duplication distribution prohibbitedandfor the degradation of phenylalanine, biosynthesis of...
TRANSCRIPT
3/15/2012
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Breakout Session A
Disease Process and Disparities
AccreditationUAN 0024-0000-12-009-L04-P
Participation in this activity earns 1.75 contact hours. To receive credit, participants must complete an evaluation form at the conclusion of this session.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Breakout A
At the completion of this activity, participants will be able to:
• Discuss research methods and approaches to address disease processes and healthaddress disease processes and health disparities; and
• Discuss strategies for translating evidence‐based clinical guidelines to their own practices.
OPENING REMARKSJanel Bailey-Wheeler, PharmD
01.01.01 – ANTIOXIDANT EFFECTS OF SEP IN LIVER TISSUE FROM DIABETIC RATS
Ugochukwu J. Agwai, BS
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Antioxidant effects of sepiapterin (SEP) in liver tissue from spontaneous diabetic (Type I) rat
Agwai Ugochukwu, Chinnatambi V, Mukhopadhyay S, Ravella K, Shackel J, Gangula PR
Meharry Medical College, Center for Women’s Health Research, Nashville, TN-37208
Background
• Aim: To investigate whether spontaneous diabetes causes a change in liver oxidative stress levels, and if so will supplementation of SEP restore levels back to ppnormal?
• Hypothesis: Levels of oxidative stress in diabetic animal liver tissue is higher compared to non-diabetic animals, as measured by antioxidative markers. Supplementation with SEP decreases levels of oxidative stress in diabetic animals compared to non-supplemented animals.
What is SEP?
• SEP is a substrate for tetrahydrobiopterin (BH4) synthesis via the salvage pathway. BH4 is an essential co-factor required for the degradation of phenylalanine, biosynthesis of neurotransmitters, and it serves as a catalyst for the production of nitric oxide (NO).
• The role of NO in the liver is still controversial, but we believe that when generated constitutively, it serves a protective function for the liver. This is primarily based on the vasodilatory effects of NO.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Design methods
• Adult ovary-intact female Sprague Dawley rats (9 wks old) were selected in the present study.
• Diabetes was induced in overnight fasted animals by a single• Diabetes was induced in overnight fasted animals by a single intraperitoneal injection of streptozotocin (STZ, 55 mg kg−1).
• Control animals were injected with the vehicle (9 mmol citrate buffer, pH 4.0).
• Blood glucose levels were examined in overnight fasted animals, 48 h post STZ injection. Animals exhibiting blood glucose levels more than 250 mg dL−1 were considered diabetic and included in the study. Blood glucose levels in vehicle-treated overnight fasting rats ranged between 80–95 mg dL−1.
• At the end of 8th week of diabetes induction, animals were divided into three groups, i.e. control female rats (C), diabetic female rats (DB), and SEP tablets (20 mg/kg b.w/10days) supplemented diabetic female rats (DB + SEP).
• Liver tissue samples were collected from non-diabetic rats as control, SEP treated rats and spontaneous diabetic rats as experiments.
• Tissue samples were snap frozen in liquid nitrogen and stored at −80 °C until analyzed. Proteins were measured by Bio-Rad protein assay (Bio-Rad, Hercules, CA, USA) and 30 μg protein was separated by 6% SDS polyacrylamide gel electrophoresis (SDS-PAGE).
• The samples were homogenized into smaller pieces, andThe samples were homogenized into smaller pieces, and protein concentration estimation was performed using Western Blotting methods.
• We explored the levels of oxidative stress in the liver from spontaneous diabetic rats using antioxidative markers.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Antioxidant markers used• Nuclear factor (erythroid-derived 2)-like 2 (NRF2): interacts with KEAP-1
to facilitate the expression of Glutamate-cysteine synthetase (GCS).
• Kelch-like ECH-associated protein 1 (KEAP-1)
H (HO 1) th t t l th d d ti f• Heme oxygenase (HO-1): an enzyme that catalyzes the degradation of heme, it responds to oxidative stress.
