FinalProgramme

International Scientific Meeting“ Thyroid Cancer and Environment”

8-10 June 2007P. NOMIKOS Conference Center,

Fira, Santorini, Greece

Presents the

Meeting Organizing Bureau

www. impressive.gre-mail: info@impressive.grtel./fax: +30 210 9962767

13 Karneadou str. 16346 Ilioupolis,Athens, Greece

Organized by

Prof. Leonidas DuntasInternal Medicine and EndocrinologyEndocrine Unit, Evgenidion Hospital

University of Athens, Greecee-mail: ledunt@otenet.gr

designed b

ywww.Artm

ade.gr

Under the Auspices of Ministry of Health & Solidarism

Santorini (Thira), GreeceAkrotiri, Wall-Painting “Spring Fresco”,15th c.B.C

One of the most important centers of the Aegean in theprehistoric period. During the early Bronze Age (3rdMillenium B.C.) there was a settlement in Akrotiri. Lateron (20th -17th century B.C.), the settlement wasexpanded and became one of the most significantcenters and ports of the Aegean .

Its large extent, its perfect urban organization ,its sewagenetwork, the artistic multi-floored buildings with somemagnificent mural decorations and the rich furnishing ,witness its great development.

The variety of imported products found within those buildings show the extension of the foreign relations ofAkrotiri. They kept strong relations with Minoan Crete, but they had communication with continental Greece,Dodecanese ,Cyprus, Syria and Egypt.

Life in the city came to an abrupt end during the last quarter of the 17th century , when its residents decidedto abandon it due to heavy earthquakes. The eruption of the volcano followed. The volcanic elements thatcovered the city and the whole island protected the buildings and their contents, until today, just like inPompey.

Elements about the settlements in Akrotiri came into light during the second half of 19th century A.C.Systematic excavations began there in 1967 by Professor Spyridon Marinatos under the aegis of theArchaeological Company based in Athens. Marinatos decided to excavate in Akrotiri, hoping to verify an oldtheory of his, published in the 30s, that the eruption of the Thira volcano caused the destruction of the Minoancivilization. After Marinatos death, in 1974, the excavation continued under the observance of ProfessorChristos Doumas. No interventions were made on the revealing monuments, except in cases where fixing wasneeded.

The Spring Fresco was found on D2 group of the Akrotiri settlement and it is dated back to 1550 B.C.( a whilebefore the eruption). Today it is exhibited in the Archaelogical Museum of Athens. Group D it is constitutedby four buildings .A room in the Eastern building was decorated with the Spring Fresco .The artist attributedwith great sensitivity a rocky landscape with blooming red flowers, with swallows flying within .

This Fresco covered three walls of a ground floor room and reaches the flooring. We observe a line ofvolcanic rocks in three colors, yellow, red and blue(or black), that give us an idea of what the whole islandlooked like. The upper part of the wall is white and is litted up with red flowers ( lilium cchalcedonicum ) withyellow stalks sprouting in three. The flowers seem to move as wind blows. On the north wall two birds withheld open the arcs of their wings seem to be making out. On the western wall the birds still seem to be makingout, while a third one is coming towards them. On the southern wall the birds with their wings lowered andtheir head down are moving in opposite directions one another. Their attitude shows the sorrow of breakingup. The Fresco is a hymn to the coming of Spring and comes by a room, that is believed was built forworshiping reasons. The birds remind the corresponding ones in the Cycladic angiography, while theportrayal of the flowers brings to mind the vessels of Phytical rhythm from Crete. But here the birds are not static like they were in the Minoan Crete art. They are described with thin and thicklines .The flowers look like those of the Ancient Triad in Crete and with those found in the house of murals, inKnosos. Moreover such flowers decorated the walls of the mansion in Amnisos

Acknowledgements

The Organizing and Scientific Committee of the International Scientific Meeting “Thyroid Cancerand Environment” wishes to express its gratitude to the following sponsors.

MAJOR SPONSORS

SPONSORS

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This meeting is financially supported by

municipalityof

THERA

Welcome Address

On behalf of my co-president Professor Furio Pacini it is my pleasure to welcome you to theInternational Scientific Meeting Thyroid Cancer and Environment in Santorini 8-10 June 2007under the patronage of the European Thyroid Association (ETA) and the Hellenic Ministry ofHealth and Solidarity.

