earlygut - technical dossier

Nutritional supplement in the form of gel in case if digestive disturbance. A specialy formulated gel for use during digestive disorders. Particular nutritional purpose Stabilisation of water and electrolyte balance.

AN INNOVATIVE RANGE OF GELS FOR YOUNG PIGLETS

Our « creamy-gel » has a close consistency to what the piglet is familiar with, i.e milk. The aroma (vanilla flavour) and the taste of our gel have been selected for an optimal intake. Here are the nutritional benefits compared to an usual dry feeding :

– A better digestibility

– A better intestinal health

– A beneficial effect on digestive flora with an increase of the microvilli’s growth

AN INNOVATIVE CONSISTENCY

This non-sticky “creamy-gel” prevents wastage and is really easy to eat for the young piglets.

Besides our gel has been formulated with high moisture content and natural intake enhancers to encourage consumption and aid in transition to dry pellets after 10 days while improving intestinal health. 75% of our ingredients are solubilized which means an increased digestibility and an intestine protection.

The acidic pH of our gel is also a way to control the harmful bacterias’ development with the natural acidification action of the stomach. It has also a key role in protein digestibility related to casein emulsification and pepsine optimum pH range of action.

A PERFECT ACIDIC pH OF OUR GEL

Each ingredient has been selected to provide :

- A highly palatable mix of ingredients

- A high digestibility of nutriments

- An improved nutrition of the intestine cells

- A perfect control of the bacterial flora

AN INNOVATIVE RAW MATETIALS’ SELECTION

- EARLYGUT is high in ash because rich in mineral (balance loss from diarrhea) and clay for a protection effect

- Lower in protein

- High in sugar to stimulate Na absorption

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EARLYGUT

Intestinal cell wall protection

Transit regulation

CARBOHYDRATES

Dextrose

Organic acids Energy (fumaric, citric)

Prebiotic sugars

PROTEIN

Enzymatic treated protein

Free amino acids

Protein Nucleotides

Bacteria flora control (MCFA)

Bacteria flora control (propionic, sorbic, lactic)

Bacteria flora control (yeast cell wall)

LIPIDS

Medium chain fatty acid

MISCELANEOUS

Vitamin minerals

Immune enhancer

Aromatic component

A SOURCE OF INTESTINAL PROTECTION

Attapulgite clay

A non-expandable clay with a positive action on the protection of enterocytes, reducing inflammation of the bowels’ surface and toxin binding.


Glycocalyx : a sieve for bacteria and big size molecules

– Clays, carbon or YCW can integrate the glycocalyx

structure, reinforcing the barrier effect.

– Glycocalyx is about 200nm length in enterocytes

– Clays have also antioxydant protective effect


Tight junctions importance for body integrity

– Clays increase the thickness of adherent mucous

– Clays protect the intestine mucosal from injuries

– Clays modify the gastrointestinal glycoprotein and enhance its polymerization

– Clays reinforce the strengthness of the

tight junctions, protecting intestine for

external invasion


Clays and intestinal wall strengthness

Mucous Role

– Calciform cells Mucus production : glucoprotein polymers, lipids, protein linked with covalent bound

– Physical barrier protecting mucosa against extraneous molecules and physical injury and competing with epithelium surface for micro organism

– Maintaining pH gradient

– Chemical barrier


Clays mode of action in intestine

– Smectite, (More et al, 1987); Attapulgite (More et al, 192) increases thickness of adherent mucus

– Due to interaction with mineral particles and mucus component (Leonard et al, 1994)

– Modification and of gastrointestinal glycoprotein and enhancement of polymerization (Droy-Lefaix et al, 1986)

– Reduces mucus degradation (Bouyssou et al, 1990) by improving reohlogical properties such as spinability

– Better mucous quality (Droy-Lefaix et al, 1985) decreases mucous solubility, increases viscosity and hydrophobicity and adhesion to intestinal cells.

Betaine

A molecule that helps the intestines fight hydric instability, such as water loss during diarrhea.

Betaine is an osmolyte, which is a molecula able to accumulate in great quantities in the cells without affecting the cells function.

During hydric stress, loss of salts, osmolytes play a major role;

Osmolytes can maintain cell volume and fluid balance.



Betaine function in enterocytes : Osmoprotection Betain is a dipolar zwiterrion

Osmoprotective properties

– Maintain cell volume constant, keeps water into cell, can replace missing minerals

– Maintain enzymes activities, more anabolism, better nutriment absorption


Betaine function in enterocytes : Osmoprotection

Betain reduces energy expenditure for ion pumping

Moeckel et al. 2002

Spared energy

– Promote cell proliferation and digestive tract development

– Increase villi height


Betaine function in enterocytes : membran activity Betaine uptake is Na+ dependent co – transport Kettunen et al. 2001

Consequence

– supplemental betaine improves Na+ absorption


Betaine function in the gut Betaine can modify the fermentation profil in broiler chicks : more lactic acid and volatil fatty acids Kettunen et al. 1999

Consequence

– Improving the positive lactic flora

– Control the pathogenous flora

Sodium glutamate

The preferred source of energy for the enterocytes it promotes the quick reconstitution of the intestinal flora following stress.