• Glutamate-cysteine synthetase catalytic and modulatory subunits (GCSc/m): the rate limiting step required for glutathione biosynthesis. Glutathione is a tripeptide that acts as an antioxidant to protect cells from free radicals.
• Dihydrofolate reductase (DHFR): an enzyme required for tetrahydrobiopterin (BH4) synthesis.
Results
1 4
2.1
2.8
0
0.7
1.4
CONT DIA-II SEP
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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0.4
0.6
0
0.2
CONT DIA-II SEP
0.3
0.45
/Act
in
0
0.15
CONT DIA-II SEP
Nrf
2/
0 2
0.3
0.4
0
0.1
0.2
CONT DIA-II SEP
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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1.5
2
0
0.5
1
CONT DIA-II SEP
1.6
2.4
0
0.8
CONT DIA-II SEP
Conclusions
• Spontaneous diabetes causes an increase of oxidative stress in the liver causing damage of liver functionsliver functions.
• According to the results, supplementation of SEP may become beneficial in reversing the damage of oxidative stress seen in diabetic patients.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Acknowledgements
The project described was supported by NIH/NCRR – 2G12RR003032-22 Meharry RCMI program and the Meharry Women’s Health Center I would like tothe Meharry Women s Health Center.. I would like to thank them for their continued support.
02.02.06DETERMINATION OF BODY FAT
Pratibha Phadke-Gupta, PhD
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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DETERMINATION OF BODY FAT: A PILOT STUDY MEASURING BODY COMPOSITION AMONG COLLEGE ATHLETES AT A HISTORICALLY BLACK COLLEGE/UNIVERSITY
Presenter :Pratibha Phadke‐Gupta, PH.D , Research Assistant P f C f All i H l h Di i i Professor , Center for Allaying Health Disparities
through Research and Education (CADRE)
Co‐Presenters; Daniel Shook, PhD.; Joshua Searcy, PhD; Greta Winbush, PhD; Karen Mathews, MD; & Kellen Winslow, JDDepartment of Health, Physical Education, and Recreation; Department of Social and Behavioral Sciences; Student Health & Counseling Services Center; & Athletics and Student Wellness
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HUMAN EXERCISE AND PERFORMANCE LABORATORY (HEPL) at Central State University
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INTRODUCTION
Obesity and Diabetes in AfricanAmericans
Objective
S ifi Ai Specific Aims
ResearchMethods
Evaluation of BodyComposition
Clinical Relevance
27
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Obesity and Diabetes in African Americans
Type 2 diabetes and obesity are major public healthpriorities because of their high prevalence and incidence
African Americans have the highest prevalence to obesity(29%) and diabetes (11%) among racial groups
Obesity and diabetes are strongly associated with otherdi ith hi h t lit tdiseases with high mortality rates: Hypertension Coronary artery disease Cancer
Non‐drug treatments: Diet Physical Activity
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Objective
The purpose of this investigation was threefold:
Present a profile of body composition assessment using air displacement plethysmography on a population of plethysmography on a population of college athletes at Central State University
Evaluate Body Composition
Determine body fat in College Athletes
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Specific Aims
1. To Determine Body composition
2.To Evaluate and asses specific Composition
3. To Identify risk associated with and based on body composition
30
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Importance Of Body Composition
With obesity on the rise and diseases associated with excess body fat becoming more involved body fat becoming more involved, the need to measure body composition has become more important than ever
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Body Composition:%Fat and %Fat Free Mass
Body composition is a measurement of a person’s fat mass and fat free (lean) mass
Testing body composition is a great way to monitor and reach realistic health and fitness goals
Weight and BMI can be less specific in relation to a person’s general health and individual goals
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Research Method
Recruited student athletes involved in any sports activities such as volley ball, basketball or any other athletic sport to participate in the study sport to participate in the study
51 college athletes male and female, (average age 21) participated in the study
33
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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The BOD POD is an Air Displacement Plethysmograph(ADP) that uses whole‐body densitometry to determine body composition (fat vs. lean)
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BOD POD measures body mass (weight) using a very precise scale, and volume by sitting inside the y gBOD POD. Body density is calculated: Density = Mass/Volume
35
The relative proportions of body fat and lean body mass are calculated. yThis 5 minute test is considered very accurate (+ or – 2%), fast, easy, and non invasive
36
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Body Composition:%Fat and %Fat Free Mass
Body composition is a measurement of aperson’s fat mass and fat free (lean) mass
Testing body composition is a great way toTesting body composition is a great way tomonitor and reach realistic health and fitnessgoals
General measurements such as weight and BMIcan be less specific in relation to a person’sgeneral health and individual goals
37
Where is the fat?
