ETHICS & KNOWLEDGE

10 YEARS OF COMMITMENT IN FAVOUR OF SCIENTIFIC RESEARCH AND INTERNATIONAL COOPERATION: A NEW STRATEGY

anniversary2005/2015

SCIENTIFIC RESEARCHAND DISSEMINATION

OF KNOWLEDGE

TRAINING INTERNATIONAL COOPERATION

Better patient understanding and improving patient management on the part of doctors by studying physiopathological and phenotypic

mechanism and investigating the psycological aspects

Supporting the scientific activities of young researchers

to promote medical-scientific skills

Contributing to the development of low- and middle-income countries

by providing scientific means and knowledge

Promoting the scientific communication

and dissemination of knowledge between public and institutions

Promoting new training schools for healthcare workers, public

and patients as part of joint initiatives with bodies active in the healthcare

and education sectors

Supporting projects which promote the full realisation of the right to health for the populations

most in need, with particular focus on neonatal health

Founded in 2005, the Chiesi Foundation is a non profit organization, expression of Chiesi Farmaceutici’s social responsibility.

MissionTo improve the health and alleviate the suffering of patients

affected by respiratory diseases and neonatal conditions.

Values• Sense of responsibility towards the environment and society

• Dissemination, without boundaries or limits, of science and knowledge• Fight against suffering and inequality

Programs The programs, through which the Foundation aims to achieve its Mission,

relate to the areas of Scientific Research, Education and International Cooperation, with specific objectives stated for each area

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Together with the support to scientific research, which has traditionally represented the main instrument for the Foundation to achieve its Mission, also International Cooperation has become a relevant commitment, with increasing attention on improving conditions of newborns.Starting from this specific focus and from the experiences gained in the field, the Chiesi Foundation decided to develop the NEST – Neonatal Essential Survival Technology, currently one of the main programs, designed and actively implemented with national and international partners.The NEST Project marks a significant change in the Chiesi Foundation’s strategy as it involves the Foundation taking on a more active role in designing and developing activities, not limiting itself to the provision of funding. The Chiesi Foundation has chosen neonatology as a strategic focus to exploit the potential of the network and experience it has gained over the years, and aims to become a catalyst of ideas, skills and resources in the sector.

SCIENTIFIC RESEARCHAND DISSEMINATION

OF KNOWLEDGE

TRAINING INTERNATIONAL COOPERATION

Better patient understanding and improving patient management on the part of doctors by studying physiopathological and phenotypic

mechanism and investigating the psycological aspects

Supporting the scientific activities of young researchers

to promote medical-scientific skills

Contributing to the development of low- and middle-income countries

by providing scientific means and knowledge

Promoting the scientific communication

and dissemination of knowledge between public and institutions

Promoting new training schools for healthcare workers, public

and patients as part of joint initiatives with bodies active in the healthcare

and education sectors

Supporting projects which promote the full realisation of the right to health for the populations

most in need, with particular focus on neonatal health

ETHICS & KNOWLEDGE

2015 has been an important year for the Chiesi Foundation, the year of the celebration of ten years of projects and activities.As the Chiesi Foundation’s tenth anniversary was approaching, it has begun a process of requalifying the mission and the instruments needed to carry it out. Over the course of 2014, new strategies have been defined both for Scientific Research program and International Cooperation projects.As far as Scientific Research program is concerned, since 2014 the Chiesi Foundation publishes two annual Calls for Proposals, which define the specific areas of scientific interest, pulmonology and neonatology, and the strategic objectives for each of the two fields, which the Foundation commits to reach through the research studies financed.

Objective Scientific Research Pulmonology

Objective Scientific Research Neonatology

To enlarge the knowledge in the medical community and in healthcare providers on the interaction between environmental and socio-economic factors and the whole respiratory tract and to foster the communication of scientific messages to the medical community and the general population.

To improve the knowledge of factors affecting neonatal disease progression and to identify strategies to prevent or minimise long-term consequences, thus ensuring better quality of life for these babies and their families.

