editorial human body fluiddownloads.hindawi.com/journals/bmri/2013/918793.pdfcost, and rapid sample...

Hindawi Publishing CorporationBioMed Research InternationalVolume 2013, Article ID 918793, 2 pageshttp://dx.doi.org/10.1155/2013/918793

EditorialHuman Body Fluid

Shih-Bin Su,1 Terence Chuen Wai Poon,2 and Visith Thongboonkerd3

1 Department of Occupational Medicine, Chi Mei Medical Center, Tainan 710, Taiwan2Department of Paediatrics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital,Shatin, New Territories, Hong Kong

3Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital,and Center for Research in Complex Systems Science, Mahidol University, Bangkok, Thailand

Correspondence should be addressed to Shih-Bin Su; [email protected]

Received 4 August 2013; Accepted 4 August 2013

Copyright © 2013 Shih-Bin Su et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Human body fluids are considered as attractive sources forclinical markers. As for disease diagnosis and prognosis,advantages of body fluid testing include low invasiveness, lowcost, and rapid sample collection and processing. Besides,altered protein expression profiles in body fluids reflect thechange of physiological states and cellular networks of thediseased tissue/organ.Thus, analysis of human body fluid hasbecome one of the most promising approaches to discoverbiomarkers or reveal pathophysiological mechanisms forhuman diseases. Human body fluid analysis is inherentlychallenging due to their unique characteristics such as proteincomplexity and the wide dynamic range of protein abun-dances. With the remarkable advances in the methods forsample preparation, proteomics technology, and quantita-tion, it is now possible to analyze body fluids with highersensitivity and robust experimental design. As the recogni-tion of the importance of “Translational Medicine” which isthe process of turning appropriate biological discoveries intodrugs and medical devices that can be used in the diagnosisand/or treatment of patients, a great quantity of researcheswere focusing on the human sample including human bodyfluids. Thus, it is conceivable that the new insight unveiledby human body fluid analysis will attract a wide audienceabroad including researchers from the field of basic sciences,bioinformatics, analytical chemistry, molecular biology, andhospital.

In the study of H. Y.Wu et al., authors performed the firstdifferential proteomic profiling between peritoneal dialysatesfrom chronic glomerulonephritis (CGN) patients at theearly and middle stage of continuous ambulatory peritoneal

dialysis (CAPD) treatment. The changed proteins provideclues to the PD-induced loss of proteins from the peritoneumand assist the identification of potential biomarkers fornoninvasive monitoring of peritoneal damage.

M. H. Yang et al. also characterized the peritonealdialysate proteins from diabetes mellitus (DM) by proteomictools. CGN peritoneal dialysate was used as control. Dif-ferentially expressed proteins in DM samples may indicatea situation for possible drug treatment and predictors ofperitonitis for a validation study in the future.

P. Badiee reviewed the evaluation of different humanbody fluids, pleural Effusion, bronchoalveolar lavage fluid,peritoneal fluid, urine, pericardial effusion, blood, cere-brospinal fluid (CSF), synovial fluid, and saliva, for diag-nosing fungal infections. Routine laboratory tests for thediagnosis of FI include urinalysis and blood analysis whileanalyses of both CSF and serum can improve the accuracyof the diagnosis.

K. Borecka et al. studied the use of Coefficient of EnergyBalance (CEB) values in a large CSF samples (𝑛 = 8183)to demonstrate that CEB enables more exact assessment ofactual energy state in the CSF compartment than glucoseand lactate alone. This study suggested that CEB combinedwith CSF cytology has a great importance for diagnosis,differential diagnosis, and early therapy of CNS diseases.

H. C. Yen et al. discussed potential interferences on theanalysis of F

2-IsoPs and F

4-NPs in CSF by GC/NICI-MS

by present analytical methods. Proper TLC purification forobtaining reliable chromatograms for F

2-IsoPs quantification

in CSF is suggested as well as the necessity of adding

2 BioMed Research International

additional holding of the column at 280∘C for a period oftime following data acquisition during F

2-IsoPs and F

4-NPs

analysis to avoid potential interferences on subsequent F4-

NPs quantification in CSF.

Acknowledgments

The guest editors of this special issue thank the reviewersand all authors for providing important contributions inthis issue. The contributions in this issue discuss novelinsights, advanced assessment as well as diagnosis. Of course,the selected topics and papers are not a comprehensiverepresentation of the area of this special issue. Nonetheless,they represent the rich knowledge that we have the pleasureof sharing with the readers.

Shih-Bin SuTerence Chuen Wai Poon

Visith Thongboonkerd

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