Visceral fat is also known as organ fat or intra‐abdominal fat
Subcutaneous fat is found underneath the skin
Fat free mass is comprised of all of the fat free l t f th b d t h l i t i ti iti f elements of the body to help maintain activities of
daily living and to help prevent diseases such as osteoporosis
It is important to eat adequate calories and use resistance training to maintain more fat free mass, especially during weight loss
38
BODY FAT IN WOMEN
39
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Study Results in Body Composition
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FEMALE DISTRIBUTIONS BY BODY FAT CATEGORIES
3
7 7
1 1
RISKY (HIGH BODY FAT) EXCESS FAT MODERATELY LEAN LEAN ULTRA LEAN RISKY (LOW BODY FAT)40
40
50
60
200
250
300
BS
FEMALES ‐ BODY MASS VS % BODY FAT
Body Mass (lb)
% Fat
0
10
20
30
0
50
100
150
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
% FAT
BODY M
ASS, LB
SUBJECT
41
60
70
80
90
100
BODY COMPOSITION IN FEMALES
0
10
20
30
40
50
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
% Fat
% FFM
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Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Body Composition Lean Weight and Body Composition Fat Weight and Body Composition % Fat:
Female Basketball Athletes
0
20
40
60
80
100
1 2 3 4 5 6
Basketball Athletes
body composition lean weight
body composition fat weight
body composition % fat
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150
200
250
BODPOD % Fat, % Fat Free Mass, Fat Mass, Fat Free Mass, Body Mass: Female Basketball Athletes
bod pod % fat
0
50
100
1 2 3 4 5 6
Basketball Athletes
bod pod % fat
bod pod % fat free mass
bod pod fat mass
bod pod fat free mass
bod pod body mass
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BODY FAT IN MEN
45
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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% FAT
BODY M
AS, LBS
MALES BODY MASS VS % BODY FAT
0
5
10
15
20
0
50
100
150
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
SUBJECT
Body Mass (lb)
% Fat
46
80
100
120
BODY COMPOSITION IN MALES
0
20
40
60
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
% Fat
% FFM
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6
7
8
9
10
MALE VS FEMALE DISTRIBUTIONS IN BODY FAT CATEGORIES
0
1
2
3
4
5
RISKY (HIGH BODY FAT)
EXCESS FAT MODERATELY LEAN
LEAN ULTRA LEAN RISKY (LOW BODY FAT)
MALES
FEMALES
48
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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MAINTAIN HEALTH
CONCLUSION:
Studies have shown that a combination of physical activity
d ll i t i d di t and a well maintained diet produce the best effect of a decrease in fat mass and a maintenance or increase in muscle mass
49
CONCLUSIONS
Body composition, or fat vs. fat‐free (lean) mass, reflects the results of a person’s physical activity and nutritional practices.
