1

Interfacultary Centre of Biomaterials – Univ. Liège

www.ceib.ulg.ac.be 4 departements – staff ~ 30 p

1. Polymer synthesis

• biodegradable polyesters

• functionalized poly(methyl)acrylate

2. Polymer processing

• Hydrogels

• Film

• Dispersed materials : micelles, nano-microparticles

• drug immobilisation

3. Analytical

• Solubility, Mw determination

• Stability, release kinetics study

• Particle characterisation

4. In vitro toxicity

• Hemocompatibiliy

• Animal cell tox

2

Polymer synthesis

Particle Drug Delivery

Drug formulation

GENERAL

ORGANISATION OF

THE RESEARCH

VALORISATION : Patents – Close collaboration with industries – Analytical services

In vivo testing

In vitro testing

Cell therapy –

Tissue engineering

3

Biodegradable polyesters

Macromolecular engineering with controlled polymerisation mechanism

of cyclic monomers such as lactides, lactones. Novel architectures: block

graft, random star-branched copolymers

PolymerTECH : more than 300 different polymer samples available

Material type : thermoplastics, hydrogels, amphiphilic gels

Batch size : from g to 100 g ; in the near future : Kg scale facilities with reactive extrusion polymerisation

Synthetic polyelectrolytes

Living radical polymerisation of acrylic monomers

Stimuli-responsive polymers.

Functionalized polymers with reactive groups for synthesis

of bioconjugates and fluorescent labelling of biomaterials.

Strongly adhering polymers

Bulk polymerisation and purification in aqueous medium

4

Tissue engineering

5

Research project proposals

6

hydrophobe hydrophile

Increase the softness of the material by increasing it’s hydrophilicity

L - H - L L - H - L

0

50

100

150

200

250

0 10 20 30 40 50 60 70

Proportion molaire de PEO [%]

Pri

se

de

ma

ss

e [

%]

15 min

24 h

1 semaine

H

Amphiphilic Biodegradable and biocompatible Hydrogels for

Tissue engineering and Drug Delivery

Biocompatibility Preclinical trials

Histological evaluation after 2 weeks of implantation (subcutaneous on rat)

With comonomer No comonomer

Membrane without comonomer is broken

Degradable textiles and

stem cells.

Multifilament Monofilament Multifilament Monofilament

Osteoblast cells Stem cells

Cell appearance after a 24 hours incubation with 3D textile (Confocal microscopy

after fibers morphology analysis (LIVE/DEAD Kit´s labeling)

Biocompatible biodegradable composite gel / textile for tissue engineering

Biocompatible nanocarrier for drug delivery systems

Poly (ethylene oxide)

-Biocompatibility

-Hydrophilicity

- Eliminable through kidney

Protein drug

(Human

Insulin)

Poly-e-(caprolactone)

-Biodegradability,

-Compatibility with a wide range of other polymer

-Relatively low cost.

-High crystallinity

PEO PCL

C

O

O O

H3CO

mn

11

Fluorescent polymer

labelling

12

Purposes : 1. Biodistribution / bioelimination studies

2. Intracellular trafficking studies

Main objective : new biocompatible polymers as possible replacement for classical non degradable polyethyethylene oxide

Techniques : 1. FACS analysis 2. Confocal microscopy

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Prof. Christian GRANDFILS

www.ceib.ulg.ac.be

C.Grandfils@ulg.ac.be

MATERIA NOVA

… in short

Materia-Nova : R&D centre

• since 2000

• non-profit organization

• 90 employees

• turnover 2011 : 8,5 Mio€

• pure project financing

• 2011: member of EMRA

Site NATISS

Ghislenghien

Site INITIALIS

Mons

INDUSTRY

SMPC

P. Dubois

SDM

M. Olivier

SCMN

R.Lazzaroni

INFLUX

P. Damman

CHIPS

R. Snyders

BIOTECH

R. Wattiez

Fondamental Research

Applied Research

Business model « Materia-

Nova »

Fields of expertise

Biodegradation

Biotechnology

Plasma technologies

Electrochemistry

Sol-gels

Polymers

(Nano-)composites

Nanotechnologies

Structured surfaces

Modelisation

Synthesis

Devices

Biopolymers

Our mission

Research programs in collaboration with industrial partners

Strategic partnership with multinational companies

... but also :

Tests et analyses

Scientific advice and consultancies

Partners AGC

ArcelorMittal

Arkema

BAT

Beaulieu

BTN

Essilor

ESE

Evian

Faurecia

Futerro

Galactic

Galvapower Group

Goodyear

Husqvarna

Inergy

Kabelwerk Eupen

Knauf

Lhoist

Matrio

Nexans

NMC

Nitto

Roquette

Sojitz

Solvay

SRC

Techspace Aero

Total

Toyota

Vallourec

Whirlpool

…

BCRC, CERTECH, CTP & MATERIA NOVA

www.emra.eu

Contact

Luc LANGER

General Manager

Avenue Nicolas Copernic, 1

B-7000 Mons, Belgium

Tel: +32 65 554902

e-mail: Luc.Langer@materianova.be

Web: www.materianova.be