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EFFECTS OF PREOPERATIVE IBUPROFEN, ANXIETY AND GENDER ON POST SEPARATOR PLACEMENT PAIN By CURTICE KARY MARRIS A THESIS PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE UNIVERSITY OF FLORIDA 2004

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EFFECTS OF PREOPERATIVE IBUPROFEN, ANXIETY AND GENDER ON POST

SEPARATOR PLACEMENT PAIN

By

CURTICE KARY MARRIS

A THESIS PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT

OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE

UNIVERSITY OF FLORIDA

2004

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ACKNOWLEDGMENTS

I thank my husband, Rod, for his love and support. I would not be where I am

today without his belief in me. I thank Dante and Mikey for their unconditional love over

the last seven years. I thank my son, Luke, for understanding all the extra time Mommy

had to spend on this project.

I thank the members of my committee Drs. Timothy Wheeler, Henrietta Logan,

Robert Yezierski, Roger Fillingim and Sue McGorray for their mentorship and guidance

throughout this project. I would also like to thank Marie Taylor for her help in

coordinating the development of my research.

ii

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TABLE OF CONTENTS Page ACKNOWLEDGMENTS .................................................................................................. ii

LIST OF TABLES............................................................................................................. iv

LIST OF FIGURES .............................................................................................................v

ABSTRACT....................................................................................................................... vi

CHAPTER

1 INTRODUCTION ..........................................................................................................1

2 MATERIAL AND METHODS......................................................................................6

3 RESULTS .....................................................................................................................10

4 DISCUSSION...............................................................................................................15

LIST OF REFERENCES...................................................................................................20

BIOGRAPHICAL SKETCH .............................................................................................24

iii

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LIST OF TABLES

Table page 1 Sample Size, Dosing and Dosing Times........................................................................6

2 Treatment Timeline........................................................................................................9

3 Baseline Characteristics. Mean (s.d.) for Groups A, B and C. ...................................10

4 Change in Pain between Day 1 and 2 for Masticatory Performance Index .................14

iv

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LIST OF FIGURES

Figure page 1 Example of Visual Analog Scale used in pain diary, test of evoked pain and

anticipation of pain.....................................................................................................7

2 Mean VAS scores and standard error for chewing ......................................................11

3 Mean VAS scores and standard error for biting ..........................................................12

4 Mean VAS scores and standard error for fitting back teeth together. .........................13

5 Mean VAS scores and standard error for fitting front teeth together. .........................13

v

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Abstract of Thesis Presented to the Graduate School

of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science

EFFECTS OF PREOPERATIVE IBUPROFEN, ANXIETY AND GENDER ON POST

SEPARATOR PLACEMENT PAIN

By

Curtice Kary Marris

May 2004

Chair: Timothy Wheeler Major Department: Orthodontics

A common experience during orthodontic treatment is that of pain. A significant

number of patients experience moderate to severe pain as a result of initial orthodontic

treatment. The purpose of this study was to assess the effectiveness of adding

preoperative ibuprofen to an ibuprofen regimen administered after separator placement in

reducing the incidence and severity of post-separator placement pain and to assess the

contribution of psychological factors and gender to the pain experience. Subjects were

selected from patients presenting for orthodontic treatment at the University of Florida

orthodontic clinics. This is an ongoing study with a current n=21 (10 female, 11 male).

Each subject was randomly assigned to one of three experimental groups: Group 1:

received 400mg ibuprofen 1 hour prior to separator placement (D1), 3 hours after

separator placement (D2) and 7 hours after separator placement (D3); Group 2: received

placebo at D1, 400mg ibuprofen at D2 and D3; Group 3: control group received placebo

at D1, D2 and D3. The investigator was blinded to the groups. Prior to separator

vi

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placement, subjects completed a State and Trait Anxiety Inventory (STAI), Positive and

Negative Affect Scale (PANAS), a Masticatory Performance Index and a Visual Analog

Scale (VAS) for expected pain and pain experienced with the Masticatory Performance

Index. A pain diary was kept for 24 hours. A follow up Masticatory Performance Index

was performed at 24 hours.