10 YEARS AT A GLANCE• More than 1 and a half million euro in favour of scientific research, granted as unrestricted research

grants and research doctorates

• 30 scientific research projects supported, which produced 15 publications on peer reviewed journals

• More than 500,000 euro for international cooperation projects in health sector, with increasing focuson improving the care of neonates in low resources countries

• More than 100,000 euro allocated for the NEST Project in 2015

Scientific research and dissemination of knowledgeOne of the main institutional aims of the Chiesi Foundation is the promotion of medical-scientific research activities, with significant social relevance and focus on the study of respiratory or neonatal diseases.During 2015, the Foundation confirmed its support for six research projects that were already underway in 2014:• New therapeutic strategies for the reduction of neona-

tal mortality in the Middle East: sustained lung inflation and brain cooling, D Gazzolo – Ospedale SS. Antonioe Biagio e Cesare Arrigo;

• New strategies in neonatal resuscitation: biochemicaland respiratory effects, Lista – Ospedale dei Bambini“V. Buzzi”;

• Rate of growth in the first year of life and wheezing at 3years of age: nature or nurture, S Brescianini – IstitutoSuperiore di Sanità;

• Genetic diagnosis of pulmonary diseases in newbornsand infants: a genomic approach through Next Gene-ration Sequencing, Cutrera and Danhaive – OspedalePediatrico Bambin Gesú;

• Clinical, functional and inflammatory characterisationof an asthmatic patient cohort: identification of phe-notypes for a personalised pharmacological approach,M Contoli – CEMICEF;

• The mechanism of mirror neurons in social cognition:an electroencephalographic high- density study, V Gal-lese – Università degli Studi di Parma.

In addition, four new research projects have been se-lected among the proposals received in response to the Calls 2014:• D. Trevisanuto, CUAMM Medici con l’Africa - Is a wo-

olen cap effective in maintaining normothermia in pre-term infants during kangaroo mother care;

• J. Rose, Stanford University – Neonatal physiologicaland neural correlates of early neurodevelopment in pre-term children;

• O. Usmani, Imperial College London - Outdoor passive smoking and vehicular traffic effect on small airway fun-ction and inflammation;

• L. Gentilucci, Università di Bologna - AsthmaZoé: na-nostructured materials for the detection of markers ofasthma and other correlated inflammatory diseases.

Education and support for young researchersThe Chiesi Foundation supports the scientific activities of young researchers, with the aim of contributing to the development of new medical-scientific compe-tences. Over the course of 2015, the Foundation conti-nued to fund three research doctorate projects, each of a 3-year duration (2014-16):• Restoring mutant CFTR with Nanobodies, Cedric Gova-

erts, Université Libre de Bruxelles;• Biological design, synthesis and assessment of new bro-

ad spectrum antivirals for the treatment of enterovirusand rhinovirus infections, Marco Radi, University ofParma;

• PPAR-gamma microparticles and receptors: potentialnew therapeutic targets in bronchial asthma and COPD,Sandra Brunelleschi - University of Eastern Piedmont.

Moreover, the Chiesi Foundation supported the Mau-rizio Vignola Gold Medal in Asthma a joint initiative ongoing for more than 5 years, set up with the Europe-an Respiratory Society (ERS), to disseminate scientific research and develop knowledge in the field of respi-ratory diseases. The 2015 award was assigned to Prof. Adnan Custovic for his studies in the field of asthma.Finally, the Chiesi Foundation promotes educational initiatives and innovative training schools with asso-ciations and entities active in the fields of social and health care, education and medical-scientific culture. An example of such projects is the RESPIRO Project, an initiative run by the Serena Foundation, promoting training courses for parents of children affected by neuromuscular diseases, with a high risk of respiratory complications, in order to monitor and check respira-tory procedures and management, and to improve the quality of life of the children and their families.

2015 ACTIVITIESanniversary

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International cooperation Over the years, international cooperation has beco-me one of the most important program of the Chiesi Foundation, which has now an active role in develop projects aimed to transfer knowledge and means to low and middle income countries, promoting the right to health for the population most in need.

Neonatology and pulmonology are, also in this area, the focus of the activities, with two main programs of intervention: the NEST – Neonatal Essential Survival Technology Project and the GASP – Global Access to Spirometry Program.

The NEST ProjectOver the course of 2014, the Chiesi Foundation decided to focus future international cooperation activities within the scope of neonatology with a new and ambitious intervention program: the NEST project – Neonatal Essential Survival Technology, designed and developed with long term perspective, with the aim of contributing to a reduction in neonatal mortality rates in low- and middle-income countries.The NEST Project aims to tackle the issue of improving the quality of neonatal care in countries with few resources, by- providing basic medical equipment for neonatal

care units, suited to be used in low resources settings;

- developing protocols for the correct use in neonates of essential drugs;

- promoting training programs on basic neonatal care and treatments for local healthcare providers, with attention to the role of the neonatal nurse.

The NEST Project adopts a specific approach for every hospital and context it deals with, since the target group of countries includes territories with different healthcare structures and varying levels of financial and human resources.

