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Duke University School of Medicine

Duke General SurgeryResident Candidate’s Guide

2016–2017

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WELCOME

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Message from the Chair

Welcome to Duke! That you have chosen to dedicate your time to visit Duke and consider our program for your residency training indicates you are seeking a high-caliber experience that will prepare you for a rewarding career in academic surgery. That you have been selected for an interview should provide affirmation you have the capacity to excel in surgery, and both derive benefit from and contribute to the field. I am thus very glad that you are here, and hope that your visit will help you determine whether Duke is the best fit for you. Your choice of training program will define your career, and indeed, our choice of residents defines our institution. As such, this is an important decision for us both.

During your visit to Duke, you will have an opportunity to meet our residents and faculty, tour our facilities, and gain insights into our training philosophy. You will no doubt find both breadth and depth in the resources available to you; including state-of-the-art clinical operating and patient care facilities, comprehensive training and simulation venues; a well-organized, enthusiastic and dedicated educational faculty engaged in a compre-hensive didactic curriculum; and an exceptionally developed and well-funded surgical research enterprise embedded within the larger environment of a world-class research university. The comprehensive offering of clinical, educational, and research platforms organized within a single institution makes Duke among the few institutions that can deliver on the promise to create future leaders in surgery, and it is my personal commitment to offer each trainee the opportunity to go beyond mere assimilation of the current standard, and aspire to define future paradigms.

I genuinely look forward to meeting each of you, learning what contribution you hope to make to the field of surgery, and determining how I can help you reach your career goals.

Sincerely,

Allan D. Kirk, MD, PhD, FACS

David C. Sabiston, Jr. Distinguished Professor and Chairman Department of Surgery Duke University School of Medicine

Surgeon-in-Chief Duke University Health System

Allan D. Kirk, M.D., Ph.D., F.A.C.S.

WELCOME

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Message from the Residency Program Director

I would like to welcome you on behalf of the Duke Depart-ment of Surgery and I am grateful for your interest in our General Surgery Residency Program. The decision on where to train in surgery represents the most important decision in the trajectory of a surgeon’s career. Formal clinical train-ing as well as research into basic or translational medicine will predict success in obtaining competitive fellowships and academic positions.

The Department of Surgery at Duke’s primary goal is to provide an outstanding clinical and investigative program for students, residents, and faculty. The clinical training program in general surgery is dedicated to providing comprehensive training in patient care and operative surgery. This encom-

passes the entire breadth of core general surgery and the general surgery subspecialties, which includes cardiothoracic, abdominal transplant, oncology, vascular, endocrine, colorec-tal, trauma, and pediatric surgery. The Duke General Surgery Residency Program offers diverse clinical settings for training and includes operative experiences at Duke University, Duke Raleigh, Duke Regional, and the Asheville/Durham Veteran’s Administration hospitals.

We have developed an exemplary and well-rounded educational program for residents in training. Formalized meetings include weekly conferences such as Grand Rounds, Deaths & Complications Conference, Chairman’s Rounds, and the Chief Resident Conference, which provide a curriculum geared toward both formal and self-directed learning. We also have integrated into the educational program a world-class simulation curriculum housed in the American College of Surgeons-accredited Simulation and Educational Activities Lab (SEAL) located in the medical school. Our simulation activities encompass the entire gamut of modalities including video/box trainers, fresh-tissue preparations, live animal studies, and cadaver experiences.

The cornerstone of the General Surgery Residency at Duke is the two-year research fel-lowship, typically integrated between the second and third clinical years. During these two years, our surgical residents begin a dedicated investigative experience designed to give each resident an opportunity to develop granular expertise in an area of their choosing. These can include basic or translational science projects, experiences in health services or clinical outcomes research, studies in global medicine, or indeed any thoughtfully conceived knowledge creation endeavor. Innumerable basic science opportunities exist not only in the Department of Surgery, but also across both the graduate and undergraduate campuses.There are also multiple dual-degree opportunities obtained via the Duke Clinical Research Training Program, the Fuqua School of Business, and the Duke Clinical Research Institute. The goal of this research experience is to create thought leaders in academic surgery at both an institutional and national level, and to provide each Duke resident with a concentrated expertise in their chosen field.

John Migaly, M.D.

WELCOME

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You should consider a number of factors when choosing a residency program and clearly one of the most important is the track record of the recent graduates. The training program is intentionally broad-based and has produced graduates with a wide variety of clinical and research interests. As you will find in the summaries enclosed, our graduates obtain access to the most highly sought-after academic jobs and specialty training fellowship programs, and make up a significant number of the chairs, chiefs, and program directors nationwide.

We are proud of our program and achievements, and we are honored that accomplished medical students like you have expressed interested in our residency. I hope that over the course of your interview experience you come away as excited as I am about our programs.We encourage questions and hope you enjoy your visit.

Sincerely yours,

John Migaly, MDProgram DirectorGeneral Surgery Residency

ABOUT THE DUKE DEPARTMENT

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About the Duke Department of Surgery

As one of the top surgery programs in the world, the Duke Department of Surgery is dedicated to providing unparalleled clinical care, conducting pioneering research, and training the next generation of leaders in clinical and academic surgery. Patients from all over the world seek treatment from its team of experts, who have access to the clinical standard in all surgical domains, as well as experimental procedures and specialized care that extends beyond the current offerings of most hospitals. This provides the best opportunity for each patient to gain their best clinical outcome, and as such attracts a patient population representing an excep-tionally broad clinical spectrum from which the trainee can learn.

Since the 1930s, Duke Surgery has led the way in medical innovations. It established the nation’s first brain tumor program in 1937 and was one of the first U.S. institutions to success-fully perform a kidney transplant nearly 30 years later. Duke surgeons were the first to treat avascular necrosis of the femoral head with a free vascularized fibular graft. More recently, in 2013, surgeons implanted a bioengineered vascular graft in a patient — a first-of-its-kind operation in the United States.

The Department of Surgery’s internationally recognized faculty is focused on making gains in basic, clinical, and translational research, and it has traditionally received more NIH funding than any other surgery department in the world. The faculty is also deeply committed to pre-paring tomorrow’s leaders for careers in surgery with the highest level of training and access to unique research and leadership training opportunities.

The Department currently provides attending surgical coverage at Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, and two VA hospitals: Asheville VA and Durham VA hospitals. The faculty maintains an exceptionally busy practice, conducting over 30,000 operative procedures per year. As the Triangle area is perennially one of the fastest growing communities in the United States, Duke continues to expand with new operative platforms and a growing clinical and research faculty. This robust clinical volume combined with remark-ably competitive faculty members adept in acquiring grant funding has led to a fiscally solvent department. It is this solvency that allows the Department to continue its unwavering dedica-tion to residency training both on the wards and in the laboratory.

ABOUT THE DUKE DEPARTMENT OF SURGERY

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Duke University Medical Center History

DUKE HOSPITAL IN THE SNOW (DUMC ARCHIVES)

1891Trinity College President John Franklin Crowell makes public a plan for starting a medical college with a teaching hospital at Trinity College.

1924James B. Duke establishes The Duke Endowment and allocates part of his $40 million gift to transform Durham’s Trinity College into Duke University.

1925James B. Duke makes an additional bequest to establish the Duke School of Medicine, Duke School of Nursing, and Duke Hospital, with the goal of improving health care in the Carolinas and nationwide.

1927Construction begins on the medical school and Duke Hospital.

1929Three thousand applicants apply to the new medical school. Seventy first- and third-year students are selected, including four women.


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1930Duke Hospital opens July 20, 1930, attracting 25,000 visitors.

Classes begin in hospital administration, dietetics, and medical technology on August 15.

Eighteen third-year and 30 first-year medical students begin classes on October 2.

1931The Duke School of Nursing’s first class of 24 undergraduate students begin classes on January 2.

The dedication ceremony for Duke Medical School and Duke Hospital is held on April 20.

The Private Diagnostic Clinic, Duke’s physician practice organization, is organized September 15.

1940The first wing is added to Duke Hospital.

The 65th General Hospital is authorized as an affiliated unit of the Duke University School of Medicine on October 17.

1957The Outpatient Clinic and Private Diagnostic Clinic as well as the Hanes and Reed private floors and operating rooms are opened.

The original medical school and hospital are renamed Duke University Medical Center.

DUKE HOSPITAL MAIN ENTRANCE, CIRCA 1940 (DUMC ARCHIVES)

Duke University Medical Center History (continued)


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1966A new hospital entrance, the Woodhall Building, opens.

1980The new $94.5 million, 616-bed Duke Hospital opens, bringing the total number of patient beds to more than 1,000.

1998The Duke University Health System (DUHS)—an integrated academic health care system serv-ing a broad area of central North Carolina—is officially created as Duke establishes partner-ships with Duke Regional Hospital, Raleigh Community Hospital, and other regional health care providers. DUHS today includes three hospitals, ambulatory care and surgery clinics, primary care medical practice clinics, home health services, hospice services, physician practice affilia-tions, managed care providers, and other related facilities and services.

2007Future DUHS expansion includes the development of the Hospital Addition for Surgery (HAFS) building.

The Emergency Department (ED) Expansion project provides 71 treatment spaces accommo-dating over 60,000 annual visits, including a full Pediatric ED, 4 trauma resuscitation rooms, CT scanner, X-ray, decontamination area, ambulance garage, a daylit waiting area, and a linear exam area arrangement for increased efficiency.

2009DUHS moves forward with the construction of a dedicated, state-of-the-art cancer center and the new Duke Medicine Pavilion, a major expansion of surgery and critical care services at Duke University Hospital.



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2012On February 27, a new landmark opens its doors on Duke’s medical center campus—the seven-story, 267,000-square-foot Duke Cancer Center. More than just a modern space, it’s an environment designed to transform the experience of every patient welcomed inside. The cen-ter consolidates outpatient cancer services and clinical research from across the campus into a patient-centered, multidisciplinary facility. The building adjoins the current Morris Cancer Clinic and is equipped with, among other features, 140 examination rooms, 75 infusion sta-tions, a pharmacy, and an outdoor garden terrace where chemotherapy patients can go while receiving their infusions.

2013The Mary Duke Biddle Trent Semans Center for Health Education opens in January. The six-floor, 104,000-square foot building houses a meeting hall, a team-based learning auditorium, teaching labs, and clinical skills and medical simulation space, including the Surgical Education and Activities Lab (SEAL).

MARY DUKE BIDDLE TRENT SEMANS CENTER FOR HEALTH EDUCATION


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DUKE MEDICINE PAVILION AT DUKE UNIVERSITY HOSPITAL, 2013

The Duke Medicine Pavilion at Duke University Hospital opens in June. The eight-floor, 608,000-square foot pavilion includes 160 critical care rooms, 18 operating rooms, and an imag-ing suite. The operating suites feature the latest in surgical technologies, as well as intraoperative magnetic resonance and computed tomography (CT) imaging capabilities that enable greater real-time precision and safety in complex procedures. With Duke University Hospital having to turn more than 900 patients away the previous year due to lack of space, the newly created criti-cal care beds were urgently needed. Also, the 64 new intermediate care beds allow for optimal transition of patients from intensive care beds to standard hospital rooms.

The expanded Duke clinical facilities also provide state-of-the-art training and education for the nearly 900 residents and fellows at Duke—one of the largest training programs in the United States.

This major expansion project follows several recent significant capital projects throughout Duke Medicine, including renovations at Duke Raleigh Hospital and Duke Regional Hospital, and the open-ing of several new clinics in Wake County (Brier Creek, Morrisville, Knightdale, and North Raleigh).

2016Duke University begins construction of a third Medical Sciences Research Building (MSRB). The $103 million, 155,000-square-foot building will exclusively house bench lab research.



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Duke Surgery Milestones

Blazing Trails in Medicine for More Than Seven Decades

1936 J. Deryl Hart, MD, introduces ultraviolet lamps into operating rooms to kill airborne germs that cause postoperative Staph infections, dramatically reducing the number of infections and related deaths.

1937 Duke establishes nation's first brain tumor program.

1955 Duke initiates children's amputation clinic for prostheses and management as part of nationwide network.

1956 Duke becomes the first institution to use systemic hypothermia during cardiac surgery. This technique of cooling patients to less than 50 degrees Fahrenheit to minimize tissue damage during lengthy surgical procedures is now standard practice worldwide.

J. DERYL HART AND SURGICAL TEAM IN PROTECTIVE CLOTHING OPERATING ON A PATIENT UNDER THE STERILAMP IN 1937 (DUMC ARCHIVES)

OPEN HEART SURGERY, DR. WILL CAMP SEALY OPERATING, CIRCA 1956 (DUMC ARCHIVES)


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1965 Duke is one of the first institutions in the country to successfully perform a kidney transplant.

1968 Duke cardiac surgeon performs first operation to treat Wolf-Parkinson- White Syndrome.

1969 Duke orthopaedic surgeon performs first total hip replacement in the South.

1971 Duke Comprehensive Cancer Center becomes one of the nation's first cancer centers.

1972 Duke surgeons are the first to reattach a severed thumb more than eight hours after it was amputated.

1979 Duke surgeons are the first to treat avascular necrosis (AVN) of the femoral head with free vascularized fibular graft.

1982 Duke conducts first and only randomized trial comparing radical surgery to radiation for adenocarcinoma of the prostate gland.

1984 Duke surgeons perform first liver transplant in the state of North Carolina.

1992 Duke physicians perform the first lung transplant and the first heart/lung transplant in hospital history.

1993 The anti-HIV drug therapy (Fuzeon) is developed by Trimeris as a direct result of research conducted in the Duke Surgical Oncology Labs.

Duke Endosurgery Center opens.

1996 Duke Surgical Research Pavilion opens.

Duke Surgery Milestones (continued)


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1997 Duke Human Fresh Tissue Lab opens.

1998 Duke Ambulatory Surgery Center opens.

2000 Duke Aesthetic Center opens.

2001 American College of Surgeons establishes oncology group at Duke.

Duke Neurosurgery Skull Base Laboratory teaching facility opens.

2003 Duke Urology surgeons perform first robotic prostatectomy in the state of North Carolina.

2004 Duke Center for Translational Research is established.

2005 Duke Anatomic Gifts Program is overseen by Division of Plastic, Maxillofacial, and Oral Surgery.

Duke Surgical Education and Activity Lab opens.

DUKE SURGICAL EDUCATION AND ACTIVITY LAB (SEAL) OPENS IN 2005

DUKE HUMAN FRESH TISSUE LABORATORY OPENS IN 1997



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2006 Duke Thoracic Surgery and Duke Urology specialty clinics open in Raleigh, NC.

Duke Weight Loss Surgery Center is designated as a Center of Excellence by the American Society of Bariatric Surgery.

2007 Duke Otolaryngology — Head and Neck specialty clinic opens in Raleigh, NC.

2008 Duke's Surgical Education and Activities Lab receives accreditation by the American College of Surgeons as Comprehensive Education Institute.

2009 Duke General Surgery specialty clinic opens in Raleigh, NC.

Duke Small Bowel Transplant Program established.

2011 Duke Neurosurgery specialty clinic opens in Raleigh, NC.

2012 Surgical Education and Activities Lab receives first in state robotic trainer.

2013 Duke surgeons begin first ever clinical trial with bioengineered blood vessel.

2014 Duke Heart Transplant team performs the 1000th heart transplant at Duke.

2015 Duke pediatric surgeons separate conjoined twins.

2016 Duke surgeons perform the first hand transplant in North Carolina.


DUKE’S FIRST HAND TRANSPLANT WAS PERFORMED ON MAY 27, 2016 (CREDIT: SHAWN ROCCO)

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J. Deryl Hart, M.D. 1930–1960

A Tradition of ExcellenceThe rich history and high standards that bore Duke University are also deeply rooted within the Department of Surgery.

Duke Surgery Department Chairs

DR. DAVID C. SABISTON, JR. CONDUCTING TEACHING ROUNDS WITH RESIDENTS UNDER THE PORTRAIT OF DR. DERYL HART, FOUNDING CHAIRMAN OF THE DUKE DEPARTMENT OF SURGERY (DUMC ARCHIVES)

Duke Hospital’s first dean, Dr. Wilburt Davison, appointed a Johns Hopkins surgeon, Dr. J. Deryl Hart, to be professor of surgery and the first chairman of the department in 1930. After stepping down as chairman in 1960, Dr. Hart served as president of Duke University. During his tenure as chairman, Dr. Hart expected faculty members to assume major clini-cal and teaching responsibilities and to pursue laboratory research. He recruited the founding members of the surgical faculty and established Duke’s surgery residency. Dr. Hart is also credited with originating the use of ultraviolet radiation to control airborne infections in surgical operating rooms.

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The emphasis Dr. Hart placed on achieving excellence in patient care and teaching by integrating research with devel-opment laid the foundation for an institution that remains one of the top medical centers in the country. His philosophy was central to the department’s mission in 1930 and continues today. Under the leadership of the successive chairs — Drs. Clarence E. Gardner (1960-1964), David C. Sabiston, Jr. (1964-1994), Robert W. Anderson (1994-2003), Danny O. Jacobs, (2003-2012), and Allan D. Kirk (2014- present) — the model system of integrating the fundamental missions of academic medical centers (patient care, education, research, and admin-istration) was enhanced within the Department of Surgery at Duke. Dr. Gardner was Dr. Hart’s first chief resident and continued on as a Duke faculty member after completing his surgical training.

Dr. David C. Sabiston, Jr. completed medical school and surgi-cal training at Johns Hopkins Hospital under the mentorship-of Dr. Alfred Blalock. He distinguished himself in the field of cardiovascular diseases. Notable among his academic achieve-ments were his pioneering work in the surgical management of coronary artery disease and, while at Duke, groundbreaking work in the diagnosis and management of pulmonary embo-lism. Dr. Sabiston will be remembered most for his profound effect on surgical education, both nationally and internation-ally. This is most evident when reviewing the list of successful graduates who have gone on to lead departments, divisions, and programs and whose portraits adorn the hallways outside of the department offices.

Dr. Robert W. Anderson followed Dr. Sabiston as chairman and returned to the site of his surgical training. Social and eco-nomic influences were rapidly altering academic medicine in 1994. Dr. Anderson, an accomplished cardiothoracic surgeon with additional training in business administration, success-fully led a department seeded as the epitome of traditional education and training, research, and clinical excellence while addressing the major changes in practice reimbursement that had occurred. This leadership solidified Duke’s fiscal stature and has facilitated a continued dedication to a tripartite mis-sion of clinical, educational, and investigational achievement.

Clarence Gardner, M.D. 1960–1964

David C. Sabiston Jr., M.D. 1964–1994

Robert W. Anderson, M.D., M.B.A. 1994–2003

Duke Surgery Department Chairs (continued)


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Dr. Danny Jacobs was recruited to Duke in 2003, where he served as the David C. Sabiston, Jr. professor and chair until October 2012. Dr. Jacobs currently is the executive vice presi-dent, provost, and dean of the School of Medicine at the University of Texas Medical Campus in Galveston. During his 10 years at Duke, Dr. Jacobs proved himself to be a highly effective leader, committed to the success of all three missions within the Department of Surgery. He left Duke in a good posi-tion for his successor to continue the legacy of excellence that is Duke Surgery.

Dr. Allan D. Kirk was named chair of the Department of Sur-gery at Duke University in May 2014. He also was named as the inaugural Surgeon-in-Chief for the Duke University Health System. Dr. Kirk received his MD from Duke University School of Medicine in 1987 and completed his PhD in immunology at Duke in 1992. He completed his general surgery residency at Duke in 1995, and his multiorgan transplant fellowship at the University of Wisconsin in 1997. An accomplished scientist and surgeon, Dr. Kirk is recognized by his peers for his pioneering work in transplantation and for his outstanding ability to lead. Prior to returning to Duke, he served as a Commander in the United States Navy at the Naval Medical Research Institute, became the inaugural Chief of the Transplantation branch at the National Institutes of Health, and served as Vice Chair for Research for the Department of Surgery at Emory University. His commitment to rigorous education and training, innovative research, and the most advanced patient care make him an excellent leader for Duke Surgery.

Danny O. Jacobs, M.D., M.P.H. 2003–2012

Allan Kirk, M.D., Ph.D. 2014–present

Duke Surgery Department Chairs (continued)


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Duke University Hospital (DUH)

Consistently ranked as one of the top ten hospitals by U.S. News & World Report, the 989-bed Duke University Hospital is a tertiary and quaternary care hospital and Level I trauma center. On its 210 acres, it houses com-prehensive diagnostic and therapeutic facilities that serve a multistate region, drawing patients routinely from the Carolinas, eastern Tennessee, southern Virginia, Georgia, and Florida. Many of its programs also attract patients from other national and interna-tional sites. The main hospital is complemented by a state-of-the-art ambulatory surgery center situated two blocks away. Recent additions to Duke Hospital continue to add operative capacity and the patient volume continues to grow, consistent with the boom-ing population moving to the Triangle area.

Duke Regional Hospital (DRH)

DRH is a 369-bed acute care hospital that has been serving the community’s health care needs since 1976. A comprehensive facility, it offers Duke surgical residents experience in inpatient, outpatient, surgical, and emergency care. The medical facility also features a level II intensive care nursery, the 30-bed Durham Regional Rehabilitation Institute, and the Davis Ambulatory Surgical Center. It also has a nine-bed coronary care unit and a 17-bed intensive care unit. Other training opportunities include the highly acclaimed Duke Bariatric Surgery and Advanced Laparoscopic programs.

Facilities

The Department of Surgery’s residency program gives students the opportunity to gain hands-on experience providing care for diverse populations and treating a wide range of conditions. With five world-class facilities, surgical residents can take advantage of valuable training oppor-tunities, from pediatric through geriatric procedures, including comprehensive experiences in hepatobiliary surgery, transplantation, vascular surgery, and advanced laparoscopic procedures. The program includes experience in community and VA-based care, which is crucial for surgeons interested in academic careers. Residents become equipped with the knowledge and skills needed to be competitive in the workforce.

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Durham Veterans Administration Hospital (DVAMC)

This 274-bed general medical and surgical facility is located just across the street from Duke Hospital. The DVAMC provides general and specialty medical, surgi-cal, psychiatric inpatient, and ambulatory services and is a major referral center for veterans in North Carolina, southern Virginia, northern South Carolina, and eastern Tennessee. In this capacity, the DVAMC accommodates veterans from these regions with complex general, vascular, and cardiothoracic needs and, in addition, serves local veterans requiring care for common general surgical disorders.

Asheville Veterans Administration Hospital (AVAH)

The Asheville VA Medical Center is a tertiary care, 112-bed acute care facility located in western North Carolina. Asheville VA operates a separate 120-bed Extended Care and Rehabilitation Center, serving the western North Carolina area and portions of South Carolina, Tennessee, and Georgia. General surgical residents rotating through AVAH gain additional expe-rience in vascular surgery, general surgery, cardiac surgery, and endoscopy.

Duke Raleigh Hospital (DRaH)

This is a 148-bed general medical and surgical hos-pital in Raleigh. The Duke Raleigh rotation provides residents with a community-based general surgery experience that includes what would be considered “bread and butter” general surgery, such as cho-lecystectomy, hernia, breast biopsy, mastectomy, and colectomy. It is currently expanding to include a comprehensive weight management program and enhanced general surgical oncology.

Facilities (continued)

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Duke Medicine and Duke University

With a top-ranked medical school, health system, and university, Duke University is a hub for academic excellence and innovation. Located in Durham, N.C. — one of the fastest grow-ing areas in the country and a center of biomedical research — it produces leaders in fields ranging from business to engineering to public policy. Duke Medicine, which comprises Duke University Health System, Duke University School of Medicine, and Duke University School of Nursing, consistently ranks as one of U.S. News & World Report’s best medical centers.

Duke Medicine is an international leader in health care, research, and training. Its state-of-the-art facilities include the flagship Duke Hospital and two community hospitals, Durham Regional and Duke Raleigh. It’s also affiliated with other health care facilities, including local hospitals, com-munity-based primary care physician practices, and hospice care. The School of Medicine has 31 departments, centers, and institutes, and employs more than 2,000 faculty members. Duke logs more than 61,000 inpatient stays and 1.8 million outpatient visits each year.

Duke Medicine offers world-class education for some of the brightest minds in medicine. Programs promote multidisciplinary collaboration between basic science, translational, and clinical faculty. Trainees are encouraged to pursue research in their area of interest and, upon graduation, are uniquely positioned for sought-after clinical or research positions.

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Durham, North Carolina

Located halfway between the stunning Blue Ridge Mountains and the spotless beaches of the Outer Banks, Durham is the fourth largest municipality in North Carolina. Visitors come to Dur-ham for its sports teams, eclectic restaurants, and diverse culture; residents live here for its reasonable cost of living, strong sense of community, and agreeable weather. From Forbes to USA Today, the Raleigh-Durham area consistently lands on the major top 10 lists of best places in the country to visit, live, and do business.

Durham has the charm of a Southern college town with the amenities of a larger city. The nearby Research Triangle Park, the largest research park in the country, is a wellspring of advancements and career opportunities in biotechnology, environmental sciences, and phar-maceuticals. The annual Full Frame Documentary Film Festival brings together people from all over the world to showcase the work of new and established filmmakers. With more than 60 parks, an extensive network of running and biking trails, and several major waterways, the city offers abundant activities for outdoors enthusiasts. Access to and from Durham is convenient, as the RDU airport just 12 miles outside the city.

(Clockwise from top left) ENO RIVER STATE PARK. Photo credit: Durham Convention & Visitors Bureau. AMERICAN TOBACCO CAMPUS. Photo credit: Durham Convention & Visitors Bureau. DURHAM BULLS ATHLETIC PARK. Photo credit: Brian Fleming Photography, Durham Bulls Athletic Park and Durham Convention & Visitors Bureau

http://BrianFlemingPhotography.com

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Community Engagement

General Surgery Interest Group The Duke Department of Surgery sponsors the General Surgery Interest Group, a student-run organization that allows students to learn more about careers in general surgery through information sessions, case discussions, hands-on experiences, and professional mentorship facilitated by student-resident partnerships.

ASSET ProgramThe Department of Surgery has partnered with the Durham Nativity School to provide surgical skills workshops as part of the Academic Success Through Surgical Education and Training (ASSET) program. This program aims to foster high achievement in science through surgical edu-cation for financially disadvantaged students at the school.

Duke Cycling TeamThe Department of Surgery sponsors the Duke University Cycling Team coached by Ben Turits. The triangle area is an exceptional area for cycling and outdoor activities in general. There are numerous cycling events year round, including group rides with the team and faculty.

RESIDENTS

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Residency Programs

General Surgery Residency

The General Surgery Residency Training Program at Duke focuses on both clinical and research education, producing competitive graduates who are prepared for careers in aca-demic surgery. Residents gain broad experience in operative surgery as they learn to evaluate and manage a high number of patients requiring all types of procedures, from vascular to hepato-pancreatic biliary surgery.

Rotations in both community and VA medical centers mean that residents get valuable, unique, and comprehensive training for a career in academic surgery. The program is broad, but trainees have the opportunity to focus on one or more specialties, such as endocrine surgery or transplantation. General surgery residents are expected to complete at least two years of focused research, and opportunities for laboratory or other discovery experiences are available within and outside of the department. Most trainees choose specialization and seek fellowship training upon completion of the residency program, and the research experience is universally cited as a major reason that Duke residents are highly competitive for academic fellowships and faculty positions.

Cardiovascular and Thoracic Surgery Residency

Duke offers two training opportunities in cardiothoracic surgery: a traditional residency pro-gram and an integrated residency program that was recently approved by the ACGME.

The Traditional Thoracic Surgery Residency Training Program is a three-year program that prepares graduates for careers in academic cardiothoracic surgery, providing them with direct experience in all clinical aspects of cardiothoracic surgery and extensive training in clinical research. Residents gain experience with adult cardiac surgery, congenital cardiac surgery, and general thoracic surgery. A core focus of the program is a mentorship system that emphasizes consistent relationships with faculty members.

The Integrated 6-Year (I-6) Thoracic Surgery Residency Training Program leads to eligibility for certification by the American Board of Thoracic Surgery. With an educational curriculum cre-ated to augment operative and clinical training, residents in this program gain experience in general and vascular surgery, critical care, cardiac anesthesia, and cardiac catheterization, as well as cardiac and thoracic surgery.

http://surgery.duke.edu/education/residency-programs/general-surgery-residency-training-program

http://surgery.duke.edu/education-and-training/residency-programs/general-surgery-residency-training-program/research-fellow

http://cardiothoracic.surgery.duke.edu/education-and-training/residency-programs

http://cardiothoracic.surgery.duke.edu/education-and-training/residency-program/traditional-thoracic-surgery-residency-program

http://cardiothoracic.surgery.duke.edu/education-and-training/residency-program/integrated-thoracic-surgery-residency-program

RESIDENTS

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Surgical Education at Duke

Duke surgical residents experience a wide variety of educational settings by rotating through Duke University Hospital, Durham Regional, Duke Raleigh, Durham VA, and Asheville VA hospitals. Residents during their first two years develop a solid foundation in patient care, ICU management, and consultations. Junior residents finish their first two years with well over the minimum 250 operative cases required by the ACGME, thanks in part to the Department’s growing number of excellent physician-extenders.

Junior and lab residents will also develop their operative skills by participating in an advanced simulation curriculum developed with input from faculty and residents. Our innovative simu-lation program optimizes the educational experience to better suit residents’ schedules and shifts it earlier in our residents’ training, where it is most effective. This curriculum allows residents to master complex operative skills earlier in their training and safely prepares them for the autonomy and operative responsibilities required during their upper-level rotations. Senior residents lead interdisciplinary surgical teams and learn to manage the complex, high-acuity patient services one would expect at a high-volume academic institution. Their role is to act predominantly as service chiefs for rotations in hepatobiliary, surgical oncology, trauma/acute care, pediatric, transplant, thoracic, vascular, colorectal, breast, and endocrine surgery. At Duke University Hospital, all services use a night float system, which means patient care is covered by a consistent overnight team led by a night in-house chief. By graduation, Duke general surgery residents have an excess of operative experience well beyond the ACGME requirement of 850 cases minimum.

