efector functions of cd4 + and cd8 + t-cells
DESCRIPTION
Efector functions of CD4 + and CD8 + T-cells. Th1. Naivna CD4 + T. Naiv e CD4 + T. Th17. Th2. Defense- intracellular pathogens, stimulation of IgG production. Or gan-specific autoim m une diseases. Defense- helmints. Allergy. Defense- e x tracel l ular bacteria, fungi. - PowerPoint PPT PresentationTRANSCRIPT
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Efector functions of CD4+ and CD8+ T-cells
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Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
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Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
IL-4
IL-12
IL-23
T-bet
GATA-3
RORt
IL-4IL-5IL-13
Macrofage activation
B-cells
EosinophilactivationB-cells…
Neutrophil activation...
IL-17IL-22
IFN-γ
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TH1respons
e
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• Macrophage activation at the site of infection
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Efector functions of TH1 cells• B-cell activation
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Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
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TH2response
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Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
![Page 18: Efector functions of CD4 + and CD8 + T-cells](https://reader035.vdocuments.site/reader035/viewer/2022062217/56814b43550346895db845c5/html5/thumbnails/18.jpg)
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TH17response
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Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
![Page 21: Efector functions of CD4 + and CD8 + T-cells](https://reader035.vdocuments.site/reader035/viewer/2022062217/56814b43550346895db845c5/html5/thumbnails/21.jpg)
CTL effector function
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Mechanisms ofCD8+ T-cellcytotoxicity
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Mechanisms ofCD8+ T-cellcytotoxicity
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Mechanisms ofCD8+ T-cellcytotoxicity
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Mechanisms ofCD8+ T-cellcytotoxicity
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CD8+ CTLTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
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CD8+ CTL
perforinTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
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granzimi
apoptosis
CD8+ CTL
perforinTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
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FasL
CD8+ CTLTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
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Ciljna ćelija
FasL Fas apoptosis
CD8+ CTL
Mechanisms ofCD8+ T-cellcytotoxicity
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Pathogens avoid cellular immunity
Inhibition of fusion of phagosome with lysosome
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Inhibition of presentation
of viral antigens
0
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Inhibition of immune response by virokines and viroreceptors
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killing virus-infected and tumor cellsj.CTL killing mechanisms are10.
perforin, granzymes, Fas-FasL interaction
i.CTL effector function is9.
intracellular pathogensh.IL-178.
IFN-γ production and macrophage activation g.
IL-4 and IL-13 induce also7.
mobilises and activates neutrophilsf.TH2 subpopulation induces6.
alternative macrophage activatione.TH2 cells are important for defense against
5.
TH1, TH2 i TH17d.TH2 effector function is4.
helminatsc.TH1 cells are important for defense against
3.
Inflammatory reaction rich in eosinophilsb.TH1 effector function is2.
production of IL-4, IL-5, IL-13a.Subpopulations of efektor CD4+ T-cells are
1.
1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____d. g. h. a. c. b. e. f. j. i.