeat

length affects receptor activity and the development of C2C12 myoblasts. Medicine and Science in

Sports and Exercise. Suppl. 42(5): S64.

40. Mazala, D. and E.R. Chin. (2010). Effects of ex vivo denervation on intracellular Ca2+

ratios in intact

mammalian single muscle fibers. Medicine and Science in Sports and Exercise. Suppl. 42(5): S584-

S585.

41. Chin, E.R., D. Mazala & D. Chen. (2011). Alterations in intracellular free Ca2+

concentrations in

intact single muscle fibres from ALS mice. Experimental Biology Meeting, FASEB J. 25:1051.49.

42. Jacobs, B., D. Chen and E.R. Chin. (2011). C2C12 cell culture model for investigating Ca2+

-

dependence of myocyte differentiation. Experimental Biology Meeting, FASEB J.

43. Mazala,D., D. Chen & E.R. Chin. (2011). Alterations in excitation-contraction coupling in mouse

models of muscular dystrophy. Experimental Biology Meeting , FASEB J. 25:lb599.

44. Wang, Y., D. Chen, A. P. Goldberg & E.R. Chin. (2011). Screening of protein glycosylation in

human muscle tissue using lectin enrichment and mass spectrometry. ACS Mid-Atlantic Meeting.

45. Chin, E.R., D. A.G. Mazala, & D. Chen (2012). Alterations in Ca2+

regulatory proteins and Ca2+

-

dependent gene expression in skeletal muscle from ALS mice. Experimental Biology Meeting.

FASEB J. 26:1075.16.

46. Mazala, D.A.G., D. Chen, S.A. English, R.W. Grange & E. R. Chin. (2012) Effects of calpain

inhibition in excitation-contraction coupling properties in dystrophic muscle exposed to fatiguing

contractions. Experimental Biology Meeting. FASEB J. 26:571.3.

47. English. S., S. Gupta, D. Clermont, D. Chen, D.A.G. Mazala & E. R. Chin. (2012) Alterations in the

myogenic capacity of satellite cells in a mouse model of ALS. Experimental Biology Meeting.

FASEB J. 26:1078.28.

48. Chen, D., D.A.G. Mazala, S.A. English & E. R. Chin. (2012). The Role of ER chaperone BiP in the

pathology of ALS. Experimental Biology Meeting. FASEB J. 26:lb783

49. Zein, M.A., E.R. Chin, B.J. Jasmin & R.N. Michel. (2012). Targeted expression of the non-native

Ca2+

-buffering protein parvalbumin exacerbates the dystrophic phenotype in mdx mouse slow muscle

fibers. Experimental Biology Meeting. FASEB J. 26:1086.23.

50. Mazala, D.A.G., S. Bonar & E.R. Chin. (2012) Evaluation of calcium clearance between different

mouse models for Duchenne muscular dystrophy. Muscular Dystrophy Association New Directions in

Biology and Disease of Skeletal Muscle Conference. June 17-20, 2012.

51. Chin, E.R., S.J. Prior, Y. Wang, D. Chen, A.S. Ryan, H.K. Ortmeyer, J. Blumenthal, J. Beans and

A.P. Goldberg. (2012). Aerobic Exercise Training Improves Glucose and Lipid Metabolism in T2DM

by Reducing Skeletal Muscle Glycoproteins and Increasing GLUT4, CPT1 and Lipoprotein Lipase

(LPL). Mid-Atlantic Diabetes Symposium.

52. Chen, D., S.J. Prior, Y. Wang, D. Chen, A.S. Ryan, H.K. Ortmeyer, J. Blumenthal, J. Beans, A.P.

Goldberg and E.R. Chin. (2013). Mass spectrometric characterization of protein glycosylation in

skeletal muscle of T2DM after aerobic exercise training. Experimental Biology Meeting. FASEB J.

27:lb703.

53. Mázala, D.A.G, Pratt, S.J.P., Chen, D, Molkentin, J.D., Lovering, R.M. and ER Chin. (2014). Skeletal

muscle damage and contraction-induced torque loss are attenuated in mdx/Utr-/-

mice by SERCA1

overexpression. New Directions Conference Proceedings, June 2014.

54. Prior, S.J., Ortmeyer, H.K., Chin, E.R., Chen, D., Blumenthal, J.B., Goldberg, A.P. and A.S. Ryan.

(2014). Increased skeletal muscle capillarization after exercise training enhances insulin sensitivity

independent of insulin signaling and glucose transport mechanisms. ADA Meeting. June 2014.

Manuscripts In Review:

Mazala, D.A.G. and E.R. Chin. The role of calpains in excitation-contraction coupling failure and

weakness in dystrophic skeletal muscle. In Review. Am. J. Physiol. Cell.

Chen, D. and E.R. Chin. GRP78/BiP Deficiency and Endoplasmic Reticulum Stress in Skeletal Muscle of

G93A*SOD1 ALS Mice. In Review. Skeletal Muscle.

