energy & fatigue - post concussion syndrome

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DIDACTIC SESSION: POST-CONCUSSION SYNDROME POST-CONCUSSION SYNDROME IDENTIFICATION AND MANAGEMENT APPROACH PROGRAM SYLLABUS All rights reserved. No part of this work can be reproduced, distributed, or otherwise used without the express permission from the American Academy of Neurology Institute. © 2015 American Academy of Neurology Institute Printed in the USA

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This three-day conference will focus on the science behind concussion. The conference will follow a newprogramming model to include five half-day sessions, each with its own general theme, faculty presentations, and a panel discussion. Poster presentations will occur on the first two days of the conference.

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Page 1: Energy & Fatigue - Post Concussion Syndrome

DIDACTIC SESSION: POST-CONCUSSION

SYNDROME

POST-CONCUSSION SYNDROME IDENTIFICATION AND

MANAGEMENT APPROACH PROGRAM SYLLABUS

All rights reserved. No part of this work can be reproduced, distributed, or otherwise used without the

express permission from the American Academy of Neurology Institute.

© 2015 American Academy of Neurology Institute Printed in the USA

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2015 AAN Sports Concussion Conference July 24-26, 2015

Didactic Session: Concussion Saturday, July 25, 2015 8:00 a.m. – 11:30 a.m.

Program Directors Jeffrey S. Kutcher, MD, FAAN – Ann Arbor, MI Christopher Giza, MD – Los Angeles, CA Program Schedule and Faculty 8:00 AM – 8:15 AM Welcome and Day Overview 8:15 AM – 8:55 AM Post-Concussion Syndrome Identification and Nicole D. Reams, MD Management Approach Ann Arbor, MI 8:55 AM – 9:35 AM Managing PCS in a Neuro Sports Clinic Gillian A. Hotz, PhD Miami, FL 9:35 AM – 9:50 AM Break 9:50 AM - 10:30 AM Vestibular Therapy Approaches to PCS Kathryn Schneider, PhD Calgary, AB, Canada 10:30 AM – 11:10 AM Post-Concussion Educational Intervention and Karen McAvoy, Psy.D Return to School Denver, CO 11:10 AM – 11:30 AM Panel Q&A Program Description: This three-day conference will focus on the science behind concussion. The conference will follow a new programming model to include five half-day sessions, each with its own general theme, faculty presentations, and a panel discussion. Poster presentations will occur on the first two days of the conference. The five half-day topics are: concussion, concussion research (epidemiology, biomechanics, and imaging), post-concussive syndrome, research (mTBI), and chronic Sequelae. In addition, there will be lunchtime breakout sessions targeted to the following audiences: professional sports, collegiate sports, high school sports, and youth sports. Learning Objectives: Participants should be able to accurately and appropriately diagnose concussion; institute appropriate and clinically useful diagnostic tests when indicated; provide state-of-the-art management of concussed athletes and individuals; make safe and appropriate return to play, school, work, and life decisions; and educate athletes, non-health care professionals, and other health care practitioners on key issues related to concussion. Recommended Audience: Neurologists, Athletic Trainers, Primary Care Physicians, Neuropsychologists, and Sports Medicine Professionals. Accreditation The American Academy of Neurology is accredited by the Accreditation Council for Continuing Medical Education

General Information: x Attendees must be registered and badged to attend the individual programs. x CME Category 1 Credit is awarded to persons registering for and participating in the AAN Regional

Programs and submitting an evaluation form. Program evaluations are online and a link to access them will be emailed to you at the end of each day. Evaluations are due within two weeks of the program.

x An email will be sent to all attendees on how to access your CME credits earned approximately six weeks after the conference.

