Study the effect of duration of Diabetes and Glycemic Controle on Pulmonary Function Tests

Abstract:

Introduction: As the prevalence of diabetes is inceasing in India and diabetic complications are known to

occur,various target organs like kidneys,eyes,cardiovascular system as well as nervous system are

involved leading to extensive morbidity and mortality. Involement of lungs in diabetics is sparingly

reported in the literature hence this study is being taken with the aim to see the effect of glycemic control

and duration of diabetes on pulmonary function test(PFT). These restrictive pattern of pulmonary function

test abnormality could be due to non-enzymatic glycosylation of collagen in lung tissue and

microangiopathy of pulmonary vasculature.

Material and Methods: The study has been carried out on 120 patients in the postgraduate Department

of Medicine, S.N. Medical College and Hospital, Agra. All previously diagnosed diabetic patients with

fluctuating blood sugar levels, not strictly controlled were taken in to this study.Patients who were non

diabetics,smokers and having underlying pulmonary diseases excluded from the study.These patients

has been subjected for detail clinical examination and for Pulmonary function test.

Results:

In this study 120 patients were involved out of which 61 males and 59 were females.These patients were

further devided into group A,B and C on the basis of duration of diabetes .Group C patient were having

significant fall in forced vital capacity(FVC) and forced expiratory volume in 1 st minute (FEV1) and

significant increase in FEV1/FVC ratio ,suggesting restrictive pattern.

Conclusion:

1) In diabetics the commonest pulmonary function test abnormality is restrictive type.

2) The restrictive type pattern abnormalities worsened with increasing duration of diabetes.

3) Worsening of glycemic control in the study group is associated with worsened restrictive pattern.

4) Correlation of the duration of diabetes and also uncontrolled diabetes has also revealed restrictive

pattern of PFT.