Monitoring body weight alone can be very misleading, because a scale can’t tell the difference between a pound of fat and a pound of muscle
50
CONCLUSIONS
Sedentary people sometimes gain fat and lose muscle without any noticeable change in their weight
While on an exercise/weight training program a person may not experience a significant change in weight, yet their muscle mass is most likely increasing, while they are also probably losing body fat
51
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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OPTIMAL HEALTH AND CLINICAL RELEVANCE
Benefits of maintaining a healthy body composition
A healthy lifestyle including a well y y gmaintained diet and adequate physical activity can produce many health benefits and increase quality of life
52
Some of these health benefits include a decrease in risk for and improve conditions in improve conditions in cardiovascular disease, diabetes, metabolic disease, osteoporosis and a host of other diseases
53
Regular physical activity and maintenance of a healthy body composition can also improve ability p p yto perform activities of daily life, increase energy and help to maintain cognitive function and decrease stress
54
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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QUESTIONS
THANK YOU
55
01.01.04RURAL COMMUNITY-BASED CANCER CLINICAL TRIAL PROGRAM
Mary S. DeShields, MD
Rural Community Based Cancer Clinical Trial Program: A National Best Practice Model Which Addresses Disparities in Clinical
Research Participation
CLAUDIA R. BAQUET, MD, MPHM De Shields, MD; J Bromwell; S Richter
University of Maryland School of Medicine, Eastern Shore Cancer Research Network; Eastern Shore AHEC, Shore Health System
Xavier University of Louisiana Fifth Annual Health Disparities Conference
March 6‐8, 2012
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Factors Contributing to Cancer and Health Disparities
• Risk factors/exposures
• Biologic and genetic determinants
• Health care determinants (access
• Socioeconomic status
• Cultural competence and cultural determinants
L k f ti t t d
58
to care, health insurance, quality, bias in care delivery)
• Co‐morbid conditions
• Treatment disparities – NOT based on clinical factors and evidence
• Lack of patient centered care
• Post‐treatment access to and compliance with care
• Low participation/retention rates in clinical trials
• Differences in pain management, palliative care
Assuring Diversity in Clinical Research Participation
• A national priority
• Minority, uninsured, poor, and rural communities have lower participation rates.
• Underserved communities experience substantial health disparities.
• Barriers across multiple levels impede participation
• Building community-academic partnerships and community trust is essential.
59
Issues in Cancer Clinical Trial Participation
• 2011: – Estimated 1.4 million new cancers diagnosed– Over 500,000 deaths projected
• 3-5% of cancer patients participate in clinical trials
• Low participation by underserved communities (African American, uninsured, poor, rural)– A declining percentage of African Americans participating
• 32% of Americans would be willing to participate in trials if asked; an additional 38% would be inclined to participate if asked but had questions/reservations.*– Factors other than patient intent or willingness present barriers to
participation in clinical trials.**
60
*Comis RL, et al. Public attitudes toward participation in cancer clinical trials. J Clin Oncol. Mar 1 2003;21(5):830‐835.
**Baquet et al. 2008.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Barriers to Research Participation
• Patient
• Health care professional
• Structural design co-morbidityStructural, design, co morbidity
• Knowledge and awareness in general public
• Insufficient community infrastructure to support clinical research and trials
• Historical factors
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Researcher Barriers
• Lack of training in:– Cultural competence – Culture and health – Disparities
• Communication skills– Literacy– Literacy– Language– Sensitivity
• Lack of culturally tailored approaches to trial accrual and retention
• Fear or distrust of academics/researchers by patients and community
• Partnership and sharing skills– Not sharing results
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Approach: Fostering Public Trust in Research and Trial Diversity
• Issues:– Lack of public trust and need for diversity in research participation
– “Research Literacy”• Community: Lack of basic information on why research is• Community: Lack of basic information on why research is
important, how it is designed and reported; concern for “helicopter research; ethical protections for research participants
• Community Primary Care Clinicians: Fear of losing control over patient care; distrust of academia and “stealing “patients; how to refer/enroll patients in studies; need for feedback from researchers
• Historical research abuses and scandals affect public trust
63
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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• Examined relationship of socio-demographic factors on accrual of Maryland cancer patients to NCI sponsored cancer treatment trials– n=2,240 Maryland cancer patients accrued onto NCI-sponsored
treatment trials (1999-2002)
• Purpose: To determine extent to which Maryland cancer patients and patients residing in lower SES and/or rural areas were accrued to cancer t i l d t ti f ll ti t i M l d
Accrual of Maryland Cancer Patients to NCI sponsored Treatment Clinical Trials Study
trials and were representative of all cancer patients in Maryland.