Significantly less pain was experienced at 6 hours and at bedtime when ibuprofen

was administered both before and after separator placement. Pain with Masticatory

Performance Index showed a significant increase on day 2. Lack of significant

differences with regard to gender and psychological factors could be due to small sample

size.

vii

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CHAPTER 1 INTRODUCTION

A common experience during orthodontic treatment is that of pain. A significant

number of patients experience moderate to severe pain as a result of initial orthodontic

treatment. 1-4 Although great inter-individual variation exists in orthodontic pain, 3 most

patients will experience the greatest amount of pain within the first three days following

initiation of orthodontic treatment. 2, 3 A study by Wilson et al.5 found that following the

placement of separators or arch wire, pain is present within 4 hours and continues until at

least 24 hours 1, 5 dissipating by day 7. 1, 5, 6

Pain is one of the leading reasons for the desire to discontinue orthodontic

treatment.7 Studies considering the factors associated with compliance have found pain

to be negatively correlated to compliance.6, 8, 9 Egolf et al. 8 asked an open-ended

question as to the reason noncompliant patients did not wear their headgear or rubber

bands. Pain was the most frequent reason cited for lack of compliance. The long-term

effects of poorly managed pain in childhood and adolescence produce anxiety in

subsequent pain situations, which in turn will amplify pain.10 For these reasons, control

of orthodontic pain should be a primary concern for the clinician and the patient.

Pain is a multi-dimensional sensation with contributions from cultural

background, past experience and psychological factors.1, 3, 11-13 A large inter individual

variation in reaction to noxious stimuli has been noted. 1-3

In a study by Firestone et al.,14 assessments were made of expectation of pain and

related side effects prior to orthodontic treatment and were compared to the perception of

1

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pain during treatment. Standardized psychometric measures for pain and anxiety were

not used and, therefore, difficulties may exist in comparing data across studies.

However, the visual analog scale (VAS) was used which is valid and reliable, 1, 15 as well

as simple enough for children to respond to without adult help.16 Results of this study

find the expectation of pain is significantly correlated to perceived pain during treatment.

Commonly, women are thought to experience pain at a greater intensity, more

frequently and for a longer period of time than men.17, 18 However, some recent studies

on orthodontic pain have not seen this gender difference in pain.1-3, 6, 19 Anxiety has been

found to be a major factor in incidence and intensity of post-operative pain.14 The

expectation of greater amounts of pain is associated with greater amounts of reported

pain.14 An investigation into the reasons patients may avoid orthodontic treatment found

that in patients less than 18 years old, anxiety increases with age and is reported more

often by girls than boys.20 In support of this finding, Brown and Moerenhout report

adolescents to have lower scores of psychological well being and that they correlate with

higher levels of pain.13 Sergl et al. 6 have suggested that patients with an internal locus of

control, where the patient attributes treatment outcome to personal efforts, have a lower

pain perception.

Application of noxious stimuli initiates conduction of sensation through primary

afferent sensory neurons ultimately resulting in an increased sensitivity of nociceptors at

the site of application. This is called peripheral sensitization. The decreased threshold of

nociceptors leads to an increase of neuronal activity into the central nervous system

(CNS). This causes changes in the CNS that contribute to persistent pain. This is called

central sensitization. Both peripheral sensitization and central sensitization lead to

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hyperalgesia. Hyperalgesia is an increased response to a stimulus that is normally

noxious.11, 17 Preemptive analgesia is an attempt to block central and peripheral

sensitization, thereby decreasing postoperative hyperalgesia.12

Studies into the effects of prostaglandin application on tooth movement 21, 22 have

found prostaglandins to enhance tooth movement in a nearly 2 to 1 ratio. Studies

assessing the effect of NSAIDs on tooth movement 23-25 have found that these drugs

cause a decrease in tooth movement due to their action in blocking prostaglandin

production. On the basis of these findings, it has been suggested that to avoid a decrease

in tooth movement, and subsequently an increase in treatment time, NSAID medications

should be avoided when controlling pain due to orthodontic treatment.23, 24 However,

prostaglandins are not the only mediators of bone resorption. Leukotrienes, cytokines

and growth factors may contribute to bone resorption.26 Saito et al.26 found that

indomethacin slowed tooth movement but did not stop it. Studies suggest that ibuprofen

has both a direct initial analgesic effect and an indirect delayed analgesic effect via

prostaglandin inhibition.27, 28 Tyrovola and Spyropoulos25 suggest only avoiding the

long-term administration of NSAID drugs. Short-term use of NSAIDs will only

temporarily reduce the levels of prostaglandins.29

A limited number of studies have focused on the control of pain in orthodontics.

