editing genome
TRANSCRIPT
Editing the genome and New technique boosts efficiency of
blood cell production from human stem cells
Jennifer Alejandra Correa GutierrezMedicine student
3rd semester
establish multi-viral resistance by rewriting code hijacked by viruses
could be used in stem cell therapies for a wide variety of conditions including cancers and immune ailments
Editing the genome
July 14, 2011 Esciencenews
Using a platform called multiplex automated
genome engineering, or MAGE, the team replaced
instances of the TAG codon with another stop codon, TAA, in living E. coli cells.
they found…A genome-scale editing tools as fast and easy as word processing have rewritten the genome of living cells using the genetic equivalent of search, replace and combined those rewrites in novel cell strains, strikingly different from their forebears.
The first: add functionality to a cell by encoding for useful new amino acids.
The second: introduce safeguards that prevent cross-contamination between modified organisms and the wild.
A third: establish multi-viral resistance.
Three Goals
Observation
The cell has the hability to adapt to different environments has
therefore been increasingly easier to manipulate and perform such studies which contribute to the
human sciences.
New technique boosts efficiency of blood cell production from human stem cells July 15, 2011 esciencenews
Researchers now want to find the precise mixes and sequences of chemical compounds needed to coax iPSCs to mature into the tissue-specific stem cells of their choice. The latter are self-renewing, and can be transplanted into the body to produce the 'progenitor' cells that multiply locally and produce mature tissue cells.
,
These may be more valuable medically than any other tissue-specific stem cell, because they can supply not only oxygen-carrying red blood cells but also all the white blood cells of the immune system.
the research team sought to do a better job of mimicking the changing conditions that naturally direct ESCs to become HSCs in the womb.
With their best such cocktail they were able to detect blood-specific markers on 84% of their cells after three weeks.
Observation
through different techniques for the study of cellular life has been to understand the different processes that take place in the cell and could provide great results for medicine.
Medical utility
Medical Utility
Beyond that provide a cure for cancer or other degenerative disease has broken through the barrier of the unknown, and thus contribute to a preventive medicine that is what the world needs.
Medical Utility
Now not only have a treatment, but also can have health in our hands and decide to do with it,
the intelligence of man has come so far that is capable of
controlling the same genome
Bibliography
Biology and nature, Editing the genome. URL:http://esciencenews.com/articles/2011/07/14/editing.genome (esciencenews) Biology and nature, New technique boosts efficiency of blood cell production from human stem cells. URL: http://esciencenews.com/articles/2011/07/15/new.technique.boosts.efficiency.blood.cell.production.human.stem.cells (esciencenews)
Martínez S. Lina María. Biología Molecular. 6 Ed. Medellín: Upb. Facultad de Medicina, 2011. p 7-36.