esophagus anatomy physiology pathology treatment
TRANSCRIPT
ESOPHAGUS
anatomy
physiology
pathology
treatment
Anatomy of esophagus length 23-25 cm esophagus begins at the level of the sixth cervical
vertebra and it enters into the superior mediastinum through the upper thoracic outlet then it descends into the posterior mediastinum and exits the thorax through esophageal hiatus of the diaphragm and enters the abdominal cavity
there are three parts of the esophagus: cervical, thoracic and abdominal esophagus
esophagus has three physiological constrictions
Anatomy of esophagus It consists of three layers :
mucosa, submucosa muscular layer (circular and longitudinal layer)
arterial blood supply from: inferior thyroid artery descending aorta left gastric artery inferior phrenic artery
venous drainage into the superior caval vein portal vein
Anatomy of esophagus
Esophagus has an extensive lymphatic drainage into cervical, posterior mediastinal, paraesophageal and celiac axis lymph nodes
Anatomy of esophagus
Carcinoma of the esophagus most common neoplasm of the esophagus is
carcinoma
its incidence is very differentiated worldwide and
depends on geographical localization that proves
its dependency on environmental factors
90% of patients with esophageal carcinoma die
incidence of esophageal carcinoma is 8-12/100000
men per year in Europe and 6/100000 in the
United States
Carcinoma of the esophagus
risk to develop carcinoma of the esophagus
increases along with the age and is the highest
between the sixth and the seventh decade of life
more frequent in males
main risk factors: smoking, alcohol
incidence of esophageal adenocarcinoma raises
Carcinoma of the esophagus Premalignant states
Plummer-Vinson syndrome
caustic burns
achalasia
Barrett’s esophagus
leukoplakia
Carcinoma of the esophagus Screening
screening exfoliative cytology in endemic
areas
Barrett’s esophagus- endoscopic biopsy
Carcinoma of the esophagus Clinical presentation
dysphagia in 95% of cases
regurgitation
weight loss
chest pain
cough
Carcinoma of the esophagus Diagnosis
barium esophagogram
flexible fiberoptic
esophagoscopy with biopsy
Computed Tomography
endoscopic ultrasound –
diagnostic accuracy 80–
90%
Bronchoscopy
Carcinoma of the esophagus Staging
Primary tumor (size of tumor and depth of infiltration)–T
regional lymph node involvement - N
distal metastasis–M
Carcinoma of the esophagus Staging
Primary tumor - T
T1 – tumor invades lamina propria or
submucosa
T2 – tumor invades muscularis propria
T3 – tumor invades adventitia
T4 - tumor invades adjacent structures
Carcinoma of the esophagus Staging
Regional lymph nodes – N
N0 – no regional node metastasis
N1 – regional node metastasis
Distant metastasis – M
M0 – no distant metastasis
M1 – distal metastasis
Carcinoma of the esophagus Surgical management
radical – resection of a tumor with adequate
oncological margins and regional lymph
nodes
palliative - to restore oral intake of food
Carcinoma of the esophagus Most common surgical procedures
1. Thoracoabdominal Ivor–Lewis esophagectomy with high intrathoracic esophagogastric anastomosis and gastric drainage procedure
2. Thoracoabdominal McKeown esophagectomy
with esophagogastric anastomosis in the neck
3. transhiatal Orringer esophagectomy with
esophagogastric anastomosis in the neck
4. esophagectomy throuh left
thoracophrenolaparotomy
Carcinoma of the esophagus How to replace the esophagus?