In 1984, White 30 found that 63% of patients that chewed aspergum after an arch wire

change reported a decrease in discomfort. However, a placebo gum was not used and

therefore the effects of chewing gum alone cannot be separated from the effects of

chewing aspergum.

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Ngan et al.,29 in a study comparing a pre-separator placement dose of ibuprofen

with aspirin and placebo, found ibuprofen and aspirin to provide significantly less pain

than placebo. Ibuprofen provided significantly less pain at 24 hours than aspirin. This

study concluded that ibuprofen is the analgesic of choice to control orthodontic pain.

Law et al.31 evaluated the effect of the administration of ibuprofen before

separator placement or after separator placement on reported pain over 7 days. At 2

hours, those subjects who took preoperative ibuprofen reported less pain than placebo or

postoperative ibuprofen groups. A small sample size may be a reason why no other

significant differences were detected. A relatively high number of placebo group

subjects sought rescue medication.

Bernhardt et al.32 compared the effectiveness of preoperative ibuprofen

administration to postoperative ibuprofen administration and a combination of pre and

postoperative therapies. At 2 hours, both groups that received preoperative ibuprofen

were found to have a significant decrease in pain severity. No significant differences

were found between the pretreatment group and the combined therapy group. Again,

small sample size may have contributed to the lack of significant findings.

Due to the effects of poorly managed pain and the importance of compliance to

orthodontic treatment, determining a method to block or lessen pain in orthodontic

patients is a worthwhile endeavor. Current standard of care in orthodontics is to decrease

pain once it has occurred by means of an over the counter analgesic. Recent

studies 27, 29, 30 have indicated that administering analgesic prior to provoking pain with

separator placement could be beneficial in decreasing orthodontic pain. However, due to

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a lack of significant findings possibly due to small sample size, further investigation is

warranted.

The purpose of this study is to assess the effectiveness of adding preoperative

ibuprofen to an ibuprofen regimen administered after separator placement in reducing the

incidence and severity of post-separator placement pain and to assess the contribution of

psychological factors and gender to the pain experience. Specifically, the purposes are 1)

to evaluate the effectiveness of anti-inflammatory medication (ibuprofen) administered

prior to and after placement of spacers on evoked orthodontic pain, 2) to evaluate the

effectiveness of anti-inflammatory medication (ibuprofen) administered after placement

of spacers on evoked orthodontic pain, 3) to evaluate the effectiveness of placebo

administration prior to and after placement of spacers on evoked orthodontic pain, 4) to

examine associations between psychological factors and pain experienced after

placement of spacers, 5) to examine sex differences in pain induced by placement of

spacers and in ibuprofen analgesia.

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CHAPTER 2 MATERIAL AND METHODS

This was a double blind, parallel arm, prospective clinical trial. Criteria for

inclusion in this study were: 1) at least 13 years of age and no older than 30 years, 2) not

pregnant, 3) starting orthodontic treatment for the first time, 4) require the placement of

at least one separator in each of four quadrants as part of his/her orthodontic treatment, 5)

no contraindications or adverse reactions to ibuprofen, 6) no contraindications or adverse

reactions to nuts, and 7) give written informed consent for participation in the study.

The 21 subjects meeting the above inclusion criteria were selected from patients

presenting for orthodontic treatment at the University of Florida orthodontic clinics.

Each subject was randomly assigned to one of three groups stratifying for gender (Table

1).

Table 1. Sample Size, Dosing and Dosing Timesa

Groups n D1 D2 D3 A 7 400mg ibuprofen 400mg ibuprofen 400mg ibuprofen B 7 Placebo 400mg ibuprofen 400mg ibuprofen C 7 Placebo Placebo Placebo aD1, one hour prior to separator placement; D2, three hours after separator placement; D3, seven hours after separator placement

We randomized in blocks of 10, with 3 assigned to Group A, 3 assigned to Group

B, and 4 assigned to Group C. The first group of 7 subjects (5 female, 2 male) received

400mg ibuprofen at D1 (1 hour prior to separator placement) D2 (3 hours after separator

placement) and D3 (7 hours after separator placement), the second group of 7 subjects (3

female, 4 male) received placebo at D1, 400mg ibuprofen at D2 and D3 and the third

6

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group of 7 subjects (2 female, 5 male) were the control group and received a placebo at

all three dosing times.