The island of Santorini combines together with its unique beauty the particularity of the volcanicsoil that may influence thyroid function and prevalence of disease. There is evidence from variousparts of the world associating the volcanic substrate with increased incidence of thyroid nodulesand cancer.

The International Scientific Meeting in Santorini, dedicated exclusively to thyroid cancer,promises to be of utmost significance in delineating new concept in diagnosis and treatment aswell as in evaluation of environmental impact.

The program is outstanding thanks to the invaluable contribution of eminent speakers and chairsfrom Europe, United States and Latin America.

Prof. Leonidas Duntas

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European Thyroid AssociationOfficers

PresidentKoehrle Josef, Germany

SecretaryFeldt-Rasmussen Ulla, Denmark

European Thyroid Association Executive Commitee

Bakker Onno, Amsterdam, The NetherlandsErdogan Murat, Ankara, TurkeyJarzab Barbara, Gliwice, PolandPaschke Ralf, Leipzig, GermanyRodien Patrice, Angers, FranceSantoro Massimo, Naples, ItalySzabolcs Istvan, Budapest, HungaryVitti Paolo, Pisa, ItalyWeetman Anthony, Sheffield, UK

Scientific Committee of the International Scientific Meeting

Duntas Leonidas, Athens, GreecePacini Furio, Siena, Italy

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Invited Speakers and Chairs

Alevizaki Maria, Athens, GreeceChrousos George, Athens, GreeceCooper David, Baltimore, USADacou - Voutetakis Ekaterini, Athens, GreeceDoumas Christos, Athens, GreeceElisei Rossella, Pisa, ItalyFeldt - Rasmussen Ulla, Copenhagen, DenmarkGaertner Roland, Muenchen, GermanyJarzab Barbara, Gliwice, PolandKoehrle Josef, Berlin, GermanyMantzoros Christos, Boston, USAMedeiros - Neto Geraldo, Sao Paulo, BrazilPaschke Ralf, Leipzig, GermanyReiners Christoph, Wuerzburg, GermanyReske Sven- Norbert, Ulm, GermanySmyth Peter, Dublin, IrelandTsatsoulis Agathoklis, Ioannina, GreeceTseleni-Balafouta Sofia, Athens, GreeceWartofsky Leonard, Washington, USAWiersinga Wilmar, Amsterdam, The NetherlandsWilliams Dillwyn, Cambridge, UK

Committees of the International Scientific Meeting“Thyroid Cancer and Environment”

Under the auspices of

ñ Ministry of Health & Solidarismñ European Thyroid Association

Organized by

Leonidas Duntas, M.D.Professor of Endocrinology

Endocrine ClinicEvgenidion Hospital

University of Athens, Greecee-mail: ledunt@otenet.gr

Meeting Organizing Bureau

www.impressive.gr13, Karneadou str.

16346 Ilioupolis, Athens, GreeceTel. /Fax: +30210 9962767e-mail: info@impressive.gr

Final Program OverviewEuropean Thyroid Association

Presents the International Scientific Meeting “Thyroid Cancer & Environment”

Granted 6 CME credits by the EACCME (European Accreditation Councilfor Continuing Medical Education Institution of the UEMS)

Friday, 08 June 2007

Hotel Rocabella Congress Hall

20.00 The special lecture: “Santorini, The consequences of an explosion” Doumas Christos, Athens

21.00 Welcome Dinner co sponsored by

Saturday, 09 June 2007

Conference Center “P. Nomikos”, Fira Lobby area

08.00 - 09.00 Registrations

Conference Center “P. Nomikos”, Fira Main Congress Hall

09.00 - 09.15 Opening - Welcome Addresses

Session I : Basics in Thyroid Cancer

Chairs: Koehrle Josef (Berlin) , Tseleni-Balafouta Sofia ( Athens)

09.15 - 09.40 Proteomics, Genomics and Thyroid CancerPaschke Ralf, Leipzig

09.40 - 10.05 Factors and causes of Thyroid Carcinoma: The importance of stratification by pathological classification Williams Dillwyn, Cambridge

10.05 - 10.30 PPARgamma agonists, Adiponectin and Thyroid CancerMantzoros Christos, Boston