Additionally, our unique, collaborative environment is dedicated to continually improving the educational experience. This collaborative purpose is exemplified by a new Surgical Educa-tion Research Group formed in the past year. SERG has already represented Duke at three national conferences, and the group has supported numerous new initiatives to improve the recruitment and training of medical students. For example, the group’s proposal for a Surgical Technique and Review (STAR) elective was recently approved by the School of Medicine and is scheduled for Spring 2017. These efforts have been driven by the advocacy of the surgery residents, the growing enthusiasm from our medical students, and the generous support from the faculty and department. Overall, SERG highlights Duke Surgery’s commitment to evolve and improve surgical education for the betterment of all learners.

It’s not just the case numbers, the challenging patients, or the simulation curriculum that will make you a great surgeon. The intangible, unquantifiable attributes of a program shape trainees not only into skillful technicians but also cultivates them into future surgical leaders. At Duke, our greatest unmeasurable strength is our faculty and residents. The supportive leadership of our faculty and the enthusiastic involvement of our residents make Duke an exceptional place to train as a surgeon and develop as a leader.

RESIDENTS

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How Does Duke Compare?

2015 FRIEDA Data

National Average Duke

Academic year

Length of accredited training 5 5

Required length 7

Average number of PY1 interviews 84.1 85

Residents

Average number of residents/fellows 31.9 32

Average percent female 36.1% 28.1%

Average percent international medical graduates 18.4% 6.25%

Faculty

Average number of full-time physician faculty 32.8 69

Average number of part-time physician faculty 3.5 0

Average percent female full-time physician faculty 18.3% 27.0%

Average ratio of full-time physician faculty to resident/fellow 1.0 2.1

Resident work hours (PY1)

Average hours on duty per week 74.0 75.2

Average maximum consecutive hours on duty 17.9 16

Average days off duty per week 1.0 1.0

Work environment and compensation (PY1)

Average percent of training in hospital outpatient clinics 17.4% 15.00%

Average percent of training in non-hospital ambulatory care community settings 8.1% NA

Average resident/fellow compensation $52,607 $53,580

Average number weeks of vacation 3.3 2

RESIDENTS

25

Conferences

Schedule

MondayIntern (PGY-1) Conference (Intern School) 5:30 p.m. – 6:30 p.m.

TuesdayDuke Regional Hospital Conference 6:30 a.m. – 7:30 a.m.

WednesdaySurgical D&C Case Conference* 6:00 a.m. – 7:00 a.m.Surgical Grand Rounds* 7:00 a.m. – 8:00 a.m.SCORE Curriculum Conference* 8:15 a.m. – 9:15 a.m.Simulation Lab* 9:30 a.m. – 12:30 p.m.

ThursdayDurham VA Conference 7:00 a.m. – 8:00 a.m.Duke Raleigh Hospital Conference 7:00 a.m. – 8:00 a.m.Chairman Walk Rounds 4:30 p.m. – 5:30 p.m.

FridayAsheville VA Conference 7:30 a.m. – 8:30 a.m.Chief Resident Conference 4:30 p.m. – 5:30 p.m.

*General Surgery Core ConferencesClinical residents are required to attend a minimum of 80 percent of core conferences (D&C, Grand Rounds, SCORE, SEAL). Research residents are required to attend the core conferences plus Chairman’s Rounds and Friday Chief’s Conference.

D&C, Grand Rounds, SCORERequired for all research and clinical residents rotating at Duke and the Durham VA. Those on night shift the night prior are required to attend.

Exceptions: ACU, SICU residents, Thoracic SAR, JTP residents rotating on cardiac, residents rotating at Asheville

SEALRequired for all residents when assigned, including DRH and Duke Raleigh.

Exceptions: Any resident who was on a night shift the night prior, ACU, SICU residents, Tho-racic SAR, JTP residents rotating on cardiac, residents rotating at Asheville

Chairman’s RoundsAll research residents and all clinical residents (at Duke and the Durham VA) not in the operat-ing room or engaged in urgent clinical care.

Chief’s Conference (Friday)All research residents and all clinical residents (at Duke and the Durham VA) not in the operat-ing room or engaged in urgent clinical care.

RESIDENTS

26

Surgical Education and Activities Lab (SEAL)The Surgical Education and Activities Lab (SEAL) is a state-of-the-art surgical simulation center designed to provide advanced and innovative training for physi-cians, residents, fellows, physician assistants, nurses, medical students, health care providers, and industry professionals in a risk-free environment. Simulation training provides learners the opportunity to develop skills and practice minimally invasive procedures with-out the pressures of the operating room to advance medical education and improve patient safety.

Human Fresh Tissue LaboratoryThe Duke Human Fresh Tissue Laboratory is a state-of-the-art medical skills lab where residents, attend-ing physicians, and medical students can perform advanced surgical training on fresh tissue. The lab has been used to provide training to medical profession-als from Duke and throughout the country since 1997.

Duke VivariumA key component of the Duke Animal Care and Use Program is the Surgical Pavilion that consists of four operating rooms as well as rooms for surgical prepa-ration, anesthetic monitoring, post-operative recovery and surgical instrument processing. This facility pro-vides resources for teaching and research endeavors and is supplied with state-of-the-art equipment and information technology.

3D Printing LabThe Duke 3D printing lab offers unique research and educational experiences for surgical trainees. We have many printers that can be accessed remotely from anywhere and higher end printers located just next to the Duke Medicine Pavilion. We also have state-of-the-art software and a partnership with the multi-D lab for help with segmentation, which is the process of picking out particular areas of anatomical interest for printing.

Educational Laboratories

https://surgery.duke.edu/education-and-training/educational-laboratories/surgical-education-and-activities-lab

https://surgery.duke.edu/education-and-training/educational-laboratories/human-fresh-tissue-laboratory

https://surgery.duke.edu/education-and-training/educational-laboratories/duke-vivarium

https://surgery.duke.edu/education-and-training/educational-laboratories/3d-printing-lab

RESIDENTS

27

InnovateMD is a program that provides residents and fellows with an educational and expe-rience-based opportunity to collaborate with engineering students and faculty in the field of medical device innovation. The program was co-founded in early 2016 by David Ranney, MD, Resident in General Surgery, and Ken Gall, PhD, Associate Director of Duke MEDx and Chair of the Department of Mechanical Engineering and Materials Science. The primary mission of InnovateMD is to provide each participate with working knowledge of topics related to medi-cal device development and the opportunity to apply that knowledge to a real-world medical device project. In addition to educational objectives, dedicated resources will be made avail-able to participants to facilitate innovation and accelerate the device development process.

Program Highlights

• Opportunities for clinical observation

• Seminars from faculty, entrepreneurs, and industry experts

• Networking events on and off campus

• Mentorship from medical, surgical, and engineering faculty

• Dedicated resources and workshops

Innovate MD

RESIDENTS

28

Program Leadership

• David Ranney, MD, Director

• Ken Gall, PhD, Assistant Director

• Allan Kirk, MD PhD, Advisory Team

• Shelley Hwang, MD MPH, Advisory Team

• Ranjan Sudan, MD, Advisory Team

• Nandan Lad, MD PhD, Advisory Team

• Suresh Balu, MBA, Advisory Team

• Bill Walker, PhD, Advisory Team

Current Fellows

• David Ranney, MD, General Surgery

• Soni Nag, MD, General Surgery

• Muath Bishawi, MD, Cardiothoracic Surgery

• Marat Fudim, MD, Cardiology

• Kim Hoang, MD, Neurosurgery

• Jacquelyn Corley, MD, Neurosurgery

• Alexa Bramall, MD PhD, Neurosurgery

• Phillip Liu, MD MBA, Internal Medicine

Ongoing Collaborations

• Duke MEDx

• Duke Institute for Health Innovation

• Department of Surgery

• Pratt School of Engineering

Contact UsPlease direct questions to David Ranney at [email protected].

Innovate MD (continued)

mailto:david.ranney%40duke.edu?subject=Innovate%20MD

RESIDENTS

29

Residents

Duke surgery residents are standouts in their field. Graduates consistently go on to land presti-gious fellowships and highly sought-after clinical positions and academic professorships. Some focus on teaching, garnering awards for training and mentoring the next generation of surgeons. Others devote their careers to research, making significant advancements in surgical care.

The residents are typically highly productive during their time in training. Most establish them-selves as bona fide authorities in a chosen field and exemplify this through significant contribu-tion to the medical literature. This productivity indicates not only the high level of talent and ingenuity typical of the Duke Surgery resident, but also speaks to the quality of mentorship in time management, prioritization, and other skills critical to academic success delivered during the residency period. The publications of the Chief Residents in Surgery from the past two years (over 200) are presented as an example of the ongoing productivity of Duke surgical trainees.

RESIDENTS

30

Positions of Chief Residents of Surgery

The most important metric of a residency program is the success of its trainees. This is best captured by the most prominent position in one’s career (for established surgeons) and the initial position obtained after residency (either faculty or fellowship for junior faculty). To assist applicants in understanding the breadth and height of the careers of trainees of the Depart-ment of Surgery, we provide the most prominent positions of all graduates of the program since 1970, and the initial appointments of new graduates for the past 20 years. You will note that approximately 70 percent of graduates follow academic careers, with numerous individu-als rising to the level of Department Chair, Dean, and other executive leadership positions.

2016

Name Initial Position Most Prominent Position

Anthony Castleberry Cardiothoracic Surgery Fellowship, Duke University Medical Center

Cardiothoracic Surgery Fellowship, Duke University Medical Center

Kristy Rialon Guevara Pediatric Surgery Fellowship, Hospital for Sick Children

Pediatric Surgery Fellowship, Hospital for Sick Children

Jennifer Hanna Cardiothoracic Surgery Fellowship, Duke University Medical Center


Georgios Kokosis Plastic & Reconstructive Surgery Fellowship, Johns Hopkins

Plastic & Reconstructive Surgery Fellowship, Johns Hopkins

Michael Lidsky Surgical Oncology Fellowship, Memorial Sloan Kettering Cancer Center

Surgical Oncology Fellowship, Memorial Sloan Kettering Cancer Center

Kevin Southerland Vascular Surgery Fellowship, Duke University Medical Center

Vascular Surgery Fellowship, Duke University Medical Center

RESIDENTS

31

Positions of Chief Residents of Surgery (continued)

2015


Nicholas Andersen Cardiothoracic Surgery Fellowship, Duke University Medical Center


Michael Barfield Critical Care Fellowship, Duke University Medical Center

Vascular Surgery Fellowship, New York University

Georgia Beasley Surgical Oncology Fellowship, Ohio State Medical Center

Surgical Oncology Fellowship, Ohio State Medical Center

Marcus Darrabie Surgical Research Fellowship, Duke University Medical Center

Critical Care Fellowship, University of Florida

David Lo Plastic Surgery Fellowship, Emory University Medical Center

Plastic Surgery Fellowship, Emory University Medical Center

Lindsay Talbot Critical Care Fellowship, Nationwide Children's Hospital

Pediatric Surgery Fellowship, University of Chicago

Ryan Turley Vascular Surgery Fellowship, Duke University Medical Center

Vascular Surgery Fellowship, Duke University Medical Center

2014


Andrew Barbas Transplant Surgery Fellow-ship, University of Toronto

Assistant Professor of Surgery, Duke University Medical Center

Syamal Bhattacharya Pediatric Surgery Fellowship, Vanderbilt University Medical Center

Assistant Professor of Surgery, UT College of Medicine

RESIDENTS

32

2014


Asad Shah Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private Practice, REX Cardiac Surgical Specialists

Robert Smith Vascular Surgery Fellowship, University of Alabama

Clinical Assistant Professor, Scott and White Memorial Hospital Associate Program Director, Vascular Surgery Fellowship Texas A&M College of Medicine

Judson Williams Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private Practice, WakeMed Heart Center

Giorgio Zanotti Cardiothoracic Surgery Fellowship, University of Colorado

Cardiothoracic Surgery Fellowship, University of Colorado

2013


Kyla Bennett Vascular Surgery Fellowship, Duke University

Assistant Professor, University of Wisconsin School of Medicine and Public Health

Nicole DeRosa Surgical Oncology Fellowship, MD Anderson, TX

Assistant Professor of Surgery, University of Nebraska Medical Center

Dawn Elfenbein Endocrine Fellowship, Madison, WI

Clinical Instructor, University of Wisconsin

Sarah Evans Plastic Surgery Fellowship, University of Cincinnati

Assistant Professor of Surgery, St. Peter’s Hospital


RESIDENTS

33

2013


Keri Lunsford Abdominal Transplant Fellowship, UCLA Medical Center

Clinical Instructor, UCLA Medical Center

Vanessa Schroder Critical Care Fellowship, Duke University Medical Center


2012


Melissa Danko Pediatric Surgery Fellowship, Vanderbilt University

Assistant Professor of Surgery, Vanderbilt University

Sapan Desai Vascular Surgery Fellowship, UT Houston

Assistant Professor of Surgery, Southern Illinois University; Director of the Quality Alli-ance and Predictive Analysis, Memorial Medical Center; Chief Executive Officer, Surgisphere Corporation

Loretta Erhunmwunsee


Assistant Professor of Surgery, City of Hope Cancer Center

Sean Lee Minimally Invasive Surgery Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Medical College of Georgia

James Padussis Minimally Invasive Surgery Fellowship, Duke University Medical Center

Assistant Professor of Surgery, University of Nebraska Medi-cal Center

Elisabeth Tomlinson-Tracy

Pediatric Surgery Fellowship, Boston Children's Hospital


Nestor Villamizar Thoracic Surgery Fellowship, Brigham & Women's Hospital

Assistant Professor of Surgery, University of Miami Hospital


RESIDENTS

34

2011


Mani Daneshmand Cardiothoracic Surgery Fellowship, Duke University Medical Center


Diana Diesen Pediatric Surgery Fellowship, UT Southwestern

Assistant Professor of Surgery, UT Southwestern Medical Center

John Haney Cardiothoracic Surgery Fellowship, Duke University Medical Center


Kelley Hutcheson Cardiothoracic Surgery Fellowship, Washington University

Assistant Professor of Surgery, Baylor University Medical Center

Luigi Pascarella Vascular Surgery Fellowship, Duke University Medical Center

Assistant Professor of Surgery, University of Iowa

Immanuel Turner Cardiothoracic Surgery Fellow-ship, University of Michigan

Assistant Professor of Surgery, Carolinas Medical Center

Brian Untch Surgical Oncology Fellowship, Memorial Sloan-Kettering Cancer Center

Assistant Professor of Surgery, Memorial Sloan-Kettering Cancer Center

2010


Keki Balsara Critical Care Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Washington University School of Medicine in St. Louis

Errol Bush Cardiothoracic Surgery Fellowship, UCSF

Assistant Professor of Surgery, UCSF

Eugene Ceppa Minimally Invasive Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Indiana University


RESIDENTS

35

2010


Sebastian de la Fuente

Surgical Oncology Fellowship, Moffitt Cancer Center

Physician Research Coordinator and Director of Research of the General Surgery Residency Program, Florida Hospital, Orlando; Assistant Professor of Surgery, University of Central Florida and Florida State University

Jeffrey Nienaber Vascular Surgery Fellowship, Mayo Clinic (Rochester)

Attending Surgeon, Asheville VA Medical Center

Srinevas Reddy Surgical Oncology Fellowship, University of Pittsburgh

Assistant Professor of Surgery, University of Maryland

Tamarah Westmoreland

Pediatric Surgical Oncology Fellowship, St. Jude Hospital (Memphis)

Assistant Professor of Surgery, Nemours Children's Hospital, FL

2009


Brian Lima Cardiothoracic Surgery Fellowship, Cleveland Clinic

Assistant Professor of Surgery, Baylor University Medical Center

Vanessa Olcese Abdominal Transplant Fellow-ship, University ol Wisconsin

Assistant Professor of Surgery, Ohio State University

Mayur Patel Surgical Critical Care and Acute Care Surgery Fellow, Vanderbilt Medical Center

Assistant Professor of Surgery; Assistant Professor of Neu-rological Surgery, Vanderbilt University

Rebecca Prince-Petersen

Minimally Invasive Surgery Fellowship, University of Washington, Seattle

Assistant Professor of Surgery, University of Washington


RESIDENTS

36

2009


Keshava Rajagopal Cardiothoracic Surgery Fellowship, Duke University Medical Center

Assistant Professor of Surgery, University of Maryland

Jacob Schroder Cardiothoracic Surgery Fellowship, Duke University Medical Center


Jin Yoo MIS/Bariatric Fellowship, Duke University Medical Center


David Sindram HPB Surgery Fellowship, Carolinas Medical Center

Faculty, Carolinas Medical Center

2008


James Appel Plastic Surgery Fellowship, Vanderbilt Medical Center

Private Practice, Calabretta Cosmetic Surgery, Charlotte, NC

Matthew Hartwig Cardiothoracic Fellowship, Duke University Medical Center


Erich Huang Assistant Professor of Surgery, Duke University Medical Center

Adjunct Assistant Professor, Duke University, Director of Cancer Research, Sage Bionetworks, Seattle, WA

Anthony Lemaire Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Robert Wood Johnson University Hospital

Mimi Pham Cardiothoracic Fellowship, Duke University Medical Center



RESIDENTS

37

2008


Jose Trani Vascular Surgery Fellowship, University of North Carolina at Chapel Hill

Assistant Professor of Surgery, Cooper University Health System, Philadelphia, PA/ Camden, NJ

2007


Jennifer H. Aldrink Pediatric Surgery Fellowship, Columbus Children's Hospital

Assistant Professor of Surgery, Nationwide Children's Hospital, Columbus, OH

Edward Cantu Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Surgery, University of Pennsylvania

Denise Ching Surgical Oncology Fellowship, MD Anderson Cancer Center

Palo Alto Medical Foundation/Sutter Medical Network

Steve Hanish Abdominal Transplant Fellowship, University of Wisconsin

Associate Professor of Surgery, University of Maryland Medical Center

Jonathan Hata MIS Fellowship, Duke Univer-sity Medical Center

Private Practice, Hickory Surgical Clinic, NC

Melissa Poh Plastic Surgery Fellowship, Vanderbilt Medical Center

Private Practice, Los Angeles, CA

Joseph Turek Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor, Cardiotho-racic Surgery, University of Iowa


RESIDENTS

38

2006


Kelli Brooks Trauma/Critical Care Fellowship, Duke University Medical Center


Elizabeth Grubbs Surgical Oncology Fellowship, MD And Anderson Cancer Center

Assistant Professor of Surgery, MD Anderson Cancer Center

Aftab Kherani Consultant, McKinsey & Company, New York

Principal of Aisling Capital Group

Jason Petrofski Colorectal Fellowship, Cleveland Clinic

Private Practice, Atlanta Colon and Rectal Surgery

Shiva Sarraf-Yazdi Instructor and Clinical Fellow, Duke-National University of Singapore

Assistant Dean of Recruitment and Admissions, Assistant Professor, Duke NUS

Richard Thompson Cardiothoracic Surgery Fellow-ship, UVA, Charlottesville, VA

Faculty, Bryan Health, NE

2005


Jeffrey Gaca Cardiothoracic Fellowship, Duke University Medical Center


Matthew Kalady Colorectal Fellowship, Cleveland Clinic

Assistant Professor of Surgery, Cleveland Clinic, among other appointments

Jamie Nathan Pediatric Surgery Fellowship, Cincinnati Children’s Hospital

Assistant Professor of Surgery, Director of Intestinal Trans-plantation Program, University of Cincinnati


RESIDENTS

39

2005


Shawn Safford United States Navy Assistant Professor of Surgery, Penn State, Milton S. Hershey Medical Center

John Scarborough Abdominal Transplant Fellow-ship, Duke University Medical Center

Associate Professor of Surgery, University of Wisconsin School of Medicine and Public Health

Rebekah White Surgical Oncology Fellowship, Memorial Sloan-Kettering Cancer Center

Associate Professor of Surgery, Duke University Medical Center

2004


Rolf Barth Abdominal Transplant Fellowship, University of Wisconsin

Associate Professor of Surgery, University of Maryland Medical Center

Patrick Domkowski Private practice, Palm Bay, FL Private Practice, Sebastian River Medical Center, Sebastian, FL

Sitaram Emani Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Children’s Hospital Boston

Jay Lee Cardiothoracic Fellowship, Brigham & Women’s Hospital

Associate Professor of Sur-gery, Chief of Thoracic Surgery, UCLA Medical Center

Mark Onaitis Cardiothoracic Fellowship, Duke University Medical Center


Gretchen Purcell Pediatric Surgery Fellowship, Children’s Hospital of Pittsburgh

Assistant Professor of Surgery, Vanderbilt University

Christopher Touloukian


Associate Professor of Surgery, Indiana University


RESIDENTS

40

2003


Thomas Aloia Surgical Oncology Fellowship, MD Anderson Cancer Center

Associate Professor of Surgery, MD Anderson

Shankha Biswas Cardiothoracic Fellowship, Duke University Medical Center

Private Practice, Partner, Synergy CT Surgery Partner-ship, Riverside, CA

G. Gonzalez- Stawinski

Cardiothoracic Fellowship, Cleveland Clinic

Chief of Heart Transplantation and MCS, Baylor University Medical Center-Dallas

G. Robert Stephenson

Abdominal Transplant Fellow-ship, University of Pennsylvania

Private Practice, Texas Health Care PLLC, Ft. Worth, TX

David White Cardiothoracic Fellowship, Duke University Medical Center


2002


B. Zane Atkins United States Air Force/ Cardiothoracic Fellowship Duke University

Clinical Assistant Professor of Surgery, UC Davis Medical Center; Chief of CT Surgery, USAF David Grant Medical Center

G. Chad Hughes Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Surgery and Director, Aortic Surgery Program, Duke University Medical Center

Christine Lau Cardiothoracic Fellowship, Washington University

Associate Professor of Surgery and Director Lung Transplant Program, University of Virginia

Kendra Merine Vascular Surgery Fellowship, Washington Hospital Center

Private practice, Miramar, FL


RESIDENTS

41

2002


Paul Mosca Assistant Professor of Surgery, Duke University Medical Center

Associate Professor of Surgery, Duke University Medical Center; Vice Chair, General Surgery Network

Aurora Pryor MIS Fellowship, Duke Univer-sity Medical Center

Professor of Surgery and Vice Chair for Clinical Affairs, Chief General Surgery Division, Director Bariatric and Meta-bolic Weight Loss Center, Stony Brook School of Medicine

Ashish Shah Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Surgery, Surgical Director of Heart and Lung Transplant, and Associate Director of Cardiac Surgery, The Johns Hopkins Hospital

2001


William Burfeind Cardiothoracic Fellowship, Duke University Medical Center

Chief of Thoracic Surgery, St. Luke’s Health Network

Paul Chai Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Clinical Surgery, Columbia University Medical Center

Lisa Clark Pickett Assistant Professor of Surgery, Duke University Medical Center

Assistant Professor of Surgery, Assistant Professor of Medicine and Chief Medical Officer, Duke University Medical Center

Pierre Dematos Private practice, Asheville, NC Private practice, Regional Sur-gical Specialists, Asheville, NC


RESIDENTS

42

2001


Thomas Hayward Trauma/Critical Care Fellow-ship, Maryland Shock Trauma


Shu Lin Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Surgery, Associate Professor in Pathol-ogy and Assistant Professor in Immunology, Duke University Medical Center

John Maurice Cardiothoracic Fellowship, Duke University Medical Center

Private practice, Newport Beach, CA

Kirsten Wilkins Colorectal Fellowship, UMDNJ–Robert Wood Johnson Hospital

Private practice, New Jersey

2000


Shabab Akhter Cardiothoracic Fellowship, University of Michigan

Professor of Surgery and Chairman Division of Cardio-thoracic Surgery, University of Wisconsin

Larkin Daniels Cardiothoracic Fellowship, Duke University Medical Center

Private practice, Cardio- Thoracic and Vascular Surgical Associates, Mobile, AB

Kimberly Gandy Cardiothoracic Fellowship, Duke University Medical Center

Adjunct Associate Profes-sor, Biomedical and Health Informatics, UMKC; Associate Clinical Professor, Pediatrics, Medical College of Wiscon-sin; Founder and CEO, Play-it Health; CMO, Infusion Express

Cleveland Lewis Jr. Cardiothoracic Fellowship, Duke University Medical Center

Private practice, Hudson Valley Thoracic Associates, NY


RESIDENTS

43

2000


Andrew Lodge Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Sur-gery and Associate Professor of Pediatrics, Duke University Medical Center

Alan Kypson Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Surgery, East Carolina University Brody School of Medicine

Robert Noone Colorectal Fellowship, Cleveland Clinic

Private practice, Main Line Health, Wynnewood PA

1999


R. Eric Lilly Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Surgery, Medical College of Wisconsin

James St. Louis Cardiothoracic Fellowship, Duke University Medical Center

Co-Director, Division of Pediatric Cardiology; Associate Profes-sor, Division of Cardiothoracic Surgery; Aldo Castaneda Profes-sorship in Congenital Heart Sur-gery, University of Minnesota

Christopher Suhr Private practice, Aiken, SC Private practice, Onslow Surgical Clinic, Jacksonville, NC

Bryan Weidner Surgical Critical Care Fellowship, Duke University Medical Center

Chief of Pediatric Surgery and Surgeon-in-Chief, Children’s Hospital at Sacred Heart, Pensacola, FL

Jeffrey H. Lawson Vascular Surgery Fellowship, Duke Univerisity Medical Center

Professor of Surgery, Profes-sor in Pathology, and Program Director for Surgery Research, Duke University Medical Center


RESIDENTS

44

1999


Charles Hoopes Cardiothoracic Fellowship, Uni-versity of Michigan

Associate Professor of Surgery, Jason Alexander Gill Professor in Thoracic Surgery, Section Chief Cardiopulmonary Trans-plant, Director Heart Mechani-cal Circulator Support, and Director Comprehensive Trans-plant Institute, University of Kentucky College of Medicine

1998


Scott C. Silvestry Cardiothoracic Fellowship, Duke University Medical Center

Associate Professor of Surgery, Division of CT Surgery, Wash-ington University, St. Louis, MO

R. Anthony Perez-Tamayo

Surgical Critical Care Fellowship, Duke University Medical Center

Associate Professor of Sur-gery, Associate Program Direc-tor, Rush University; Senior Attending, Stroger Hospital of Cook County (former Chief of CT 2006–2012); Associate Professor of Surgery, Loyola University, Chicago, IL

Adrian H. Cotterell Transplantation Surgery Fel-lowship, University of Miami/Jackson Memorial Hospital

Associate Professor of Surgery, Division of Transplant Surgery, Virginia Commonwealth University Health System

Louis DiBernardo Cardiothoracic Fellowship, Duke University Medical Center

Assistant Professor of Pathology, Duke University Medical Center


RESIDENTS

45

1998


Paul Kirshbom Cardiothoracic Surgery Fellowship, Duke University Medical Center

Professor of Surgery and Chief Pediatric Cardiac Surgery, Yale School of Medicine

Christopher Mantyh Colorectal Surgery Fellowship, Cleveland Clinic Foundation

Professor of Surgery and Chief of Gastrointestinal and Colorectal Surgery, Duke University Medical Center

Bryan Clary Surgical Oncology Fellowship, Memorial Sloan Kettering Cancer Center

Professor and Chair of the Department of Surgery, M.J. Orloff Family Endowed Chair in Surgery, Surgeon-in-Chief , UC San Diego Health System

1997


Carmelo Milano Cardiothoracic Surgery Fellowship, Duke University Medical Center

Professor of Surgery and Surgi-cal Director of Cardiac Trans-plant and LVAD Programs, Duke University Medical Center

Scott H. Pruitt Assistant Professor of Surgery, Duke University Medical Center

Senior Principal Scientist, Merck Research Labs

Lynne Skaryak Cardiothoracic Surgery Fellowship, Duke University Medical Center

Attending Surgeon, Medstar Georgetown University Hospital, Baltimore, MD

Harmuth Bittner Cardiothoracic Surgery Fellowship, Duke University Medical Center

Director of Heart and Lung Transplantation, Florida Hospital, Orlando, FL


RESIDENTS

46

1997


Bradley H. Collins Transplant Surgery Fellowship, University of Wisconsin Hospital and Clinics


Mark Davies Vascular Surgery Fellowship, University of Washington

Professor of Surgery, Vice Chairman of Cardiovascular Surgery, The Methodist Hospital; Associate Quality Officer, The Methodist Hospital System, Houston, TX

Joseph M. Forbess Cardiothoracic Surgery Fellowship, Duke University Medical Center

Professor of Surgery and Chairman of the Division of Pediatric Cardiothoracic Surgery, UT Southwestern Medical Center; Co-Director of the Heart Center, Children’s Medical Center Dallas; Pogue Distinguished Chair in Pediatric Cardiac Surgery Research

1996


Cary H. Meyer Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private practice, Cardiovascular Associates, Kingsport, TN

Clarence H. Owen Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private practice, Triad Cardiac and Thoracic Surgery, Greensboro, NC

Jeffrey C. Pence Cardiothoracic Surgery Fellowship, Duke University Medical Center

Associate Professor of Sur-gery and Associate Residency Program Director, Childrens Medical Center of Dayton, OH


RESIDENTS

47

1996


Christina Weltz Assistant Professor of Surgery, Mt. Sinai School of Medicine, NY

Mark Tedder Cardiothoracic Surgery Fellowship, Duke University Medical Center

Attending, St. Thomas Health, Nashville TN; Private practice, Cardiovascular Associates, Nashville, TN

Mark Anstadt Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private practice, Miami Valley Heart & Lung Surgeons; Holds voluntary faculty positions at Boonshoft School of Medicine, Wright State, OH; Formerly Professor of Surgery, Associate Professor of Pharmacology and Toxicology, Chair of CT Surgery, and Vice Chair of Department of Surgery)

Ravi Chari Hepatobiliary and Abdominal Transplant Fellowship, University of Toronto

Vice President of Clinical Excel-lence, Clinical Services Group, Hospital Corporation of Amer-ica (HCA)

