eecp: the natural bypass (enhanced external counterpulsation) · •vegf- increases 21% with 1 hour...

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EECP: The Natural Bypass (Enhanced External Counterpulsation)

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Page 1: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

EECP: The Natural Bypass (Enhanced External Counterpulsation)

Page 2: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”
Page 3: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Objectives

o Identify patient populations who should & should not have EECP.

o Summarize mechanism by which EECP tx is provided.

o Cite changes that occur to blood flow and blood vessels as a result of EECP tx.

o List EECP’s wide ranging benefits.

Page 4: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

What is EECP?

• Treatment clinically proven to improve blood circulation and strengthen the CV system

• BP cuffs

• Promotes development of new blood vessels

• Reduction of s/s

Page 5: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Origin of EECP

o hydraulic device, water

o 1970’s

• Studies

• Focus on high tech, invasive approaches

o Renewed interest early ‘90’s

• FDA approved 1995

• Medicare 1999

Page 6: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Early external

counterpulsation

devices had

hydraulic pulsator

chambers.

Page 7: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Why Do We Need EECP?

o 10 million patients chronic angina

o 1/4-1/3 refractory angina

Page 8: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Who Should Have EECP?

o Coronary artery disease and angina

• CCS III and IV

Page 9: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Who Should Not Have EECP?

o Severe aortic insufficiency

o AAA >5 cm

o Hemophilia

o Uncontrolled hypertension >180/110 mmHg

o Pregnant, fever, open wound, current blood clot

Page 11: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Qualities of EECP Therapist

o Clinical assessment

o Wrap cuffs tightly

o Full Pressure (280 mmHg)

o Timing

o Coach

Page 12: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Safe

o NO risk of stroke, infection, cognitive impairment, bleeding.

Page 13: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

No Recovery Time

o No convalescence- before work, lunch break.

Page 14: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Noninvasive

o No drugs, needles, IV, tubes, knives.

Page 15: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Painless

o Sleep, t.v. , music, chat

o “Bouncing appearance”

Page 16: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Saves $$

o Up front cost: $6000 full course EECP-

1/3 cost PCI, 1/6 cost CABG.

o Long term savings

o $215.6 billion lost annually

Page 17: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Good for the Soul

• Quality of life, emotional improvements

Page 18: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

What Does EECP Do To Blood Flow?

o Diastolic augmentation- (sequential)

• Enhances venous blood flow

• Retrograde flow coronary circulation =

myocardial perfusion

o Systolic “unloading”- (simultaneous)

• Decreases heart’s demand for blood and oxygen

• Beat with increased force

Page 19: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Principles of Operation

Systolic Deflation Simultaneously deflate all three

sets of cuffs at the end of diastole

Effect:

Systolic Unloading

Reduce Cardiac

Workload

Increase

Cardiac

Output

Lower

Thigh

Cuffs

Upper

Thigh Cuffs

Calf Cuffs

Diastolic

Augmentation

Increase

Coronary Perfusion

Increase

Cardiac Output

Sequential inflate three

sets of cuffs at the end of

systole

Diastolic Inflation

ECG

Normal

EECP

Effects:

Increase

Venous Return

Lower

Thigh Cuffs

Upper Thigh

Cuffs

Calf Cuffs

Page 20: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Blood Vessels

o Organs- alive, dynamic, growing

o Exercise blood vessels- adequate blood transport

Page 21: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

What Happens To Blood Vessels During EECP?

o Enhances vascular reactivity o Shear stress= anti-inflammatory properties o Endothelin (ET-1)- constricts, retains water & salt

• Decreases 40% during • 20% at one month post

o Nitric oxide- dilates and strengthens • Increases 60% during • 20% at one month post

o Endothelium release natural chemicals angiogenic growth factors • VEGF- increases 21% with 1 hour EECP

Page 22: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Natural Bypass

o Collaterals- “potential” blood vessels

o “wake up” or “recruite”

o Enlarge, strengthen, new lasting pathways

Page 23: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Heart Untreated Heart Treated with EECP

Page 24: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Benefits Of EECP!

o Increased: • Activity level • Blood flow • Quality of life • Energy • Cardiac output

o Decreased: • Anginal episodes 72-85% • Hospitalizations, ED visits 85% (in year following tx) • Nitroglycerin use 81% • Functional classification (CCS) by 1 class • Depression, anxiety

Page 25: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

“Off Label” Uses of EECP

o PVD o Sleep o Erectile dysfunction o Athletes o Ocular o Renal o RLS o Tinnitus o Stroke o Alzheimer’s o Parkinson’s

Page 26: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

Case Study

o 65 year old

o MI & CABG 1996

o Ischemic cardiomyopathy, EF= 25-30%

o ICD 2011

o TIA post PCI 2014

o Chronic angina

Page 27: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”
Page 28: EECP: The Natural Bypass (Enhanced External Counterpulsation) · •VEGF- increases 21% with 1 hour EECP . Natural Bypass o Collaterals- “potential” blood vessels o “wake up”

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