ebm and prevention

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  • 7/26/2019 EBM and Prevention

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    What is the question asking?How many without disease have a positive test?

    How many false positives are expected?

    Total without disease TN cases= # False positives

    Prevalence = number of people with diseasePeople w/o disease = 1000-(5% * 1000) = 950

    Specificity= 75%of people without disease will be TNcasesSpec(TN) cases= .75*950 = 712.5 TN cases

    FPcases = 950-712.5= 237 FP cases

    The answer is C. 237

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    Drug X is investigated in a meta-analysis for itseffect on mortality after a myocardialinfarction. It is found that mortality dropsfrom 10 to 2% when administered. What is theARR?

    A. 2%

    B. 8%

    C. 20%

    D. 80%

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    ANSWER IS B 8%

    ARR = Difference between risk in Exposed

    (Exposed Event Rate) vs risk in Control(Control Even Rate)

    ARR= CER-EER

    10%-2%=8%

    The RELATIVE RISK REDUCTION=ARR/

    CER= 8%/10%=80%

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    How many patients will have to be treated with

    drug X to prevent one death? A. 2

    B. 8

    C. 12.5

    D. 50

    E. 93

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