stomach- the best organ to replace the
esophagus
colon- the second organ for reconstruction
small intestine (pedicle or free graft)- least
appropriate
Carcinoma of the esophagus Complications
Postoperative complications from 20 to 40%
perioperative mortality 3–10%, 20% was also
reported
Carcinoma of the esophagus Radiation therapy
patients with advanced disease patients refusing to undergo surgery irradiation with a dose of 55–60 Gy usually used as a palliative treatment,
unusually as a radical treatment has no influence on survival 5-year survival rate less than 6%
Carcinoma of the esophagus Chemotherapy
Effective for a short time
recently advocated regimen is cisplatin with
vindesine, bleomycin and 5-fluorouracil
complete and partial response rates are
reported for 25-50 %
Carcinoma of the esophagus Combination therapy
Results of monotherapy are bad
5-year survival rate after surgery alone is 10–
15 %
most patients die due to distant metastases,
hence local treatment is combined with
systemic treatment
Carcinoma of the esophagus Combination therapy - benefits
decrease in tumor size
early therapy for micrometastases
enables the assessment of response to a used
treatment and reassessment of staging after
induction therapy
surgery 3-6 weeks after induction therapy
some authors question the role of surgery in
improving survival
Carcinoma of the esophagus Palliative therapy
50% of patients have distant metastases at the
time of diagnosis
main problem reported by a patient – dysphagia
radiation therapy combined or not with
chemotherapy offers immediate clinical
improvement in dysphagia
Carcinoma of the esophagus Palliative endoscopic treatment
dilatation self-expanding stents stents laser ablation endoluminal brachytherapy photodynamic therapy
Palliative resection, bypass procedures and gastrectomy are presently not advocated
Self-expanding stents
Carcinoma of the esophagus Prevention
cessation of smoking and alcohol
consumption
treatment of Barrett’s esophagus
detection of p53 gene mutation
screening programs
Rare esophageal malignancies
Epithelial carcinoma planoepithelialae partim fusocellularae adenocarcinoma carcinoma basocellularae carcinoma microcellularae
Non-epithelial leiomyosarcoma melanoma rhabdomyosarcoma fibrosarcoma
Benign esophageal tumors Deriving from submucosa
adenoma haemangioma papilloma fibrolipoma neurofibroma
Deriving from muscular layer (intraparietal) leiomyoma lipoma fibroma
Chemical burns of the esophagus
Necrosis occurs directly after burn and is
irreversible!
Chemical burns of the esophagus
Acids - they produce coagulative necrosis that is rarely full-thickness one. Similar injury should be expected in the stomach and duodenum.
Caustic agents - they produce colliquative
full-thickness necrosis including perforation.
Classification of chemical burns of the esophagus
I. Erythema, superficial exfoliation of esophageal epithelium
II. shallow ulcerations not penetrating beyond submucosa, whitish discolorations
A. superficial erosions and ulcerations
B. deep, circumferential ulcerations
III. deep ulcerations penetrating into the muscularis propria or producing perforation
Chemical burns of the esophagus
Clinical presentation
a) severe retrosternal pain
b) dysphagia
c) shock
d) respiratory disturbances
e) subcutaneous emphysema in the neck-
sometimes
f) stridor and peritonitis- rarely
Chemical burns of the esophagus
First-aid treatment
Oral administration of small amount of water administration of antidotes, advocated in the
past, can trigger exothermic reaction and compound injury
vomits shouldn’t be induced administration of antibiotics, steroids and
analgesic agents. in a case of acute airway obstruction
tracheostomy should be performed intravenous access
Chemical burns of the esophagus
First-aid treatment
cessation of oral food intake chest x-ray examination esophagoscopy performed within 12-24 hours after
burn preceded by laryngoscopy part of surgeons is of the opinion that endoscopy
mustn’t be done and they advocate esophagogram using a water-soluble contrast medium if esophageal perforation is suspected, if not esophagoscopy can be done 2-3 days after burn and then 3 weeks after burn.
Chemical burns of the esophagus
Perforation of the esophagus occurs usually between 2 and 8 days after
burn.
Stricture of the esophagus after burn - treatment
dilatation of stricture resection of the narrowed fragment of the
esophagus and esophagoesophageal anastomosis- short strictures only
esophagectomy and reconstruction using the stomach, colon or small bowel (possible malignant degeneration)- extensive esophageal strictures
Thal or Collis gastroplasty- stenosis of gastroesophageal junction
Perforation of the esophagus
Esophageal perforation is a serious diagnostic problem.
Incidence:1case per 8000 hospitalized patients
per year and still increases due to growing
number of diagnostic and therapeutic endoscopies.
