epidemiology of hcv...zibbell et al. increases in hepatitis c virus infection related to injection...
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Epidemiology of HCV
Jonathan Moorman, M.D. Ph.D.
Professor of Medicine and Division Chief, Infectious Diseases
Co-Director, Center of Excellence in Inflammation, Infectious
Diseases and Immunity
ETSU Quillen College of Medicine
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Disclosures
Grant funding from NIH NIAID, NIDDK, NIA, and VA Merit
No financial interests involved in this presentation
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Acute HCV 2015: 2,436 cases of HCV reported from 41 states
0.8 cases/100,000 in U.S.
TN: 2.6 cases/100,000
10 states accounted for about 60% of the cases
ACTUAL acute cases estimated to be 13.9 times that rate in any given year
Estimated 33,900 new cases in 2015
https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm
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https://www.cdc.gov/hepatitis/
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https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm
How many?
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Hepatitis C Incidence in United States, 1982-2014
https://www.cdc.gov/hepatitis/statistics/2014surveillance/index.htm
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https://www.cdc.gov/hepatitis
Where?
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Where is it most concentrated?
Patrick et al. Hepatitis C Virus Infection Among Women Giving Birth—Tennessee and United States, 2009-2014. MMWR 2017; 66: 18, p. 470-473.
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Local epidemiology
Patrick et al. Hepatitis C Virus Infection Among Women Giving Birth—Tennessee and United States, 2009-2014. MMWR 2017; 66: 18, p. 470-473.
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It’s a rural thing
Xc
Zibbell et al. Increases in Hepatitis C Virus Infection Related to Injection Drug Use Among Persons Aged <30 years---Kentucky, Tennessee, Virginia,
and West Virginia, 2006-2012. MMWR 2015; 64: 17, p. 453-458.
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What age groups?
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Men or women?
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What are the risk factors?
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CDC, National Notifiable Diseases Surveillance System
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CDC, National Notifiable Diseases Surveillance System
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Locally…
Zibbell et al. Increases in Hepatitis C Virus Infection Related to Injection Drug Use Among Persons Aged <30 years---Kentucky, Tennessee, Virginia,
and West Virginia, 2006-2012. MMWR 2015; 64: 17, p. 453-458.
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Van Handel et al. J Acquir Immune Defic Syndr 2016; 73(3): 323-331.
Why we worry
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HCV in the U.S. 2.7-3.9 million in the U.S. with chronic HCV
Estimated 19,659 deaths in 2014
HCV is the leading indication for liver transplants in the U.S.
Denniston et al. Ann
Intern Med
2014;160;293-300.
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Mortality
Ly et al. Ann Intern Med 2012;156;271-278.
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Mortality Estimates going forward
Rein et al. Dig Liver Dis 2011;43:66-72.
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