Conference Center “P. Nomikos”, Fira Foyer

10.30 - 11.00 Coffee Break Sponsored by

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municipalityof

THERA

Conference Center “P. Nomikos”, Fira Main Congress Hall

Session II: Clinical I

Chairs: Wiersinga Wilmar (Amsterdam) , Alevizaki Maria (Athens)

11.00 - 11.25 Global rising incidence of Thyroid Cancer: increased detection or higher radiation exposure?Wartofsky Leonard, Washington

11.25 - 11.50 Thyroid Cancer in childhood and adolescenceDacou - Voutetakis Ekaterini, Athens

11.50 - 12.15 Autoimmunity in DTC: Significance and related clinical problemsFeldt-Rasmussen Ulla, Copenhagen

12.15 - 12.40 Volcanoes and Thyroid CancerDuntas Leonidas, Athens

Session III : Clinical II

Chairs: Reske Sven - Norbert (Ulm) , Chrousos George (Athens)

12.45 - 13.10 Imaging in the diagnosis and treatment of DTCElisei Rossella, Pisa

13.10 - 13.35 TSH Suppression in the long term management of DTCCooper David, Baltimore

Venue to be announced by the meeting secretariat

13.45 Lunch Break

Conference Center “P. Nomikos”, Fira Main Congress Hall

14.45 - 15.10 Recombinant TSH-aided radioiodine ablation and treatment of DTC: benefits, limitations and dose of radioactivityPacini Furio, Siena

15.10 - 15.35 An Update on the modalities of treatment of metastatic DTC.Jarzab Barbara, Gliwice

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Conference Center “P. Nomikos”, Fira Main Congress Hall

Session IV: Environment & DTC

Chairs: Medeiros - Neto Geraldo (Sao Paulo) , Tsatsoulis Agathoklis (Ioannina)

15.40 - 16.05 Iodine and DTCSmyth Peter, Dublin

16.05 - 16.30 Radioactivity and Thyroid CancerReiners Christoph, Wuerzburg

16.30 - 16.55 The essential role of iodine and iodolactones in growth and apoptosisof thyroid epithelial cellsGaertner Roland, Muenchen

16.55 - 17.20 The role of Selenium and Selenoproteins in Thyroid CancerKoehrle Josef, Berlin

17.20 Synopsis Wiersinga Wilmar, Amsterdam

End of Scientific Program

Conference Center “P. Nomikos”, Fira

21.00 Farewell Dinner

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Lecturers and Coordinators

ALEVIZAKI MARIA: Professor, Endocrine Unit, Evgenidion Hospital, Athens University School ofMedicine, Athens, Greece.

CHROUSOS GEORGE: Professor, Head of Dept. of Pediatrics, Childrens Hospital, University ofAthens, Greece.

COOPER DAVID: Professor, Division of Endocrinology Sinai Hospital of Baltimore and InternationalHealth, John Hopkins University School of Medicine, President of the ATA, Baltimore, USA.

DACOU - VOUTETAKIS EKATERINI: Professor, Dept. of Pediatrics, Agia Sophia Children’s Hospital,University of Athens, Greece.

DOUMAS CHRISTOS: Professor, Dept. of Archeology, University of Athens, Greece.

DUNTAS LEONIDAS: Professor, Endocrinology and Internal Medicine, Endocrine Unit, EvgenidionHospital, University of Athens, Greece.

ELISEI ROSSELLA: Professor, Dept. of Endocrinology & Metabolism, University of Pisa, Italy.

FELDT-RASMUSSEN ULLA: Professor, Dept. of Endocrinology, Ringshospitalet, University ofCopenhagen, Secretary of the ETA, Copenhagen, Denmark.

GAERTNER ROLAND: Professor, Dept. of Endocrinology, Medizinische Klinik πnnenstadt, University ofMunich, Germany.

JARZAB BARBARA: Professor, Dept. of Nuclear Medicine & Endocrine Oncology, University ofGliwice, Poland.

KOEHRLE JOSEF: Professor, Dept. of Endocrinology and Molecular Biology, UniversitaetsklinikumCharite, University of Berlin, President of the ETA, Berlin, Germany.

MANTZOROS CHRISTOS: Professor, Division of Endocrinology, Diabetes and Metabolism, BethIsrael Deaconess Medical Center, Boston, USA.

