EGR1200 Freshman Mini ProjectBiomedical Signal Analysis

InstructorsMeltem Izzetoglu, PhD

Electrical & Computer Engineering

And

Andrea Welker, PhDCivil and Environmental Engineering

Fall 2018

Engineering Disciplines and Concepts

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Electrical Engineering Computer Programming

Mechanical EngineeringBiomedical Engineering

Biomedical Signal Analysis Mini Project

Objective and Structure of the Project

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Objective:

To introduce engineering students to engineering solutions from sensor design to signal analysis for the monitoring of electrical, mechanical and acoustic activities in the human body, primarily the heart in this project

Structure:• In class overview of concepts on

• Basics on anatomy and physiology• Biosensor designs• Signal acquisition and analysis

• Hands on Laboratory Experiments• Real time data collection and recording

• From your own heart • Using iWorx systems and sensors• Under different conditions, e.g resting,

exercise, breath holding• Data analysis using LabScribe and Matlab

• To extract biomarkers

Human Heart

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• Human Heart:– Responsible with Transportation of Blood (transport vehicle)– Carries oxygen, nutrients, wastes, and hormones– Movement provided by pumping of heart

• Anatomy and Functioning of the Heart:– Made up of 4 chambers and 4 valves and very strong muscles– As a result of autorhythmic electrical activity heart contracts

(systole) and relaxes (diastole) – Pressure difference generated by the heart causes the blood

to flow– Opening and closing of the heart valves causes heart sounds

• Other interesting facts:– The heart is about the same size as your fist.– The heart beats on average 70 times per minute; 4,200 beats

per hour; 100,000 beats per day; 365 million beats per year; 30 billion beats in an average life time of 80 years.

– An adult heart pumps 7,500 liters of blood daily.– It takes about 20 seconds to pump blood to every cell in your

body.– If you lined up all the blood vessels in your body end-to-end,

they would wrap around the earth twice.

Bioelectric Signals

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• Origins: Generated by electrical activity of nerve and muscle cells Source is the membrane potential

Analysis: Heart Rate Heart Rate variability Heart Rhythms

•Acquisition: Can travel to the surface Measured by

•biopotential electrodes, •electroencephalogram (ECG)

Biomechanical Signals

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• Origins: Mechanical function of the biologic system

• Motion and displacement signals, • Pressure, tension and flow signals

• Analysis: Blood pressure Blood flow velocity Cardiac output Heart Rate Oxygen saturation

Acquisition: Should be measured at the site Blood pressure sensors Pulse plethysmograph (PPG)

Pressure, flow, resistance in a blood vessel

Bioacoustic Signals

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• Origins:Many biomedical phenomena create acoustic signals:

• heart, lung, joints

• Analysis:• S1-S2-S3-S4 sound waves• Heart murmurs• Heart rate

• Acquisition: Can travel to the surface, Measured by

• Stethoscope, • Phonocardiogram• Respirosonogram

Heart Signals Altogether

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Data Acquisition and Analysis

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https://www.youtube.com/watch?v=OGp8-r5-nrsiWorx Tutorial

The iWorx Systems BIK-TA Bioinstrumentation Teaching Kit includes: • Hardware and components to measure:

• cardiovascular, • respiratory, and • neuromuscular physiology.

• LabScribe software for data collection and analysis

In this Mini Project we will use:

• iWorx Systems, ECG, PPG, blood pressure and stethoscope sensors to acquire heart signals

• Labscribe and Matlab software for data analysis

• Under various conditions, resting, exercise, breath holding, cold compress, etc.

Learned Skills:

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Technical Skills:

• Use of mathematical concepts to reach engineering solutions -Algorithm development, biomarker extraction

• Biomedical concepts, human anatomy and physiology

• Bioelectricity• Biomechanics• Bioacoustics• Sensor design• Computer programming• Data collection and analysis• Technical report writing,

presentation preparation

Non-technical Skills

• Teamwork • Time management• Leadership• People skills• Oral presentation skills

Contact for more Info or Questions:

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Instructor: Meltem Izzetoglu, PhD.

Villanova UniversityECE Dept.Tolentine: Room 424Tel: 610-5194982Email: mizzetog@villanova.edu

TA: Brianna Conte

Villanova UniversityECE Dept.Email: bconte@villanova.edu