• Data sources: – NCI’s Cancer Therapy and Evaluation Program (CTEP) for Maryland
cancer patients– Maryland Cancer Registry – US Census and the Department of Agriculture
64Baquet CR, Ellison, G, Mishra, S et al. Analysis of Maryland Cancer Patient Participation in NCI Supported Cancer Treatment Clinical Trials. Journal of Clinical Oncology. July 2008.
Accrual of Maryland Cancer Patients to NCI sponsored Treatment Clinical Trials
Baquet CR, Ellison, G, Mishra, S et al. Analysis of Maryland Cancer Patient Participation in NCI Supported Cancer Treatment Clinical Trials. Journal of Clinical Oncology.July 2008. 65
Maryland Clinical Trial Barrier Research“Multivariate Predictors of Recruitment and Participation in Clinical Trials”
• Were significantly more likely to be recruited:– in poor health (OR=1.83, CI=1.21-2.76), – had public health insurance coverage (OR=1.98, CI=1.57-2.51), and – had some college or higher level of education (OR=2.32, CI=1.84-2.92).
• Were significantly more likely to actually participate:e e s g ca t y o e e y to actua y pa t c pate– informed about clinical trials by their health care provider (OR=1.69,
CI=1.08-2.65), – knowledgeable about clinical trials (OR=2.09, CI=1.26-3.46), and– able to make the time commitment (OR=1.67, CI=1.06-2.63).
• Black respondents were significantly less likely to be recruited (OR=0.61, CI=0.44-0.85) and less likely to participate (OR=0.38, CI=0.21-0.68) in clinical trials.
66Baquet CR, et al. Recruitment and Participation in Clinical Trials: Socio‐Demographic, Rural/Urban, and Health Care
Access Predictors. Cancer Detection and Prevention. 2006; 30.
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Strategies for Overcoming Barriers and Increasing Participation
FORMAL PARTNERSHIPS : • Public and Ministers Model (Times Community Services)• Clinical Eastern Shore (Eastern Shore CRN)• Print Media
COMMUNITY PARTICIPATION AND EMPOWERMENT:• Faith and community based organizations: Ministerial Alliances • Local health departments and community hospitals and FQHCs• Print and broadcast media• Policy makers
TRAINING for research personnel regarding:• Community concerns• Communication • Sharing results
INFRASTRUCTURE: Cover regulatory & data expenses
COMMUNITY HEALTH PROFESSIONAL: AHECs CME/CE:• Physicians and Nurses• Urban and rural
67
Maryland Community Clinical Trial Program Components
• Research: Barriers and Strategies– Random digit dial (RDD)– Qualitative research– Results used to target
educational/awareness efforts– Theory based
education/outreach
• Community engagement – Faith-based– AHECs– Print Media– CBOs– Local Health Departments– FQHCseducation/outreach
• Track accrual rates/trends– CTEP analysis
• Health care professionals– Trial referral– Continuing Education– Grand Rounds
• Training for Researchers
– Formal Partnerships
• Policy Research and Advocacy
• Community based infrastructure
• Technical Assistance for elected officials and staff
68
Clinical Trials in Rural Maryland
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Why rural community based trials?