Ibuprofen tablets of 200mg were re-encapsulated and placebos were made to

match. At each dosing time 400mg or two tablets were administered. In order to blind

the investigator to the groups, the investigational drug pharmacy at Shands Hospital

dispensed the tablets.

All subjects completed the following instruments immediately prior to time D1

(time of first dosing):

1. Expectation of pain: subjects were asked to rate their expectation of pain consequent to separator placement using a 100mm Visual Analog Scale (VAS) (figure 2). Anchors of “no pain at all” (0mm) and “worst pain imaginable” (100mm) were used .33

2. Pre-existing affective state was assessed using the State and Trait Anxiety Inventory (STAI) 34 and the Positive and Negative Affect Scale (PANAS).35

3. Mastication Performance Index:36 the subjects were asked to chew a bagged almond five times on the right side of the mouth without swallowing. This was repeated on the left side of the mouth. The protocol has been modified from Al-Ali, Heath and Wright, 1999.36 Subjects were asked to rate pain as a consequence of chewing the almond on a VAS for both right and left sides.

4. If patient is female and is of childbearing potential (i.e., post-menarche), a pregnancy test will also be administered at this time.

Please make a check ( ) on each of the lines below so as to show how much pain you are having in the following areas.

Example

no pain at all worst pain imaginable Figure 1. Example of Visual Analog Scale used in pain diary, test of evoked pain and

anticipation of pain

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Separators were placed (T0) one hour after the first dosing and administration of the

above tests. Ormco posterior separators were used unless the clinical situation warranted

the use of metal separators. At least one separator was placed in each quadrant. The

methods of placement, either over or under contact, and type of separator, were recorded

for each subject. Pain on placement of separator was recorded on a VAS.

Over 24 hours, subjects recorded discomfort when biting, chewing, fitting front

teeth together and fitting back teeth together in a VAS pain diary, similar to that used in

other studies.1, 29, 31, 32 Subjects recorded in the pain diary at: T1 (2 hours post separator

placement), T2 (6 hours post separator placement), T3 (at bedtime), T4 (upon awakening)

and T5 (24 hours post separator placement). At 24 hours (T5), the subject self-

administered the Masticatory Performance Index with VAS (Table 2). The completed

pain diary and the chewed bagged almonds were returned by mail.

The Visual Analog Scale (VAS) was used in this study to assess expectation of

pain, pain on placement, and evoked pain (via pain diary and known force test). The

VAS has been shown to be reliable and valid.1, 15, 16, 29, 33, 37

The State and Trait Anxiety inventory (STAI) was used to assess situational anxiety

(state anxiety), and anxiety as part of personality (trait anxiety).34 The STAI has been

used to assess dental anxiety reliably.38-40

The Positive and Negative Affect Scale (PANAS) provides a brief, easy to administer

measure of mood state, characterized along the separate dimensions of positive and

negative affect. The PANAS has demonstrated reliability and discriminant validity.35 It

is widely used in clinical and experimental pain research.

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Table 2. Treatment Timelineb

bT0, prior to dosing; Tx, separator placement; T1, 2 hours after separator placement; T2, 6 hours after separator placement; T3, bedtime; T4, awakening, T5, 24 hours after separator placement; D1, time of first dosing; D2, time of second dosing; D3, time of third dosing

To D1 Tx T1 D2 T2 D3 T3 T4 T5 Group A: 400mg Ibuprofen

Group A: 400mg Ibuprofen

Group A: 400mg Ibuprofen

Group B: Placebo

Group B: 400mg Ibuprofen

Group B: 400mg Ibuprofen

Consent Randomize Expected pain rating STAI, PANAS Masticatory Performance Index and Experienced Pain Rating

Group C: Placebo

Experienced Pain Rating

Pain

Dia

ry

Group C: Placebo Pa

in D

iary

Group C: Placebo Pa

in D

iary

Pain

Dia

ry

Masticatory Performance Index and Experienced Pain Rating

-1.25 hr -1hr Separator +2hr +3hr +6hr +7hr Bed Wake 24hr

The Masticatory Performance Index was described in the literature by Manly and

Braley in 1950.41 Modifications to the method have been made throughout the years.36, 42,

43, 44 The protocol used in this study has been modified from Al-Ali, Heath and Wright

(1999),36 using microwaved and bagged almonds to reduce oil and saliva. This makes a

dry sieving process possible increasing the efficiency of the analysis.