MEDEIROS - NETO GERALDO: Professor of Endocrinology, Dept. of Medicine, Hosp. ClinicasUniversity of Sao Paulo, Brazil.

PACINI FURIO: Professor, Dept. of Endocrinology, University of Pisa, Siena, Italy.

PASCHKE RALF: Professor, Dept. of Medical Clinic and Policlinic III, University Clinic of Leipzig,Leipzig, Germany.

REINERS CHRISTOPH: Professor, Dept. of Nuclear Medicine, University Clinic of Wuerzburg,Germany.

RESKE SVEN-NORBERT: Professor, Dept. of Nuclear Medicine, University of Ulm, Germany.

SMYTH PETER:Professor, Endocrine Laboratory, Dept of Medicine/Woodview, University College ofDublin, Ireland.

TSATSOULIS AGATHOKLIS: Professor, Dept. of Endocrinology, University of Ioannina, Greece.

TSELENI - BALAFOUTA SOFIA : Professor, Dept. of Pathology, Medical School, University of Athens,Greece.

WARTOFSKY LEONARD: Professor, Dept. of Medicine, Washington Hospital Center, WashingtonD.C.,USA.

WIERSINGA WILMAR: Professor, Dept. of Internal Medicine, Endocrinology & Metabolism, AcademicMedical Centre, University of Amsterdam, The Netherlands.

WILLIAMS DILLWYN: Professor, Thyroid Carcinogenesis Research Group, Strangeways ResearchLaboratories, Worts Causeways, Cambridge, UK.

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Registration - Information

Registration Fees Before 10 April, 2007 After 11 April, 2007All Professions €270,00 €350,00Residents €180,00 €200,00Accompanying Persons €80,00 €80,00

Delegates Registration Fees, include:ñ Admission to all Scientific Sessionsñ Congress bag containing material kit and Final Programñ Coffee Break ñ Lunch Breakñ Certificate of Attendanceñ Participation to the Opening Lecture and Welcome Dinnerñ Participation to the Farewell Dinner

Accompanying Persons Registration Fees, include:ñ Participation to the Opening Lecture and Welcome Dinnerñ Participation to the Farewell Dinner

Please note that reduced fees only apply, if both registration form and payment are received, not later thanApril 10th, 2007, by Impressive (Meeting Secretariat):Tel. /Fax: + 30 210 99 62767 / e-mail: info@impressive.gr

Terms of Payment Payment of registration and other fees should be made in Euro € as follows :

ñ Bank TransferPlease transfer payment to: ALPHA BANK ( Avenue Protopappa Branch)Account name: S. CONSTANTINOU IMPRESSIVE Ltd.Account Number: 361.00.2320.001465 IBAN: GR28 0140 3610 3610 0232 0001 465SWIFT Code: CRBAGRAAXXXDetails of payment: Please do not forget to clearly state your company’s name and the indication International Scientific Meeting “Thyroid Cancer & Environment”Please note that bank charges must be fully covered by the participant

ñ Credit CardPlease enter your card number and expiry date in the appropriate space on the registration Form. Please note that only MasterCard & VISA credit cards are accepted. Please do not forget to also enter the Card Validation Code (CVC) which is printed on the reverse side ofyour credit card at the signature panel, after the number of your credit card (additional three digits).

ReconfirmationsFor those registration forms received completed and prepaid (proof of payment) in due time, aconfirmation letter and registration number will be received by the delegates from the Meeting Secretariat. YÔu are kindly requested to present this confirmation letter upon your arrival at the pre-registration desk, inorder to pick up the congress material.

Cancellation Policy - Refunds All cancellations must be sent in written and addressed to Impressive Meeting Secretariat.ñ All written cancellations received by Impressive before April 10, 2007, the amount of € 45,00 will becharged as administrative fees.ñ All written cancellations received by Impressive before April 25, 2007, an amount equal to 50% of the totalfees will be refunded. ñ No refund will be possible after April 25, 2007.ñ However a copy of the Meeting Edition could be mailed to the delegate, upon request.

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Social Events

Friday, June 8th, 2007

21.00 Welcome Dinner, Rocabella Hotel, Fira

Saturday, June 9th, 2007

21.00 Farewell Dinner, P. NOMIKOS Conference Center, Fira, Santorini

Receipt of printed invitations concerning social events of the meeting, will be delivered at the pre-registration desk at the congress venue, under the condition that a statement of attendance has beenfilled in and sent in advance.