Michael Demaio Cardiothoracic Surgery Fellowship, Duke University Medical Center

Professor of Surgery, Director of the Lung/Heart-Lung Trans-plant Program, and Director of Research, Department of CT Sur-gery, UT Southwestern Medical Center; Founder, Spectral MD

1995


James R. Mault Cardiothoracic Surgery Fellowship, Duke University Medical Center

Vice President and CMO of Qualcomm Life


RESIDENTS

48

1995


David S. Peterseim Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private practice, Charleston, SC

William N. Pugh Private practice Private practice, American Fork Surgical Associates, American Fork, UT

Cemil M. Purut Cardiothoracic Surgery Fellowship, Duke University Medical Center

Private practice, Hickory Heart Lung and Vascular, NC

Paul M. Aheanne Surgical Oncology Fellowship, MD Anderson

Private practice, Regional Surgi-cal Specialists, Asheville, NC

Francis Duhaylongsod


VP and Chief Medical Director, Edwards Lifesciences

Allan D. Kirk Multi-Organ Transplant Fellowship, University of Wisconsin

Chair of Surgery and Surgeon-in-Chief, Duke University Medical Center

Theodore Koutlas Fellowship, Duke University Medical Center

Professor of Surgery, Pediatric Cards, ECU

1994

Name Most Prominent Position

Thomas A. D’Amico Professor of Surgery; Chief, Section of General Thoracic Surgery; Vice Chair of Surgery; and Chief Medical Officer of Duke Cancer Institute, Duke University Medical Center

Andrew Davidoff Chair of Surgery, St. Jude’s Children Research Hospital, Memphis, TN

Stanley A. Gall Jr. Prairie Thoracic and Cardiovascular Surgeons, Prairie Heart Institute, Springfield Illinois


RESIDENTS

49

1994


Jeffrey S. Heinle Pediatric Cardiovascular Surgery, Cook Children’s Medical Center, Fort Worth, TX

Scott H. Johnson Assistant Professor, Department of Surgery, Washington University School of Medicine

Kevin P. Landolfo Assistant Professor of Surgery, Duke University Medical Center

Lewis B. Schwartz Assistant Professor, Section of Vascular Surgery, University of Chicago

Mark W. Sebastian Assistant Professor, Department of Surgery, Duke University Medical Center

1993


Gene D. Branum Assistant Professor, Department of Surgery, Emory University Hospital

Nancy J. Crowley Tolnitch Surgical Associates, Raleigh, NC

Joseph R. Elbeery Assistant Professor of Surgery, Division of Cardiovascular Surgery, East Carolina University School of Medicine

J. Scott Kabas AnMed Health Heart and Vascular Center, Anderson, SC

Theodore C. Koutlas Assistant Professor, Division of Cardiovascular Surgery, East Carolina University School of Medicine

John C. Lucke Assistant Consulting Professor, Duke University Medical Center

Mark D. Plunkett Fellow in Congenital Cardiac Surgery, Division of Cardiothoracic Surgery, UCLA Medical Center

Phillip D. Shadduck Clinical Assistant Professor of Surgery, Duke University Medical Center


RESIDENTS

50

1992


R. Duane Davis Jr. Professor of Surgery, Director Transplant Services, Department of Surgery, Duke University Medical Center

Gregory P. Fontana Assistant Clinical Professor, Department of Thoracic and Cardiovascular Surgery, UCLA School of Medicine

Robert C. Harland Chief of Surgical Immunology and Transplantation, Brody School of Medicine

David H. Harpole Jr. Professor of Surgery, Associate Professor in Pathology, Vice Chief Division of Surgical Sciences, Duke University Medical Center

Douglas A. Tyler Chairman of Surgery, University of Texas Medical Branch

Ronald J. Weigel Assistant Professor of Surgery, Stanford University Medical Center

1991


Louis A. Brunsting Associate Professor, University of Alabama at Birmingham

Robin G. Cummings Medicaid Director, NC Dept. of Health & Human Services

James W. Gaynor Associate Professor of Surgery, Perelman School of Medicine, University of Pennsylvania

Robert L. Quigley Regional Medical Director and Senior Vice President of Medical Assistance, Americas at International SOS

Michael A. Skinner Professor of Surgery, Washington State University

Craig L. Slinghuff Professor of Surgery, University of Virginia School of Medicine

Christopher R. Watters

Clinical Associate, Department of Surgery, Duke University Medical Center


RESIDENTS

51

1990


Thomas D. Christopher

Cardiothoracic Surgical Associates, Richmond, VA

Michael E. Jessen Professor and Chairman of the Department of Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center

James J. Morris Associate Professor of Surgery, University of North Carolina School of Medicine

Charles E. Murphy Assistant Professor of Surgery, Director Cardiothoracic ICU and Stepdown Units, Duke University Medical Center

John A. Spratt Cardiothoracic Surgery of Charleston, Charleston, SC

Bert A. Bowers Sarasota Memorial Hospital, Sarasota, FL

H. Kim Lyerly Professor of Surgery, Assistant Professor in Immunology and Associate Professor of Pathology, Duke University Medical Center

Raymond G. Makhoul

Surgical Associates of Richmond, Richmond, VA

George W. Maier Carolina Cardiovascular & Thoracic Surgery Associates, Gastonia, NC

1989


Ralph H. Damiano Jr. Professor of Surgery and Chief Division of Cardiothoracic Surgery, Washington University School of Medicine

James M. Douglas Jr. Peacehealth Medical Group, Bellingham, WA

Donald D. Glower Jr. Professor of Surgery, Duke University Medical Center

Richard J. Peterson Riverview Cardiac Surgery, FL

Stuart J. Knechtle Distinguished Professor of Surgery, Duke University and Executive Director of the Duke Transplant Center


RESIDENTS

52

1989


S. Chace Lottich Center for Women’s Health, Greenwood, IN

David H. Mahvi Professor of Surgery, President Northwestern Medical Group, Northwestern University

Francis S. Rotolo Finney Trimble Surgical Associates at Greater Baltimore Medical Center

1988


T. Bruce Ferguson East Carolina Heart Institute at ECU, Brody School of Medicine

Richard D. Floyd IV St. Joseph Hospital, Lexington , KY

George S. Tyson Jr. Thoracic Surgeon, St. Petersburg, FL

John F. Lucas III Lucas Surgical Group, Greenwood, MS

Walter B. Vernon SurgOne, P.C., Englewood, CO

1987


William L. Holman Professor of Surgery, University of Alabama at Birmingham; Chief Surgical Services, Birmingham VA Medical Center

Robert B. Peyton Clinical Associate Professor of Surgery, University of North Carolina School of Medicine

Peter K. Smith Professor of Surgery and Division Chief, Cardiovascular and Thoracic Surgery, Duke University Medical Center

Ross M. Ungerleider Professor of Surgery, Wake Forest Baptist Health


RESIDENTS

53

1987


Warren J. Kortz Private practice, Denver, CO

Douglas S. Reintgen Professor of Surgery, Director of Cancer Initiatives, University of South Florida

Laurence H. Ross Finney Trimble Surgical Associates at Greater Baltimore Medical Center

1986


Gary K. Lofland Children’s Mercy Hospitals and Clinic, Kansas City, MO

J. Mark Williams Chairman, Department of Cardiovascular Sciences, East Carolina Heart Institute at ECU

Craig O. Olsen Cardiovascular & Chest Surgical Associates, Boise, ID

Peter Van Trigt III Triad Cardiac & Thoracic Surgeons, Greensboro, NC

Stephen K. Rerych Pleasant Valley Hospital, Point Pleasant, WV

Thomas L. Novick Southeast Surgical Specialists, Charlotte, NC

1984


Robert L.R. Wesly North Florida Regional Med Ctr, Gainesville, FL

L. George Alexander Locums Physician, Catawba Piedmont Cardiovascular and Thoracic Surgery, Rock Hill, SC

Walter R. Chitwood Jr. Director, East Carolina Heart Institute; Senior Associate Vice Chancellor for Health Sciences, Brody School of Medicine


RESIDENTS

54

1984


Richard A. Hopkins Endowed Chair in Pediatric Surgery Research and Director, Cardiac Regenerative Surgery Research Laboratories, Children’s Mercy Kansas City

J. Dirk Iglehart Director, Susan F. Smith Center for Women’s Cancers, Dana-Farber Cancer Institute

Erle H. Austin III Professor of Surgery, University of Louisville School of Medicine

James D. Sink Professor of Surgery, Allegheny University of the Health Sciences, Philadelphia, PA

Ronald C. Hill VA Medical Hospital, Asheville, NC

Robert N. Jones MidMichigan Physicians Group, Midland, MI

Peter M. Thurlow Associated Physicians, Madison, WI

Bruce D. Schirmer Professor of Surgery and Vice Chair, Department of Surgery, University of Virginia School of Medicine

1983


Lary A. Robinson Director, Division of Cardiovascular and Thoracic Surgery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Peter Scholz Professor of Surgery, Robert Wood Johnson Medical School

Jon F. Moran ECU Physician, Thoracic Surgery, Brody School of Medicine

Thomas L. Spray Chief, Division of Cardiothoracic Surgery, Endowed Chair in Pediatric Cardiothoracic Surgery, The Children’s Hospital of Philadelphia

Charles E. Cox CEO, Breast Health CRISP (Clinical and Research Integrated Strategic Program); McCann Foundation Endowed Professor of Breast Surgery, USF Health, Tampa, FL


RESIDENTS

55

1983


Richard L. McCann Professor of Surgery, Duke University Medical Center; Assistant Chief of Surgery, Veterans Administration Medical Center

William C. Meyers Founder, Vincera Institute, Philadelphia, PA

Arthur J. Ross III Dean, West Virginia University School of Medicine

1980


John C. Alexander Professor of Clinical Surgery, University of Chicago

Stephen A. Mills Associate Professor of Surgery, University of North Carolina School of Medicine

Norman A. Silverman Henry Ford Health System, Detroit, MI

R. Randal Bollinger Professor of Surgery, Duke University Medical Center (Retired)

R. Morton Bolman Professor of Surgery, Harvard Medical School

George A. Parker Commonwealth Surgeons, Richmond, VA

James E. Lowe Professor of Surgery and Professor of Pathology, Duke University Medical Center

W. Robins Howe Founder, Director Cardiac Surgery Program, Western Baptist Hospital, Paducah, KY; Clinical Faculty, University of Louisville & University of Kentucky

J. Scott Rankin Associate Clinical Professor, Vanderbilt University Medical Center

Walter D. Holder Jr. Polyclinic, Seattle, WA

Richard M. Larson Clinical Associate Professor, East Carolina University

Charles H. Edwards II Hawthorne Cardiovascular Surgeons, Charlotte, NC


RESIDENTS

56

1980


W. Peter Graper Sarasota Cardiovascular-Thoracic, Sarasota, FL

Thomas H. Marsicano Cardiac surgeon, Savannah, GA

John B. Hanks Professor of Surgery, University of Virginia School of Medicine

Jeffrey A. Norton Professor of Surgery and Chief of Oncologic and General Surgery, Stanford University

Worthington G. Schenk III

Professor of Surgery, University of Virginia School of Medicine

1979


Lynn H. Harrison Professor and Chief, Cardiothoracic Surgery, University of Massachusetts Medical School

Wiliam C. DeVries Clinical Professor of Surgery, George Washington School of Medicine and Health Sciences

Dana K. Anderson Professor and Vice-Chair of Surgery, Johns Hopkins; Surgeon-in-Chief, Johns Hopkins-Bayview Medical Center

George S. Leight Jr. Professor of Surgery, Duke University Medical Center

Bruce M. Smith Associate Professor of Surgery, Georgetown University School of Medicine

1978


James L. Cox Chairman and Chief Executive Officer, World Heart Foundation; Emeri-tus Professor of Surgery, Washington University School of Medicine


RESIDENTS

57

1978


John W. Hammon Professor of Surgery, Wake Forest University School of Medicine

John P. Grant Professor of Surgery and Director of the Bariatric Surgery Pro-gram, Duke University Medical Center

Gregory S. Georgiade Professor of Surgery, Chief of Division of Plastic Surgery, and Vice Chair of Department of Surgery, Duke University Medical Center

David K. Wellman Chief Medical Officer, United Emergency Services, Durham, NC

1977


Kent W. Jones Clinical Professor of Surgery, University of Utah; Surgeon, Intermountain Healthcare and Intermountain Medical Center

Roger C. Millar Intermountain Cardiovascular, St. George, UT

William R. Beltz Susquehanna Health Wound Healing Center, Williamsport, PA

Richard A. Perryman Chief of Cardiac Surgical Service, Memorial Healthcare System, Hollywood, FL

1976


Fred A. Crawford Jr. Distinguished University Professor, Medical University of South Carolina

M. Wayne Flye Chief, Thoracic Surgery, St. Louis Veterans Administration Hospital; Chief of Surgery, Saint Louis Connect Care Health Systems

John W. Yarbrough Thoracic Cardiovascular Assoc, Columbia , SC

Lewis H. Stocks III Stocks Surgical Center, Raleigh, NC


RESIDENTS

58

1976


Robert P. Barnes Department Chair, Cardiovascular Services, St. Luke’s Hospital, Boise, ID

Richard O. Gregory Private practice, plastic surgery, Orlando, FL

1975


Thomas M. Daniel Chief, Section of General Thoracic Surgery, University of Virginia

Robert H. Jones Professor of Surgery, Duke University Medical Center

1974


James A. Alexander Professor of Surgery, University of Florida College of Medicine

Andrew S. Wechsler Professor of Surgery, Drexel University College of Medicine

Kenneth P. Ramming Professor of Surgery, UCLA

1973


Sewell H. Dixon President & CEO, St. Kitts Medical, Inc.

S. Kirby Orme Cardiovascular & Chest Surgical Associates, Boise, ID

James C.A. Fuchs Union Memorial Hospital, Baltimore, MD

Bradley M. Rogers Primary Care Center, Charlottesville, VA


RESIDENTS

59

1972


Don E. Detmer University Professor of Health Policy Emeritus and Professor of Medical Education, University of Virginia

1971


C. Linwood Puckett University of Missouri Health System, Columbia, MO

Robert E. Cline President of Cline Cardiovascular Associates, FL

William A. Gay Jr. Professor Emeritus of Surgery, Washington University School of Medicine

Robert W. Anderson Chairman of Surgery, Duke University Medical Center

Walter G. Wolfe Professor of Surgery, Duke University Medical Center; Chief of Thoracic Surgery, VA Medical Center

1970


H. Newland Oldham Jr. Professor of Surgery, Duke University Medical Center (Retired)

John M. Porter Chief of Vascular Surgery, University of Oregon

Samuel A Wells Jr. Chairman of Surgery, Washington University


RESIDENTS

60

Chief Resident Profiles

Hamza Aziz, MD

Education: MD, Duke University School of Medicine, 2010

Training: General Surgery (PGY1), 6/24/2010-6/30/2011 General Surgery (PGY2), 7/1/2011-6/30/2012 Surgery Research Fellowship – Duke (PGY3), 7/1/2012-7/31/2012 Surgery Research Fellowship – Johns Hopkins (PGY3), 8/1/2012-6/30/2013 Surgery Research Fellowship – Johns Hopkins (PGY4), 7/1/2013-6/30/2014 General Surgery (PGY5), 7/1/2014-6/30/2015 General Surgery (PGY6), 7/1/2015-6/30/2016 General Surgery (PGY7), 7/1/2016-Present Research Interests: Genetic etiologies of ascending aortic aneurysm

Clinical Interests: Cardiothoracic

Publications: Aziz, H., A. Zaas and G. S. Ginsburg. “Peripheral Blood Gene Expression Profiling for Cardiovascular Disease Assessment.” Genomic Med 1, no. 3-4 (2007): 105-12.

Cowen, L. E., S. D. Singh, J. R. Kohler, C. Collins, A. K. Zaas, W. A. Schell, H. Aziz, E. Mylonakis, J. R. Perfect, L. Whitesell and S. Lindquist. “Harnessing Hsp90 Function as a Powerful, Broadly Effective Therapeutic Strategy for Fungal Infectious Disease.” Proc Natl Acad Sci U S A 106, no. 8 (2009): 2818-23.

Zaas, A. K.*, H. Aziz*, J. Lucas, J. R. Perfect and G. S. Ginsburg. “Blood Gene Expression Signatures Predict Invasive Candidiasis.” Sci Transl Med 2, no. 21 (2010): 21ra17. *Co-first Authors

Habashi, J. P., J. J. Doyle, T. M. Holm, H. Aziz, F. Schoenhoff, D. Bedja, Y. Chen, A. N. Modiri, D. P. Judge and H. C. Dietz. “Angiotensin Ii Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice through Erk Antagonism.” Science 332, no. 6027 (2011): 361-5.

Gould, R. A., R. Sinha, H. Aziz, R. Rouf, H. C. Dietz, 3rd, D. P. Judge and J. Butcher. “Multi-Scale Biomechanical Remodeling in Aging and Genetic Mutant Murine Mitral Valve Leaflets: Insights into Marfan Syndrome.” PLoS One 7, no. 9 (2012): e44639.

Hanna, J. M., N. D. Andersen, H. Aziz, A. A. Shah, R. L. McCann and G. C. Hughes. “Results with Selective Preoperative Lumbar Drain Placement for Thoracic Endovascular Aortic Repair.” Ann Thorac Surg 95, no. 6 (2013): 1968-74; discussion 1974-5.

RESIDENTS

61

Speicher, P. J., S. D. Bhattacharya, H. Aziz and K. M. Baerman. “Septic Thrombophlebitis of the Superior Mesenteric Vein: An Unusual Complica-tion of Appendicitis.” Am Surg 79, no. 1 (2013): E31-2.

Adam, M. A., L. M. Lee, J. Kim, M. Shenoi, M. Mallipeddi, H. Aziz, S. Stinnett, Z. Sun, C. R. Mantyh and J. K. Thacker. “Alvimopan Provides Addi-tional Improvement in Outcomes and Cost Savings in Enhanced Recovery Colorectal Surgery.” Ann Surg, (2015).

Aziz, H., P. K. Marcom and E. S. Hwang. “Implications of Her2-Targeted Therapy on Extent of Surgery for Early-Stage Breast Cancer.” Ann Surg Oncol 22, no. 5 (2015): 1404-5.

Bennett, C. L., H. Aziz, E. Sparks, T. Shah, M. Yoder, G. MacCarrick and H. C. Dietz. “Massive Hemoptysis in Loeys-Dietz Syndrome.” Am J Med Genet A, (2015).

Aziz H, Scheri R, Baker J, Hwang ES (2015) “Use of Radioactive Seed to Localize Axillary Lymph Node in Breast Cancer.” Surgery Curr Res 5:236. doi: 10.4172/2161-1076.1000236

Brian Englum, MD

Education: MD, Johns Hopkins University School of Medicine, 2010

Training: General Surgery (PGY1), 6/24/2010-6/30/2011 General Surgery (PGY2), 7/1/2011-6/30/2012 Surgery Research Fellowship (PGY3), 7/1/2012-6/30/2013 Surgery Research Fellowship (PGY4), 7/1/2013-6/30/2014 General Surgery (PGY5), 7/1/2014-6/30/2015 General Surgery (PGY6), 7/1/2015-6/30/2016 General Surgery (PGY7), 7/1/2016-Present

Research Interests: Pediatric surgery; pediatric surgical oncology; variation in care; pragmatic clinical trials

Clinical Interests: Pediatric surgery; pediatric surgical oncology; congenital anomalies

Publications: Englum BR, Villegas C, Bolorunduro O, Haut ER, Cornwell EE, 3rd, Efron DT, Haider AH. Racial, ethnic, and insurance status disparities in use of posthospitalization care after trauma. Journal of the American College of Surgeons 2011:213(6):699-708.

Chief Resident Profiles (continued)

RESIDENTS

62

Englum BR, Andersen ND, Husain AM, Mathew JP, Hughes GC. Degree of hypothermia in aortic arch surgery - optimal temperature for cerebral and spinal protection: deep hypothermia remains the gold standard in the absence of randomized data. Annals of cardiothoracic surgery 2013:2(2):184-93.

Tracy ET, Englum BR, Barbas AS, Foley C, Rice HE, Shapiro ML. Pediatric injury patterns by year of age. Journal of pediatric surgery 2013:48(6):1384-8.

Englum BR, Hopkins MB, Migaly J. Technical Challenges: Reoperative Sur-gery in Ross, H., Lee, S., Mutch, M., Rivadeneira, D. E., & Steele, S. (Eds.). (2014). Minimally Invasive Approaches to Colon and Rectal Disease: Tech-nique and Best Practices. Springer, 2014.

Caceres M, Ma Y, Rankin JS, Saha-Chaudhuri P, Englum BR, Gammie JS, Suri RM, Thourani VH, Esmailian F, Czer LS, Puskas JD, Svensson LG. Mor-tality characteristics of aortic root surgery in North America. European journal of cardio-thoracic surgery: official journal of the European Associa-tion for Cardio-thoracic Surgery 2014:46(5):887-93.

Crestanello JA, Higgins RS, He X, Saha-Chaudhuri P, Englum BR, Brennan JM, Thourani VH. The association of chronic lung disease with early mor-tality and respiratory adverse events after aortic valve replacement. The Annals of thoracic surgery 2014:98(6):2068-77.

Englum BR, Pavlisko EN, Mack MC, Ganapathi AM, Schechter MA, Hanna JM, Hughes GC. Pseudoaneurysm formation after medtronic freestyle porcine aortic bioprosthesis implantation: a word of caution. The Annals of thoracic surgery 2014:98(6):2061-7.

Ganapathi AM, Englum BR, Hanna JM, Schechter MA, Gaca JG, Hurwitz LM, Hughes GC. Frailty and risk in proximal aortic surgery. The Journal of thoracic and cardiovascular surgery 2014:147(1):186-91.e1.

Ganapathi AM, Englum BR, Schechter MA, Vavalle JP, Harrison JK, McCann RL, Hughes GC. Role of cardiac evaluation before thoracic endovascular aortic repair. Journal of vascular surgery 2014:60(5):1196-203.

Ganapathi AM, Hanna JM, Schechter MA, Englum BR, Castleberry AW, Gaca JG, Hughes GC. Antegrade versus retrograde cerebral perfusion for hemiarch replacement with deep hypothermic circulatory arrest: does it matter? A propensity-matched analysis. The Journal of thoracic and cardio-vascular surgery 2014:148(6):2896-902.

Ganapathi AM, Speicher PJ, Castleberry AW, Englum BR, Osho AA, Davis RD, Hartwig MG. The effect of prior pneumonectomy or lobec-tomy on subsequent lung transplantation. The Annals of thoracic surgery 2014:98(6):1922-8; discussion 8-9.

Ganapathi AM, Speicher PJ, Englum BR, Castleberry AW, Migaly J, Hsu DS,


RESIDENTS

63

Mantyh CR. Adjuvant chemotherapy for t1 node-positive colon cancers provides significant survival benefit. Diseases of the colon and rectum 2014:57(12):1341-8.

Greason KL, Kim S, Suri RM, Wallace AS, Englum BR. Hypothermia and operative mortality during on-pump coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery 2014:148(6):2712-8.

Hess CN, Lopes RD, Gibson CM, Hager R, Wojdyla DM, Englum BR, Mack MJ, Califf RM, Kouchoukos NT, Peterson ED, Alexander JH. Saphenous vein graft failure after coronary artery bypass surgery: insights from PRE-VENT IV. Circulation 2014:130(17):1445-51.

Hughes GC, Ganapathi AM, Keenan JE, Englum BR, Hanna JM, Schech-ter MA, Wang H, McCann RL. Thoracic endovascular aortic repair for chronic DeBakey IIIb aortic dissection. The Annals of thoracic surgery 2014:98(6):2092-7; discussion 8.

Speicher PJ, Englum BR, Jiang B, Pietrobon R, Mantyh CR, Migaly J. The impact of laparoscopic versus open approach on reoperation rate after segmental colectomy: a propensity analysis. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 2014:18(2):378-84.

Speicher PJ, Ganapathi AM, Englum BR, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. Induction therapy does not improve survival for clini-cal stage T2N0 esophageal cancer. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 2014:9(8):1195-201.

Speicher PJ, Ganapathi AM, Englum BR, Onaitis MW, D’Amico TA, Berry MF. Survival in the elderly after pneumonectomy for early-stage non-small cell lung cancer: a comparison with nonoperative management. Journal of the American College of Surgeons 2014:218(3):439-49.

Speicher PJ, Ganapathi AM, Englum BR, Vaslef SN. Laparoscopy is safe among patients with congestive heart failure undergoing general surgery procedures. Surgery 2014:156(2):371-8.

Suri RM, Thourani VH, Englum BR, Rankin JS, Badhwar V, Svensson LG, Ailawadi G, Mack MJ, He M, Brennan JM, Schaff HV, Gammie JS. The expanding role of mitral valve repair in triple valve operations: contem-porary North American outcomes in 8,021 patients. The Annals of thoracic surgery 2014:97(5):1513-9; discussion 9.

Castleberry AW, Englum BR, Snyder LD, Worni M, Osho AA, Gulack BC, Palmer SM, Davis RD, Hartwig MG. The utility of preoperative six-minute-walk distance in lung transplantation. American journal of respiratory and critical care medicine 2015:192(7):843-52.


RESIDENTS

64

Englum BR, Ganapathi AM, Hughes GC. Reply: To PMID 25301369. The Annals of thoracic surgery 2015:100(4):1508.

Englum BR, Pura J, Reed SD, Roman SA, Sosa JA, Scheri RP. A bedside risk calculator to preoperatively distinguish follicular thyroid carcinoma from follicular variant of papillary thyroid carcinoma. World journal of surgery 2015:39(12):2928-34.

Englum BR, Rialon KL, Speicher PJ, Gulack B, Driscoll TA, Kreissman SG, Rice HE. Value of surgical resection in children with high-risk neuroblas-toma. Pediatric blood & cancer 2015:62(9):1529-35.

Englum BR, Saha-Chaudhuri P, Shahian DM, O’Brien SM, Brennan JM, Edwards FH, Peterson ED. The impact of high-risk cases on hospitals’ risk-adjusted coronary artery bypass grafting mortality rankings. The Annals of thoracic surgery 2015:99(3):856-62.

Englum BR, Schechter MA, Irish WD, Ravindra KV, Vikraman DS, Sanoff SL, Ellis MJ, Sudan DL, Patel UD. Outcomes in kidney transplant recipients from older living donors. Transplantation 2015:99(2):309-15.

Erhunmwunsee L, Englum BR, Onaitis MW, D’Amico TA, Berry MF. Impact of pretreatment imaging on survival of esophagectomy after induction therapy for esophageal cancer: who should be given the benefit of the doubt?: esophagectomy outcomes of patients with suspicious metastatic lesions. Annals of surgical oncology 2015:22(3):1020-5.

Farjah F, Backhus L, Cheng A, Englum B, Kim S, Saha-Chaudhuri P, Wood DE, Mulligan MS, Varghese TK. Failure to rescue and pulmonary resec-tion for lung cancer. The Journal of thoracic and cardiovascular surgery 2015:149(5):1365-71; discussion 71-3.e3.

Ganapathi AM, Englum BR, Keenan JE, Schechter MA, Wang H, Smith PK, Glower DD, Hughes GC. Long-term survival after bovine pericardial versus porcine stented bioprosthetic aortic valve replacement: does valve choice matter? The Annals of thoracic surgery 2015:100(2):550-9.

Ganapathi AM, Speicher PJ, Englum BR, Perez A, Tyler DS, Zani S. Gangre-nous cholecystitis: a contemporary review. The Journal of surgical research 2015:197(1):18-24.

Gulack BC, Englum BR, Castleberry AW, Daneshmand MA, Smith PK, Per-rault LP. Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data. Annals of cardiothoracic surgery 2015:4(3):266-72.

Gulack BC, Englum BR, Lo DD, Nussbaum DP, Keenan JE, Scarborough JE, Shapiro ML. Leukopenia is associated with worse but not prohibitive outcomes following emergent abdominal surgery. The journal of trauma and acute care surgery 2015:79(3):437-43.


RESIDENTS

65

Gulack BC, Englum BR, Rialon KL, Talbot LJ, Keenan JE, Rice HE, Scarbor-ough JE, Adibe OO. Inequalities in the use of helmets by race and payer status among pediatric cyclists. Surgery 2015:158(2):556-61.

Gulack BC, Schweitzer M, Englum BR, Kuchibhatla M, Prasad VK, Adibe OO. Predictors of gastrostomy placement in children with inherited meta-bolic diseases treated by umbilical cord blood transplantation. Journal of pediatric surgery 2015:50(7):1109-11.

Hess CN, Lopes RD, Gibson CM, Hager R, Wojdyla DM, Englum BR, Mack MJ, Kouchoukos NT, Peterson ED, Alexander JH. Response to letters regarding article, saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV. Circulation 2015:132(4):e29.

Kaneko T, Vassileva CM, Englum B, Kim S, Yammine M, Brennan M, Suri RM, Thourani VH, Jacobs JP, Aranki S. Contemporary outcomes of repeat aortic valve replacement: a benchmark for transcatheter valve-in-valve procedures. The Annals of thoracic surgery 2015:100(4):1298-304; discussion 304.

McCoy CC, Englum BR, Keenan JE, Vaslef SN, Shapiro ML, Scarborough JE. Impact of specific postoperative complications on the outcomes of emergency general surgery patients. The journal of trauma and acute care surgery 2015:78(5):912-8; discussion 8-9.

Nussbaum DP, Speicher PJ, Ganapathi AM, Englum BR, Keenan JE, Man-tyh CR, Migaly J. Laparoscopic versus open low anterior resection for rectal cancer: results from the national cancer data base. Journal of gas-trointestinal surgery: official journal of the Society for Surgery of the Alimen-tary Tract 2015:19(1):124-31; discussion 31-2.

Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Englum BR, Kirsch DG, Tyler DS, Blazer DG, 3rd. Long-term oncologic outcomes after neoad-juvant radiation therapy for retroperitoneal sarcomas. Annals of surgery 2015:262(1):163-70.