Glutamate is an important precursor of bioactive molecules such as glutamine, proline, argininine, histidine and ornithine and serves as a key constitutive amino acid of glutathione the major cellular anti-oxidant in the intestinal cells.



Glutamate effects on piglet Improved effective gastric secretions

– Improved digestion (Pepsinogen – pepsin) – Improved regulated digestive – Improved appetite (Umami sensors)

Trophic effect on intestinal villi = elongation of the intestinal villi

– Enhanced nutrients absorbtion – Improved effectivity of M-cells and goblet cells – Stimulated cell proliferation – Reduction/ inhibition of apoptosis – Highly positive mitosis – to apoptosis ratio – Rapid restoration of crypts injured by

enterotoxic E-coli

A SOURCE OF TRANSIT REGULATION

Natural fiber

Purified cellulose that contributes to regulating the digestive transit, particularly in the event of digestive problems. Because it is not absorbed through the bowels, it helps preserve polymeric structures in fecal matter, inducing drier feces.

Natural Fiber consists of finest, fibrillated fibres which for a stable and solid network.

The typical capillary effects of these fibres bind free water in it´s fibre capillaries and thus makes it unavailable for microorganism – the water activity consequently reduces.



Consequence

– Control of fluid in case of diarrhea risk

– Restore quickly a ferm structure of the feces

Inulin

A FOS source, this prebiotic contributes to the development of a balanced digestive flora by stimulating bifidobacteria and inhibiting pathogens.



Inuline effects on digestive flora

– Regulate intestinal transit and fecal mass

– Acidify fecal content and increase fatty acid volatil production in colon

• Strong health effect on digestive system health and development

– Reduces the amoniac level of amoniac in the intestine • Optimal balance of digestive flora • Reduction of bacterial toxin risk

– Improves mineral assimilation (especially in the second part of the digestive tract)

– Stimulates the sanitary status of the piglet

– Improves immunity resistance

Sanguinarine

It is a natural anti-inflammatory from the alkaloid family, it has a beneficial action against pathogen bacteria.

Tannin extracted from chesnut tree

A hydrolysable polyphenol that activates the intestinal mucus layer, beneficial for intestinal cell protection and offering additional positive action by reducing the body’s oxidation.


A SOURCE OF ENERGY

CARBOHYDRATES

A SOURCE OF ENERGY / CARBOHYDRATES

Dextrose

The simplest and most important sugar, its digestion requires no enzymes. It helps balance the fundamental hormonal regulation process by regulating insulin levels.

The most simple sugar, 100% digestible without any enzyme.

Potassium sorbate An interesting source of energy with antibacterial and antifungal activity, potassium sorbate also contributes, combined with trisodium citrate, to regulating the acid-base balance.

Propionic acid A very specific monocarboxylic acid, a source of energy for animals and a strong antibacterial and antifungal component.

Citric acid, fumaric acid Two powerful acidulants that stimulate salivation and reduce pH, in order to reach a pH value allowing good preservation and optimum digestion in the animals' bowels.

A SOURCE OF ENERGY / CARBOHYDRATES

A SOURCE OF PROTEIN

1- VEGETAL PROTEIN

Soya protein concentrate

A protein derived from soybeans, very rich in essential amino acids and enzymatically processed; the product, featuring small-sized proteins, is free of allergenic effects and any standard soybean antinutritional factors, therefore offering optimum digestibility.

A SOURCE OF PROTEIN / VEGETAL PROTEIN

Glycinine :

– Globuline wich represents 40% of total protein.

– Molar weight 320 – 350 KDa

– Composed of 12 sub units (6 acid sub units (A, 40 KDa) et 6

– basic sub units (B, 20 KDa).

High size protein of soybean meal, Glycinine and beta conglycinine are responsible of allergy.

Enzymatic treatment reduce considerably the protein size and modify its structure in order to suppress the allergenic effect.

Soybean protein : responsible of allergy



Reduction of antinutrional factors of soybean by fermentation Anti-trypsique factor

– 0.3 à 2.5% of protein 8 à 20 KDa (2 main proteins) – Link irreveribly with trypsine reducing its activity, and so reduce protein

digestibility – Reinforce the allergenic power of the storage protein

Lectines – 5 à 200 ppm – 60 à 120 KDa – Fixation on intestinal membranes

• Reduction amino acid, Vitamin B12, polysaccharides absorption – Can reach blood stream when intestine is damaged

• Association with enterocytes membranes, function alteration – Growth reduction, anemia, colites, etc..


Urease – Less damaging at a nutritional point of vue because easily destroyed with

heat – Degrade urea in amonia, which is more toxic and create damage in

intestinal membrane

Enzymatic treatment reduce considerably the protein structure in order to suppress the antinutritionnal function.