• 80% of cancer patients are treated in community clinics
• Participants should reflect the heterogeneity of the US l iUS population
• Accrual shortens the time from discovery to delivery of novel therapies
• Provide state of the art therapy
Stakeholders
• Patients/participants
• Society
• Physicians
• Local Health Systems
Shore Regional Cancer Center
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Barriers to Participation
• Less than 5% of adult participants are enrolled in clinical trials:
– Clinical trials not available
– Not presented as a treatment option
– Screen failure due to stringent eligibility requirements
– Enrollment failure due to fear/mistrust
Unique Challenges in Rural Communities
Elderly population
Cultural and geographic Barriersgeographic Barriers
Physician refusal
Patient refusal
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Key Components
• For a successful community program:– Funding Source(s)
– Physician “champion”
– Dedicated on site clinical trials research nurse
– Data manager
– Institutional Review Board; local or central
– Infrastructure
3/15/2012 76
Three Point Approach
• Physician awareness and support
• Patient awareness
• Community awareness
Outcomes
• Clinical trials for all major sites of cancer opened within the first year
• Three major cancer prevention trials NSABP P1, NSABP P2 and SELECT opened with excellent accrual
• Cumulative patient enrollment increased from three to 136 as of December 2011
• 20% African American Participants (2011)
• Successful completion of audits by CTSU, ECOG, SWOG
3/15/2012 78
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Clinical Trials Accrual 1999‐2008
40
50
60
70
80
90
# Trials
0
10
20
30
40
1999‐20002001‐2002
2003‐20052005‐2008
# Accrued
#Total
Funding and Support
• NCI U01 CA 144650
• Maryland Statewide Health Network
• Susan G. Komen for the Cure, Maryland
• Research Bases: Eastern Cooperative Oncology Group and ACOSOG
• Fox Chase Cancer Center Community Affiliate
• Cancer Trials Support Unit (CTSU)
National Best Practice Award
US Department of Health and Human Services
Secretary’s Committee on Science and Policy
Maryland Community Clinical Trial Program
• A Model For Increasing Availability Of Community-Based Cancer Clinical Trials In Rural Eastern Shore Maryland, September 2004
– http://www.cancer.gov/newscenter/benchmarks-vol6-issue4/page1
• Awarded to Claudia Baquet, MD, MPH and
Mary De Shields, MD
81Supported by: NCI MSPN/CNP; NIH/NCMHD P60; MD CRF; Susan G. Komen For The Cure Maryland
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Bioethics Research Infrastructure/Center Grant
• Funding agency: NIMHD/NIH
• Grant number: RC2MD004761
• Goals: – foster public trust in research, – education/training on bioethics, and – increase minority, rural and underserved community
diversity in research participation including clinical trials.
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Health Professional CME/CE Programs
• Initial programs have been 2-hour live (face to face)
• Pre/Post Assessments
• CME evaluation and credits
• Web based programs currently being developed
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Community Bioethics Mini Medical School
• The Mini Med program provides the general public to receive basic i f ti bi thi
Goal: Remove mystery and stigma of research and participation
information on bioethics, clinical trials, how research participants are protected and the role of ethical research in improving health.
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Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Bioethics Center Programs and Research: Taking Our Expertise Nationally
• Community Bioethics Mini Medical Schools
• Physician and Nurse CME/CE
• Faculty, Trainee Summer Course and Fellowship
• African American Community Newspaper Journalist TrainingTraining
• National AHEC Organization
• Research on Informed Consent and Ethics
• Summer High School Science Teachers
• Web based HSP and HIPAA Training
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Outcomes to Date
Public education
– 2100 trained in research ethics, bioethics, clinical trials 101
– Nurses/Physicians: 160 CME/CE
– 25% rural African American cancer trial participation
– Cancer Center: 38% African American accrual
– CKD Trials: 60% African American
– 15 National Bioethics Fellows
– Two community IRB members: 6 additional being processed
– Greater willingness to participate in research studies as well as tissue donation
– Greater willingness to refer patients to trials
– Over 2000 web based trainees/certificates
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Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
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Thank You
QUESTIONS AND ANSWERSPanel Discussion
Thank you for your participation!
Presented at the Xavier of Louisiana College of Pharmacy's Fifth Health Disparities Conference | March 6-8, 2012 | New Orleans, LA
All Rights Reserved - No forms of duplication nor distribution allowed without author's consent
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