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(ACCME) to provide continuing medical education for physicians. AMA PRA Credit The AAN designates these educational activities for a maximum number of hours in category 1 credit toward the AMA Physician's Recognition Award. The number of credits assigned to each individual program is outlined in the program's description. Each physician should only claim those hours of credit that he/she actually spent in the activity. Certificates for Non-Physicians Non-physician participating in the programs will receive a certificate of attendance indicating attendance at an activity designated for AMA PRA category 1 credit. Education/Posters Disclaimer The primary purpose of the AAN Sports Concussion Conference is to provide educational programs and information. Information presented, as well as publications, posters, technologies, products and/or services discussed, are intended to inform attendees about the knowledge, techniques, and experiences of physicians and other professionals who are willing to share such information with colleagues. A diversity of opinions exists in the medical field, and the view of the conference’s faculty and other presenters is offered solely for educational purposes. Faculty members' and presenters’ views represent neither those of the AAN nor constitute endorsement by the AAN. The AAN disclaims any and all liability for all claims which may result from the use of information, posters, publications, products, and/or services discussed at the AAN Sports Concussion Conference. Faculty's Disclosure of Commercial Relationships Consistent with the AAN and ACCME policies, faculty must disclose any significant financial or other relationship with the manufacture(s) of any commercial product(s) or service(s) discussed in their course. This policy is intended to make participants aware of all speakers' financial or other relationship(s), so that attendees may form their own judgments about material discussed during the educational activity. Full disclosure of faculty's commercial relationships will appear in the individual program materials. All faculty must sign a letter of agreement stating explicitly that they understand and will adhere to AAN and ACCME guidelines that require full disclosure of commercial relationships, unlabeled use of products, and identification of data sources.

Faculty Commercial Relationship Disclosures x Jeffrey S. Kutcher, MD – Dr. Kutcher has received personal compensation for activities with the National

Basketball Association Concussion Program as a director, with National Hockey League Players Association and ElMindA, Ltd. As a consultant. Dr. Kutcher has received research support from ElMindA, Ltd. For a research grant.

x Christopher Giza, MD – Dr. Giza has received personal compensation for activities with the Medical Education Speakers Bureau and for medicolegal consultation with Alcobra and Pearson TLC.

x Nicole D. Reams, MD – Dr. Reams has nothing to disclose. x Gillian A. Hotz, PhD – Dr. Hotz has received royalty payments from Brooks publishing. x Kathryn Schneider, PhD – Dr. Schneider has nothing to disclose. x Karen McAvoy, Psy.D – Dr. McAvoy has nothing to disclose.

Unlabeled Use of Product Disclosure The AAN, as an ACCME accredited provider, requires all faculty members to disclose if a product is not labeled for the use being discussed or that the product is still investigational. Faculty Unlabeled Use of Product Disclosures

x Dr. Reams will not include any information on unlabeled use of products or investigational uses during the presentation.

x Dr. Hotz will not include any information on unlabeled use of products or investigational uses during the presentation.

x Dr. Schneider will not include any information on unlabeled use of products or investigational uses during the presentation.

x Dr. McAvoy will not include any information on unlabeled use of products or investigational uses during the presentation.

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POST-CONCUSSION SYNDROME IDENTIFICATION AND MANAGEMENT APPROACH

Nicole D. Reams, MD Northshore University Health System

Ann Arbor, MI

Definition: Postconcussion syndrome (PCS) generally refers to a large number of neurologic, behavioral, cognitive, and psychiatric symptoms and signs that occur following concussion and persist beyond 3 months. These symptoms cause impairment in social or occupational functioning and are considered a significant decline or alteration from previous level of functioning. ICD-10 definition includes that there are organic and psychogenic features of this disorder. PCS should be delineated from prolonged symptoms of acute concussion. It is important to delineate PCS from prolonged symptoms of acute concussion because athletes who remain injured will not be encouraged in the same way to push cognitive or physical exertion due to concern that this would worsen or exacerbate underlying injury.

x What can prolong symptoms of acute concussion? o Underrest o Overrest o Personal or family history of migraine, ADHD, mood disorder, other psychiatric disorder o Medication overuse o Untreated vestibular or cervicogenic disturbance o Re-injury (second hit prior to full recovery from initial insult)

x Clues to look for that it is PCS and not acute concussion:

o Timing (> 3 months is no longer acute concussion) o Pattern of symptoms: if symptoms are fluctuating, intermittent, unpredictable, and not following an

overall trajectory of improvement, this would make you lean towards PCS as a diagnosis How to manage a PCS patient

o Investigate for the root of the symptoms and focus on treatment (ie. is anxiety driving symptoms? are chronic migraines the reason for poor school return and sleep disturbance?)

o Consider NSAID or prednisone burst to break a headache cycle o Consider sleep aids (melatonin), migraine prophylactics (TCAs, AEDs), antidepressants or

anxiolytics (SSRIs) for short- to moderate-term management o Consider referrals for manual physical therapy, vestibular therapy, psychology o Initiate physical exertion to symptom threshold with gradual gains in duration and intensity

References: Rose SC, Fischer AN, Heyer GL. Brain Inj. How long is too long? The lack of consensus regarding the post-

concussion syndrome diagnosis.2015 Apr 14:1-6. Morgan CD, Zuckerman SL, Lee YM, King L, Beaird S, Sills AK, Solomon GS. Predictors of postconcussion

syndrome after sports-related concussion in young athletes: a matched case-control study. J Neurosurg Pediatr. 2015 Jun; 15(6):589-98.

Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Benefits of strict rest after acute concussion: a randomized controlled trial. Pediatrics. 2015 Feb; 135(2):213-23.

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Kutcher & Giza Continuum 2014

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Hovda Neurotrauma 1995

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Animal studies show the biochemical changes
resolve after days to weeks
Not month so why the symptoms?
Concussion resolved- Hard to know when
3- 4 months and exertional can differentiate
But not accurate as PCS can also
Imaging hopefully will help someday soon
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Majerske J AthlTr 2008

0: no school or physical1: school only2: school + light activity (jogging, 

mowing)3: school activity and sports        

practice4:school activity and 

participation in sports game

Majerske J AthlTr 2008Chen JNNP 2007

Has been validated against fMRI changes in the bilateral prefrontal cortex and with computerized cognitive testing

Brown Pediatrics 2014

level 0 and level 4 dont tend to do as well
when tested impact and 2 and 3 do better
the issue here is COmplete rest or restrictions
of sorts vs no restriction and no restriction
does poorly but restrictions and complete
do more or less the same
ALSO- total rest tends to show longer persistence
of symptoms vs gradual return
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Thomas Pediatrics 2015

Griesbach Phys Med & Rehab 2011

Guskiewicz KM JAMA 2003.Meehan WP 3rd Neurosurgery 2011. 

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Rose Brain Inj 2015

Alexander Neurology 1995

The survey on this data is in Journal of BraIN INJURY
Published this year and no consensus
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Jotwani Curr Sports Med Rep 2010

Dischinger J Trauma 2009Lau Clin J Sports Med 2009Meehan Neurology 2014

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Yeates Pediatric 2009 

Wood Brain Inj 2004Silverberg Neurorehab 2011Mittenberg JNNP 1992

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Woodrome J Int Neuropsy Soc 2011Peterson Anx Disorders 1987

Broshek Brain Inj 2015

Rathbone et al. Brain Behav Immun. 2015

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Korn J Clin Neurophysiol 2005Clausen J Head Trauma Rehab 2015Polak J Head Trauma Rehab 2015

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Overlap of Psych and Physio
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Johannson Brain Inj 2014Mychasiuk Front Behav Neurosci 2015Silverberg J Head Trauma Rehab 2013Leddy J Head Trauma Rehab 2013

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Rose SC Fischer AN Heyer GL Brain Inj.

Morgan CD Zuckerman SL Lee YM King L Beaird S Sills AK Solomon GSJ Neurosurg Pediatr.

Rathbone AT Tharmaradinam S Jiang S Rathbone MP Kumbhare DABrain Behav

Immun.

Brown NJ Mannix RC O'Brien MJ Gostine D Collins MW Meehan WP 3rdPediatrics.

Giza CC Kutcher JS Continuum (Minneap Minn).

Thomas DG Apps JN Hoffmann RG McCrea M HammekeTPediatrics.

Jen‐Kai Chen Karen M Johnston Alex Collie Paul McCrory Alain Ptito

Rose SC Fischer AN HeyerGL Brain Inj.

JotwaniV, Harmon KG.  Curr Sports Med Rep.

Meehan WP 3rd1, Mannix R2, MonuteauxMC2, Stein CJ2, Bachur RG2. Neurology.

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Johansson B1, Wentzel AP, Andréll P, Odenstedt J, MannheimerC, Rönnbäck L. 

Brain Inj.

Broshek DK De Marco AP Freeman JRBrain Inj.

Clausen M Pendergast DR Willer B Leddy J J Head Trauma Rehabil.

Polak P Leddy JJ Dwyer MG Willer B Zivadinov R

J Head Trauma Rehabil.

Mychasiuk R Hehar H Ma I Esser MJ

Front Behav Neurosci.Silverberg ND Hallam BJ Rose A Underwood H Whitfield K Thornton AEWhittal ML

J Head Trauma Rehabil.Rathbone AT Tharmaradinam S Jiang S Rathbone MP Kumbhare DABrain Behav Immun.