Nussbaum DP, Speicher PJ, Gulack BC, Keenan JE, Ganapathi AM, Englum BR, Tyler DS, Blazer DG, 3rd. Management of 1- to 2-cm carcinoid tumors of the appendix: Using the National Cancer Database to address con-troversies in general surgery. Journal of the American College of Surgeons 2015:220(5):894-903.

Rialon KL, Englum BR, Gulack BC, Guevara CJ, Bhattacharya SD, Shapiro ML, Rice HE, Scarborough JE, Adibe OO. Comparative effectiveness of treatment strategies for severe splenic trauma in the pediatric popula-tion. American journal of surgery 2015.

Rialon KL, Gulack BC, Englum BR, Routh JC, Rice HE. Factors impacting survival in children with renal cell carcinoma. Journal of pediatric surgery 2015:50(6):1014-8.


RESIDENTS

66

Rice HE, Englum BR, Gulack BC, Adibe OO, Tracy ET, Kreissman SG, Routh JC. Use of patient registries and administrative datasets for the study of pediatric cancer. Pediatric blood & cancer 2015:62(9):1495-500.

Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. American journal of hematology 2015:90(3):187-92.

Scarborough JE, Bennett KM, Englum BR, Pappas TN, Lagoo-Deenadaya-lan SA. The impact of functional dependency on outcomes after complex general and vascular surgery. Annals of surgery 2015:261(3):432-7.

Speicher PJ, Englum BR, Ganapathi AM, Mulvihill MS, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. Adjuvant chemotherapy is associated with improved survival after esophagectomy without induction therapy for node-positive adenocarcinoma. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 2015:10(1):181-8.

Speicher PJ, Englum BR, Ganapathi AM, Nussbaum DP, Mantyh CR, Migaly J. Robotic low anterior resection for rectal cancer: a national perspective on short-term oncologic outcomes. Annals of surgery 2015:262(6):1040-5.

Speicher PJ, Englum BR, Ganapathi AM, Onaitis MW, D’Amico TA, Berry MF. Outcomes after treatment of 17,378 patients with locally advanced (T3N0-2) non-small-cell lung cancer. European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Sur-gery 2015:47(4):636-41.

Speicher PJ, Ganapathi AM, Englum BR, Gulack BC, Osho AA, Hirji SA, Castleberry AW, Snyder LD, Duane Davis R, Hartwig MG. Single-lung transplantation in the United States: what happens to the other lung? The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015:34(1):36-42.

Speicher PJ, Wang X, Englum BR, Ganapathi AM, Yerokun B, Hartwig MG, D’Amico TA, Berry MF. Induction chemoradiation therapy prior to esopha-gectomy is associated with superior long-term survival for esophageal cancer. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus / ISDE 2015:28(8):788-96.

Englum BR, Ganapathi AM, Schechter MA, Harrison JK, Glower DD, Hughes GC. Changes in risk profile and outcomes of patients undergoing surgical aortic valve replacement from the pre- to post-transcatheter aortic valve replacement eras. The Annals of thoracic surgery 2016:101(1):110-7.


RESIDENTS

67

Englum BR, Ganapathi AM, Speicher PJ, Gulack BC, Snyder LD, Duane Davis R, Hartwig MG. Impact of donor and recipient hepatitis C status in lung transplantation. The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation 2016:35(2):228-35.

Englum BR, Hui X, Zogg CK, Chaudhary MA, Villegas C, Bolorunduro OB, Stevens KA, Haut ER, Cornwell EE, Efron DT, Haider AH. Association between insurance status and hospital length of stay following trauma. The American surgeon 2016:82(3):281-8.

Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Not-tage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE. Hematologic outcomes after total splenec-tomy and partial splenectomy for congenital hemolytic anemia. Journal of pediatric surgery 2016:51(1):122-7.

Gulack BC, Rialon KL, Englum BR, Kim J, Talbot LJ, Adibe OO, Rice HE, Tracy ET. Factors associated with survival in pediatric adrenocortical car-cinoma: An analysis of the National Cancer Data Base (NCDB). Journal of pediatric surgery 2016:51(1):172-7.

Harskamp RE, Alexander JH, Ferguson TB, Jr., Hager R, Mack MJ, Englum B, Wojdyla D, Schulte PJ, Kouchoukos NT, de Winter RJ, Gibson CM, Peter-son ED, Harrington RA, Smith PK, Lopes RD. Frequency and predictors of internal mammary artery graft failure and subsequent clinical outcomes: insights from the project of ex-vivo vein graft engineering via transfection (PREVENT) IV Trial. Circulation 2016:133(2):131-8.

Keenan JE, Wang H, Ganapathi AM, Englum BR, Kale E, Mathew JP, Husain AM, Hughes GC. Electroencephalography during hemiarch replacement with moderate hypothermic circulatory arrest. The Annals of thoracic sur-gery 2016:101(2):631-7.

Scarborough JE, Schumacher J, Pappas TN, McCoy CC, Englum BR, Agar-wal SK, Jr., Greenberg CC. Which complications matter most? Prioritizing quality improvement in emergency general surgery. Journal of the Ameri-can College of Surgeons 2016:222(4):515-24.

Schechter MA, Ganapathi AM, Englum BR, Speicher PJ, Daneshmand MA, Davis RD, Hartwig MG. Spontaneously breathing extracorporeal mem-brane oxygenation support provides the optimal bridge to lung trans-plantation. Transplantation 2016.

Schechter MA, Shah AA, Englum BR, Williams JB, Ganapathi AM, Davies JD, Welsby IJ, Hughes GC. Prolonged postoperative respiratory support


RESIDENTS

68

after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor? Journal of critical care 2016:31(1):125-9.

Speicher PJ, Englum BR, Ganapathi AM, Wang X, Hartwig MG, D’Amico TA, Berry MF. Traveling to a high-volume center is associated with improved survival for patients with esophageal cancer. Annals of surgery 2016. [epub ahead of print]

Schwann TA, Habib RH, Suri RM, Brennan JM, He X, Thourani VH, Engoren M, Ailawadi G, Englum BR, Bonnell MR, Gammie JS. Variation in warfarin use at hospital discharge after isolated bioprosthetic mitral valve replace-ment - an analysis of the society of thoracic surgeons adult cardiac sur-gery database. Chest 2016. [epub ahead of print]

Hartwig MG, Ganapathi AM, Osho AA, Hirji SJ, Englum BR, Speicher PJ, Palmer SM, Davis RD, Snyder LD. Staging of bilateral lung transplantation for high-risk patients with interstitial lung disease: one lung at a time. Am J Transplant 2016. [epub ahead of print]

Harskamp RE, Alexander JH, Ferguson TB, Jr., Hager R, Mack MJ, Englum B, Wojdyla D, Schulte PJ, Kouchoukos NT, de Winter RJ, Gibson CM, Peter-son ED, Harrington RA, Smith PK, Lopes RD. Response to letters regard-ing article, “Frequency and predictors of internal mammary artery graft failure and subsequent clinical outcomes: insights from the project of ex-vivo vein graft engineering via transfection (PREVENT) IV trial”. Circula-tion 2016:133(21):e665.

Kim J, Sun Z, Englum BR, Allori AC, Adibe OO, Rice HE, Tracy ET. Lapa-roscopy is safe in infants and neonates with congenital heart disease: a national study of 3684 patients. J Laparoendosc Adv Surg Tech A 2016. [epub ahead of print]

Englum BR, Gulack BC, Rice HE, Scarborough JE, Adibe OO. Management of blunt pancreatic trauma in children: Review of the National Trauma Data Bank. J Pediatr Surg 2016:51(9):1526-31.

Keenan JE, Wang H, Gulack BC, Ganapathi AM, Andersen ND, Englum BR, Krishnamurthy Y, Levy JH, Welsby IJ, Hughes GC. Does moderate hypo-thermia really carry less bleeding risk than deep hypothermia for circula-tory arrest? A propensity-matched comparison in hemiarch replacement. The Journal of thoracic and cardiovascular surgery 2016.


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Asvin Ganapathi, MD

Education: MD, Case Western Reserve University, 2010

Training: General Surgery (PGY1), 6/24/2010-6/30/2011 General Surgery (PGY2), 7/1/2011-6/30/2012 Surgery Research Fellowship (PGY3), 7/1/2012-6/30/2013 Surgery Research Fellowship (PGY4), 7/1/2013-6/30/2014 General Surgery (PGY5), 7/1/2014-6/30/2015 Jt General Surgery and Thoracic Surgery (PGY6), 7/1/2015-6/30/2016 Jt General Surgery and Thoracic Surgery (PGY7), 7/1/2016-Present

Research Interests: Cardiac bioengineering; animal models of cardiac research; clinical out-comes specific to variations and quality of care

Clinical Interests: Adult cardiac surgery; critical care; therapies for organ failure, specifically mechanical support and transplantation

Publications: Asvin M. Ganapathi, Douglas S. Tyler and Paul J. Mosca (2011). Chal-lenging Problems in the Surgical Management of Melanoma, Current Management of Malignant Melanoma, Ming Y. Cao (Ed.). ISBN: 978-953-307-264-7, InTech

Ganapathi A, McCarron JA, Chen X, Iannotti JP. Predicting Normal Glenoid Version From The Pathologic Scapula: A comparison of 4 methods in 2- and 3-dimensional Models. J Shoulder Elbow Surg 2011; 20:234-44.

Piacentino V, Troupes CD, Ganapathi AM, Blue LJ, Mackensen GB, Swaami-natham M, Felker GM, Stafford-Smith M, Lodge AJ, Rogers JG, Milano CA. Clinical Impact of Concomitant Tricuspid Valve Procedures During Left Ventricular Assist Device Implantation. Ann Thorac Surg 2011; 92:1414-9.

Ganapathi AM, Westmoreland T, Tyler D, Mantyh CR. Bevacizumab-Asso-ciated Fistula Formation in Postoperative Colorectal Cancer Patients. J Am Coll Surg 2012; 214: 582-8.

Ganapathi AM, Piacentino V, Stafford-Smith M, Patel C, Simeone A, Rog-ers JG, Milano CA. Utility of Concomitant Tricuspid Valve Procedures for Patients Undergoing Continuous Flow Left Ventricular Device Implanta-tion. J Thorac Cardiovasc Surg 2012; 144:1217-21

Asvin M. Ganapathi, Sandhya Lagoo (2012). Biliary Anatomy and Anatomi-cal Variants, Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, Dan G Blazer, Paul C Kuo, Theodore Pappas, Bryan Clary (Ed.). ISBN: 978-9814293051, World Scientific Publishing Company.


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Rajagopal, K, Daneshmand MA, Patel CB, Ganapathi AM, Schechter MA, Rogers JG, Milano CA. Natural History and Clinical Effect of Aortic Valve Regurgitation After Left Ventricular Assist Device Implantation. J Thorac Cardiovasc Surg 2013; 145:1373-9.

Ganapathi AM, Andersen ND, Prastein DJ, Hashmi ZA, Rogers JG, Milano CA, McCann RL, Hughes GC. Endovascular Stent Grafting of a Left Ven-tricular Assist Device Outflow Graft Pseudoaneurysm. Circ Heart Fail 2013; 6:e16-18.

Atkins BZ, Hashmi ZA, Ganapathi AM, Harrison JK, Hughes GC, Rogers JG, Milano CA. Surgical Correction of Aortic Valve Insufficiency After Left Ventricular Assist Device Implantation. J Thorac Cardiovasc Surg 2013; 146:1247-52.

Asvin M. Ganapathi, Andrew J. Lodge (2013). Surgical Considerations for Congenital Heart Defects, Caffey’s Pediatric Diagnostic Imaging, 12th Ed, Brian D. Coley (Ed.). ISBN: 000-0323081762, Saunders.

Hanna JM, Andersen ND, Ganapathi AM, McCann RL, Hughes GC. Five-Year Results for Endovascular Repair of Acute Complicated Type B Aortic Dissection. J Vasc Surg 2014; 59:96-106.

Ganapathi AM, Englum BR, Hanna JM, Schechter MA, Gaca JG, Hughes GC. Frailty and Risk in Proximal Aortic Surgery. J Thorac Cardiovasc Surg 2014; 147: 186-191.

Ganapathi AM, Andersen ND, Hanna JM, Gaca JG, McCann RL, Hughes GC. Comparison of Attachment Site Endoleak Rates in Dacron Versus Native Aorta Landing Zones Following Thoracic Endovascular Aortic Repair. J Vasc Surg 2014; 50: 921-9.

Andersen ND, Ganapathi AM, Hanna JM, Williams JB, Gaca JG, Hughes GC. Outcomes of Acute Type A Dissection Repair Before and After Implemen-tation of a Multidisciplinary Thoracic Aortic Surgery Program. J Am Coll Cardiol 2014; 63: 1796-1803.

Speicher PJ, Ganapathi AM, Englum BR, Onaitis MW, D’Amico TA, Berry MF. Survival in the Elderly Following Pneumonectomy for Early Stage Non-Small Cell Lung Cancer: A Comparison with Non-operative Manage-ment. J Am Coll Surg 2014; 218: 439-49.

Andersen ND, Hanna JM, Ganapathi AM, Bhattacharya SD, Williams JB, Gaca JG, McCann RL, Hughes GC. Insurance Status Predicts Acuity of Tho-racic Aortic Operations. J Thorac Cardiovasc Surg 2014. In Press

Osho AA, Castleberry AW, Snyder LD, Ganapathi AM, Palmer SM, Lin SS, Davis RD, Hartwig MG. Determining Eligibility For Lung Transplantation: Should There Be A Minimum Acceptable Glomerular Filtration Rate? Ann Thorac Surg 2014; 98: 283-9.


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Speicher PJ, Ganapathi AM, Englum BR, Vaslef SN. Laparoscopy Is Safe Among Patient with Congestive Heart Failure Undergoing General Sur-gery Procedures. Surgery 2014; 156: 371-8.

Ganapathi AM, Hanna JM, Schechter MA, Englum BR, Gaca JG, Hughes GC. Antegrade Versus Retrograde Cerebral Perfusion for Hemi-Arch Replacement With DHCA: Does it Matter? A Propensity-Matched Analysis. J Thorac and Cardiovasc Surg 2014. In Press

Speicher PJ, Ganapathi AM, Englum BR, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. Induction Therapy Does Not Improve Survival for Clinical Stage T2N0 Esophageal Cancer. J Thorac Oncol 2014; 9: 1195-1201.

Schechter MA, Joseph J, Krishnamoorthy A, Finet JE, Ganapathi AM, Lodge A, Milano C, Patel C. Efficacy and durability of Central Oversewing for Treatment of Aortic Valve Insufficiency in Patients with Continuous Flow Left Ventricular Assist Devices. J Heart Lung Transplant 2014; 33: 937-42.

Ganapathi AM, Englum BR, Schechter MA, Vavalle JP, Harrison JK, McCann RL, Hughes GC. Role of Cardiac Evaluation Prior to Thoracic Endovascular Aortic Repair. J Vasc Surg 2014. In Press

Andersen ND, Keenan JE, Ganapathi AM, Gaca JG, McCann RL, Hughes GC. Current Management and Outcome of Chronic Type B Aortic Dis-section: Results with Open and Endovascular Repair since the Advent of Thoracic Endografting. Ann Cardiothorac Surg 2014;3: 264-74.

Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Englum BR, Kirsch DG, Tyler DS, Blazer DG 3rd. Long-Term Oncologic Outcomes Following Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas. Ann Surg 2014. In Press

Speicher PJ, Englum BR, Ganapathi AM, Onaitis MW, D’Amico TA, Berry MF. Outcomes after treatment of 17,378 patients with locally advanced (T3N0-2) non-small cell lung cancer. Eur J Cardiothorac Surg 2014. In Press

Osho AA, Castleberry AW, Snyder LW, Palmer SM, Ganapathi AM, Hirji S, Lin SS, Davis RD, Hartwig MG. Differential Outcomes with Early and Late Repeat Transplantation in the Era of the Lung Allocation Score. Ann Tho-rac Surg 2014. In Press

Ganapathi AM, Speicher PJ, Castleberry AW, Englum BR, Osho AA, Davis RD, Hartwig MG. The Effect of Prior Pneumonectomy or Lobectomy on Subsequent Lung Transplantation. Ann Thorac Surg 2014. In Press

Hughes GC, Ganapathi AM, Englum BR, Keenan JE, Hanna JM, Schechter MA, Wang H, McCann RL. Thoracic Endovascular Aortic Repair for Chronic DeBakey Type IIIb Aortic Dissection. Ann Thorac Surg 2014. In Press

Englum BR Pavlisko E, Mack M, Ganapathi AM, Schechter MA, Hanna JM, Hughes GC. Catastrophic Immunologic Reaction and Pseudoaneurysm


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Formation After Stentless Porcine Aortic Bioprosthetic Implantation: A Word Of Caution. Ann Thorac Surg 2014. In Press

Nussbaum DP, Speicher PJ, Ganapathi AM, Englum BR, Keenan JE, Man-tyh CR, Migaly J. Laparoscopic Versus Open Low Anterior Resection for Rectal Cancer: Results from the National Cancer Data Base. J Gastrointes Surg 2014; 23: 155-160.

Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Keenan JE, Kirsch DG, Tyler DS, Blazer DG 3rd. The Effect of Neoadjuvant Radiation Therapy on Perioperative Outcomes Among Patients Undergoing Resection of Retroperitoneal Sarcomas. Surg Oncol 2014. In Press

Ganapathi AM, Speicher PJ, Englum BR, Castleberry AW, Migaly J, Hsu DS, Mantyh CR. Adjuvant Chemotherapy For T1 Node Positive Colon Cancers Provides Significant Survival Benefit. Dis Col Rectum 2014. In Press

Speicher PJ, Wang X, Englum BR, Ganapathi AM, Yerokun B, Hartwig MG, D’Amico TA, Berry MF. Induction Chemoradiation Therapy Prior to Esoph-agectomy is Associated With Superior Long-Term Survival For Esophageal Cancer. Dis Esoph 2014. In Press

Speicher PJ, Englum BR, Ganapathi AM, Nussbaum DP, Mantyh CR, Migaly J. Robotic Low Anterior Resection for Rectal Cancer: A National Perspective on Short-term Oncologic Outcomes. Ann Surg 2014. In Press

Speicher PJ, Englum BR, Ganapathi AM, Mulvihill MS, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. Adjuvant Chemotherapy is Associated with Improved Survival After Esophagectomy without Induction Therapy for Node-positive Adenocarcinoma. J Thor Oncol 2014. In Press

Keenan JE, Vavalle JP, Ganapathi AM, Harrison JK, Wang A, Hughes GC. Factor VIIa for Annulus Rupture After Transcatheter Aortic Valve Replace-ment. Ann Thorac Surg 2015; 100:313-5.

Speicher PJ, Ganapathi AM, Englum BR, Gulack BC, Osho AA, Hirji SA, Castleberry AW, Snyder LD, Davis RD, Hartwig MG. Single Lung Trans-plantation In The United States: What Happens to the Other Lung? J Heart Lung Transplant 2014. In Press

Osho AA, Castleberry AW, Snyder LD, Ganapathi AM, Speicher PJ, Hirji SA, Stafford-Smith M, Daneshmand MA, Davis RD, Hartwig MG. Determin-ing Eligibility for Lung Transplantation: A Nationwide Assessment of the Cutoff Glomerular Filtration Rate. J Heart Lung Transplant 2014. In Press

Ganapathi AM, Hirji SA, Wang A, Patel CB, Gaca JG, Schroder JN. Bridge to Long Term Mechanical Circulatory Support with a Left Ventricular Assist Device: Novel Use of Transcatheter Aortic Valve Replacement. Ann Thorac Surg 2014. In Press

Ganapathi AM, Englum BR, Keenan JE, Schechter MA, Wang H, Smith PK,


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Glower DD, Hughes GC. Long-Term Survival Following Bovine Pericardial Versus Porcine Stented Bioprosthetic Aortic Valve Replacement: Does Valve Choice Matter? Ann Thorac Surg 2015. In Press

Ganapathi AM, Speicher PJ, Englum BR, Perez A, Tyler DS, Zani S. Gan-grenous Cholecystitis: A Contemporary Review. J Surg Res 2015. In Press

Nussbaum DP, Speicher PJ, Gulack BC, Keenan JE, Ganapathi AM, Englum BR, Tyler DS, Blazer DG 3rd. Management of 1- to 2-cm Carcinoid Tumors of the Appendix: Using the National Cancer Data Base to Address Contro-versies in General Surgery. J Am Coll Surg 2015. In Press

Wang H, Hanna JM, Ganapathi AM, Keenan JE, Hurwitz LM, Vavalle JP, Kiefer TL, Wang A, Harrison JK, Hughes GC. Comparison of Aortic Annulus Size by Transesophageal Echocardiography and Computed Tomography Angiography With Direct Surgical Measurement. Am J Cardiol 2015. In Press

Englum BR, Ganapathi AM, Schechter MA, Harrison JK, Glower DD, Hughes GC. Changes in Risk Profile and Outcomes of Patients Undergo-ing Surgical Aortic Valve Replacement from the Pre- to Post-Transcatheter Aortic Valve Replacement Eras. Ann Thorac Surg 2015; In Press

Gulack BC, Ganapathi AM, Speicher PJ, Meza JM, Hirji SA, Snyder LD, Davis RD, Hartwig MG. What Is the Optimal Transplant for Older Patients With Idiopathic Pulmonary Fibrosis? Ann Thorac Surg 2015. In Press

Keenan JE, Wang H, Ganapathi AM, Englum BR, Kale E, Matthew J, Hus-sain A, Hughes GC. Electroencephalography during Hemiarch Replace-ment with Moderate Hypothermic Circulatory Arrest. Ann Thorac Surg 2015; In Press.

Gulack BC, Nussbaum DP, Keenan JE, Ganapathi AM, Sun Z, Worni M, Migaly J, Mantyh CR. Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer without Metastasectomy is Associated with Improved Overall Survival Compared to Chemotherapy/Radiation Therapy Alone. Dis Col Rectum 2015. In Press

Nussbaum DP, Adam MA, Youngwirth LM, Ganapathi AM, Roman SA, Tyler DS, Sosa JA, Blazer DG 3rd. Minimally Invasive Pancreaticoduode-nectomy Does Not Improve Use or Time to Initiation of Adjuvant Che-motherapy for Patients With Pancreatic Adenocarcinoma. Ann Surg Oncol 2016; 23:1026-33.

Englum BR, Ganapathi AM, Hughes GC. Reply: To PMID 25301369. Ann Thorac Surg. 2015 Oct;100(4):1508.

Englum BR, Ganapathi AM, Speicher PJ, Gulack BC, Snyder LD, Davis RD, Hartwig MG. Impact of Donor and Recipient Hepatitis C Status in Lung Transplantation. J Heart Lung Transplant 2016; 35: 228-35.


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Schechter MA, Shah AA, Englum BR, Williams JB, Ganapathi AM, Davies JD, Welsby IJ, Hughes GC. Prolonged Postoperative Respiratory Support After Proximal Thoracic Aortic Surgery: Is Deep Hypothermic Circulatory Arrest a Risk Factor? J Crit Care 2016; 31: 125-9.

Speicher PJ, Englum BR, Ganapathi AM, Wang X, Hartwig MG, D’Amico TA, Berry MF. Traveling to a High Volume Center is Associated with Improved Survival for Patients with Esophageal Cancer. Ann Surg 2016. In press.

Brandon Henry, MD, MPH

Education: MD, University of Pennsylvania School of Medicine, 2010 MPH, Rollins School of Public Health, Emory, 2010


Research Interests: Surgical education; surgical simulation

Clinical Interests: Vascular surgery

Publications: Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. Journal of the American Medical Associa-tion. 2007 Jul 11; 298(2):179-86.

Henry BV, Sudan R. Opportunities in Medical Education. In Sippel, Pugh. Success in Academic Surgery: Developing a Career in Medical Education. Springer. London. 2013 pp7-18

Henry BV, Clark P, Sudan R. Cost and logistics of implementing a tissue-based American College of Surgeons/Association of Program Directors in Surgery surgical skills curriculum for general surgery residents of all clini-cal years. American Journal of Surgery. 2014 Feb;207(2):201-8.

Barbas AS, Haney JC, Henry BV, Heflin MT, Lagoo SA. Development and implementation of a formalized geriatric surgery curriculum for general surgery residents. Gerontology & Geriatric Education. 2014 Mar: 35(4)380-94.


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75

Sudan R, Clark P, Henry BV. Cost and logistics of implementing the American College of Surgeons (ACS) Objective Structured Clinical Exami-nation (OSCE). American Journal of Surgery. 2015 Jan: 209(1): 140-4.

Sudan R, Henry BV, Podolsky E. Robotic Assisted Bariatric Surgery. In Agrawal. Obesity, Bariatric and Metabolic Surgery: A Practical Guide. Springer. London. 2015. pp367-373.

Mohan Mallipeddi, MD

Education: MD, Vanderbilt University School of Medicine, 2010


Research Interests: Health services research – i.e., health care economics, resource utiliza-tion, outcomes; basic science – i.e., nascent interest in GI physiology after bariatric surgery

Clinical Interests: Foregut surgery; bariatric surgery

Publications: Mallipeddi MK and Onaitis MW. The Contemporary Role of Minimally Invasive Esophagectomy in Esophageal Cancer. Curr Oncol Rep. 2014 Mar;16(3):374.

Mallipeddi MK, Pappas TN, Shapiro ML and Scarborough JE. Gallstone Ileus: Revisiting Surgical Outcomes Using NSQIP Data. J Surg Res. 2013 May 31. Epub ahead of print (PMID: 23764312).

Mallipeddi MK, Lagoo SA. “Urgent Workup for Upper Gastrointestinal Bleeding.” Gastrointestinal Bleeding: A Practical Approach to Diagnosis and Management, 2nd edition. Eds Pryor AD, Pappas TN, Branch MS. New York: Springer.

Mallipeddi MK, Pappas TN. “Selective and Non-Selective Vagotomies.” Mastery of Surgery, 7th edition. Eds Fischer JE, Jones DB, Pomposelli FB, Upchurch GR. Philadelphia: Lippincottt Williams & Wilkins.


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76

Matthew Schechter, MD

Education: MD, Duke University School of Medicine, 2010


Research Interests: Molecular mechanisms of heart failure; primary graft dysfunction; out-comes of mechanical circulatory support and cardiac transplant

Clinical Interests: Heart failure; transplantation

Publications: Schechter MA, Ganapathi AM, Englum BR, Speicher PJ, Daneshmand MA, David RD, Hartwig MG. Spontaneously Breathing Extracorporeal Mem-brane Oxygenation Support Provides the Optimal Bridge to Lung Trans-plantation. Transplantation 2016 [In Press]

Schechter MA, Watson MJ, Feger BJ, Southerland KW, Mishra R, Bibernardo LR, Kuchibhatla M, Schroder JN, Daneshmand MA, Patel CB, Rogers JG, Milano CA, Bowles DE. Elevated Cardiac Troponin I in Preservation Solution is Associ-ated with Primary Graft Dysfunction. J Card Fail 2016 Feb;22(2):158-62.

Schechter MA, Shah AA, Englum BR, Williams JB, Ganapathi AM, Daview JD, Welsby IJ, Hughes GC. Prolonged Postoperative Respiratory Support after Proximal Thoracic Aortic Surgery: Is Deep Hypothermic Circulatory Arrest a Risk Factor? J Crit Care 2016 Feb;31(1):125-9.

Englum BR, Ganapathi AM, Schechter MA, Harrison JK, Glower DD, Hughes GC. Changes in Risk Profile and Outcomes of Patients Undergo-ing Surgical Aortic Valve Replacement from the Pre- to Post-Transcatheter Aortic Valve Replacemetn Eras. Ann Thorac Surg. 2015 [In Press]

Ganapathi AM, Englum BR, Keenan JE, Schechter MA, Wang H, Smith PK, Glower DD, Hughes GC. Long-Term Survival After Bovine Pericardial Ver-sus Porcine Stented Bioprosthetic Aortic Valve Replacement: Does Valve Choice Matter? Ann Thorac Surg 2015; 100:550-9.

Englum BR, Schechter MA, Irish WD, Ravindra KV, Vikraman DS, Sanoff SL, Ellis MJ, Sudan DL, Patel UD. Outcomes in Kidney Transplant Recipi-ents from Older Living Donors. Transplantation 2015; 99:309-15.


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77

Schechter MA, Patel CB, Blue LJ, Welsby I, Rogers JG, Schroder JN, Milano CA. Improved Early Survival with a Non-Sternotomy Approach for Con-tinuous Flow Left Ventricular Assist Device Replacement. Ann Thorac Surg 2015; 99:561-6

Hughes GC, Ganapathi AM, Keenan JE, Englum BR, Hanna JM, Schech-ter MA, Wang H, McCann RL. Thoracic Endovascular Repair for Chronic DeBakey IIIb Aortic Dissection. Ann Thorac Surg. 2014; 98:2092-7.

Schechter MA, Hsieh MK, Njoroge LW et al. Phosphoproteomic Profiling of Human Myocardial Tissues Distinguishes Ischemic from Non-Ischemic End Stage Heart Failure. PLoS One 2014; 9:e104157.

Schechter MA, Joseph JT, Krishnamoorthy A, Emanuel Finet J, Ganapathi AM, Lodge AJ, Milano CA, Patel CB. Efficacy and Durability of Central Oversewing for Treatement of Aortic Insufficiency in Patients with Continuous-Flow Left Ventricular Assist Devices. J Heart Lung Transplant 2014; 33:937-42.

Ganapathi AM, Englum BR, Schechter MA, Vavalle JP, Harrison JK, McCann RL, Hughes GC. Role of Cardiac Evaluation before Thoracic Endovascular Aortic Repair. J Vasc Surg 2014. 60:1196-203.

Schechter MA, Southerland KW, Feger BJ, Linder Jr. D, Ali AA, Njoroge L, Milano CA, Bowles DE. An Isolated Working Heart System for Large Ani-mal Models. J Vis Exp 2014; 88.