All participants should carry all printed invitations in order to be able to enter social program venue.

Shuttle Buses

There will be shuttle bus service from all the hotels of the International Scientific Meeting to:

P. NOMIKOS Conference Center with return, for the Opening Ceremony and the Scientific Programon 9th June 2007.

P. NOMIKOS Conference Center with return, for the Farewell Dinner, on 9th June 2007.

Shuttle bus schedule will be announced, at the Hospitality Desk of each Hotel booked through theMeeting Secretariat

Note: The participant acknowledges that he/she has no right to lodge damage claims against the organisers should the handling ofthe Meeting be hindered or prevented by unexpected political or economic events or generally by force major, or should the nonappearance of speakers or other reasons necessitate programme changes. With registration, the participant accepts this proviso.

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General Information

Meeting VenueP. NOMIKOS Conference Center, Fira, Santorini, Greece

DatesFriday, 8 June 2007Saturday, 9 June 2007See the Final Program Overview

Official LanguageEnglish.

ClimateThe average temperature in Santorini island, during June is between 28ÔC - 34ÔC.

Certificate of Attendance

Granted 6 CME credits by the EACCME (European Accreditation Council for Continuing MedicalEducation Institution of the UEMS)

Address before and after the meeting Impressive13, Karneadou street163 46 Ilioupolis, Athens,GreeceTel. / Fax : +30 210 9962767http://www.impressive.gre-mail: info@impressive.gr

Final ProgrammeA copy of the Final Programme will be handed out to each registered Participant upon presentation ofhis/ her registration confirmation to the Registration Desk/Secretariat. Please do not forget to bring yourconfirmation letter.

Registration desk/SecretariatAll documents will be handed over to the registered participants during the following opening hours:Saturday, June 9, 2007 08.00 - 19.00

Tours and Excursions, Car rentalImpressive, the Exclusive and Official Meeting Organizing Bureau is fully responsible in organising avariety of optional tours, excursions, car rental for participants and for accompanying persons as well.To pre-book please contact Impressive.

Audiovisual equipment - Slide ReceptionData projector, overhead projector and slide projector equipment will be available during the Meetingsessions.Speakers are kindly requested to contact the slide reception desk, at least 1 hour before his/her lecture.

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Hotel Accommodation

Accommodation has been reserved in several hotels in Santorini by Impressive.

Above prices are per room per night on bed and American breakfast basis. All applicable taxes areincluded.There is an obligatory stay of 2 overnights. In order to guarantee your reservation one night deposit, isrequired. Upon receipt of the deposit, each participant will receive a confirmation letter.

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Hotel

RocabellaLuxury Suites

Imerovigli

RocabellaLuxury Suites

Imerovigli

AndromedaImerovigli

Xenones FiloteraImerovigli

Imerovigli PalaceImerovigli

Santorini ImageMessaria

Pegassus SuitesImerovigli

Dana VillasFirostefani

Category

De Luxe

De Luxe

De Luxe

De Luxe

De Luxe

Superior4 stars

De Luxe

De Luxe

SingleOccupancy

Studio€260,00

Apartment€280,00

Suites€230,00

Apartment€165,00

Sup.Apartment€240,00

Stand. Studio€195,00

Suites€250,00

Room€119,00

Sup.Studio€205,00

Junior Suite€240,00

Trad. Suites€205,00

Junior Suites€230,00

DoubleOccupancy

Studio€260,00

Apartment€280,00

Suites€250,00

Apartment€180,00

Sup.Apartment€280,00

Stand. Studio€215,00

Suites€340,00

Room€140,00

Sup.Studio€215,00

Junior Suite€250,00

Trad. Suites€215,00

Junior Suites€240,00

TripleOccupancy

N/A

Apartment€320,00

N/A

Price / room/ nighton b/b basis

Caldera view

Caldera view

Caldera view

Aegean view

Caldera view

Caldera view

Caldera view

Caldera view

Method of payment

Payment of hotel reservation should be made in Euro € as follows :

