dyslipidemia case study
DESCRIPTION
Dyslipidemia case studyTRANSCRIPT
Male patient aged 35 Male patient aged 35 ysys
C/o of skin lesions over the C/o of skin lesions over the extensor surface of both extensor surface of both
elbows and kneeselbows and knees
Bp 130/80, pulse 80 regularBp 130/80, pulse 80 regular
NeckNeck ChestChest HeartHeart AbdAbd N SN S
Lab ValuesLab Values
Total cholesterol 508 mg%Total cholesterol 508 mg% Trigliceride 2894Trigliceride 2894 Random Sugar 338Random Sugar 338 ECG T wave changes in LIII, aVF,V3-ECG T wave changes in LIII, aVF,V3-
V6V6
Ask patient 3 questionsAsk patient 3 questions
Family history DM,Family history DM, DyslipedimiaDyslipedimia Early IHD in familyEarly IHD in family Thyroid diseaseThyroid disease Drug intakeDrug intake Liver,kidney diseases Liver,kidney diseases
Inferiolateral ischemiaInferiolateral ischemia
Investigations recomendedInvestigations recomended
Lipid profileLipid profile Liver functionLiver function Renal functionRenal function Thyroid functionThyroid function Cardiology consultation Why?Cardiology consultation Why?
Causes of secondary Causes of secondary hyperlipidemiahyperlipidemia
Cholestatic liver diseasesCholestatic liver diseases Nephrotic syndromeNephrotic syndrome Chronic renal failureChronic renal failure HypothyroidismHypothyroidism Cigarette smokingCigarette smoking ObesityObesity DrugsDrugs
Expected complicationsExpected complications
IHD, accelerated atherosclerosisIHD, accelerated atherosclerosis PancreatitisPancreatitis Gall bladder diseaseGall bladder disease Related to medicationsRelated to medications Complications of Diabetes Complications of Diabetes
LipoproteinLipoprotein
Type of lipoproteinsType of lipoproteins
Lipoproteins suclassesLipoproteins suclasses
DyslipedimiaDyslipedimia
Lipid Fredrekhsen Lipid Fredrekhsen classificationclassification
Plan of your treatmentPlan of your treatment
DietDiet Diabetes controlDiabetes control IHD, accelerated atherosclerosisIHD, accelerated atherosclerosis Hypolipemic Hypolipemic
medications,Statin,Fibrate,Resin medications,Statin,Fibrate,Resin uptake,ezetimibe, nicotinic acid,lipid uptake,ezetimibe, nicotinic acid,lipid apheresisapheresis
othersothers
Mechanism of action StatinsMechanism of action Statins
Are specific competitive inhibitors of Are specific competitive inhibitors of microsomal enzyme HMG-CoA microsomal enzyme HMG-CoA reductase, which catalyses the reductase, which catalyses the conversion HMG-Co Aconversion HMG-Co A
To mevalonate, a rate- determining To mevalonate, a rate- determining step in cholesterol synthesis step in cholesterol synthesis
Mechanism of action of Mechanism of action of FibratesFibrates
ADR of StatinsADR of Statins
Statins , Rhabdomyalgia , Statins , Rhabdomyalgia , RhabdomyolysisRhabdomyolysis
Renal impairementRenal impairement Raise transaminasesRaise transaminases GITGIT
APHERESISAPHERESIS