Ganapathi AM, Hanna JM, Schechter MA, Englum BR, Castleberry AW, Gaca JG, Hughes GC. Antegrade versus Retrograde Cerebral Perfusion for Hemiarch Replacement with Deep Hypothermic Circulatory Arrest: Does It Matter? A Propensity-Matched Analysis. J Thorac Cardiovasc Surg 2014. 148:2896-902

Schechter MA, Patel CB, Rogers JG, Milano CA. Temporary Extracorporeal Left Ventricular Assist Device Support for Implantable Left Ventricular Assist Device Replacement Cases. J Thorac Cardiovasc Surg 2014; 147:e46-8.

Schechter MA, Daneshmand MA, Patel CB, Blue LJ, Rogers JG, Milano CA. Outcomes Following Implantable Left Ventricular Assist Device Replace-ment Procedures. ASAIO J 2014; 60:44-8.

Ganapathi AM, Englum BR, Hanna JM, Schechter MA, Gaca JG, Koweek LM, Hughes GC. Frailty and Risk in Proximal Aortic Surgery. J Thorac Car-diovasc Surg 2014; 147: 186-91.

Rajagopal K, Daneshmand MA, Patel CB, Ganapathi AM, Schechter MA, Rogers JG, Milano CA. Natural History and Clinical Effect of Aortic Valve Regurgitation after Left Ventricular Assist Device Implantation. J Thorac Cardiovasc Surg 2013; 145(5):1373-9.

Schechter MA, O’Brien PJ, Cox MW. Retrieval of Iatrogenic Intravascular Foreign Bodies. J Vasc Sur 2013; 57(1):276-81.


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78

Schechter MA, Shortell CK, Scarborough JE. Regional Versus General Anesthesia for Carotid Endarterectomy: The American College of Sur-geons National Surgical Quality Improvement Program Perspective. Surgery 2012; 152(3): 309-314.

Paul Speicher, MD

Education: MD, Northwestern University Feinberg School of Medicine, 2010

Training: General Surgery (PGY1), 6/24/2010-6/30/2011 General Surgery (PGY2), 7/1/2011-6/30/2012 Surgery Research Fellowship (PGY3), 7/1/2012-6/30/2013 Surgery Research Fellowship (PGY4), 7/1/2013-6/30/2014 General Surgery (PGY5), 7/1/2014-6/30/2015 Jt General Surgery and Thoracic Surgery (PGY6), 7/1/2015-6/30/2016 Jt General Surgery and Thoracic Surgery (PGY7), 7/1/2016-Present

Research Interests: Health services research; comparative effectiveness; resource utilization and decision-making; phase I/II clinical trials; statistical modeling

Clinical Interests: Thoracic oncology; lung transplantation

Publications: Speicher P, Rodriguez HE. Infectious Aortitis. In: Yao JST, Pearce WH, Eskandari M, Morasch M, Matsumura (eds): Vascular Surgery: Therapeutic Strategies. Shelton, CT: PMPH-USA, 2010; 409-420. ISBN 978-1-60795-055-4.

Rodriguez H, Turner JP, Speicher P, Daskin MS, Darosa D. “A model for evaluating resident education h a focus on continuity of care and educa-tional quality.” J Surg Educ. 2010;67(6):352-8.

Turner JP, Rodriguez HE, Daskin MS, Mehrotra S, Speicher P, DaRosa DA. “Overcoming obstacles to resident-patient continuity of care.” Ann Surg. 2012;255(4):618-622.

Rodriguez HE, Speicher P. Balloon Angioplasty and Stenting of Peripheral Arterial Lesions. In: Yao JST, Pearce WH (eds): Atlas of Vascular Surgery, 6th edition. Shelton, CT: PMPH-USA, 2013. ISBN 978-1-60795-021-9.

Speicher P, Tyler D, Mosca P. Management of In-transit Malignant Mela-noma. In: Duc (ed): Melanoma-From Early Detection to Treatment. InTech 2013: 255-274. ISBN 978-953-51-0961-7.

Speicher PJ, Aziz H, Bhattacharya S, Baerman K. “Septic thrombophlebitis


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of the superior mesenteric vein: An unusual complication of appendici-tis.” Am Surg. 2013;79(1):31-2.

Speicher PJ, Lagoo S, Galanos A, Pappas TN, Scarborough JE. “Expecta-tions and outcomes in geriatric patients with do-not-resuscitate orders undergoing emergent surgical management of bowel obstruction.” JAMA Surg. 2013;148(1):23-28.

Elfenbein DM, Scarborough JE, Speicher PJ, Scheri RP. “Comparison of laparoscopic versus open adrenalectomy: results from ACS-NSQIP.” J Surg Res. 2013;184:216-20.

Speicher PJ, Barbas AS, Li GZ, Tyler DS. Duodenal Stump Blowout. In: Pawlik, Merchant, Maithel (eds): strointestinal Surgery: Management of Complex Perioperative Complications. New York: Springer, 2014. In press.

Speicher PJ, Lagoo-Deenadayalan SA. The Approach to Reoperations in the Geriatric Population. In: Mizrahi, Reissman, Polk (eds): Reoperative Abdominal Surgery. London: JP Medical Publishers, 2014. In press.

Nussbaum DP, Speicher PJ. Informed consent and other ethical and regulatory considerations in emergency research. In: Medical Ethics: Per-spectives, Outcomes and Legal Implications. Hauppauge, New York: Nova Science Publishers, 2014. In press.

Speicher PJ, Englum BR, Jiang B, Pietrobon R, Mantyh CR, Migaly J. “The impact of laparoscopic versus open approach on reoperation rate after segmental colectomy: a propensity analysis.” J Gastrointest Surg. 2014;18(2):378-84.

Speicher PJ, Beasley G, Jiang B, Lidsky M, Palmer G, Scarbrough P, Mosca P, Dewhirst M, Tyler D. “Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemo-therapy for melanoma.” Ann Surg Onc. 2014;21(5):1435-40.

Speicher PJ, Ligh C, Scarborough JE, Thacker JK, Mantyh CR, Turley RS, Migaly J. “A simple scoring system for risk-stratifying rectal cancer patients prior to radical resection.” Tech Coloproctol. 2014;18(5):459-65.

Speicher PJ, Turley RS, Sloane JL, Mantyh CR, Migaly J. “Pelvic exenteration for the treatment of locally advanced colorectal and bladder malignan-cies in the modern era.” J Gastrointest Surg. 2014;18(4):782-8.

Lidsky ME, Speicher PJ, Jiang BS, Tsutsui M, Tyler DS. “Isolated limb infu-sion as a model to test new agents to treat metastatic melanoma”. J Surg Oncol. 2014;109(4):357-65.

Lidsky ME, Speicher PJ, Turley RS, Barbas AS, Clary BM. “Does the pres-ence of coronary artery disease impact perioperative outcomes following partial hepatectomy?” J Gastrointest Surg. 2014;18(4):709-18.


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Beasley GM, Speicher PJ, Sharma K, Seigler H, Salama AKS, Mosca PJ, Tyler DS. “Efficacy of repeat sentinel lymph node biopsy for patients who develop recurrent melanoma.” J Am Coll Surg. 2014;218(4):686-92.

Speicher PJ, Ganapathi AM, Englum BR, Onaitis MW, D’Amico TA, Berry MF. “Survival in the elderly following pneumonectomy for early stage non-small cell lung cancer: A comparison with non-operative manage-ment.” J Am Coll Surg. 2014;218(3):439-49.

Li GZ, Speicher PJ, Lidsky ME, Darrabie MD, Scarborough JE, White RR, Turley RS, Clary BM. “Hepatic resection for hepatocellular carcinoma: Do contemporary morbidity and mortality rates demand a transition to abla-tion as first-line treatment?” J Am Coll Surg. 2014;218(4):827-34.

Speicher PJ, Goldsmith ZG, Nussbaum DP, Turley RS, Peterson AC, Man-tyh CR. “Ureteral stenting in laparoscopic colorectal surgery”. J Surg Res. 2014;190(1):98-103.

Nussbaum DP, Penne K, Speicher PJ, Stinnett SS, Perez A, White RR, Clary BM, Tyler DS, Blazer DG III. “The role of clinical care pathways: An experi-ence with distal pancreatectomy.” J Surg Res. 2014;190(1):64-71.

Jiang BS, Beasley GM, Speicher PJ, Mosca PJ, Morse MA, Hanks B, Salama A, Tyler DS. “Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma”. Ann Surg Onc. 2014;21(8):2525-31.

Speicher PJ, Nussbaum DP, Scarborough JE, Zani S, White RR, Blazer DG III, Mantyh CR, Tyler DS, Clary BM. “Wound classification reporting in HPB surgery: Can a single word change public perception of institutional per-formance?” HPB. 2014;16(12):1068-73.

Speicher PJ, Barbas AS, Mureebe L. “Open versus endovascular repair of ruptured abdominal aortic aneurysms.” Ann Vasc Surg. 2014;28(5): 1249-57.

Keenan JE, Speicher PJ, Thacker JKM, Walter M, Kuchibhatla M, Mantyh CR. “The preventative surgical site infection bundle in colorectal surgery: An effective approach for surgical site infection reduction and healthcare cost savings”. JAMA Surgery. 2014;149(10):1045-52.

Speicher PJ, Ganapathi AM, Englum BR, Vaslef SN. “Laparoscopy is safe among patients with congestive heart failure undergoing general surgery procedures”. Surgery. 2014;156(2):371-8.

Barbas AS, Speicher PJ, Clary BM. “Hepatic and pancreatic resection in patients with end-stage renal disease: A propensity analysis.” HPB. 2014;16(11):1016-22.

Speicher PJ, Ganapathi AM, Englum BR, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. “Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer.” J Thorac Oncol. 2014;9:1195-1201.


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Jiang BS, Speicher PJ, Thomas S, Mosca PJ, Abernethy AP, Tyler DS. “Quality of life after isolated limb infusion for in-transit melanoma of the extremity”. Ann Surg Oncol. 2015;22(5):1694-1700.

Speicher PJ, Nussbaum DP, White RR, Zani S, Mosca PJ, Blazer DG III, Clary BM, Pappas TN, Tyler DS, Perez A. “Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy.” Ann Surg Oncol. 2014;21(12):4014-9.

Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Englum BR, Kirsch DG, Tyler DS, Blazer DG III. “Long-term oncologic outcomes regarding neoadjuvant radiation therapy for retroperitoneal sarcomas.” Ann Surg. 2015;262:163-70.

Speicher PJ, Meriwether CH, Tyler DS. “Regional therapies for in-transit disease.” Surg Oncol Clin N Am. 2015;24(2):309-322.

Speicher PJ, Englum BR, Ganapathi AM, Onaitis MW, D’Amico TA, Berry MF. “Outcomes after treatment of 17,378 patients with locally advanced (T3N0-2) non-small cell lung cancer.” Eur JCardiothorac Surg. 2014;47(4):636-41.

Adam MA, Speicher P, Pura J, Dinan MA, Reed SD, Roman SA, Sosa JA. “Robotic thyroidectomy for cancer in the United States: Patterns of use and short-term outcomes.” Ann Surg Onc. 2014;21(12):3859-64.

Ganapathi AM, Speicher PJ, Castleberry AW, Englum BR, Osho AA, Davis RD, Hartwig MG. “The effect of prior pneumonectomy or lobectomy on subsequent lung transplantation.” Ann Thorac Surg. 2014;98(6):1922-9.

Nussbaum DP, Zani S, Penne K, Speicher PJ, Stinnett SS, Clary BM, White RR, Pappas TN, Tyler DS, Blazer DG III. “Feeding jejunostomy tube place-ment in patients undergoing panctreaticoduodenectomy: An ongoing dilemma.” J Gastrointest Surg. 2014;18(10):1752-9.

Nussbaum DP, Speicher PJ, Ganapathi AM, Englum BR, Keenan JE, Man-tyh CR, Migaly J. “Laparoscopic versus open low anterior resection for rectal cancer: Results from the National Cancer Data Base.” J Gastrointest Surg. 2015;19(1):124-31.

Nussbaum DP, Penne K, Stinnett SS, Speicher PJ, Cocieru A, Blazer DG III, Zani S, Clary BM, Tyler DS, White RR. “A standardized care plan is associ-ated with shorter hospital length of stay in patients undergoing pancre-aticoduodenectomy.” J Surg Res. 2015;193(1):237-45.

Beasley GM, Speicher P, Augustine CK, Dolber PC, Peterson BL, Mosca PJ, Royal R, Ross M, Zager JS, Tyler DS. “A multi-center Phase I dose escala-tion trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.” Ann Surg Oncol. 2015;22(1):287-94.


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Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Keenan JE, Kirsch DG, Tyler DS, Blazer DG III. “The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of ret-roperitoneal sarcomas.” Surg Oncol. 2014;23(3):155-60.

Lidksy ME, Antoun G, Speicher PJ, Adams B, Turley RS, Augustine C, Tyler DS, Ali-Osman F. “Mitogen-activated protein kinase hyper-activation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells.” J Biol Chem. 2014;289(40):27714-26.

Speicher PJ, Wang X, Englum BR, Ganapathi AM, Yerokun B, Hartwig MG, D’Amico TA, Berry MF. “Induction chemoradiation therapy prior to esophagectomy is associated with superior long-term survival for esoph-ageal cancer.” Dis Esoph. 2015;28(8):788-96.

Nussbaum DP, Speicher PJ, Gulack BC, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. “Defining the role for adjuvant chemotherapy following lobectomy for typical bronchopulmonary carcinoid tumors.” Ann Thorac Surg. 2014;23(3):155-60.

Speicher PJ, Ganapathi AM, Englum BR, Gulack BC, Osho AA, Hirji SA, Castleberry AW, Snyder LD, Davis RD, Hartwig MG. “Single lung transplan-tation in the United States: What happens to the other lung?” J Heart Lung Transplant. 2015;34(1):36-42.

Speicher PJ, Englum BR, Ganapathi AM, Nussbaum DP, Mantyh CR, Migaly J. “Robotic low anterior resection for rectal cancer: A national perspective on short-term oncologic outcomes.” Ann Surg. 2015;262(6):1040-5.

Speicher PJ, Englum BR, Ganapathi AM, Mulvihill MS, Hartwig MG, Onaitis MW, D’Amico TA, Berry MF. “Adjuvant chemotherapy is associated with improved survival after esophagectomy without induction therapy for node-positive adenocarcinoma.” J Thor Oncol. 2015;10(1):181-8.

Ganapathi AM, Speicher PJ, Englum BR, Castleberry AW, Migaly J, Hsu DS, Mantyh CR. “Adjuvant chemotherapy for T1 node positive colon cancers provides significant survival benefit.” Dis Col Rectum. 2014;57(12):1341-8.

Sahu RP, Ocana JA, Harrison KA, Ferracini M, Touloukian CE, Al-Hassani M, Sun L, Loesch M, Murphy RC, Althouse SK, Perkins SM, Speicher PJ, Tyler DS, Konger RL, Travers JB. “Chemotherapeutic agents subvert tumor immunity by generating platelet-activating factor agents.” Cancer Res. 2014;74(23):7069-78.

Osho AA, Castleberry AW, Snyder LD, Ganapathi AM, Speicher PJ, Hirji SA, Stafford-Smith M, Daneshmand MA, Davis RD, Hartwig MG. “Determining eligibility for lung transplantation: A nationwide assessment of the cutoff glomerular filtration rate.” J Heart Lung Transplant. 2014;34(4):571-9.

Rialon KL, Speicher PJ, Ceppa EP, Rendell T, Vaslef SN, Beaven A, Tyler DS,


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Blazer DG. “Outcomes following splenectomy in patients with myeloid neoplasms”. J Surg Onc 2015;111(4):389-95.

Nussbaum DP, Speicher PJ, Gulack BC, Keenan JE, Ganapathi AM, Englum BR, Tyler DS, Blazer DG III. “Management of 1-2 centimeter carcinoid tumors of the appendix: Using the National Cancer Data Base to address controversies in general surgery.” J Am Coll Surg. 2015;220(5):894-903.

Speicher PJ, Gu L, Wang X, Hartwig MG, D’Amico TA, Berry MF. “Adjuvant chemotherapy after lobectomy for T1-2N0 non-small cell lung cancer: are the guidelines supported?” J Natl Compr Canc Netw. 2015;13(6):755-61.

Meyerhoff RR, Yang CJ, Speicher PJ, Gulack BC, Hartwig MG, D’Amico TA, Harpole DH, Berry MF. “Impact of mesothelioma histologic subtype on outcomes in the SEER database.” J Surg Res. 2015;196(1):23-32.

Englum BR, Rialon KL, Speicher PJ, Gulack B, Driscoll TA, Kreissman SG, Rice HE. “Value of surgical resection in children with high-risk neuroblas-toma.” Pediatr Blood Cancer. 2015;62(9):1529-35.

Ganapathi AM, Speicher PJ, Englum BR, Perez A, Tyler DS, Zani S. “Gangre-nous cholecystitis: A contemporary review.” J Surg Res. 2015;197(1):18-24.

Lazarides A, Eward W, Speicher P, Hou CH, Nussbaum D, Green C, Blazer DG III, Kirsch DG, Brigman B. “The use of radiation therapy in well-differ-entiated soft tissue sarcoma of the extremities: An NCDB review.” Sar-coma. 2015; Epub DOI: 10.1155/2015/186581.

Keenan JE, Speicher PJ, Nussbaum DP, Adam MA, Walter M, Miller TE, Mantyh CR, Thacker JKM. “Improving outcomes in colorectal surgery by sequential implementation of multiple standardized care programs.” J Am Coll Surg. 2015;221(2):404-14.

Gulack BC, Ganapathi AM, Speicher PJ, Meza JM, Hirji SA, Snyder LD, Davis RD, Hartwig MG. “What is the optimal transplant for older patients with idiopathic pulmonary fibrosis?” Ann Thor Surg. 2015;100(5):1826-33.

Hou CH, Lazarides AL, Speicher PJ, Nussbaum DP, Blazer DG III, Kirsch DG, Brigman BE, Eward WC. “The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.” Ann Surg Oncol. 2015;22(9):2831-8.

Sun Z, Nussbaum DP, Speicher PJ, Czito BG, Tyler DS, Blazer DG 3rd. “Neoadjuvant radiation therapy does not increase perioperative morbid-ity among patients undergoing gastrectomy for gastric cancer.” J Surg Onc. 2015;112(1):46-50.

Lane WO, Cramer CK, Nussbaum DP, Speicher PJ, Gulack BC, Stinnett SS, Czito BG, Kirsch DG, Tyler DS, Blazer DG 3rd. “Analysis of periopera-tive radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.” J Surg Onc. 2015;112(4):352-8.


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Sun Z, Shenoi MM, Nussbaum DP, Keenan JE, Gulack BC, Tyler DS, Speicher PJ, Blazer 3rd DG. “Feeding jejunostomy tube placement during resection of gastric cancers.” J Surg Res. 2016;200(1):189-94.

Speicher PJ, Gu L, Gulack BC, Wang X, D’Amico TA, Hartwig MG, Berry MF. “Sublobar resection for clinical stage IA non-small cell lung cancer in the United States.” Clin Lung Cancer. 2016;17(1):47-55.

Yang CJ, Gulack BC, Gu L, Speicher PJ, Wang X, Harpole DH, Onaitis MW, D’Amico TA, Berry MF, Hartwig MG. “Adding radiation to induction chemo-therapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.” J Thorac Cardiovasc Surg. 2015;150(6):1484-93.

Javidfar J, Speicher PJ, Hartwig MG, D’Amico TA, Berry MF. “Impact of posi-tive margins on survival in patients undergoing esophagogastrectomy for esophageal cancer.” Ann Thorac Surg. 2016;101(3):1060-7.

Englum BR, Ganapathi AM, Speicher PJ, Schechter MA, Gulack BC, Lin S, Palmer S, Snyder L, aneshmand M, Hartwig MG. “The impact of donor and recipient hepatitis C status in lung transplant.” J Heart Lung Trans-plant. 2016;35(2):228-35.

Gulack BC, Yang CFJ, Speicher PJ, Meza JM, Gu L, Wang X, D’Amico TA, Hartwig MG, Berry MF. “The impact of tumor size on the association of the extent of lymph node resection and survival in clinical stage I non-small cell lung cancer.” Lung Cancer. 2015;90(3):554-60.

Sun Z, Kim J, Adam MA, Nussbaum DP, Speicher PJ, Mantyh CR, Migaly J. “Minimally invasive versus open low anterior resection: Equivalent sur-vival in a national analysis of 14,033 patients with rectal cancer.” Ann Surg. 2016;263(6):1152-8.

Schechter MA, Ganapathi AM, Englum BR, Speicher PJ, Daneshmand M, Davis RD, Hartwig MG. “Spontaneously breathing extracorporeal mem-brane oxygenation support provides the optimal bridge to lung trans-plantation”. Transplantation. 2016; PMID 26910331, Epub ahead of print.

Yang CF, Chan DY, Speicher PJ, Gulack BC, Hartwig MG, Berry MF, Onaitis MW, Tong BC, D’Amico TA, Harpole DH. “Role of adjuvant therapy in a population-based cohort of patients with early stage small cell lung can-cer.” J Clin Oncol. 2016;34(10):1057-64.

Yang CF, Sun Z, Speicher PJ, Saud S, Gulack BC, Hartwig MG, Harpole DH, Onaitis MW, Tong BC, D’Amico TA, Berry MF. “Use and outcomes of minimally invasive lobectomy for stage I non-small cell lung cancer in the National Cancer Data Base.” Ann Thorac Surg. 2016;101(3):1037-42.

Yang CJ, Meyerhoff RR, Mayne NR, Singhapricha T, Toomey CB, Speicher PJ, Hartwig MG, Tong BC, Onaitis MW, Harpole DH Jr, D’Amico TA, Berry MF. “Long-term survival following open versus thoracoscopic lobectomy


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after preoperative chemotherapy for non-small cell lung cancer.” Eur J Cardiothorac Surg. 2016;49(6):1615-23.

Speicher PJ, Englum BR, Ganapathi AM, Wang X, Hartwig MG, D’Amico TA, Berry MF. “Traveling to a high volume center is associated with improved survival for patients with esophageal cancer.” Ann Surg. 2016; PMID 26982688, Epub ahead of print.

Yerokun BA, Sun Z, Yang CF, Gulack BC, Speicher PJ, Adam MA, D’Amico TA, Onaitis MW, Harpole DH, Berry MF, Hartwig MG. “Minimally invasive versus open esophagectomy for esophageal cancer: A population-based analysis.” Ann Thorac Surg. 2016;102(2):416-23.

Speicher PJ, Fitch ZW, Gulack BC, Yang CFJ, Tong BC, Harpole DH, D’Amico TA, Berry MF, Hartwig MG. “Induction chemotherapy is not superior to a strategy of surgery-first for clinical N1 non-small cell lung cancer.” Ann Thorac Surg. 2016;102(3):884-94.

Hartwig MG, Ganapathi AM, Osho AA, Hirji SA, Englum BR, Speicher PJ, Palmer S, Wilbur M, Davis RD, Snyder LD. “Staging of bilateral lung rrans-plantation for high-risk patients with interstitial lung disease: One lung at a time.” Am J Transplant. 2016; PMID 27233085, Epub ahead of print.

Yang CF, Yan BW, Meyerhoff RR, Saud SM, Gulack BC, Speicher PJ, Hartwig MG, D’Amico TA, Harpole DH, Berry MF. “Impact of age on long-term outcomes of surgery for malignant pleural mesothelioma.” Clin Lung Cancer. 2016; PMID 27236386, Epub ahead of print.

Gulack BC, Yang CFJ, Speicher PJ, Yerokun B, Tong BC, Onaitis MW, D’Amico TA, Harpole DH, Hartwig MG, Berry MF. “A risk score to assist selecting lobectomy versus sublobar resection for early stage non-small cell lung cancer.” Ann Thorac Surg. 2016; PMID 27592602, Epub ahead of print.

Castleberry AW, Bishawi M, Worni M, Erhunmwunsee L, Speicher PJ, Osho AA, Snyder LD, Hartwig MG. “Medication non-adherence following lung transplantation in adult recipients.” Ann Thorac Surg. 2016; PMID 27624294, Epub ahead of print.

Lidsky ME, Sun Z, Nussbaum DP, Adam MA, Speicher PJ, Blazer DG 3rd. “Going the extra mile: Improved survival for pancreatic cancer patients traveling to high-volume centers.” Ann Surg. 2016; PMID 27429020, Epub ahead of print.


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Current Residents

PGY-1David Becerra, MDMedical school: Indiana University School of MedicineCollege/university: Rose-Hulman Institute of Technology

Norma Farrow, MDMedical school: Johns Hopkins University School of MedicineCollege/university:University of Virginia

Zachary Fitch, MDMedical school:Eastern Virginia Medical SchoolCollege/university:College of William and Mary

Oliver Jawitz, MDMedical school:Yale University School of MedicineCollege/university:Washington University in St. Louis

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PGY-1Vignesh Raman, MDMedical school:Geisel School of Medicine at DartmouthCollege/university:University of California San Diego

Christopher Reed, MDMedical school: Virginia Tech Carilion School of MedicineCollege/university: Johns Hopkins University

David Thompson, MD Medical school:Tulane University School of MedicineCollege/university:New York University

PGY-2Justin Barr, MD, PhDMedical school: University of Virginia School of MedicineCollege/university: Washington University in St. Louis (BA) and Yale University (PhD)

Current Residents (continued)

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PGY-2Whitney Lane, MDMedical school:Duke University Medical SchoolCollege/university: Duke University

Carrie Moore, MDMedical school: Vanderbilt University School of MedicineCollege/university: Vanderbilt University

Paul Schroder, MDMedical school: The University of Toledo College of MedicineCollege/university: John Carroll University

Karenia Soto, MDMedical school: University of Miami Leonard M. Miller School of MedicineCollege/university: Harriet Wilkes Honors College, Florida Atlantic University


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PGY-2Joshua Watson, MDMedical school: Johns Hopkins University School of MedicineCollege/university: Georgetown University

John Yerxa, MDMedical school: Duke University School of MedicineCollege/university: Boston College

PGY-3Ehsan Benrashid, MDMedical school: University of Virginia School of MedicineCollege/university: Clemson University

Jina Kim, MDMedical school: University of Michigan Medical SchoolCollege/university:Massachusetts Institute of Technology


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PGY-3Daniel Nussbaum, MDMedical school: Keck School of Medicine of the University of Southern CaliforniaCollege/university: University of Wisconsin-Madison

Linda Youngwirth, MDMedical school: University of Wisconsin Medical SchoolCollege/university: University of Wisconsin

PGY-4Mohamed Adam, MDCollege/university: Omdurman Islamic University

Brian Gulack, MDMedical school: University of PittsburghCollege/university: Union College


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PGY-4Jeffrey Keenan, MDMedical school: University of Maryland School of MedicineCollege/university: University of North Carolina at Chapel Hill

Christopher McCoy, MDMedical school: Emory University School of MedicineCollege/university: Duke University

Mithun Shenoi, MDMedical school: University of Minnesota Medical SchoolCollege/university: Carnegie Mellon University

Chi-fu Jeffrey Yang, MDMedical school: Harvard Medical SchoolCollege/university: Harvard College


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PGY-5Hamza Aziz, MDMedical school: Duke University School of MedicineCollege/university: Duke University

Brian Englum, MDMedical school: Johns Hopkins University School of MedicineCollege/university: Indiana University

Asvin Ganapathi, MDMedical school: Case Western Reserve University School of MedicineCollege/university: Stanford University

Brandon Henry, MD, MPHMedical school: University of Pennsylvania School of MedicineCollege/university: Rollins School of Public Health - Emory University


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PGY-5Mohan Mallipeddi, MDMedical school: Vanderbilt University School of MedicineCollege/university: Stanford University

Matthew Schechter, MDMedical school: Duke University School of MedicineCollege/university: Haverford College

Paul Speicher, MDMedical school: Northwestern University Feinberg School of MedicineCollege/university: University of Virginia

Surgical Research FellowsYear 1Morgan Cox, MDMedical school: Indiana University School of MedicineCollege/university: Butler University


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Surgical Research FellowsYear 1Robert Davis, MD, PhDMedical school: Michigan State UniversityCollege/university: Kalamazoo College

Brian Ezekian, MDMedical school: University of Virginia School of MedicineCollege/university: Pennsylvania State University

Brian Gilmore, MDMedical school: Duke University School of MedicineCollege/university: Emory University

Uttara Nag, MDMedical school: University of Pittsburgh School of MedicineCollege/university: Columbia University


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Surgical Research FellowsYear 1Cecilia Ong, MDMedical school: Duke University School of MedicineCollege/university: Yale University

Megan Turner, MDMedical school: University of Washington School of MedicineCollege/university: University of Washington

Surgical Research FellowsYear 2Michael Mulvihill, MDMedical school: Duke University School of MedicineCollege/university: Pomona College

David Ranney, MDMedical school: University of MichiganCollege/university: University of Michigan


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Surgical Research FellowsYear 2Shanna Sprinkle, MDMedical school: University of PennsylvaniaCollege/university: Johns Hopkins University

Alice Wang, MDMedical school: Duke University School of MedicineCollege/university: University of Chicago

Babatunde Yerokun, MDMedical school: The Pritzker School of Medicine, University of ChicagoCollege/university: Stanford University


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Surgical Research FellowsYear 3Adam Shoffner, MDMedical school: Yale University School of MedicineCollege/university: University of Kansas

Zhifei Sun, MDMedical school: University of Texas Southwestern Medical SchoolCollege/university: Rice University


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Dedicated Resident Research Program in General Surgery

The General Surgery Residency Program offers a two-year research experience following the PGY2 year that is dedicated both to research experiences and learning.

The research experiences are under the guidance of experienced mentors and include clini-cal and/or basic science research projects, applications for funding, and meeting abstract and paper submissions. Research topic and mentor selection officially begins during the PGY1 year and is aided through quarterly meetings with the Program Director for the research program and the Associate Director for Research Education. Together the resident and their mentor(s) design a research plan, which is presented to the Chair of Surgery during the PGY2 year.