One investigator did all data collection and separator placement. A Fisher Exact

test was performed for differences in sex. Analysis of Variance tests were performed for

differences between groups for STAI, PANAS, chewing performance index and VAS

scales for chewing performance index, expected pain, pain on separator placement, and

pain diary time points. Exact Wilcoxon Rank Sum Tests were performed to identify

which groups differed if p<.05. Wilcoxon Rank Sum tests were also used to assess

change between expectation of pain and pain on placement, as well as, differences

between day 1 and day 2 for chewing efficiency index and VAS scores for chewing

efficiency index.

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CHAPTER 3 RESULTS

Baseline data showed no difference between groups with regard to gender, STAI,

PANAS, expected pain and pain on separator placement (Table 3).

Table 3. Baseline Characteristics. Mean (s.d.) for Groups A, B and C.c

Group A Group B Group C p-value gender(% Female) 71.4 42.9 28.6 .42 age 15.7 (3.2) 14.9 (2.4) 16.0 (3.7) .78 sanx 37.7 (7.0) 34.7 (8.8) 31.3 (7.8) .34 tanx 37.3 (5.3) 33.6 (7.0) 34.0 (8.9) .58 panasp 32.3 (5.7) 33.3 (6.9) 33.0 (9.0) .97 panasn 15.1 (5.9) 16.6 (3.0) 14.1 (3.7) .59 vasexp 5.1 (1.8) 5.3 (1.8) 4.6 (1.5) .77 vasplace 3.2 (2.9) 4.9 (3.4) 4.4 (2.2) .53 csanx, state anxiety; tanx, trait anxiety; panasp, positive affect; panasn, negative affect; vasexp, expectation of pain; vasplace, pain on placement

Three time points for the 24-hour pain diary showed significant differences

(Figures 2-5). At 2 hours, fitting front teeth together and fitting back teeth together were

significantly different between groups (p<.05). Group A (ibuprofen at all 3 dosing times)

was significantly different (p<.05) from both group B (ibuprofen after separator

placement only) and group C (placebo) for fitting front teeth together. For fitting back

teeth together, group A was significantly different (p<.05) from group B but not group C.

At 6 hours, chewing on the left side, biting on the left side and fitting front teeth

together were significantly different (p<.05). Group A was significantly different (p<.05)

from both group B and group C for biting on the left side. For chewing on the left side

and fitting front teeth together, group A was significantly different (p<.05) from group B

but not group C.

10

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A) Chewing Right

0

2

4

6

8

10

12

2hrs 6hrs bedtime awakening 24 hrs

Time

Mea

n V

AS S

core

Group AGroup BGroup C

*

A) Chewing Left

0

2

4

6

8

10

12

2hrs

Mea

n V

AS S

core

Figure 2. Mean VAS scsides of the m

*

6hrs bedtime awakening 24 hrs

Time

Group AGroup BGroup C*

ores and standard error for chewing on the a) right and b) left outh. *p<.05

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A) Biting Right

0

2

4

6

8

10

12

2hrs 6hrs bedtime awakening 24 hrs

Time

Mea

n V

AS S

core

Group AGroup BGroup C

B) Biting Left

0

2

4

6

8

10

12

2hrs 6hrs bedtime awakening 24 hrs

Time

Mea

n V

AS S

core

Group AGroup BGroup C* *

*

Figure 3. Mean VAS scores and standard error for biting on the a) right and b) left sides of the mouth. *p<.05

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Fitting Back Teeth

0

2

4

6

8

10

12

2hrs 6hrs bedtime awakening 24 hrs

Time

Mea

n V

AS S

core

Group AGroup BGroup C

*

Figure 4. Mean VAS scores and standard error for fitting back teeth together.