ñ Bank TransferPlease transfer payment to : ALPHA BANK ( Avenue Protopappa Branch)Account name: S. CONSTANTINOU IMPRESSIVE LTD.Account Number: 361.00.2320.001465 IBAN: GR 28 0140 3610 3610 0232 0001 465SWIFT Code: CRBAGRAAXXXDetails of paymentPlease do not forget to clearly state your company’s name and the indication International ScientificMeeting “Thyroid Cancer & Environment”. Please note that bank charges must be fully covered bythe participant

ñ Credit CardPlease enter your card number and expiry date in the appropriate space on the hotel reservationForm. Please note that only MasterCard & VISA credit cards are accepted. Please do not forget to also enter the Card Validation Code (CVC) which is printed on the reverseside of your credit card at the signature panel, after the number of your credit card (additional threedigits).

Full pre-payment has to be made to Impressive until, May 5, 2007.

Cancellation Policy - Refunds All cancellations must be sent in written and addressed to Impressive, Meeting Secretariat.ñ All written cancellations received by Impressive, before April 10th 2007, the amount of € 45,00 willbe charged as administrative fees.ñ All written cancellations received by Impressive before April 25th, 2007, an amount equal to 50%of the total fees will be refunded. ñ No refund will be possible after April 25th, 2007.

Confirmations and receipt of payments will be mailed after this date

For participants willing to extend their stay in the hotel, the reduced congress rates will be appliedonly if reservations and payments are made via Impressive.

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Flight Arrangements

Impressive the Exclusive and Official Organizing Bureau of the International Scientific Meeting “ThyroidCancer and Environment” in exclusive co-operation with Navigator Travel, is fully responsible for all flightarrangements and issuing of air tickets for participants and for accompanying persons as well.

Air Carrier Dates Departure from Athens ETA Dep/Arr.ñ A3 354 7 June Athens - Santorini 11:15 - 12:00ñ A3 358 7 June Athens - Santorini 19:00 - 19:45ñ A3 350 8 June Athens - Santorini 05:55 - 06:45ñ A3 354 8 June Athens - Santorini 11:15 - 12:00ñ A3 350 9 June Athens - Santorini 05:55 - 06:45

Air Carrier Dates Departure from Santorini ETA Dep/Arr.ñ A3 355 10 June Santorini - Athens 12:35 - 13:20ñ A3 359 10 June Santorini - Athens 20:20 - 21:05ñ A3 357 11 June Santorini - Athens 14:00 - 14:45

CostñAir ticket cost € 290,00 + airport taxes € 43,00 with Aegean Airlines (A3)Price per person includes shuttle bus transportation from airport to hotel and vice versa, upon arrival anddeparture. Reservations Deadline: April 20th, 2007

Method of PaymentPayment of registration and other fees should be made in Euro € as follows : ñ Bank TransferPlease transfer payment to : ALPHA BANK ( Avenue Protopappa Branch)Account name: S. CONSTANTINOU IMPRESSIVE LTD.Account Number: 361.00.2320.001465 IBAN: GR28 0140 3610 3610 0232 0001 465SWIFT Code: CRBAGRAAXXXDetails of payment: Please do not forget to clearly state your name or your company’s name and theindication International Scientific Meeting “Thyroid Cancer & Environment”Please note that bank charges must be fully covered by the participant

ñ Credit CardPlease enter your card number and expiry date in the appropriate space on the hotel reservation Form.Please note that only MasterCard & VISA credit cards are accepted. Please do not forget to also enter the Card Validation Code (CVC) which is printed on the reverse side ofyour credit card at the signature panel, after the number of your credit card (additional three digits).

Cancellation Policy-Refunds All cancellations must be sent in written and addressed to Impressive, Meeting Secretariat.ñ All written cancellations received by Impressive, before April 10th, 2007 the amount of €45,00 will becharged as administrative fees.ñ All written cancellations received by Impressive, before April 25th , 2007, an amount equal to 50% ofthe total fees will be refunded. ñ No refund will be possible after April 25th , 2007.

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Meeting Professionals International

Marketing & Communication ñ Event Management ñ Meetings ñ Incentives Management

Destinations Management ñ Professional Congress & Conferences Management

www.impressive.gr13 Karneadou str. 16346, Ilioupolis, Athens, Greecetel./fax: +30 210 9962767 e-mail: info@impressive.gr

designed b

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ade.gr