Funding for the research years is shared between the Department of Surgery and the mentor’s division. All PGY2 residents develop and submit a Kirchstein National Research Service Award (NRSA) proposal for the April deadline prior to their first research year.

The unique interaction between basic science and clinical faculty within the Department of Surgery, which includes the Division of Surgical Science and other education initiatives (Duke SCORES and DUKE MERITS), allows the resident to choose from a wide range research topics that can include cardiovascular, oncology, biomedical engineering, immunology, and trans-plant sciences. This interdisciplinary research and clinical education provides an essential academic experience—applying for a grant from the NIH—and gives fellows the opportunity to develop a research plan for internal NIH-funded fellowship (institutional T32) grants, the DCRI Research Fellowship Training Program, or foundation fellowships such as the Thoracic Surgery Foundation for Research and Education (TSFRE), Ethicon-SUS (Society of University Surgeons), American College of Surgeons Clinical Scholars in Residence Program, or American Cancer Society, amongst others.

Progress is monitored by quarterly meetings with the residents and their mentors with the Research Residency Director and Associate Director for Research Education. Adjustments can be made along the way, depending on progress and interest. This oversight ensures a reward-ing and successful experience for each resident. Metrics for success include project funding application submission, meeting abstract submissions and presentations, and paper writing, submission, and publications.

If you have questions, contact:

David H. Harpole, MDResident Research DirectorProfessor of SurgeryCardiovascular and Thoracic Surgery

Gayathri R. Devi, MS., PhDAssociate Professor of SurgeryAssociate Director for Research EducationSurgical Sciences

https://surgery.duke.edu/divisions/surgical-sciences

https://surgery.duke.edu/research/health-services-research/surgical-center-outcomes-research-scores

https://surgery.duke.edu/research/health-services-research/surgical-center-outcomes-research-scores

https://surgery.duke.edu/education-and-training/advanced-education/duke-merits

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Research Laboratories

An internationally recognized leader in laboratory and clinical investigation, the Duke Depart-ment of Surgery receives over $35 million dollars of grant and award funding each year. It has been the top department of surgery recipient of NIH awards for over 20 years.

Our team of over 200 faculty members publish hundreds of articles annually in peer-reviewed journals, disseminating key findings and insights far beyond our walls. We welcome the contri-butions of our residents in advancing the science of surgery in our research labs.

Highlights of research performed at Duke Surgery follow. Find more information at surgery.duke.edu.

http://surgery.duke.edu

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Duke Endocrine Neoplasia Diseases Research Group

Principal InvestigatorJulie Sosa, MD

Research in the Duke Endocrine Neopla-sia Research Group focuses on benign and malignant diseases of the thyroid, parathyroid, pancreas, and adrenal glands. Although our primary emphasis is health services research and health outcomes, we are also interested in examining different issues along the continuum of patient care, including translational research, the psychologi-cal and economic impact on patients of endocrine diseases and their subsequent treatment, and patients’ decisions regarding the different diagnostic and treatment strategies available to them. The group comprises surgeons, endocrinologists, medical and radiation oncologists, residents, fellows, health services researchers, epidemiologists, pathologists, biostatisticians, surgical scientists, pharmacologists, and environmental health scientists at Duke, as well as surgery and biomedical engineering faculty from UNC-Chapel Hill and NC State.

Websitehttps://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/duke-endocrine-neoplasia-research-group

Recent PublicationsGoffredo, P, Robinson, TJ, Youngwirth, LM, Roman, SA, and Sosa, JA. “Intensity-modulated radiation therapy use for the localized treatment of thyroid cancer: Nationwide practice pat-terns and outcomes.” Endocrine 53, no. 3 (September 2016): 761-773.

Anderson, KL, Youngwirth, LM, Scheri, RP, Stang, MT, Roman, SA, and Sosa, JA. “T1a Versus T1b differentiated thyroid cancers: do we need to make the distinction?” Thyroid: official journal of the American Thyroid Association 26, no. 8 (August 2016): 1046-1052.

Kitahara, CM, and Sosa, JA. “The changing incidence of thyroid cancer.” Nature reviews. Endo-crinology (July 15, 2016). (Review)

Pontius, LN, Youngwirth, LM, Thomas, SM, Scheri, RP, Roman, SA, and Sosa, JA. “Lymphovascular invasion is associated with survival for papillary thyroid cancer.” Endocrine-related cancer 23, no. 7 (July 2016): 555-562.

Yip, L, and Sosa, JA. “Molecular-directed treatment of differentiated thyroid cancer: advances in diagnosis and treatment.” JAMA surgery 151, no. 7 (July 2016): 663-670.

https://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/duke-endocrine-neoplasia-research-group

https://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/duke-endocrine-neoplasia-research-group

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101

Determinants of Progression in Early Breast and Ovarian Cancer

Principal InvestigatorsJeffrey Marks, PhDEun-Sil Shelley Hwang, MD, MPH

Research in the Marks-Hwang labora-tory focus on the earliest stages of breast cancer, exploring the genetics, microenvironment, and evolution of early breast cancer. We are studying primary human ductal carcinoma in situ (DCIS) lesions that have not progressed to invasive cancer and comparing these to lesions that have progressed to invasive and metastatic dis-ease. Our central hypothesis regarding progression is that principles of evolution applied to human cancer can help to predict which lesions should be aggressively treated from those that are indolent and unlikely to progress. The lab is highly interdisiciplinary and integrates scien-tific collaborators from UCSF, OHSU, Stanford University, USC, and member institutions of the TBCRC, a clinical trials translational research network.

Websitehttps://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/determinants-progression-early-breast-and-ovarian-cancer

PublicationsRyser, MD, Worni, M, Turner, EL, Marks, JR, Durrett, R, and Hwang, ES. “Outcomes of active surveillance for ductal carcinoma in situ: a computational risk analysis.” Journal of the National Cancer Institute 108, no. 5 (May 2016).

Nakhlis, F, Gilmore, L, Gelman, R, Bedrosian, I, Ludwig, K, Hwang, ES, Willey, S, Hudis, C, Igle-hart, JD, Lawler, E, Ryabin, NY, Golshan, M, Schnitt, SJ, and King, TA. “incidence of adjacent syn-chronous invasive carcinoma and/or ductal carcinoma in-situ in patients with lobular neoplasia on core biopsy: results from a prospective multi-institutional registry (TBCRC 020).” Annals of surgical oncology 23, no. 3 (March 2016): 722-728.

Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, CL, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O’Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Science translational medicine 8, no. 320 (January 2016): 320ra4-.

Worni, M, Akushevich, I, Greenup, R, Sarma, D, Ryser, MD, Myers, ER, and Hwang, ES. “Trends in treatment patterns and outcomes for ductal carcinoma in situ.” Journal of the National Cancer Institute 107, no. 12 (December 2015): djv263-.

Acerbi, I, Cassereau, L, Dean, I, Shi, Q, Au, A, Park, C, Chen, YY, Liphardt, J, Hwang, ES, and Weaver, VM. “Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.” Integrative biology: quantitative biosciences from nano to macro 7, no. 10 (October 2015): 1120-1134.

https://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/determinants-progression-early-breast-and-ovarian-cancer

https://surgery.duke.edu/divisions/advanced-oncologic-and-gastrointestinal-surgery/research/research-laboratories/determinants-progression-early-breast-and-ovarian-cancer

RESEARCH LABS

102

Cardiothoracic Surgery Translational Research Laboratory

Principal InvestigatorCarmelo Milano, MD

The mission of the Cardiothoracic Sur-gery Translational Research Laboratory is to gain knowledge that will directly impact the clinical practice of cardiac surgery, heart failure therapy, heart transplantation, and mechanical circula-tory support. We conduct translational research by utilizing clinical specimens obtained through the Duke Human Heart Repository and large and small animal models. The lab has expertise and experience with molecular assays, cell culture stud-ies, tissue banking, biomarker development, viral-based gene therapy and large animal models of disease states. We welcome undergraduates, graduate and medical students, postgradu-ates, and medical residents interested in research investigation in these areas.

Websitehttps://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/ research-laboratories/cardiothoracic-surgery-translational-research-laboratory

Recent PublicationsCooper, LB, Milano, CA, Williams, M, Swafford, W, Croezen, D, Van Bakel, AB, Rogers, J, and Patel, CB. “Thyroid hormone use during cardiac transplant organ procurement.” Clinical trans-plantation (October 11, 2016).

Doll, JA, Ohman, EM, Patel, MR, Milano, CA, Rogers, JG, Wohns, DH, Kapur, NK, and Rao, SV. “A team-based approach to patients in cardiogenic shock.” Catheterization and cardiovascular interventions: official journal of the Society for Cardiac Angiography & Interventions 88, no. 3 (September 2016): 424-433.

Krishnamurthy, Y, Cooper, LB, Parikh, KS, Felker, GM, Milano, CA, Rogers, JG, Hernandez, AF, and Patel, CB. “Pulmonary hypertension in the era of mechanical circulatory support.” ASAIO journal (American Society for Artificial Internal Organs: 1992) 62, no. 5 (September 2016): 505-512.

Luo, N, Rogers, JG, Dodson, GC, Patel, CB, Galanos, AN, Milano, CA, O’Connor, CM, and Mentz, RJ. “Usefulness of palliative care to complement the management of patients on left ventricu-lar assist devices.” The American journal of cardiology 118, no. 5 (September 2016): 733-738.

Cooper, LB, Mentz, RJ, Edwards, LB, Wilk, AR, Rogers, JG, Patel, CB, Milano, CA, Hernandez, AF, Stehlik, J, and Lund, LH. “Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.” The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation (July 17, 2016).

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/cardiothoracic-surgery-translational-research-laboratory

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/cardiothoracic-surgery-translational-research-laboratory

RESEARCH LABS

103

Cardiovascular and Pulmonary Biology Laboratory

Principal InvestigatorShu Shiuh-Shi Lin, MD, PhD

Research in the Cardiovascular and Pulmonary Biology Laboratory has investigated various aspects of chronic aspiration-induced lung injury in non-transplant settings by using a rodent model of chronic gastric fluid aspiration. Our ongoing studies have revealed that the develop-ment of obliterative bronchiolitis in this model, a major cause of chronic lung allograft dysfunc-tion (CLAD) in patients, is dependent on a three-hit injury involving: (a) ischemia-reperfusion injury, (b) alloimmunity, and (c) chronic aspiration. In collaboration with Dr. William Parker at Duke, we also conduct research into factors present in post-industrial society that lead to aber-rant immune function.

Websitehttps://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/ research-laboratories/cardiovascular-and-pulmonary-biology-laboratory

Recent PublicationsLeung, JH, Chang, JC, Bell, SM, Holzknecht, ZE, Thomas, SM, Everett, ML, Parker, W, Davis, RD, and Lin, SS. “The role of soluble and insoluble gastric fluid components in the pathogenesis of obliterative bronchiolitis in rat lung allografts.” Transplant international: official journal of the European Society for Organ Transplantation 29, no. 2 (February 2016): 253-261.

Leung, JH, Chang, JC, Foltz, E, Bell, SM, Pi, C, Azad, S, Everett, ML, Holzknecht, ZE, Sanders, NL, Parker, W, Davis, RD, Keshavjee, S, and Lin, SS. “Clearance of bile and trypsin in rat lungs fol-lowing aspiration of human gastric fluid.” Experimental lung research 42, no. 1 (January 2016): 37-43.

Foltz, E, Azad, S, Everett, ML, Holzknecht, ZE, Sanders, NL, Thompson, JW, Dubois, LG, Parker, W, Keshavjee, S, Palmer, SM, Davis, RD, and Lin, SS. “An assessment of human gastric fluid composition as a function of PPI usage.” Physiological reports 3, no. 1 (January 27, 2015).

Shah, AA, Gregory, SG, Krupp, D, Feng, S, Dorogi, A, Haynes, C, Grass, E, Lin, SS, Hauser, ER, Kraus, WE, Shah, SH, and Hughes, GC. “Epigenetic profiling identifies novel genes for ascend-ing aortic aneurysm formation with bicuspid aortic valves.” The heart surgery forum 18, no. 4 (January 2015): E134-E139.

Pi, C, Allott, EH, Ren, D, Poulton, S, Lee, SY, Perkins, S, Everett, ML, Holzknecht, ZE, Lin, SS, and Parker, W. “Increased biodiversity in the environment improves the humoral response of rats.” PloS one 10, no. 4 (January 2015): e0120255-.

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/cardiovascular-and-pulmonary-biology-laboratory

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/cardiovascular-and-pulmonary-biology-laboratory

RESEARCH LABS

104

Duke Center for Aortic Disease Research Program

Prinicipal InvestigatorG. Chad Hughes, MD

The goal of the Duke Center for Aortic Disease Research Program is to further our under-standing of the pathophysiology of aortic diseases, develop better surgical and non-surgical treatments, and improve short- and long-term outcomes after thoracic aortic surgery. Our key projects include treatment and outcomes of acute and chronic aortic dissection; improv-ing outcomes after proximal aortic surgery; improving outcomes after thoracic endovascular aortic repair; and developing and advancing transcatheter aortic valve replacement.

Websitehttps://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/ research-laboratories/duke-center-aortic-disease-research-program

Recent PublicationsIribarne, A, Keenan, J, Benrashid, E, Wang, H, Meza, JM, Ganapathi, A, Gaca, JG, Kim, HW, Hur-witz, LM, and Hughes, GC. “Imaging surveillance after proximal aortic operations: is it neces-sary?” The Annals of thoracic surgery (September 24, 2016).

Andersen, ND, and Hughes, GC. “Concomitant replacement of the ascending aorta is free-for some.” The Journal of thoracic and cardiovascular surgery 152, no. 3 (September 2016): 799-800.

Reardon, MJ, Kleiman, NS, Adams, DH, Yakubov, SJ, Coselli, JS, Deeb, GM, O’Hair, D, Gleason, TG, Lee, JS, Hermiller, JB, Chetcuti, S, Heiser, J, Merhi, W, Zorn, GL, Tadros, P, Robinson, N, Petrossian, G, Hughes, GC, Harrison, JK, Maini, B, Mumtaz, M, Conte, JV, Resar, JR, Aharonian, V, Pfeffer, T, Oh, JK, Huang, J, and Popma, JJ. “Outcomes in the randomized CoreValve US Pivotal High-risk Trial in patients with a Society of Thoracic Surgeons risk score of 7% or less.” JAMA cardiology (August 17, 2016).

Benrashid, E, Wang, H, Andersen, ND, Keenan, JE, McCann, RL, and Hughes, GC. “Comple-mentary roles of open and hybrid approaches to thoracoabdominal aortic aneurysm repair.” Journal of vascular surgery (July 18, 2016).

Nauta, FJ, Tolenaar, JL, Patel, HJ, Appoo, JJ, Tsai, TT, Desai, ND, Montgomery, DG, Mussa, FF, Upchurch, GR, Fattori, R, Hughes, GC, Nienaber, CA, Isselbacher, EM, Eagle, KA, and Trimarchi, S. “Impact of retrograde arch extension in acute type B aortic dissection on management and outcomes.” The Annals of thoracic surgery (July 14, 2016).

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/duke-center-aortic-disease-research-program

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/duke-center-aortic-disease-research-program

RESEARCH LABS

105

Mechanical Support for Heart and Lung Disease Research

Principal InvestigatorMani Daneshmand, MD

Our research focuses on the use of mechanical circulatory support for individuals with acute treatable con-ditions causing lung or heart failure. Dr. Daneshmand and co-investigators seek to study important clinical ques-tions regarding variables that influence outcomes for therapies for advanced heart or lung failure and how mechanical support is best applied in various clinical settings. We’ve used large databases and registries such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), and the Nationwide Inpatient Sample (NIS) to evaluate cost-effectiveness, safety, and quality of life for mechanical circulatory support therapies.

Websitehttps://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/ research-laboratories/mechanical-support-heart-and-lung-disease-research

Recent PublicationsKeenan, JE, Schechter, MA, Bonadonna, DK, Bartz, RR, Milano, CA, Schroder, JN, and Danesh-mand, MA. “Early experience with a novel cannulation strategy for left ventricular decompres-sion during nonpostcardiotomy venoarterial ECMO.” ASAIO journal (American Society for Artificial Internal Organs: 1992) 62, no. 3 (May 2016): e30-e34.

Krishnamurthy, Y, Cooper, LB, Lu, D, Schroder, JN, Daneshmand, MA, Rogers, JG, Milano, CA, Hernandez, AF, and Patel, CB. “Trends and outcomes of patients with adult congenital heart disease and pulmonary hypertension listed for orthotopic heart transplantation in the United States.” The Journal of heart and lung transplantation: the official publication of the Interna-tional Society for Heart Transplantation 35, no. 5 (May 2016): 619-624.

Schechter, MA, Watson, MJ, Feger, BJ, Southerland, KW, Mishra, R, Dibernardo, LR, Kuchibhatla, M, Schroder, JN, Daneshmand, MA, Patel, CB, Rogers, JG, Milano, CA, and Bowles, DE. “Elevated cardiac troponin I in preservation solution is associated with primary graft dysfunction.” Jour-nal of cardiac failure 22, no. 2 (February 2016): 158-162.

Schechter, MA, Ganapathi, AM, Englum, BR, Speicher, PJ, Daneshmand, MA, Davis, RD, and Hartwig, MG. “Spontaneously breathing extracorporeal membrane oxygenation support pro-vides the optimal bridge to lung transplantation.” Transplantation (January 20, 2016).

Maxwell, C, Cherry, A, Daneshmand, M, Swaminathan, M, and Nicoara, A. “Assessment of coro-nary blood flow by transesophageal echocardiography.” Journal of cardiothoracic and vascular anesthesia 30, no. 1 (January 2016): 258-260.

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/mechanical-support-heart-and-lung-disease-research

https://surgery.duke.edu/divisions/cardiovascular-and-thoracic-surgery/research/research-laboratories/mechanical-support-heart-and-lung-disease-research

RESEARCH LABS

106

Fibrosis and Wound Healing

Principal InvestigatorHoward Levinson, MD

This laboratory investigates the mechanisms of fibrosis and tissue remodeling and aims to develop a novel small molecule inhibitor to prevent fibrocontractile disease progression. There is a large unmet need for an effective pharmaceutical to prevent fibrosis. The main projects in the laboratory currently seek to: (1) evaluate the clinicopathologic correlation between expres-sion of NMMII (isoforms IIA, IIB, IIC), myosin light chain kinase (MLCK), Rho kinase, MRLC, MYPT, and a-SMA as they relate to scar contracture progression and (2) clarify the relationship between NMMII regulation in fibroblasts, protomyofibroblasts, and myofibroblasts and trac-tional force generation.

Websitehttps://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/ research-laboratories/fibrosis-and-wound-healing

Recent PublicationsZhao, Y, Maher, JR, Ibrahim, MM, Chien, JS, Levinson, H, and Wax, A. “Deep imaging of absorp-tion and scattering features by multispectral multiple scattering low coherence interferom-etry.” Biomedical Optics Express 7, no. 10 (October 1, 2016): 3916-3926.

Cho, EH, Garcia, RM, Pien, I, Kuchibhatla, M, Levinson, H, Erdmann, D, Levin, LS, and Hollen-beck, ST. “Vascular considerations in foot and ankle free tissue transfer: Analysis of 231 free flaps.” Microsurgery 36, no. 4 (May 2016): 276-283.

Lorden, ER, Miller, KJ, Ibrahim, MM, Bashirov, L, Hammett, E, Chakraborty, S, Quiles-Torres, C, Selim, MA, Leong, KW, and Levinson, H. “Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction in an immune-competent murine model.” Acta biomaterialia 32 (March 2016): 100-109.

Cho, EH, Garcia, RM, Blau, J, Levinson, H, Erdmann, D, Levin, LS, and Hollenbeck, ST. “Micro-vascular anastomoses using end-to-end versus end-to-side technique in lower extremity free tissue transfer.” Journal of reconstructive microsurgery 32, no. 2 (February 2016): 114-120.

Bennett, KM, Levinson, H, Scarborough, JE, and Shortell, CK. “Validated prediction model for severe groin wound infection after lower extremity revascularization procedures.” Journal of vascular surgery 63, no. 2 (February 2016): 414-419.

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/fibrosis-and-wound-healing

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/fibrosis-and-wound-healing

RESEARCH LABS

107

Laboratory for Effectiveness, Quality, Implementation & Policy in Health Care (EQUIP)

Principal InvestigatorAlexander C. Allori, MD

The Laboratory for Effectiveness, Quality, Implementation & Policy in Health Care (EQUIP) utilizes epidemiology, research-design principles, biostatistics, and computational data-science methods to focus on these areas of research: comparative effectiveness research; pragmatic health-systems research; health-technology assessment; quality assessment, control and improvement; dissemination and implementation science; geospatial analysis; disparities of care; health policy; and health care economics.

Websitehttps://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/ research-laboratories/laboratory-effectiveness-quality-implementation-policy-health-care-equip

PublicationsSobol, DL, Allori, AC, Carlson, AR, Pien, IJ, Watkins, SE, Aylsworth, AS, Meyer, RE, Pimenta, LA, Strauss, RP, Ramsey, BL, Raynor, E, and Marcus, JR. “Nasal airway dysfunction in children with cleft lip/palate: Results of a cross-sectional population-based study, with anatomic and surgical considerations.” Plastic and reconstructive surgery (August 15, 2016).

Kim, J, Sun,Z, Englum, BR, Allori, AC, Adibe, OO, Rice, HE, and Tracy, ET. “Laparoscopy is safe in infants and neonates with congenital heart disease: a national study of 3684 patients.” Journal of laparoendoscopic & advanced surgical techniques. Part A (July 25, 2016).

Allori, AC, Kelley, T, Meara, JG, Albert, A, Bonanthaya, K, Chapman, K, Cunningham, M, Daskalagi-annakis, J, de Gier, H, Heggie, AA, Hernandez, C, Jackson, O, Jones, Y, Kangesu, L, Koudstaal, MJ, Kuchhal, R, Lohmander, A, Long, RE, Magee, L, Monson, L, Rose, E, Sitzman, TJ, Taylor, JA, Thorn-burn, G, van Eeden, S, Williams, C, Wirthlin, JO, and Wong, KW. “A standard set of outcome mea-sures for the comprehensive appraisal of cleft care.” The Cleft palate-craniofacial journal: official publication of the American Cleft Palate-Craniofacial Association (May 25, 2016).

Anolik, RA, Allori, AC, Pourtaheri, N, Rogers, GF, and Marcus, JR. “Objective assessment of the interfrontal angle for severity grading and operative decision-making in metopic synostosis.” Plastic and reconstructive surgery 137, no. 5 (May 2016): 1548-1555.

Atisha, DM, Burr, T, Allori, AC, Puscas, L, Erdmann, D, and Marcus, JR. “Facial fractures in the aging population.” Plastic and reconstructive surgery 137, no. 2 (February 2016): 587-593.

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/laboratory-effectiveness-quality-implementation-policy-health-care-equip

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/laboratory-effectiveness-quality-implementation-policy-health-care-equip

RESEARCH LABS

108

Tissue Engineering and Implantable Devices

Principal InvestigatorBruce Klitzman, PhD

Researchers in this lab are currently working on the attachment of endothelial cells to vascu-lar grafts in order to impart a more blood-compatible surface. We are also studying methods to implant glucose sensors for diabetics, developing a new generation of glaucoma drain-age devices, and improving the biocompatibility of implants through the coating of a special material that releases nitric oxide. Our projects receive funding from the National Institutes of Health and the Department of Defense.

Websitehttps://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/ research-laboratories/tissue-engineering-and-implantable-devices

Recent PublicationsLaux, P, Tralau, T, Tentschert, J, Blume, A, Al Dahouk, S, Bäumler, W, Bernstein, E, Bocca, B, Alimonti, A, Colebrook, H, de Cuyper, C, Dähne, L, Hauri, U, Howard, PC, Janssen, P, Katz, L, Klitzman, B, Kluger, N, Krutak, L, Platzek, T, Scott-Lang, V, Serup, J, Teubner, W, Schreiver, I, Wilkniß, E, and Luch, A. “A medical-toxicological view of tattooing.” Lancet (London, England) 387, no. 10016 (January 2016): 395-402. (Review)

Vallejo-Heligon, SG, Brown, NL, Reichert, WM, and Klitzman, B. “Porous, Dexamethasone-loaded polyurethane coatings extend performance window of implantable glucose sensors in vivo.” Acta biomaterialia 30 (January 2016): 106-115.

Gastrell, P, Cho, J, and Klitzman, B. “Improving the biocompatibility of implants in irradiated tis-sue using an adipose-derived stromal-vascular fraction.” November 1, 2015.

Register, JK, Fales, AM, Wang, HN, Norton, SJ, Cho, EH, Boico, A, Pradhan, S, Kim, J, Schroeder, T, Wisniewski, NA, Klitzman, B, and Vo-Dinh, T. “In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models.” Analytical and bioanalytical chemistry 407, no. 27 (November 2015): 8215-8224.

Jung, Y, Ji, H, Chen, Z, Chan, H, Atchison, L, Klitzman, B, Truskey, G, and Leong, KW. “Fabrication of scaffold-free tissue engineered blood vessel using nanopatterned human mesenchymal stem cell sheet.” September 1, 2015.

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/tissue-engineering-and-implantable-devices

https://surgery.duke.edu/divisions/plastic-maxillofacial-and-oral-surgery/research/research-laboratories/tissue-engineering-and-implantable-devices

RESEARCH LABS

109

Immune Management Laboratory

Principal InvestigatorAllan Kirk, MD, PhD

Research in the Immune Management Laboratory is directed toward understanding trans-plant rejection and translating this understanding into less morbid therapies for transplant recipients. Our group uses in vitro and animal models to develop transplant strategies and then investigates them in clinical trials. We also receive samples from patients in clinical trials to help understand what the next questions should be. We have successfully targeted several costimulatory molecules with monoclonal antibodies in primates and in humans, and are currently working to determine the best means of using these molecules to prevent kidney transplant rejection.

Websitehttps://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/ research-laboratories/immune-management-laboratory

Recent PublicationsModena, BD, Milam, R, Harrison, F, Cheeseman, JA, Abecassis, MM, Friedewald, J, Kirk, AD, and Salomon, DR. “Changes in urinary microbiome populations correlate in kidney transplants with interstitial fibrosis and tubular atrophy documented in early surveillance biopsies.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (September 6, 2016).

Chinnadurai, R, Copland, IB, Garcia, MA, Petersen, CT, Lewis, CN, Waller, EK, Kirk, AD, and Gal-ipeau, J. “Cryopreserved mesenchymal stromal cells are susceptible to T-cell mediated apopto-sis which is partly rescued by IFNγ Licensing.” Stem cells (Dayton, Ohio) 34, no. 9 (September 2016): 2429-2442.

Buchman, TG, Billiar, TR, Elster, E, Kirk, AD, Rimawi, RH, Vodovotz, Y, and Zehnbauer, BA. “Preci-sion medicine for critical illness and injury.” Critical Care Medicine 44, no. 9 (September 2016): 1635-1638.

Zheng, HB, Watkins, B, Tkachev, V, Yu, S, Tran, D, Furlan, S, Zeleski, K, Singh, K, Hamby, K, Hotchkiss, C, Lane, J, Gumber, S, Adams, A, Cendales, L, Kirk, AD, Kaur, A, Blazar, BR, Larsen, CP, and Kean, LS. “The knife’s edge of tolerance: inducing stable multilineage mixed chimerism but with a significant risk of CMV reactivation and disease in rhesus macaques.” American journal of transplantation: official journal of the American Society of Transplantation and the Ameri-can Society of Transplant Surgeons (August 8, 2016).

George, RP, Mehta, AK, Perez, SD, Winterberg, P, Cheeseman, J, Johnson, B, Kwun, J, Monday, S, Stempora, L, Warshaw, B, and Kirk, AD. “Premature T cell senescence in pediatric CKD.” Journal of the American Society of Nephrology: JASN (July 13, 2016).

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/immune-management-laboratory

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/immune-management-laboratory

RESEARCH LABS

110

Knechtle Lab

Principal InvestigatorStuart Knechtle, MD

Research in the Knechtle Lab focuses on the immunology of organ transplantation. Two unsolved problems in transplantation are: (1) injury caused by antibody directed at the donor organ and (2) recurrence of autoimmune disease after transplantation. Neither of these immu-nologic injuries is well addressed by current immunosuppressive therapy, and both prevent successful long-term allograft function. Our laboratory works in animal models to address the first of these problems and is engaged in human clinical trials to address the second.

Websitehttps://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/ research-laboratories/knechtle-lab

Recent PublicationsKnechtle, SJ, and Fairchild, RL. “Regulating T-cell behavior.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Trans-plant Surgeons 16, no. 7 (July 2016): 1949-1950.

Burghuber, CK, Kwun, J, Page, EJ, Manook, M, Gibby, AC, Leopardi, FV, Song, M, Farris, AB, Hong, JJ, Villinger, F, Adams, AB, Iwakoshi, NN, and Knechtle, SJ. “Antibody-mediated rejection in sen-sitized nonhuman primates: modeling human biology.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Trans-plant Surgeons 16, no. 6 (June 2016): 1726-1738.

Ludwig, JM, Webber, GR, Knechtle, SJ, Spivey, JR, Xing, M, and Kim, HS. “Percutaneous manage-ment of benign biliary strictures with large-bore catheters: comparison between patients with and without orthotopic liver transplantation.” Journal of vascular and interventional radiology: JVIR 27, no. 2 (February 2016): 219-225.e1.

Suhre, K, Schwartz, JE, Sharma, VK, Chen, Q, Lee, JR, Muthukumar, T, Dadhania, DM, Ding, R, Ikle, DN, Bridges, ND, Williams, NM, Kastenmüller, G, Karoly, ED, Mohney, RP, Abecassis, M, Friedewald, J, Knechtle, SJ, Becker, YT, Samstein, B, Shaked, A, Gross, SS, and Suthanthiran, M. “Urine metabolite profiles predictive of human kidney allograft status.” Journal of the American Society of Nephrology: JASN 27, no. 2 (February 2016): 626-636.

