effectiveness of topical mangosteen pericarp extract...

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Page 1: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et
Page 3: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et
Page 4: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et

90.87

64.59

42.48

20.56

p<0.001120

100

80

60

40

20

0

95%

C

Page 5: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et

Alteration of proteins (structural and enzmizatic)

UVB & UVA radiation

Page 6: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et

VEGF-A TSP-1Keratinocytes

Skin damage

Ang1 Tie2

Blood vessel

Pericyte

Endothelial cells

Immune cells

Pericyte detachment

Angiogenesis

Vascular dilation

Vascular leakage Inflammation-induced

Matrix degradation

UVB irradiation

Page 7: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et
Page 8: Effectiveness of Topical Mangosteen Pericarp Extract ...docsdrive.com/pdfs/ansinet/pjn/2016/745-751.pdf · substances as well as the formation of granulation tissue (Yuhernita et