Fitting Front Teeth

0

2

4

6

8

10

12

2hrs 6hrs bed

Tim

Mea

n V

AS S

core

Group A*

Figure 5. Mean VAS scores and standard e

*

Group BGroup C

*

time awakening 24 hrs

e

rror for fitting front teeth together.

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At bedtime, chewing on the right and left side, biting on the right and left side and

fitting front teeth together were significantly different (p<.05). Group A was

significantly different (p<.05) from both group B and group C for chewing on the left

side and biting on the left side. For biting on the right side and chewing on the right side,

group A was significantly different (p<.05) from group B but not group C. For fitting

front teeth together, group B was significantly different (p<.05) from group A and C.

Comparing gender for baseline variables, no significant differences were found.

However, a trend exists (p=.06) toward more pain on placement with males.

Masticatory Performance Index and VAS for Masticatory Performance Index

showed no differences between groups for both day 1 and day 2. Change in pain rating

between day 1 and day 2 for Masticatory Performance Index was significantly different

(p<.0001) despite no differences between groups (Table 4). Gender was compared for

difference in change in pain rating for Masticatory Performance Index but was not

significant.

Table 4. Change in Pain between Day 1 and 2 for Masticatory Performance Index Mean s.d. Median p-values Right -6.92 2.59 -7.30 <.0001 Left -6.94 2.81 -7.80 <.0001

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CHAPTER 4 DISCUSSION

This study was undertaken with the aim of assessing the effectiveness of adding

preoperative ibuprofen to an ibuprofen regimen administered after separator placement in

reducing the incidence and severity of post-separator placement pain and assessing the

contribution of psychological factors and gender to pain. The principle findings of this

study indicate that if ibuprofen is administered both before and after separator placement,

less pain is experienced at 2 hours after separator placement when fitting front teeth

together, 6 hours after separator placement when biting, and at bedtime when biting and

chewing. Also, a significant increase in pain exists from day 1 to day 2 when performing

the chewing efficiency index with no differences seen between the different dosing

regimens. No contributions to pain could be determined for psychological factors and

gender.

Ngan, et al.1 assessed pain after separator placement without analgesic at 4 hours,

24 hours and 7 days. Increases in pain were found for 4 hours and 24 hours. Our study

found no significant difference between groups for pain at 24 hours. However,

differences in pain between groups at 6 hours in our study are somewhat consistent with

the increase in pain found in the Ngan et al. study at 4 hours. Also, consistent with our

study, the Ngan et al. study found no differences between genders.

Law et al.31 assessed pain after separator placement using ibuprofen as an

analgesic. Subjects were assigned to 1 of 3 groups: 1) ibuprofen before separator

placement, 2) ibuprofen after separator placement and 3) placebo. Pain was assessed at 2

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hours, 6 hours, 24 hours, as well as at 2 days, 3 days and 7 days. Significantly less pain

was observed at 2 hours. Our study found a difference between groups at 2 hours after

separator placement only when fitting front teeth together.

Bernhardt et al.32 also assessed pain after separator placement using ibuprofen as

an analgesic. The three experimental groups were slightly different from our study: 1)

ibuprofen before separator placement, 2) ibuprofen after separator placement and 3)

ibuprofen both before and after separator placement. Pain was assessed at 2 hours, 6

hours, at bedtime, upon awakening, at 2 days, 3 days and 7 days. Differences were found

for the time points 2 hours and bedtime. Our study similarly found differences at 2 hours

and at bedtime. Lack of additional significant findings for Bernhardt et al.32 could be

contributed to by small sample size, high incidence of subjects turning to rescue

medication and uneven distribution of gender among groups.

Although previous studies of this type31, 32 had a high incidence of subjects

resorting to rescue medication, this study had no medication requests. This is perhaps

due to the protocol followed in instructing the subjects and parents about rescue

medications. Subjects and parents, if the subject was under 18 years old, were told to call

anytime day or night if the subject was experiencing enough pain to need medication. At

this time, the investigator would instruct the subject or parent on what medication could

be taken and the dosage.

Geographic sampling bias may exist in this study. Subjects were chosen from

patients presenting to the University of Florida graduate and faculty clinics. Patients

presenting themselves to a teaching facility may have a scientific curiosity, which may

not represent the true population of all orthodontic patients.