Landers-Ramos, R.Q., Sapp, R.M, Jenkins N.T., Murphy, A.E., Cancre, L., Chin, E.R., Spangenburg, E.E.

and Hagberg, J.M. Chronic endurance exercise affects paracrine action of CD31+ and

CD34+ cells on endothelial tube formation. In Review. J. Physiol.

Manuscripts Pending Submission (May-July 2014):

Chen, D., D.A.G. Mazala & E.R. Chin. 6-Gingerol improves skeletal muscle function of G93A*SOD1 ALS

mice. Targeted for J. Cell. Biochem.

Mázala, D.A.G, Pratt, S.J.P., Chen, D, Molkentin, J.D., Lovering, R.M. and ER Chin. Skeletal muscle damage

and contraction-induced torque loss are attenuated in mdx/Utr-/-

mice by SERCA1 overexpression. Targeted

for Human Molecular Genetics.

Chen, D., Wang, Y. and E.R. Chin. A mass spectrometry-based method for identification and analysis of N-

linked glycoproteins in human skeletal muscle. Targeted for Molecular and Cellular Biochemistry.

English, S.A. & E.R. Chin. Alterations in the myogenic capacity of satellite cells in a mouse model of

Amyotrophic Lateral Sclerosis. Targeted for Muscle & Nerve.

English, S.A. & E.R. Chin. Defects in myocyte function in Amyotrophic Lateral Sclerosis (Review article).

Targeted for Skeletal Muscle.

Chen, D., Mazala, D.A.G. and E.R. Chin. SERCA1 overexpression attenuates disease progression in the

G93A*SOD1 mouse model of ALS. Targeted for Pflugers Archiv.

Chin,E.R. Adaptive changes in skeletal muscle from G93A*SOD1 mice: Activation of the calcineurin

transcriptional program. Targeted for Neuromuscular Disorders.

Jacobs, B.L., Chen, D. & E.R. Chin. C2C12 cell culture model for investigating Ca2+

-dependence of myocyte

differentiation

Manuscripts In Preparation:

Chin, E.R. Chen, D., Wang, Y., Prior, S.J., Ryan, S.J., Ortmeyer, H.K., Blumenthal, J.Beans, J., and. A.P.

Goldberg, A.P. Characterization of protein glycosylation in skeletal muscle of Type 2 diabetics after aerobic

exercise training.

Chin, E.R., D. Chen, L. Ostrow and Y. Wang. A proteomics-based approach to identifying skeletal muscle

protein biomarkers to differentiate ALS from other neuromuscular diseases.

Genido, J. and E.R. Chin. Regulation of fast and slow fibre-type specific genes by myostatin and TGF.

Chin, E.R. and D.G. Allen. Changes in intracellular free Ca2+

concentration during constant 10 Hz stimulation

of mouse single skeletal muscle fibres.

Chin, E.R., F.-W. Bangerter and J.M. Renaud. Alterations in intracellular Ca2+

transients in single muscle

fibers from old compared to young rats.

Renaud, J.M., J.P. O’Malley and E.R. Chin. Effects of denervation on intracellular Ca2+

levels and unloaded

shortening velocity.

Theses

Ph.D. Assessment of Sarcoplasmic Reticulum Ca2+

Sequestration in Rat Gastrocnemius Muscle

Following Prolonged Activity

Advisor: Dr. H.J. Green

Completed: August 1993, University of Waterloo, Canada

M.Sc. Effects of Lactacidosis on Muscle Metabolism and Ionic Flux in Inactive Skeletal Muscle of

the Isolated Perfused Rat Hindlimb

Advisor: Dr. J.D. MacDougall

Completed: September 1987, McMaster University, Canada

Patents/Patent Applications:

Eva R. Chin, Jeffery Molkentin, Eric. Olson & R. Sanders Williams. 1999. A method to alter specialized

characteristics of skeletal myofibers.

Eva R. Chin, Chikwendu Ibebunjo, Philip A. Krasney, Junming Yie, Joseph Zachwieja & Larry Green. 2007.

Antibodies to myostatin. WO2006116269 A3.

Eva R. Chin & Dapeng Chen. 2013. Markers for diagnosing Amyotrophic Lateral Sclerosis.

WO2103/155365

Disclosures to UMCP:

LS-2011-111: E.R. Chin, Method for Early Diagnosis of ALS I

LS-2012-046: E.R. Chin & D. Chen, Method for Early Diagnosis of ALS II

LS-2012-109: E.R. Chin, Small molecule therapeutic for the treatment of NMD

LS-2013-134: E.R. Chin, A method for differential diagnosis of ALS and for monitoring disease progression

LS-2013-XXX: J. Hagberg, R. Landers-Ramos, E.R. Chin, E.E. Spangenburg, Novel CD31 and CD34 Stem

Cell Secreteome Proteins Affecting Angiogenesis

INVITED PRESENTATIONS

Invited Seminar Presentations

“Intracellular calcium signalling in striated muscle: Decoding a complex message.” University of Ottawa,

Department of Cellular and Molecular Medicine, Graduate Seminar Series. August 17, 2000.