A SOURCE OF PROTEIN

2- AMINO ACIDS

Lysine, Methionine, L Thréonine, Tryptophane

The main essential amino acids are : Lysine for growth and enzymatic activities; methionine for liver metabolism and muscle deposition; threonine for the immune system's development and tryptophane (a precursor of serotonin) for feed intake stimulation

A SOURCE OF PROTEIN / AMINO ACIDS

Synthetic amino acids

100% digestible to balance and supplement piglet according to its requirement

A SOURCE OF LIPIDS

A SOURCE OF LIPIDS / MCFA

Two times smaller than most standard fatty acids (18-carbon), caprylic (8-carbon) and capric (10-carbon) acids are highly digestible lipids that quickly provide high amounts of energy to piglets. These MCFA have also an anti-bacterial activity by weakening the harmful bacterias’ membrane.

– Fat is essential because the most concentrated source of energy

– Digestibility requires emulsification and then lipase action

Medium-chain fatty acids

MCFA = C8 and C10 fatty acid Caprylic and Capric fatty acid

– The lower the chain, the easier to emulsify. C8 water solubility is 75mg/100ml, vs 0.04mg for palmitic acid, a common milk fatty acid

– The lower the chain, the more affinity with the lipase

– The lipase hydrolyze preferentially the shorter chain fatty acid

MCFA are a very important source of energy for the young piglet because easily digested.


– MCFA have an antibacterial role

– MCFA incorporate in the membrane of bacteria inducing a weakness in the membrane

MCFA contributes to avoid the development of pathogen bacteria.


A SOURCE OF MINERALS

– Diarrhea induce loss of water and also mineral

• Na from gut lumen • K from cell content • Mg from cell content

– Na absorption is linked with glucose absorption • Correlation with Na and glucose on proportion


Potassium chloride

Provides potassium, an essential mineral in intestinal cells, and helps maintain the product’s mineral balance.

Magnesium oxide

A source of magnesium, an important mineral in cells, necessary to compensate the losses that occur during diarrhea.


MISCELANEOUS

A SOURCE OF VITAMINS

Vitamins A,D3,E,B group,C

Hydro-and liposoluble vitamins are essential for the piglets' metabolism (Vit. A, D3, E, B1, B2, B5, B6, B12, A. folique, Vit. K3, PP, Biotine)

Vitamin supplementation – Vitamins are essential for the optimum function of the metabolism

– EARLY WEAK is supplementated in all vitamins : • Liposoluble A, D3, E, K3 • Hydrosoluble B group

– Vitamins stimulates protein and energy metabolism

MISCELANEOUS / A SOURCE OF VITAMINS

MISCELANEOUS

A SOURCE OF IMMUNE ENHANCER

Calcium butyrate

Calcium butyrate affects the bowels' maturation, helps regulate the immune system and controls pathogen flora by regulating the production of digestive hormones (gastrin, ghrelin, etc.) and the maturation of the digestive nervous system.

It is also a milk component recognized by piglets, which stimulates their feed consumption

MISCELANEOUS / A SOURCE OF IMMUNE ENHANCER

= Nutritional additive for enterocytes

– Reinforcement of intestinal cell wall

– Development of intestinal villi

– Increase of digestive enzymatic production

= Nutritional additive for intestinal flora balance

– Stimulates development of positive bifidobacteria flora

– Inhibit pathogen flora development

– Repress pathogenic activity of pathogen bacteria


Algae extract ( DHA )

The most important omega-3 fatty acid that regulates the balance between ecosanoid hormones, prostaglandins, thromboxanes and leukotrienes

– Omega 3 is essential for young animal development

– DHA is the most important omega 3 fatty acid and the very young animals have poor ability to transform shorter chain omega 3 into DHA

– Extra supplementation of DHA improves heath, immunity development, reduce inflammation, ….


MISCELANEOUS

A SOURCE OF MOS AND BETA GLUCANS

Premium yeast cell wall

MISCELANEOUS / A SOURCE OF MOS AND BETA GLUCANS

Rich in MOS (manno-oligosaccharides) and βeta Glucans.

At low levels, this components are known to have an immune booster effect especially through the mannane mode of action.

βeta Glucans are also very important components responsible of the aggregation of pathogen bacteria on the beta glucan cell membranes.

– Pathogen bacteria used to agglomerate on mannose of the yeast cell wall, reducing by this way their pathogenicity

– Macrophages activity is boosted by the contact with yeast beta glucan, resulting in a better immune answer

MISCELANEOUS / A SOURCE OF MOS AND BETA GLUCANS

MISCELANEOUS

A SOURCE OF ORGANIC ACIDS

– Mix of acid and salt of organic acid to provide an optimum pH (<4), ideal for stimulation of lactic acid flora development, feed digestibility

– Dicarboxylic acid like fumaric acid as a regulator of acidity and 100% digestible energy source

– Monocarboxylic acid such as propionic as pathogen bacteria control and regulator of acidity

Organic acid supplementation

MISCELANEOUS / A SOURCE OF ORGANIC ACIDS

Please do not hesitate to contact us should you need any further information; our EarlyPIG team will be happy to assist you.

[email protected]

THANK YOU

earlygut - technical dossier

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