Within the scope of the NEST project, the first pilot in-terventions have been introduced in contexts and ho-spitals where the Chiesi Foundation operates and can collaborate directly with local healthcare providers.

ETHICS & KNOWLEDGE

Saint Camille Hospital, Ouagadougou Burkina FasoSince 2010, the Chiesi Foundation has worked jointly with the Saint Camille Hospital in Ouagadougou, managed by the Camillian Fathers. The Foundation supports the neonatal care unit of the Hospital, developing projects aimed at transferring scientific means and knowledge, in order to improve the quality of care and treatment standards for premature and sick neonates. In 2015 the work for expanding the existing neonatal care unit has started, entirely supported by the Chiesi Foundation through its own resources and fundraising initiatives.During September 2015, it has been organized the charity initiative “African Lullaby”, which allowed to raise more than 47,000 euro (deducting all the expenses) devoted to the conclusion of the work within the end of 2016.

Hospital Saint Jean de Dieu, Tanguietá BeninThe Chiesi Foundation collaborates with the Fatebenefratelli Congregation, which runs the Saint Jean de Dieu Hospital in Tanguietá. Here a new neonatal care unit was inaugurated in 2012 completed with Foundation funding. Beginning in 2014, the Chiesi Foundation now provides a three-year study grant for a young doctor specialising in paediatric surgery, in order to ensure healthcare worker loyalty and guarantee the regular functioning of the unit.In the frame of the NEST, the Hospital is currently supported with the provision of adequate equipment, answering to the needs of the neonatal care unit, and with the development of training programs for the local staff, together with retention strategies.

Hospital of Ngozi, Burundi Over the course of 2014, the Chiesi Foundation began a three-year joint initiative with Cardinal Tonini’s Pro-Africa Foundation, relating to a training/healthcare project for the neonatal care unit, which is going to be created within the new maternal and infant Centre at

the Ngozi Hospital. The Chiesi Foundation is involved in reorganising the care of the neonates, in setting up and equipping the new unit and promoting training for the local staff.

Azerbaijan and MongoliaThe Chiesi Foundation supports the project “National School in Neonatology”, started in 2014 in Azerbaijan and 2015 in Mongolia. The training programme consists of courses involving international experts in intensive neonatal care and it is addressed to the most motivated and specialised local physicians. The objective of the training is to share skills and international experiences in neonatal care, in order to contribute to reduce the mortality rate of premature neonates in the countries.

The GASP ProgramThe GASP – Global Access to Spirometry Program is a model of intervention, designed by Prof. Robert Levy, Professor of Medicine at the British Columbia University in Vancouver, who has coordinated the project of the creation of the first spirometry laboratory and chronic respiratory diseases management in Guyana, South America.The Project Partners in care – “Optimizing Asthma & COPD Diagnosis and Chronic Disease Management in Guyana”, supported by the Chiesi Foundation since 2014, is a medical training, which focusses on the development of specific clinical skills for the diagnosis and management of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD) and on the education for the patients and their families.From this pilot project, the GASP model was born, highlighting the strengths, pitfalls, instruments and benefits of the interventions developed in Guyana, in order to allow to bring them in other countries with limited resources or undeserved areas of developed nations.The Chiesi Foundation decided to take on the model GASP and is committed to transfer it in other contexts with low resources.

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Values in euro 2015Scientific research and dissemination of knowledge

313.946

Education 97.000

International Cooperation 130.200

Other initiatives 21.029

Amount released for Institutional Activities 562.175

Personnel costs 40.054

Administrative costs 29.204

Total OUTFLOWS 631.433

Values in euro 2015Chiesi Farmaceutici 487.710

Valline 80.000

From fundraising activities * 88.672

Other donations 43.674

Total DONATIONS 728.170

5xmille (2013) 11.768,40

Income from financial management 54,7

Totale INFLOWS 739.993,5*

Compared to 2014, the Chiesi Foundation received more donations both from the Founder and other donors. This higher level of available resources have enabled the Foundation to confirm and consolidate its own role and commitment to supporting particu-larly scientific research and international cooperation projects.

*Including 47,000 euro raised during 2015, thanks to the fundraising initiative African Lullaby, donated to the Saint Camille Hospital at the beginning of 2016.

FINANCIALS

ETHICS & KNOWLEDGE

FOUNDATION

Chiesi Foundation OnlusL.go Belloli, 11a - 43122 Parma, Italy

info@chiesifoundation.orgwww.chiesifoundation.orgFiscal Code 92130510347

IBAN IT83P0335901600100000138268 BIC BCITITMX