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A socioeconomic bias may also exist. Subjects participating in this study were

offered a reduction in their orthodontic fee of $200. Socioeconomic need may have been

a significant motivator in consent to participate.

Differences may exist between those who will sign an informed consent and those

who will not. A person’s refusal to participate in this study may be a reflection of the

desire to avoid pain, an expectation of pain or the anticipated reaction to pain.

Previous pain experience may influence the pain response. We controlled this

extraneous factor by not accepting individuals who have prior experience with

orthodontic treatment. Bergius et al.45 assessed pain after separator placement by

telephone interview over 7 days. Previous pain experience was found related to VAS

assessments made on days 3 through 7.

The most important limitation of the current study is small sample size. The lack

of differences found for gender, psychological factors, expected pain and pain on

separator placement might be due to small sample size. With regard to gender, percent

female is 71% in group A, 43% in group B and 29% in group C. While this is not

particularly well distributed, not enough power exists to say that it is statistically

significant.

For five data points, fitting back teeth together at 2 hours after separator placement,

chewing on the left side and fitting front teeth together at 6 hours after separator

placement and chewing on the biting on the right side at bedtime, experimental groups A

and B differ but neither differs from the placebo group. For one data point, fitting front

teeth together at bedtime, group B experienced more pain than group A or the placebo

group. Again, small sample size could contribute to these unlikely occurrences. Other

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possible contributions could be from the method of placement of the separator, whether

over or under the contact, and need for use of metal separator. Both the use of a metal

separator and the placement of an elastic separator under the contact could generate more

pain than an over the contact placement of an elastic separator.

Despite no differences between groups with regard to chewing efficiency and pain

with Masticatory Performance Index, a significant increase in pain exists from day 1 to

day 2. The lack of differences between groups could be because no ibuprofen was in the

bloodstream at the time of the assessments. The last dose of ibuprofen was taken 7 hours

after separator placement and the second Masticatory Performance Index is taken at 24

hours.

Modifications made to methods used in previous studies are among the strengths of

this study. Ibuprofen administered before and after separator placement was compared to

both ibuprofen administered after separator placement and placebo. This essentially is

adding a preoperative dose of ibuprofen to the current standard of care, administration of

ibuprofen after the noxious insult, and comparing both to placebo. Previous studies

collected data over time points covering 7 days. Since significant differences were only

seen over the short term in these studies, the protocol was modified to cover several time

points within 24 hours. The Masticatory Performance Index was added as a measure of

function relating pain to the ability to chew food. In addition, this study added

psychometric measures as experimental factors.

The current study is ongoing and, therefore, the sample size will increase. At the

current sample size of 21 with 7 per group, no definitive conclusions can be made, only

observations. The first observation is that the use of pre-emptive analgesia is effective in

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reducing pain at 6 hours after separator placement and at bedtime. The second

observation is that despite the use of analgesics a significant increase in pain exists when

chewing on day 2 compared to day 1.

Several directions for future research in this area are apparent. Differences in

chewing efficiency at 24 hours may be seen if the ibuprofen regimen is continued through

24 hours. If a higher dosage of ibuprofen is used, greater differences may be seen

between groups. Medications besides ibuprofen, such as COX-2 inhibitors or

acetaminophen, may be more effective with fewer side effects. While most patients

would not discontinue orthodontic treatment due to pain caused by separators, pain does

influence compliance 6-9 which is crucial to many aspects of orthodontic treatment.

Therefore, continued research into orthodontic pain will hopefully yield a method to

decrease pain, thereby, increasing compliance producing more favorable orthodontic

outcomes.

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BIOGRAPHICAL SKETCH

Curtice Kary Marris was born in Rochester, New York, in 1967. She graduated

cum laude from University of Central Florida in 1997 with a B.S. in microbiology and

molecular biology. Kary attended the University of Florida for her dental education and

graduated with honors in 2001 obtaining a Doctor of Dental Medicine degree. She is a

Hinman Scholar and a member of Omicron Kappa Upsilon. Kary continued her dental

education at the University of Florida to complete a degree of Master of Science with a

certificate in orthodontics. She plans to complete her residency in May of 2004 and then

enter private practice in Orlando, Florida.

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