Halazun, KJ, Mathur, AK, Rana, AA, Massie, AB, Mohan, S, Patzer, RE, Wedd, JP, Samstein, B, Subramanian, RM, Campos, BD, and Knechtle, SJ. “One size does not fit all--regional variation in the impact of the share 35 liver allocation policy.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 1 (January 2016): 137-142.

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/knechtle-lab

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/knechtle-lab

RESEARCH LABS

111

Vascularized Composite Allograft Laboratory

Principal InvestigatorLinda Cendales, MD

Our research facilitates the translation of vascularized composite allotransplan-tation (VCA) from the bench to the bed-side. VCA refers to the transplantation of multiple tissues, such as skin, muscle, tendon, nerve, and bone, as a func-tional unit (e.g., a hand). Several recent advances in clinical organ transplant immunosuppression and experimental VCA have now made it feasible to consider clinical VCA for functional restoration in patients with the loss of one or both hands or large tissue defects that may not be reconstructed with autologous tissue.

Websitehttps://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/ research-laboratories/vascularized-composite-allograft-laboratory

Recent PublicationsZheng, HB, Watkins, B, Tkachev, V, Yu, S, Tran, D, Furlan, S, Zeleski, K, Singh, K, Hamby, K, Hotchkiss, C, Lane, J, Gumber, S, Adams, A, Cendales, L, Kirk, AD, Kaur, A, Blazar, BR, Larsen, CP, and Kean, LS. “The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism But With A Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (August 8, 2016).

Schneider, M, Cardones, AR, Selim, MA, and Cendales, LC. “Vascularized Composite Allotransplanta-tion: A Closer Look at the Banff Working Classification.” Transplant international: official journal of the European Society for Organ Transplantation 29, no. 6 (June 2016): 663-671. (Review)

Freitas, AM, Samy, KP, Farris, AB, Leopardi, FV, Song, M, Stempora, L, Strobert, EA, Jenkins, JA, Kirk, AD, and Cendales, LC. “Studies Introducing Costimulation Blockade for Vascularized Com-posite Allografts in Nonhuman Primates.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2240-2249.

Cendales, L, Bray, R, Gebel, H, Brewster, L, Elbein, R, Farthing, D, Song, M, Parker, D, Stillman, A, Pearson, T, and Kirk, AD. “Tacrolimus to Belatacept Conversion Following Hand Transplan-tation: A Case Report.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 8 (August 2015): 2250-2255.

Samy, K, Freitas, A, Farris, A, Leopardi, F, Song, M, Strobert, E, Jenkins, J, Kirk, A, and Cendales, L. “Costimulation Blockade Prolongs Rejection-Free Survival of Vascularized Composite Allografts in Non-Human Primates.” July 15, 2014.

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/vascularized-composite-allograft-laboratory

https://surgery.duke.edu/divisions/abdominal-transplant-surgery/research/research-laboratories/vascularized-composite-allograft-laboratory

RESEARCH LABS

112

Vascular Surgery Research Laboratory

Principal InvestigatorJeffrey Lawson, MD, PhD

The Vascular Surgery Research Laboratory is actively pursuing basic, translational, and clini-cal research activities related to the fields of blood coagulation, vascular biology, and vascular surgery. The laboratory has become a leader in the field of vascular translational research and has successfully developed a number of molecular, cellular, and tissue engineered technolo-gies through translational animal studies to first-in-man clinical trials. Projects include pre-clinical and clinical evaluation of human tissue engineered blood vessels; venous remodeling after arterial bypass and vascular access creation; and human blood coagulation response to trauma and elective surgery.

Websitehttps://surgery.duke.edu/divisions/vascular-surgery/research/research-laboratories/ vascular-surgery-research-laboratory

Recent PublicationsBenrashid, E, McCoy, CC, Youngwirth, LM, Kim, J, Manson, RJ, Otto, JC, and Lawson, JH. “Tissue engineered vascular grafts: Origins, development, and current strategies for clinical applica-tion.” Methods (San Diego, Calif.) 99 (April 2016): 13-19. (Review)

Gilmore, B, Benrashid, E, Youngwirth, LM, and Lawson, JH. “Paradoxical embolus following percutaneous thrombectomy of hemodialysis reliable outflow graft.” The journal of vascular access 16, no. 6 (November 2015): 533-536.

Yerxa, J, Gage, SM, and Lawson, JH. “Hemodialysis Reliable Outflow device impingement in the subclavian position: a case report.” The journal of vascular access 16, no. 5 (September 2015): 428-430.

Williams, JB, Harskamp, RE, Bose, S, Lawson, JH, Alexander, JH, Smith, PK, and Lopes, RD. “The preservation and handling of vein grafts in current surgical practice: findings of a survey among cardiovascular surgeons of top-ranked us hospitals.” JAMA surgery 150, no. 7 (July 2015): 681-683.

Turley, RS, Unger, J, Cox, MW, Lawson, J, McCann, RL, and Shortell, CK. “Atypical aortic throm-bus: should nonoperative management be first line?” Annals of vascular surgery 28, no. 7 (October 2014): 1610-1617.

https://surgery.duke.edu/divisions/vascular-surgery/research/research-laboratories/vascular-surgery-research-laboratory

https://surgery.duke.edu/divisions/vascular-surgery/research/research-laboratories/vascular-surgery-research-laboratory

RESEARCH LABS

113

Antiviral Drug Discovery Laboratory

Principal InvestigatorChin Ho Chen, PhD

The Laboratory of Antiviral Drug Discov-ery conducts research for the develop-ment of novel therapeutics against HIV-1 and influenza viruses. Projects include novel small molecules against HIV-1 and influenza viruses; identification of biological active principles from natural products; lead optimization of antivirals; and molecular mechanisms of antiviral actions. Among our achievements is the discovery of HIV-1 entry inhibitors through the study of HIV-1 Env-mediated cell-cell fusion.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ antiviral-drug-discovery-laboratory

Recent PublicationsZhao, Y, Gu, Q, Morris-Natschke, SL, Chen, CH, and Lee, KH. “Incorporation of privileged struc-tures into Bevirimat can improve activity against wild-type and Bevirimat-resistant HIV-1.” Journal of medicinal chemistry (September 22, 2016).

Zhong, JD, Zhao, XW, Chen, XQ, Li, HM, Chen, CH, Xia, XS, and Li, RT. “Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri.” Archives of pharmacal research 39, no. 6 (June 2016): 771-777.

Liu, N, Wei, L, Huang, L, Yu, F, Zheng, W, Qin, B, Zhu, DQ, Morris-Natschke, SL, Jiang, S, Chen, CH, Lee, KH, and Xie, L. “Novel HIV-1 Non-nucleoside reverse transcriptase inhibitor agents: optimization of Diarylanilines with high potency against wild-type and Rilpivirine-resistant E138K mutant virus.” Journal of medicinal chemistry 59, no. 8 (April 12, 2016): 3689-3704.

Dang, Z, Zhu, L, Lai, W, Bogerd, H, Lee, KH, Huang, L, and Chen, CH. “Aloperine and its deriva-tives as a new class of HIV-1 entry inhibitors.” ACS medicinal chemistry letters 7, no. 3 (March 2016): 240-244.

Jiang, C, Luo, P, Zhao, Y, Hong, J, Morris-Natschke, SL, Xu, J, Chen, CH, Lee, KH, and Gu, Q. “Caro-lignans from the aerial parts of euphorbia sikkimensis and their anti-HIV activity.” Journal of natural products 79, no. 3 (March 2016): 578-583.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/antiviral-drug-discovery-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/antiviral-drug-discovery-laboratory

RESEARCH LABS

114

Cardiovascular Biology Laboratory

Principal InvestigatorBruce Sullenger, PhD

The Cardiovascular Biology Laboratory is focused on multidisciplinary translational research approaches to the study of blood coagulation, inflammation, and atherogenesis at the molecu-lar level. Novel anti-coagulation approaches developed within the program are presently undergoing preclinical and clinical evaluation. Ongoing studies are aimed at exploring molecu-lar therapeutic approaches in the treatment of cardiovascular disease. We strive to develop novel, safe, and effective nucleic acid therapeutics. The lab currently focuses on two areas: (1) RNA and DNA repair via targeted trans-splicing and (2) the development of RNA ligands to protein targets to block or alter their function.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ cardiovascular-biology-laboratory

Recent PublicationsJackman, JG, Juwarker, H, Poveromo, LP, Levinson, H, Leong, KW, and Sullenger, BA. “Polyca-tionic nanofibers for nucleic acid scavenging. (Published online)” Biomacromolecules (October 14, 2016).

Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, AR, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.” Nature chemical biology 12, no. 9 (September 2016): 709-716.

Lee, J, Xu, L, Gibson, TM, Gersbach, CA, and Sullenger, BA. “Differential effects of toll-like recep-tor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts.” Bio-chemical and biophysical research communications 478, no. 3 (September 2016): 1484-1490.

Holl, EK, Shumansky, KL, Borst, LB, Burnette, AD, Sample, CJ, Ramsburg, EA, and Sullenger, BA. “Scavenging nucleic acid debris to combat autoimmunity and infectious disease.” Proceedings of the National Academy of Sciences of the United States of America 113, no. 35 (August 15, 2016): 9728-9733.

Lee, Y, Urban, JH, Xu, L, Sullenger, BA, and Lee, J. “2’fluoro modification differentially modulates the ability of RNAs to activate pattern recognition receptors.” Nucleic acid therapeutics 26, no. 3 (June 2016): 173-182.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/cardiovascular-biology-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/cardiovascular-biology-laboratory

RESEARCH LABS

115

Cell Death Laboratory

Principal InvestigatorGayathri R. Devi, PhD

Our research group focuses on trans-lational and clinical applications of programmed cell death signaling. We are particularly interested in elucidat-ing molecular mechanisms of stress-induced cell survival/death signaling in normal and cancer cells and how this process regulates immune response. Current funded research projects in the lab focus on innovative approaches toward immunosuppressive minimization; in vitro and in vivo tumor biology models; novel approaches toward islet xenotransplantation; and innovative preclinical models and strategies to modulate this anti-cell death.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ cell-death-laboratory

Recent PublicationsNath, S, and Devi, GR. “Three-dimensional culture systems in cancer research: Focus on tumor spheroid model.” Pharmacology & therapeutics 163 (July 2016): 94-108. (Review)

Evans, MK, Sauer, SJ, Nath, S, Robinson, TJ, Morse, MA, and Devi, GR. “X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity.” Cell death & disease 7 (January 28, 2016): e2073-.

Devi, GR, and Nath, S. “Delivery of Synthetic mRNA Encoding FOXP3 Antigen into Dendritic Cells for Inflammatory Breast Cancer Immunotherapy.” Methods in molecular biology (Clifton, N.J.) 1428 (January 2016): 231-243.

Allensworth, JL, Evans, MK, Bertucci, F, Aldrich, AJ, Festa, RA, Finetti, P, Ueno, NT, Safi, R, McDon-nell, DP, Thiele, DJ, Van Laere, S, and Devi, GR. “Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.” Molecular oncology 9, no. 6 (June 2015): 1155-1168.

Evans, MK, Sauer, SJ, Aldrich, AJ, Geradts, J, Vermeulen, P, Dirix, L, Van Laere, S, and Devi, GR. “Abstract P6-14-05: A novel link between anti-apoptotic signaling, NFκB, and SMAD7 in IBC pathobiology.” May 1, 2015.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/cell-death-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/cell-death-laboratory

RESEARCH LABS

116

Center for Applied Therapeutics

Principal InvestigatorH. Kim Lyerly, MD

The Center for Applied Therapeutics encompasses a broad array of research activities involved in the development, preclinical testing, and clinical testing of novel therapies targeting cancer or precancerous conditions. Major research areas of focus are early cancer genomics and biology; in vivo detection of malignant cells; immune therapy of cancer; population sciences; environ-mental health scholars; and international/global studies.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ center-applied-therapeutics

Recent PublicationsQuiroga, D, Lyerly, HK, and Morse, MA. “Deficient mismatch repair and the role of immuno-therapy in metastatic colorectal cancer.” Current treatment options in oncology 17, no. 8 (August 2016): 41-. (Review)

Vaidyanathan, G, McDougald, D, Choi, J, Koumarianou, E, Weitzel, D, Osada, T, Lyerly, HK, and Zalutsky, MR. “Preclinical evaluation of 18F-labeled anti-HER2 nanobody conjugates for imag-ing HER2 receptor expression by immuno-PET.” Journal of nuclear medicine: official publica-tion, Society of Nuclear Medicine 57, no. 6 (June 2016): 967-973.

Price, TT, Burness, ML, Sivan, A, Warner, MJ, Cheng, R, Lee, CH, Olivere, L, Comatas, K, Magnani, J, Kim Lyerly, H, Cheng, Q, McCall, CM, and Sipkins, DA. “Dormant breast cancer micrometasta-ses reside in specific bone marrow niches that regulate their transit to and from bone.” Science translational medicine 8, no. 340 (May 2016): 340ra73-.

Kohrt, HE, Tumeh, PC, Benson, D, Bhardwaj, N, Brody, J, Formenti, S, Fox, BA, Galon, J, June, CH, Kalos, M, Kirsch, I, Kleen, T, Kroemer, G, Lanier, L, Levy, R, Lyerly, HK, Maecker, H, Marabelle, A, Melenhorst, J, Miller, J, Melero, I, Odunsi, K, Palucka, K, Peoples, G, Ribas, A, Robins, H, Robinson, W, Serafini, T, Sondel, P, Vivier, E, Weber, J, Wolchok, J, Zitvogel, L, Disis, ML, and Cheever, MA. “Immu-nodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.” Journal for immunotherapy of cancer 4 (January 2016): 15-. (Review)

Oldham, M, Yoon, P, Fathi, Z, Beyer, WF, Adamson, J, Liu, L, Alcorta, D, Xia, W, Osada, T, Liu, C, Yang, XY, Dodd, RD, Herndon, JE, Meng, B, Kirsch, DG, Lyerly, HK, Dewhirst, MW, Fecci, P, Walder, H, and Spector, NL. “X-Ray psoralen activated cancer therapy (X-PACT).” PloS one 11, no. 9 (January 2016): e0162078-.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/center-applied-therapeutics

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/center-applied-therapeutics

RESEARCH LABS

117

Endocrine Neoplasia Laboratory

Principal InvestigatorJames Koh, PhD

In collaboration with Dr. Julie Sosa, the Endocrine Neoplasia Laboratory employs a combination of molecular, murine modeling, and live-cell imaging approaches to examine the underly-ing mechanisms of disrupted calcium sensing in parathyroid tumors. Our group has shown recently that parathy-roid adenomas are comprised of functionally discrete and separable cellular subpopulations that respond differentially to extracellular calcium stimulation and that arise in many cases following polyclonal expansion of progenitor cells within the parathyroid gland. Our goal is to understand how perturbed biochemical signaling can contribute to the development of preneoplastic lesions in human endocrine neoplasia.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ endocrine-neoplasia-laboratory

Recent PublicationsKoh, J, Hogue, JA, Wang, Y, DiSalvo, M, Allbritton, NL, Shi, Y, Olson, JA, and Sosa, JA. “Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behav-iour in primary hyperparathyroidism.” Journal of cellular and molecular medicine 20, no. 2 (February 2016): 351-359.

Koh, J, Hogue, JA, and Sosa, JA. “A Novel Ex Vivo Method for Visualizing Live-Cell Calcium Response Behavior in Intact Human Tumors.” PloS one 11, no. 8 (January 2016): e0161134-.

Koh, J, Allbritton, NL, and Sosa, JA. “Single-cell approaches for molecular classification of endo-crine tumors.” Current opinion in oncology 28, no. 1 (January 2016): 43-49. (Review)

Boquoi, A, Arora, S, Chen, T, Litwin, S, Koh, J, and Enders, GH. “Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.” Aging cell 14, no. 1 (February 2015): 139-147.

Lowe, R, Overhoff, MG, Ramagopalan, SV, Garbe, JC, Koh, J, Stampfer, MR, Beach, DH, Rakyan, VK, and Bishop, CL. “The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.” Genome biology 16 (January 2015): 194-.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/endocrine-neoplasia-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/endocrine-neoplasia-laboratory

RESEARCH LABS

118

Immune Dysfunction and Evolutionary Mismatch Laboratory

Principal InvestigatorsWilliam Parker, PhD

The primary focus of our laboratory is the concept of “evolutionary mismatch” and how that affects immune function in the modern world. An evolutionary mismatch is simply described as a con-dition in which an organism’s current environment leads to disease because it does not match the environment which drove the evolution of that organism’s genes. We are interested in normalizing immune function in Western society, in particular by dealing with one of the most profound and impactful consequences of evolutionary mismatch, “biome depletion”—the loss of biodiversity from the ecosystem of the human body.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ immune-dysfunction-and-evolutionary-mismatch-laboratory

Recent PublicationsBono-Lunn, D, Villeneuve, C, Abdulhay, NJ, Harker, M, and Parker, W. “Policy and regulations in light of the human body as a ‘superorganism’ containing multiple, intertwined symbiotic rela-tionships.” Clinical Research and Regulatory Affairs 33, no. 2-4 (October 2016): 39-48.

Kirman, CR, Suh, M, Hays, SM, Gürleyük, H, Gerads, R, De Flora, S, Parker, W, Lin, S, Haws, LC, Harris, MA, and Proctor, DM. “Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling.” Toxicology and applied pharmacology 306 (September 2016): 120-133.

“Lessons learned from drug design and development.” Perspectives in public health 136, no. 4 (July 1, 2016): 195-196.

Liu, J, Morey, RA, Wilson, JK, and Parker, W. “Practices and outcomes of self-treatment with hel-minths based on physicians’ observations.” Journal of helminthology (May 31, 2016): 1-11.

Parker, W, Berek, JS, Pritts, E, Olive, D, Kaunitz, AM, Chalas, E, Clarke-Pearson, D, Goff, B, Bris-tow, R, Taylor, HS, Farias-Eisner, R, Fader, AN, Maxwell, GL, Goodwin, SC, Love, S, Gibbons, WE, Foshag, LJ, Leppert, PC, Norsigian, J, Nager, CW, Johnson, T, Guzick, DS, As-Sanie, S, Paulson, RJ, Farquhar, C, Bradley, L, Scheib, SA, Bilchik, AJ, Rice, LW, Dionne, C, Jacoby, A, Ascher-Walsh, C, Kilpatrick, SJ, Adamson, GD, Siedhoff, M, Israel, R, Paraiso, MF, Frumovitz, MM, Lurain, JR, and Al-Hendy, A et al. “An open letter to the Food and Drug Administration regarding the use of morcellation procedures in women having surgery for presumed uterine myomas.” Journal of minimally invasive gynecology 23, no. 3 (March 2016): 303-308.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-dysfunction-and-evolutionary-mismatch-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-dysfunction-and-evolutionary-mismatch-laboratory

RESEARCH LABS

119

Immune Mechanisms of Disease Pathogenesis Laboratory

Principal InvestigatorJohn S. Yi, PhD

The Immune Mechanisms of Disease Pathogenesis laboratory is focused on developing a comprehensive under-standing of the cell-mediated immune responses to diseases spanning from cancer to autoimmune diseases. This disease spectrum is an example of the benefits and consequences of the immune response and the critical bal-ance that is required to achieve immune homeostasis. In our laboratory, we are deeply interested in how this balance in the immune response gets skewed in favor of autoimmunity or skewed in the opposite direction to elicit a strong immune response to eliminate pathogens without damaging the host. To profile the immune response, we utilize high dimensional flow cytometry and multiplex cellular assays to define the phenotype and functional capacity of immune cell subsets.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ immune-mechanisms-disease-pathogenesis-laboratory

Recent PublicationsGuptill, JT, Juel, VC, Massey, JM, Anderson, AC, Chopra, M, Yi, JS, Esfandiari, E, Buchanan, T, Smith, B, Atherfold, P, Jones, E, and Howard, JF. “Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis.” Autoimmunity (August 11, 2016): 1-8.

Yi, JS, Russo, MA, Weinhold, KJ, and Guptill, JT. “Adaptive immune response to therapy in HMGCR autoantibody myopathy.” Muscle & nerve 53, no. 2 (February 2016): 313-317.

Snyder, LD, Chan, C, Kwon, D, Yi, JS, Martissa, JA, Copeland, CA, Osborne, RJ, Sparks, SD, Palmer, SM, and Weinhold, KJ. “Polyfunctional T-Cell signatures to predict protection from cytomega-lovirus after lung transplantation.” American journal of respiratory and critical care medicine 193, no. 1 (January 2016): 78-85.

Abedini-Nassab, R, Joh, DY, Van Heest, MA, Yi, JS, Baker, C, Taherifard, Z, Margolis, DM, Garcia, JV, Chilkoti, A, Murdoch, DM, and Yellen, BB. “Characterizing the switching thresholds of mag-netophoretic transistors.” Advanced materials (Deerfield Beach, Fla.) 27, no. 40 (October 2015): 6176-6180.

Guptill, JT, Juel, VC, Massey, JM, Anderson, AC, Yi, JS, Chopra, M, and Jr, HJF. “Effect of therapeu-tic plasma exchange on immunoglobulins.” October 2015.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-mechanisms-disease-pathogenesis-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-mechanisms-disease-pathogenesis-laboratory

RESEARCH LABS

120

Immune Responses and Virology Laboratory

Principal InvestigatorGeorgia Tomaras, PhD

The goal of the Immune Responses and Virology Laboratory is to understand the cellular and humoral immune response to HIV-1 infection and vaccination that are involved in protection from HIV-1. Research in our laboratory centers around the following three main proj-ects: (1) antiviral CD8+ T cell responses in HIV-1 infection and post-vaccination, (2) mucosal and systemic antibody responses to infection and vaccination in both non-human primates and humans, and (3) the ontogeny of neutralizing antibodies in HIV-1 infection.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ immune-responses-and-virology-laboratory

Recent PublicationsFerrari, G, Haynes, BF, Koenig, S, Nordstrom, JL, Margolis, DM, and Tomaras, GD. “Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection.” Nature reviews. Drug discovery (October 7, 2016).

Gordon, SN, Liyanage, NP, Doster, MN, Vaccari, M, Vargas-Inchaustegui, DA, Pegu, P, Schi-fanella, L, Shen, X, Tomaras, GD, Rao, M, Billings, EA, Schwartz, J, Prado, I, Bobb, K, Zhang, W, Montefiori, DC, Foulds, KE, Ferrari, G, Robert-Guroff, M, Roederer, M, Phan, TB, Forthal, DN, Stablein, DM, Phogat, S, Venzon, DJ, Fouts, T, and Franchini, G. “Boosting of ALVAC-SIV vaccine-primed macaques with the CD4-SIVgp120 Fusion protein elicits antibodies to V2 associated with a decreased risk of SIVmac251 acquisition.” Journal of immunology (Baltimore, Md.: 1950) 197, no. 7 (October 2016): 2726-2737.

Andersson, AC, Ragonnaud, E, Seaton, KE, Sawant, S, Folgori, A, Colloca, S, Labranche, C, Montefiori, DC, Tomaras, GD, and Holst, PJ. “Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations.” Vaccine 34, no. 44 (October 2016): 5344-5351.

Townsley, S, Mohamed, Z, Guo, W, McKenna, J, Cleveland, B, LaBranche, C, Beaumont, D, Shen, X, Yates, NL, Pinter, A, Tomaras, GD, Ferrari, G, Montefiori, DC, and Hu, SL. “Induction of het-erologous tier 2 HIV-1-neutralizing and cross-reactive V1/V2-specific antibodies in rabbits by prime-boost immunization.” Journal of virology 90, no. 19 (October 2016): 8644-8660.

Safrit, JT, Tomaras, GD, Hanke, T, deCamp, AC, and Voronin, Y. “The landscape of targeted immune responses in the HIV-1 vaccine field.” AIDS research and human retroviruses 32, no. 10-11 (October 2016): 944-946.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-responses-and-virology-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immune-responses-and-virology-laboratory

RESEARCH LABS

121

Immunologic Signatures Laboratory

Principal InvestigatorKent J. Weinhold, PhD

The Immune Signatures Laboratory is the academic home for the Duke Immune Profiling Core (DIPC), a School of Medicine Shared Resource. In addi-tion to our ongoing HIV/AIDS research projects, we’re presently focused on utilizing a comprehensive repertoire of highly standardized and formerly vali-dated assay platforms to profile the human immune system in order to identify immunologic signatures that predict clinical outcomes. These are the very same assay platforms that have proven extraordinarily useful in profiling immunologic changes during acute and chronic HIV infection as well as in the context of elite virologic control.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ immunologic-signatures-laboratory

Recent PublicationsYi, JS, Russo, MA, Weinhold, KJ, and Guptill, JT. “Adaptive immune response to therapy in hmgcr autoantibody myopathy.” Muscle & nerve 53, no. 2 (February 2016): 313-317.

Zidar, DA, Mudd, JC, Juchnowski, S, Lopes, JP, Sparks, S, Park, SS, Ishikawa, M, Osborne, R, Washam, JB, Chan, C, Funderburg, NT, Owoyele, A, Alaiti, MA, Mayuga, M, Orringer, C, Costa, MA, Simon, DI, Tatsuoka, C, Califf, RM, Newby, LK, Lederman, MM, and Weinhold, KJ. “Altered maturation status and possible immune exhaustion of cd8 t lymphocytes in the peripheral blood of patients presenting with acute coronary syndromes.” Arteriosclerosis, thrombosis, and vascular biology 36, no. 2 (February 2016): 389-397.

Snyder, LD, Chan, C, Kwon, D, Yi, JS, Martissa, JA, Copeland, CA, Osborne, RJ, Sparks, SD, Palmer, SM, and Weinhold, KJ. “Polyfunctional T-Cell signatures to predict protection from cytomega-lovirus after lung transplantation.” American journal of respiratory and critical care medicine 193, no. 1 (January 2016): 78-85.

Guptill, JT, Yi, JS, Sanders, DB, Guidon, AC, Juel, VC, Massey, JM, Howard, JF, Scuderi, F, Bartoccioni, E, Evoli, A, and Weinhold, KJ. “Characterization of B cells in muscle-specific kinase antibody myas-thenia gravis.” Neurology® neuroimmunology & neuroinflammation 2, no. 2 (April 2015): e77-.

Foster, MW, Morrison, LD, Todd, JL, Snyder, LD, Thompson, JW, Soderblom, EJ, Plonk, K, Wein-hold, KJ, Townsend, R, Minnich, A, and Moseley, MA. “Quantitative proteomics of bronchoal-veolar lavage fluid in idiopathic pulmonary fibrosis.” Journal of proteome research 14, no. 2 (February 2015): 1238-1249.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immunologic-signatures-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immunologic-signatures-laboratory

RESEARCH LABS

122

Immunology, Inflammation, and Immunotherapy Laboratory

Principal InvestigatorSmita Nair, PhD

The research in our laboratory focuses on the design and testing of novel vaccines against cancer and viral infections using murine and human assay systems. In a pioneering study, our group demonstrated that dendritic cells, pulsed with unfractionated total RNA isolated from tumor cells, stimulates tumor immunity both in murine tumor models and in vitro human assays. A large number of our preclinical strategies have been translated into Phase I clinical trials in cancer patients. The focus and challenge of our laboratory, both at the preclinical and clinical level, is to augment the clinical benefit associated with immunotherapy. Our long-term goals are to: (1) evaluate the combined effects of individual strategies, (2) extend the clinical exploration to multiple cancers, and (3) combine immunotherapy and immune modulation with targeted cytotoxic therapy (radiotherapy, chemotherapy, immunotoxin therapy, and oncolytic poliovirus therapy).

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ immunology-inflammation-and-immunotherapy-laboratory

Recent PublicationsBoczkowski, D, and Nair, SK. “The RNAissance period.” Discovery medicine 22, no. 119 (August 2016): 67-72.

Kreiter, S, Diken, M, Pascolo, S, Nair, SK, Thielemans, KM, and Geall, A. “RNA vaccination therapy: advances in an emerging field.” Journal of immunology research 2016 (January 2016): 9703914-.

Dannull, J, and Nair, SK. “Transfecting human monocytes with RNA.” Methods in molecular biol-ogy (Clifton, N.J.) 1428 (January 2016): 177-186.

Pratico, ED, Feger, BJ, Watson, MJ, Sullenger, BA, Bowles, DE, Milano, CA, and Nair, SK. “RNA-mediated reprogramming of primary adult human dermal fibroblasts into c-kit(+) cardiac progenitor cells.” Stem cells and development 24, no. 22 (November 2015): 2622-2633.

Nair, SK, Driscoll, T, Boczkowski, D, Schmittling, R, Reynolds, R, Johnson, LA, Grant, G, Fuchs, H, Bigner, DD, Sampson, JH, Gururangan, S, and Mitchell, DA. “Ex vivo generation of dendritic cells from cryopreserved, post-induction chemotherapy, mobilized leukapheresis from pediatric patients with medulloblastoma.” Journal of neuro-oncology 125, no. 1 (October 2015): 65-74.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immunology-inflammation-and-immunotherapy-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/immunology-inflammation-and-immunotherapy-laboratory

RESEARCH LABS

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Innate and Adaptive Cellular Cytotoxicity Laboratory

Principal InvestigatorGuido Ferrari, MD

The overall goal of the laboratory is to understand the ontogeny of HIV-1 specific MHC class I-restricted and non-restricted immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vac-cine candidates. The studies gravitate around class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in effector cellular subsets, and development of Ab-based molecules that can engage cytotoxic effector subsets.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ innate-and-adaptive-cellular-cytotoxicity-laboratory

Recent PublicationsFerrari, G, Haynes, BF, Koenig, S, Nordstrom, JL, Margolis, DM, and Tomaras, GD. “Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection.” Nature reviews. Drug discovery (October 7, 2016).

