ebm and prevention
TRANSCRIPT
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What is the question asking?How many without disease have a positive test?
How many false positives are expected?
Total without disease TN cases= # False positives
Prevalence = number of people with diseasePeople w/o disease = 1000-(5% * 1000) = 950
Specificity= 75%of people without disease will be TNcasesSpec(TN) cases= .75*950 = 712.5 TN cases
FPcases = 950-712.5= 237 FP cases
The answer is C. 237
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Drug X is investigated in a meta-analysis for itseffect on mortality after a myocardialinfarction. It is found that mortality dropsfrom 10 to 2% when administered. What is theARR?
A. 2%
B. 8%
C. 20%
D. 80%
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ANSWER IS B 8%
ARR = Difference between risk in Exposed
(Exposed Event Rate) vs risk in Control(Control Even Rate)
ARR= CER-EER
10%-2%=8%
The RELATIVE RISK REDUCTION=ARR/
CER= 8%/10%=80%
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How many patients will have to be treated with
drug X to prevent one death? A. 2
B. 8
C. 12.5
D. 50
E. 93
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