“Intracellular calcium signalling in striated muscle: Decoding a complex message.” Boston University,

Department of Health Sciences, Graduate Seminar Series. Boston, MA. June 22, 2001.

“Regulation of skeletal muscle gene expression by intracellular calcium signalling.” The Children’s Hospital

at Westmead, Sydney, Australia. August, 28, 2001.

“The role of calcium signalling in skeletal muscle gene expression.” University of Illinois at Chicago, College

of Applied Health Sciences, Graduate Seminar Series. Chicago, IL. October 26, 2001.

“The role of Calcium-dependent signals in skeletal muscle hypertrophy and fibre type adaptations.”

University of California-Irvine, Department of Orthopaedics Seminar Series. Irvine, CA. December 1, 2004.

“The role of Calcium-dependent signals in skeletal muscle hypertrophy and fibre type adaptations.”

Concordia University, Department of Exercise Sciences, Montreal, QC, Canada. February 10, 2006.

“Understanding Ca2+

signaling pathways in skeletal muscle: Could this lead to an exercise pill?” University

of Dundee, Molecular Physiology Group, Dundee, Scotland, UK. July 18, 2007.

“The exercise signal: Decoding a complex message to regulate muscle phenotype.” Children’s National

Medical Center Research Seminars, Washington, DC. June 15, 2009.

“Understanding Ca2+

signaling pathways in skeletal muscle: Could this lead to an exercise pill?” VA Medical

Center, Baltimore, MD. October 22, 2009.

“The role of intracellular Ca2+

in skeletal muscle contraction, damage and muscle disease”. Safety

Pharmacology group, FDA, Silver Spring, MD. November 18, 2010.

“Development of a high throughput bioengineered skeletal muscle array”. BioEngineering, The University of

Maryland, College Park, MD. May 2012.

“Cellular defects in skeletal muscle in ALS: Is the muscle talking back to the nerve?” Seminar presentation

given to Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State

University, Blacksburg, VA, November 2012.

“Cellular defects in skeletal muscle in ALS: Is the muscle talking back to the nerve?” Seminar presentation

given to the School of Physiotherapy and Rehabilitative Sciences, University of Maryland, Baltimore MD,

December 2012.

Invited Conference Presentations

“The role of calcium-dependent transcriptional pathways for regulating skeletal muscle diversity.” Princess

Diana Lecture and Symposium, The Victor Chang Cardiac Research Institute, Sydney, Australia. November

1, 1999

“Calcineurin signalling of gene expression in skeletal muscle.” Gordon Conference on Excitation-contraction

coupling, New London, NH. June 12, 2003

“Role of Calcium and calmodulin kinases in fibre type and mitochondrial biogenesis.” International

Biochemistry of Exercise Meetings, Maastricht, The Netherlands. July 15, 2003.

“Calcineurin and Muscle Growth.” International Biochemistry of Exercise Meetings, Maastricht, The

Netherlands. July 16, 2003.

“Calcium signalling in skeletal muscle: Decoding a complex message.” Howard J. Green Symposium, The

University of Waterloo, Ontario Canada. September 24, 2004.

“The boomerang approach to science: Research across the world and back.” International Union of

Physiological Societies, San Diego, CA. April 3, 2005.

“Ca2+

/Calmodulin-based signaling in the regulation of the muscle fiber phenotype.” International

Biochemistry of Exercise Meeting, Seoul, Korea. October 20, 2006.

“Functional roles of SR, myoplasmic and extracellular calcium in determining force generation.” APS/ACSM

Integrative Biology of exercise Meeting, Hilton Head, SC. September 2008.

“The exercise mimetic: The promise and challenge of replacing exercise with a pill.” ACSM Annual Meeting,

Baltimore, MD June 4, 2010.

“Biomarker identification easing up target and drug discovery”. Orphan Drug Meeting, Washington DC, April

2013.

“The valuable role of exercise scientists to bring treatments to clinical trials”. ACSM Translational Group

Symposium, American College of Sports Medicine Annual Meeting, Indianapolis IN, May 2013.

Symposia Chair:

2004 APS/ACSM Integrative Biology of Exercise Meeting, Austin, TX. “Striated Muscle Hypertrophy:

Factors Controlling Cell Enlargement and Phenotype Transformations”.

2008 APS/ACSM Integrative Biology of Exercise Meeting, Hilton Head, SC. “Signaling Mechanisms

Regulating Metabolic and Transcription Processes in Skeletal Muscle”.

2010 Experimental Biology Meeting, Anaheim, CA. “To Exercise or Not to Exercise: Can we replace physical

activity with a pill?”. Symposium Organizer & Co-Chair.

2011 American College of Sports Medicine Annual Meeting, Denver CO. ACSM Translational Group

Symposium: NCATS: The New Face of NIH Support for Translational Research and its Impact on Exercise

Science. Symposium Co-Organizer & Chair.