epilepsy surgery. history definition seizure convulsion epilepsy

Download Epilepsy surgery. History Definition Seizure Convulsion Epilepsy

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  • Slide 1
  • Epilepsy surgery
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  • History
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  • Definition Seizure Convulsion Epilepsy
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  • Epidemiology Prevalence : 52,000,000 around the world 700,000 in Iran
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  • Pathophysiology Developmental pathology of brain Neuronal and glial disorders Kindling phenomenon Reorganization of cortical tissue in response to hypoxia
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  • Kindling phenomenon
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  • Treatment Standard : monotherapy by antiepileptic drugs Traditional : phenobarbital, phenytoin, primidone, carbamazepine, valproic acid New : lamotrigine, topiramate, levatiracetam,
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  • Failure of medical therapy Misdiagnosis Irregular follow up Irregularity in treatment Life style factors Brain tumors Sever traumatic brain injury
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  • Refractory epilepsy 30 % of patients
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  • Causes of refractory epilepsy Temporal lob epilepsy : the most common Neuronal structural disorders Inflammatory disorders Autoimmune mechanisms Tumors and sever traumatic brain injuries
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  • Temporal lobectomy and lesionectomy
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  • Callosotomy
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  • Indications Tuberos sclerosis Infantile spasm Lenox Gustaut syndrome
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  • Hemispher - ectomy, tomy
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  • Rasmussen's encephalitis
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  • Multiple subpial transection
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  • Vagal nerve stimulation
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  • Mechanism Nor epinephrine GABA Reticular activating system
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