Perforation of the esophagus Etiology
Iatrogenic from inside
endoscopy dilatations variceral sclerosis esophageal intubation laser
Perforation of the esophagus Etiology
from outside mediastinoscopy intraoperative injuries (thyroid resection,
enucleation of esophageal myoma, vagotomy, pneumonectomy)
radiation therapy
Traumatic blunt trauma penetrating trauma caustic injury
Perforation of the esophagus Etiology
Spontaneous perforation
postemetic
others e.g. childbirth
Foreign body
Neoplasms
Paraesophageal infections
Perforation of the esophagus
Bacteria in saliva
Air Gastric juice
Infection Emphysema
Chemical burn
Abscess, empyema, sepsis
Tension pneumothorax
Disturbances in water and
electrolyte balance
shock
mediastinum
Perforation of the esophagus Clinical presentation
Cervical esophagus neck ache increased on swallowing hemoptysis or hematemesis subcutaneous emphysema fever local tenderness change in the timbre of voice hydropneumothorax pneumothorax neck abscess
Perforation of the esophagus Clinical presentation.
Thoracic esophagus chest pain dyspnea subcutaneous emphysema pneumo- and hydrothorax tachycardia and tachypnea cyanosis fever
Perforation of the esophagus Clinical presentation
Abdominal esophagus
peritonitis
retrosternal pain radiating to the arms
tachycardia and tachypnea
fever
Perforation of the esophagus Differential diagnosis
Chronic gastric and duodenal
ulcer disease
myocardial infarction
acute pancreatitis
dissecting aortic aneurysm
pneumonia
pneumothorax
Perforation of the esophagus Crucial aims of surgical treatment
Elimination of sources of bacterial infection
and chemical injury
drainage of infected areas
secure food intake
Perforation of the esophagus Surgical management
1. primary repair of the perforation
2. primary repair of the perforation buttressed with well-vascularized autologous tissue
3. temporary exclusion of the perforated esophagus
4. drainage procedures (T-tube drainage, washing drainage, intraesophageal drainage)
5. partial or total esophageal resection
Perforation of the esophagus Surgical management
The earlier esophageal perforation is
diagnosed the easier is a treatment.
The later it is diagnosed the more
aggressive should be a surgical
management.
Disorders of esophageal motility
Disorders of esophageal motility can result both
from its increased and decreased neuromotor
activity .
Cricopharyngeal achalasia
Clinical presentation Cervical dysphagia Barium esophagogram demonstrates hypertonicity
of the upper esophageal sphincter (narrowing of esophageal lumen)
Presence of Zenker's diverticulum in some patients
Treatment Cervical esophagomyotomy from the level of the
superior cornu of the thyroid cartilage iferiorly to 1-2 cm behind the clavicle
Neuromotor diturbances of esophageal motility
Usually myotonic
Observed in diseases such as:
miasthenia gravis,
dystrophia myotonica
Pathologies of the peripheral and central nervous
system.
Diffuse esophageal spasm
Clinical presentation Dysphagia, chest pain (retrosternal) Anxiety, signs and symptoms appear
periodically x-ray examination and esophageal
manometry demonstrate hypermotilityTreatment Nitrates, calcium channel blockers Liquid, small-volume meals Long esophagomyotomy
Achalasia
Clinical presentation dysphagia regurgitation Lack of primary esophageal peristalsis,
dilatation of the esophagus and the distal bird-beak taper of the esophagogastric junction on barium swallowing examination
Luck of primary esophageal peristatlsis on manometry
Achalasia
Alteration of the central or peripheral vagal innervation.
In many cases the lack or disintegration of
ganglion cells in the myenteric (Auerbach's)
plexus is observed.
Etiology of achalasia is unknown.
AchalasiaTreatment
Myorelaxants have weak or no therapeutic
effect
Dilatation of the lower esophageal sphincter
Esophagomyotomy (Heller procedure) – 15%
of cases
Uchyłki przełykuPodział
wrodzone nabyte prawdziwe rzekome
Typ z uwypuklenia - uwypuklenia błony śluzowej i podśluzowej przez osłabiona mięśniówkę.
Typ z pociągania - pociąganiu ściany od zewnątrz przełyku przez zapalnie lub bliznowato zmienione okołooskrzelowe i śródpiersiowe węzły chłonne.
Diverticula of the esophagusClinical presentation
Dysphagia
Regurgitation
Bad breath
Chest pain
Typical roentgenographic picture
Diverticula of the esophagus Complications
Often asymptomatic clinical course Diverticulitis Fistula Abscess Bleeding
Symptomatic patients or patients in whom
complications occured should undergo surgical
treatment.