Gordon, SN, Liyanage, NP, Doster, MN, Vaccari, M, Vargas-Inchaustegui, DA, Pegu, P, Schi-fanella, L, Shen, X, Tomaras, GD, Rao, M, Billings, EA, Schwartz, J, Prado, I, Bobb, K, Zhang, W, Montefiori, DC, Foulds, KE, Ferrari, G, Robert-Guroff, M, Roederer, M, Phan, TB, Forthal, DN, Stablein, DM, Phogat, S, Venzon, DJ, Fouts, T, and Franchini, G. “Boosting of ALVAC-SIV vaccine-primed macaques with the CD4-SIVgp120 fusion protein elicits antibodies to v2 associated with a decreased risk of SIVmac251 acquisition.” Journal of immunology (Baltimore, Md: 1950) 197, no. 7 (October 2016): 2726-2737.

Townsley, S, Mohamed, Z, Guo, W, McKenna, J, Cleveland, B, LaBranche, C, Beaumont, D, Shen, X, Yates, NL, Pinter, A, Tomaras, GD, Ferrari, G, Montefiori, DC, and Hu, SL. “Induction of het-erologous tier 2 HIV-1-neutralizing and cross-reactive V1/V2-specific antibodies in rabbits by prime-boost immunization.” Journal of virology 90, no. 19 (October 2016): 8644-8660.

Costa, M, Pollara, J, Edwards, RW, Seaman, M, Gorny, MK, Montefiori, D, Liao, HX, Ferrari, G, Lu, S, and Wang, S. “Fc receptor mediated activities by Env-specific human mAbs generated from volunteers receiving the DNA prime-protein boost HIV vaccine DP6-001.” Journal of virology (September 14, 2016).

Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, HX, Santra, S, Haynes, BF, Klot-man, ME, and Cara, A. “Immunization with an SIV-based IDLV expressing HIV-1 Env 1086 clade C elicits durable humoral and cellular responses in rhesus macaques.” Molecular therapy: the journal of the American Society of Gene Therapy (July 26, 2016).

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/innate-and-adaptive-cellular-cytotoxicity-laboratory

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/innate-and-adaptive-cellular-cytotoxicity-laboratory

RESEARCH LABS

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Laboratory for AIDS Vaccine Research and Development

Principal InvestigatorDavid Montefiori, PhD

Our major research interests are viral immunology and HIV vaccine development, with a special emphasis on neutralizing antibodies. One of our highest priorities is to identify immu-nogens that generate broadly neutralizing antibodies for inclusion in vaccines. Many aspects of neutralizing antibodies are studied in our laboratory, including mechanisms of neutraliza-tion, viral escape from neutralization, and epitope diversity among the many different genetic subtypes and geographic distributions of the virus.

Websitehttps://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/ laboratory-aids-research-and-development

Recent PublicationsJeffries, TL, Sacha, CR, Pollara, J, Himes, J, Jaeger, FH, Dennison, SM, McGuire, E, Kunz, E, Eudai-ley, JA, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, DC, Haynes, BF, Liao, HX, Ferrari, G, Alam, SM, Moody, MA, and Permar, SR. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.” Mucosal immunol-ogy 9, no. 2 (March 2016): 414-427.

Khattar, SK, DeVico, AL, LaBranche, CC, Panda, A, Montefiori, DC, and Samal, SK. “Enhanced immune responses to HIV-1 envelope elicited by a vaccine regimen consisting of priming with Newcastle disease virus expressing HIV gp160 and boosting with gp120 and SOSIP gp140 pro-teins.” Journal of virology 90, no. 3 (February 2016): 1682-1686.

Walsh, SR, Moodie, Z, Fiore-Gartland, AJ, Morgan, C, Wilck, MB, Hammer, SM, Buchbinder, SP, Kalams, SA, Goepfert, PA, Mulligan, MJ, Keefer, MC, Baden, LR, Swann, EM, Grant, S, Ahmed, H, Li, F, Hertz, T, Self, SG, Friedrich, D, Frahm, N, Liao, HX, Montefiori, DC, Tomaras, GD, McElrath, MJ, Hural, J, Graham, BS, and Jin, X. “Vaccination With heterologous HIV-1 envelope sequences and heterologous adenovirus vectors increases T-Cell responses to conserved regions: HVTN 083.” The Journal of infectious diseases 213, no. 4 (February 2016): 541-550.

de Taeye, SW, Ozorowski, G, Torrents de la Peña, A, Guttman, M, Julien, JP, van den Kerkhof, TL, Burger, JA, Pritchard, LK, Pugach, P, Yasmeen, A, Crampton, J, Hu, J, Bontjer, I, Torres, JL, Arendt, H, DeStefano, J, Koff, WC, Schuitemaker, H, Eggink, D, Berkhout, B, Dean, H, LaBranche, C, Crotty, S, Crispin, M, Montefiori, DC, Klasse, PJ, Lee, KK, Moore, JP, Wilson, IA, Ward, AB, and Sanders, RW. “Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes.” Cell 163, no. 7 (December 2015): 1702-1715.

Arrildt, KT, LaBranche, CC, Joseph, SB, Dukhovlinova, EN, Graham, WD, Ping, LH, Schnell, G, Sturdevant, CB, Kincer, LP, Mallewa, M, Heyderman, RS, Rie, AV, Cohen, MS, Spudich, S, Price, RW, Montefiori, DC, and Swanstrom, R. “Phenotypic correlates of HIV-1 macrophage tropism.” Journal of virology 89, no. 22 (November 2015): 11294-11311.

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/laboratory-aids-research-and-development

https://surgery.duke.edu/divisions/surgical-sciences/research/research-laboratories/laboratory-aids-research-and-development

FACULTY

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Faculty

Duke Surgery faculty members are both expert practitioners and valuable mentors. They have been trained at some of the most prestigious institutions in the country, and many are regarded internationally as experts in their field. Every year, they perform more than 30,000 procedures, publish hundreds of articles in peer-reviewed journals, and treat some of the rar-est and most challenging medical conditions.

At the same time, they are committed to providing comprehensive training and education to medical students, residents, and fellows. Faculty members show a high level of responsibil-ity for trainees’ futures, taking the time to develop relationships that support a collaborative learning environment. Residents are encouraged to begin mentorship relationships with faculty in the first year of their training and to develop these into lasting collaborative associa-tions. This direct access to experts allows residents to gain direct knowledge that cannot be found through classroom instruction.

In addition to being the academic home for faculty in the traditional general surgical special-ties, the Department houses faculty in Cardiovascular and Thoracic Surgery, Otolaryngol-ogy, Plastic Surgery, Urologic Surgery, and Vascular Surgery, as well as basic science faculty within the Division of Surgical Sciences. This enhances the breadth of experience afforded the general surgery resident. Members of the General Surgery and Cardiovascular and Thoracic faculty are listed below, as rotations on these specialties are most prevalent for the general surgery resident.

FACULTY

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Dan G. “Trey” Blazer III, MDAssociate Professor of Surgery

Title: Director, Hepatopancreatobiliary (HPB) Fellowship

Training: MD, Duke University School of Medicine, 1999

Residency: General Surgery, University of Michigan, 1999–2006

Fellowship: Surgical Oncology, National Cancer Institute, Maryland, 2002–2004

Surgical Oncology, University of Texas, MD Anderson Cancer Center, 2006–2008

Clinical Interests: Diagnosis and surgical management of solid tumors, includ-ing colorectal, hepatobiliary, and pancreatic malignancies; soft tissue sarcomas; regional perfusion strategies including hyper-thermic intraperitoneal chemotherapy (HIPEC)

Research Interests: Biology and therapeutic approaches toward sarcomas

Gayle Ackerman DiLalla, MDAssistant Professor of Surgery

Training: MD, University of Missouri–Kansas City School of Medicine, 1987

Advanced Oncologic and GI Surgery

FACULTY

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Oluwadamilola Motunrayo Fayanju, MD, AB, MAAssistant Professor of Surgery

Training: MD, Washington University School of Medicine, 2007

Residency: General Surgery Resident, Surgery, Washington University School of Medicine, 2007–2015

Fellowship: Breast Surgical Oncology Fellow, Surgery, University of Texas MD Anderson Cancer Center, 2015–2016

Other Training: A.B., Harvard University, 2001

M.A., Harvard University, 2001

MPHS, Washington University School of Medicine, 2011

Rachel Adams Greenup, MD, MPHAssistant Professor of Surgery

Title: Director, Breast Fellowship

Training: MD, Medical College of Wisconsin, 2004

Residency: General Surgery, Medical College of Wisconsin and Affiliated Hospitals, 2004–2011

Fellowship: Breast Surgical Oncology, Massachusetts General Hospital, Dana-Farber Cancer Institute and Brigham and Women’s Hospi-tal, 2011–2012

Other Training: MPH, University of Wisconsin-Madison School of Medicine and Public Health, 2010

Clinical Interests: Surgical treatment of breast disease, nipple-sparing mastec-tomies, clinical outcomes in young women with breast cancer, quality of life after breast cancer treatment

Advanced Oncologic and GI Surgery (continued)

FACULTY

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M. Benjamin Hopkins, MDAssistant Professor of Surgery

Training: MD, Wake Forest University School of Medicine, 2004

Residency: General Surgery, Ochsner Clinic Foundation, Louisiana, 2009

Fellowship: Colon and Rectal Surgery, Ochsner Clinic Foundation, Louisiana, 2010

Clinical Interests: Colorectal surgery, laparoscopic colorectal surgery, surgery for inflammatory bowel disease, endorectal ultrasound, benign anorectal disease, sphincter-saving procedures, ileal-pouch pro-cedures, rectal-prolapse repair, fecal incontinence, diverticulitis, presacral tumors, anal cancer

Eun-Sil Shelley Hwang, MD, MPHProfessor of Surgery

Title: Vice-Chair of Research

Chief, Section of Breast Surgery

Training: MD, University of California-Los Angeles David Geffen School of Medicine, 1991

Residency: General Surgery, Kaiser Permanente–Los Angeles, 1991–1992

General Surgery, Cornell University New York Hospital, 1992–1996

Fellowship: Breast Surgery, Memorial Sloan-Kettering Cancer Center, New York, 1996–1997

Surgical Oncology, Singapore General Hospital, 1997–1998

Clinical Interests: Diagnosis and treatment of early-stage breast cancer, manage-ment of patients at high risk for breast cancer, surgical treat-ment of patients with breast disease

Research Interests: Biology of early-stage breast cancer and evolution of metastatic disease.


FACULTY

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Sandhya Anand Lagoo-Deenadayalan, MD, PhDAssociate Professor of Surgery

Training: MD, B.J. Medical College, University of Poona, India, 1981

Residency: General Surgery, University of Mississippi Medical Center, 1995–2000

Fellowship: Endosurgery, Duke University Medical Center, 2000–2002

Training: PhD, Immunology, MD Anderson Cancer, Texas, 1990

Clinical Interests: Gastrointestinal surgery (open and laparoscopic), including inguinal and ventral hernia repair; cholecystectomy; splenec-tomy; anti-reflux procedures; Heller myotomy for achalasia

Research Interests: Surgical geriatrics, global health

Billy Y. Lan, MDAssistant Professor of Surgery

Training: MD, Tufts University School of Medicine, 2007

Residency: Categorical General Surgery Resident, Surgery, University of Hawaii, John A. Burns School of Medicine, 2007–2009

Categorical General Surgery Resident, Surgery, Cleveland Clinic Lerner College of Medicine of Case Western University, 2010–2015

Fellowship: Colorectal Surgery Fellow, Surgery, Cleveland Clinic Lerner College of Medicine of Case Western University, 2015–2016

Other Training: BS, Tufts University, 2001


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Laura Lazarus, MDAssistant Professor of Surgery

Training: MD, Drexel University College of Medicine, 1996

Residency: General Surgery Residency, Surgery, Louisiana State University School of Medicine in New Orleans, 1996–2001

Fellowship: Breast Surgery Fellowship, Northwestern University Feinberg School of Medicine, 2001–2002

Other Training: BS, Tufts University, 1992

Christopher Ritchie Mantyh, MDProfessor of Surgery

Title: Chief, Section of Gastrointestinal and Colorectal Surgery

Training: MD, University of Wisconsin Medical School, 1991

Residency: General Surgery, Duke University Medical Center, North Carolina, 1991–1998

Fellowship: Colorectal Surgery, Cleveland Clinic Foundation, Ohio, 1998–1999

Clinical Interests: Colorectal surgery; surgery for inflammatory bowel disease; benign anal/rectal surgery; sphincter-saving procedures for rectal cancer; fecal incontinence surgery; rectal prolapse repair; familial polyposis surgery; laparoscopic colon surgery; treat-ment of diverticulitis, anal cancer, Crohn’s disease, ulcerative colitis, ileus, motility, and neurogenic inflammation

Research Interests: Neurogenic inflammation, ulcerative colitis, Crohn’s disease, neuropeptides, receptors, vanilloid receptor, substance P, intestinal motility, colorectal cancer outcomes, colon cancer, rectal cancer


FACULTY

131

John Migaly, MDAssociate Professor of Surgery

Title: Director, General Surgery Residency Program

Training: MD, New York University School of Medicine, 1996

Residency: General Surgery, Temple University Health Sciences Center, 1997–2004

Fellowship: Colon and Rectal Surgery, Cleveland Clinic Foundation, Florida, 2005

Clinical Interests: Surgical treatment of colon and rectal cancer, Crohn’s disease, ulcerative colitis, diverticulitis, and benign anorectal diseases; laparoscopic colon and rectal surgery; sphincter-saving proce-dures; ileal-pouch procedures.

Harvey Gorden Moore, MDAssistant Professor of Surgery

Training: MD, Medical University of South Carolina School of Medicine, 1994

Residency: Surgical Resident, Surgery, Yale University School of Medicine, 1994–1999

Colorectal Surgery Resident, Surgery, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, 1999–2000

Other Training: BA, Furman University, 1990


FACULTY

132

Paul Joseph Mosca, MD, PhD, MBAAssociate Professor of Surgery

Training: MD, University of Virginia School of Medicine, 1995

Residency: General Surgery, Duke University Medical Center, 2002

Other Training: PhD, Biophysics, University of Virginia, 1994

MBA, Healthcare Systems Management, DeSales University, Pennsylvania, 2011

Clinical Interests: General surgery and surgical oncology, with special interest in melanoma and tumors of the liver, pancreas, upper and lower GI tract, skin, and soft tissues

Research Interests: Dr. Mosca’s research focuses on two areas. One is the devel-opment of more effective and entirely novel treatments for melanoma. He has a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of inter-est is palliative surgery for cancer, with an emphasis on under-standing the optimal role and application of this type of surgery in the care of advanced malignancy.

Thomas Leonard Novick, MDAssistant Professor of Surgery


Residency: Residency General & Thoracic Surgery, Surgery, Duke University School of Medicine, 1978–1980

Resident Orthopaedic Surgery, Surgery, Duke University School of Medicine, 1980–1981

Resident General Surgery, Surgery, Duke University School of Medicine, 1982–1986


FACULTY

133

David Masao Ota, MDProfessor of Surgery

Training: MD, University of Chicago, 1973

Theodore N. Pappas, MDProfessor of Surgery

Title: The Duke Surgical Innovation Professorship

Chief, Division of Advanced Oncologic and Gastrointestinal Surgery

Training: MD, The Ohio State University School of Medicine, 1981

Residency: Surgery, Brigham and Women’s Hospital, Massachusetts, 1981–1988

Clinical Interests: Gastrointestinal surgery; advanced laparoscopic surgery; surgical complications of pancreatitis; benign and malignant esophageal, biliary, pancreatic and gastric disease; complicated abdominal-wall reconstructions

Research Interests: Dr. Pappas’ laboratory is engaged in several areas of research, all relating to gastrointestinal physiology. They are currently studying: (1) upper gut motility as it relates to the cycloxygen-ace pathway; (2) colonic motility as it relates to short chain fatty acid (SCFA); (3) the role of pig small intestine as a prosthetic agent in the treatment of gastrointestinal perforation.


FACULTY

134

Alexander Perez, MDAssociate Professor of Surgery

Training: MD, Universidad El Bosque, Colombia, 2000

Residency: Surgery, Brigham and Women’s Hospital, Massachusetts, 2002–2003

Surgery, Baystate Medical Center, Massachusetts, 2003–2007

Fellowship: Gastrointestinal Surgery Research, Brigham and Women’s Hos-pital, Massachusetts, 2000–2002

Minimally Invasive Surgery, Duke University Medical Center, 2007–2008

Clinical Interests: Advanced minimally invasive surgery for diseases of the stom-ach, intestine, gallbladder, pancreas, spleen, adrenal gland, and hernias

Jennifer K. Plichta, MD, MSAssistant Professor of Surgery

Training: MD, Indiana University School of Medicine, 2008

Residency: General Surgery Resident, Surgery, Loyola University Medical Center, 2008–2015

Fellowship: Breast Surgery Fellowship, Surgery, Massachusetts General Hospital, 2015–2016

Breast Surgery Fellowship, Surgery, Dana Farber Cancer Insti-tute, 2015–2016

Breast Surgery Fellowship, Surgery, Brigham and Women’s Hospital, 2015–2016

Other Training: BA, Depauw University, 2002

MS, Loyola University Medical Center, 2012


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135

Sanziana Alina Roman, MDProfessor of Surgery

Title: Director, Endocrine Surgery Fellowship

Training: MD, Columbia University College of Physicians and Surgeons, 1994

Residency: Internship, Surgery, Yale New Haven Hospital, 1994–1995

Surgery, Yale New Haven Hospital, 1995–1998 (Chief Resident, 1998–1999)

Other Training: BA, Cornell University, 1990

Fellow, American College of Surgeons

Clinical Interests: Endocrine surgery, including adrenal, thyroid and parathyroid benign diseases and cancers; advanced stage cancer; medullary and anaplastic thyroid cancer; familial syndromes (i.e., multiple endocrine neoplasia 1, 2 A and B, FMTC, von Hippel-Lindau, etc.); minimal access/minimally invasive parathyroidectomy and laparoscopic techniques, including posterior retroperitoneo-scopic adrenalectomy

Laura Horst Rosenberger, MDAssistant Professor of Surgery

Training: MD, Jefferson Medical College of Thomas Jefferson University, 2008

Residency: General Surgery Resident, Surgery, University of Virginia School of Medicine, 2008–2015

Other Training: BS, Eastern Mennonite University, 2003


FACULTY

136

Randall Paul Scheri, MDAssociate Professor of Surgery

Training: MD, University of Virginia, 1996

Residency: General Surgery, Barnes Hospital/Washington University in St. Louis, 1996–2003

Fellowship: Surgical Oncology, John Wayne Cancer Institute, California, 2004–2007

Clinical Interests: Endocrine surgery, including for disorders of the thyroid, parathyroid glands, and adrenal glands; minimally invasive techniques, including radio-guided parathyroidectomy; thyroid-ectomy with recurrent laryngeal nerve monitoring; laparoscopic adrenalectomy; surgical oncology, including for melanoma and malignant diseases of the breast; clinical trials; sentinel lymphnode biopsy; neoadjuvant endocrine therapy and chemo-therapy for breast conservation

Kevin Naresh Shah, MDAssistant Professor of Surgery

Training: MD, Drexel University College of Medicine, Pennsylvania, 2007

Residency: General Surgery, Cleveland Clinic, Ohio

Fellowship: Surgical Oncology and Hepatobiliary Surgery, Duke University Medical Center

Clinical Interests: Surgical treatment of upper gastrointestinal malignancies, par-ticularly benign and malignant diseases of the liver, pancreas and bile duct; minimally invasive HPB, duodenal and gastric surgery

Research Interests: Improving outcomes from HPB surgery; pancreatic cancer, pan-creatic cysts, primary and metastatic tumors of the liver


FACULTY

137

Karen Lynn Sherman, MDAssistant Professor of Surgery

Training: MD, Loyola University Chicago Stritch School of Medicine, 2008

Residency: General Surgery Resident, Surgery, Northwestern University, 2008–2011

General Surgery Chief Resident, Surgery, Northwestern Univer-sity, 2013–2015

Fellowship: Surgical Outcomes Research Fellow, Surgery, Northwestern University, 2011–2013

Other Training: BA, Kalamazoo College, 2004 MSc, Northwestern University, 2013


FACULTY

138

Julie Ann Sosa, MDProfessor of Surgery

Title: Director, Surgical Center for Outcomes Research (SCORES) Chief, Section of Endocrine Surgery

Training: MD, Johns Hopkins University School of Medicine, 1994

Residency: Internship, Surgery, Johns Hopkins Hospital, 1994–1995

Assistant Resident, Surgery, Johns Hopkins Hospital, 1995–1996

Specialist Registrar, John Radcliffe and Churchill Hospitals, Oxford, England, 2000

Senior Resident, Surgery, Johns Hopkins Hospital, 1998–2000 (Chief Resident, 2000–2001)

Fellowship: Robert Wood Johnson Clinical Scholar, Johns Hopkins Hospital, 1996–1998

Surgical Oncology, Johns Hopkins Hospital, 2001–2002

Other Training: AB, Princeton University, 1988 MA, University of Oxford, England, 1990 Fellow, American College of Surgeons

Clinical Interests: Endocrine surgery, including surgery for thyroid cancer; mini-mally invasive parathyroidectomy and laparoscopic adrenalec-tomy (posterior retroperitoneal); clinical trials; surgical oncology

Research Interests: Dr. Sosa is widely published in outcomes analysis as well as cost-effectiveness analysis, meta-analysis, and survey-based research. Her research group is multi-disciplinary, and she has collabora-tors in health services research and outcomes, biostatistics, geri-atrics, endocrinology, oncology, vascular surgery, breast surgery, pharmacology and cancer biology, and stem cell research.


FACULTY

139

Michael Tracey Stang, MDAssociate Professor of Surgery

Training: MD, University of Nebraska Omaha, 2000

Residency: Categorical General Surgery Resident, Surgery, University of Pittsburgh, 2000–2008

Fellowship: Fellow, Endocrine Surgery, Surgery, University of Pittsburgh School of Medicine, 2008–2009

Other Training: BS, Creighton University, 1995

John Hubert Stewart, MD, MBAAssociate Professor of Surgery

Training: MD, Howard University College of Medicine, 1995

Residency: General Surgery Resident, Surgery, Temple University School of Medicine, 1995–1998

General Surgery Resident, Surgery, Vanderbilt University, 2002–2004

Fellowship: Tumor Immunotherapy Fellow, National Institutes of Health, 1998–1999

Surgical Oncology Fellow, National Institutes of Health, 1999–2002

Other Training: BS, Louisiana Tech University, 1991 MBA, Wake Forest University, 2014


FACULTY

140

Julie K. Marosky Thacker, MDAssociate Professor of Surgery

Title: Medical Director, Clinical Research Unit


Residency: General Surgery, University of Utah Health Sciences Center, 1998–2004

Fellowship: Colon and Rectal Surgery, Mayo Clinic, Minnesota, 2005

Clinical Interests: Surgical treatment of primary and recurrent colon and rectal cancer; laparoscopic colon and rectal surgery; surgical manage-ment of inflammatory bowel disease, polyposis syndromes, complex pelvic tumors, and anorectal disease

Lisa Anne Tolnitch, MDAssistant Professor of Surgery

Training: MD, University of Louisville School of Medicine, 1983


FACULTY

141

Sabino Zani, MDAssistant Professor of Surgery

Training: MD, Albany Medical College, 2003

Residency: General Surgery, University of Connecticut Integrative, 2003–2010

Fellowship: Surgical Oncology, Duke University Medical Center, 2010–2012

Other Training: BS, Biology, Rensselaer Polytechnic Institute, 1997 MS, Biology, Rensselaer Polytechnic Institute, 1999

Clinical Interests: Surgical oncology; benign and malignant hepatobiliary, pancre-atic, and gastrointestinal disease; advanced laparoscopic surgery


FACULTY

142

Vascular Surgery

Mitchell Wayne Cox, MDAssociate Professor of Surgery

Title: Director, Vascular Surgery Fellowship

Training: MD, Case Western Reserve University, 1996

Residency: General Surgery, Wright State University, Ohio, 2001

Fellowship: Vascular Surgery, Baylor College of Medicine, Texas, 2004

Clinical Interests: Minimally invasive and surgical treatment of all aspects of peripheral arterial and venous disease, including aortic aneu-rysm, carotid stenosis, and lower-extremity occlusive disease; arteriovenous access for hemodialysis; IVC filter complications; central vein occlusion.

Ellen DeAnne Dillavou, MDAssociate Professor of Surgery

Training: MD, University of Arizona College of Medicine, 1996

Residency: General Surgery Residency, Surgery, Thomas Jefferson University, 1996–2002

Fellowship: Vascular Surgery Fellowship, Surgery, University of Pittsburgh, 2002–2004

Other Training: BA, Macalester College, 1991

FACULTY

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Vascular Surgery (continued)

Jeffrey Harold Lawson, MD, PhDProfessor of Surgery

Training: MD, University of Vermont, 1991

Residency: General and Thoracic Surgery, Duke University Medical Center, 1992–1999

Fellowship: Vascular Surgery, Duke University Medical Center, 2001–2002

Other Training: PhD, Cell and Molecular Biology, University of Vermont, 1992

Clinical Interests: Vascular surgery, hemodialysis access, peripheral arterial disease, aortic disease, carotid artery disease, endovascu-lar surgery, surgical disorders of vascular thrombosis, blood coagulation

Research Interests: The research interests of Dr. Lawson’s laboratory include the study of vascular biology and cellular differentiation of vascular tissue, the proteolytic and cell-mediated regulation of blood coagulation, inflammatory mediated thrombosis, and the devel-opment of bioengineered blood vessels. The clinical interests of his laboratory include the study of novel therapies for vascular and cardiovascular surgery, thrombosis related to surgical pro-cedures, clinical inhibitors of blood coagulation proteases, and the study of the immune response to biologics used in surgery.

FACULTY

144

Chandler Alexander Long, MDAssistant Professor of Surgery

Training: MD, Case Western Reserve University School of Medicine, 2007

Residency: General Surgery Internship, Surgery, Vanderbilt University, 2007–2008

General Surgery Residency, Surgery, University of Tennessee–Knoxville, 2008–2014

Fellowship: Post Doctoral Research Fellowship, Surgery, Harvard Medical School, 2010–2011

Vascular Surgery Fellowship, Surgery, Emory University School of Medicine, 2014–2016

Other Training: BA, Hamilton College, 2003

Roberto Jose Manson, MDAssistant Professor of Surgery

Training: MD, National University of Tucuman, Argentina, 1996

Residency: General Surgery, Hospital Italiano de Buenos Aires, 2002

Fellowship: MIS Research Fellowship, Duke University, 2005 Vascular Research Fellowship, Duke University, 2008

Clinical Interests: Vascular access

Research Interests: Vascular access, surgical device preclinical trials, surgical train-ing skills


FACULTY

145

Richard L. McCann, MDProfessor of Surgery

Training: MD, Cornell University Medical College, 1974

Residency: Surgery and Vascular Surgery, Duke University Medical Center, 1974–1983

Clinical Interests: Endovascular and open surgery for abdominal and thoracic aortic aneurysms; endovascular and open surgery for periph-eral vascular disease; carotid artery disease; lower-extremity vascular obstruction

Research Interests: Current research interests involve the application of endovas-cular technology to the treatment of peripheral vascular dis-eases. These activities include the use of commercially available and experimental designs of stent grafts for abdominal aortic aneurysm and the use of angioplasty and stenting for the man-agement of difficult carotid artery disease.

Leila Mureebe, MD, MPHAssociate Professor of Surgery

Training: MD, Medical College of Pennsylvania, 1992

Residency: General Surgery, Medical College of Pennsylvania, 1999

Fellowship: Vascular Research, Harvard Longwood Fellowship, 1995–1997

Vascular Surgery, Yale-New Haven Hospital, Connecticut, 1999–2001

Other Training: MPH, University of North Carolina at Chapel Hill, 2011

Clinical Interests: Vascular and endovascular surgery; diagnosis and management of the full spectrum of arterial and venous diseases; minimally invasive procedures for vascular disease, including endograft repair of aortic aneurysms, angioplasty, and stenting of the carotid, renal, and mesenteric arteries as well as angioplasty and stenting of the arteries to treat peripheral vascular disease.


FACULTY

146


Daiva Nevidomskyte, MDAssistant Professor of Surgery

Training: MD, Boston University School of Medicine, 2011

Residency: Vascular Surgery Residency, University of Washington, 2011–2016

Other Training: BA, Wellesley College, 2005

Cynthia Keene Shortell, MDProfessor of Surgery

Title: Chief of Staff Chief, Division of Vascular Surgery

Training: MD, Weill Cornell Medical College, 1984

Residency: General Surgery, University of Rochester, New York, 1984–1989

Fellowship: Vascular Surgery, University of Rochester, 1989–1993

Clinical Interests: Open and endovascular aortic repair, thrombolytic therapy for acute arterial and venous occlusions, endovascular and minimally invasive therapies for venous disorders, percutaneous interven-tions for lower-extremity occlusive disease, vascular anomalies.

FACULTY

147

Abdominal Transplant Surgery

Andrew Serghios Barbas, MDAssistant Professor of Surgery


Residency: General Surgery Resident, Surgery, Duke University, 2007–2014

Fellowship: Abdominal Transplant and HPB Surgery Fellow, Surgery, University of Toronto (Canada), 2014–2016

Other Training: BSE, Duke University, 2003

Todd Victor Brennan, MD, MSAssociate Professor of Surgery

Training: MD, Harvard Medical School, Massachusetts, 1999

Residency: General Surgery, UCSF Medical Center, California, 1999–2007

Fellowship: Abdominal Transplantation, UCSF Medical Center, California, 2007–2009

Clinical Interests: General, laparoscopic, and hepatobiliary surgery; liver-, kidney-, and pancreas-transplant surgery

Research Interests: Dr. Brennan studies the regulation of T-cell subsets by innate immune signals. The goal of his laboratory is to understand the contribution of innate pathway stimulation on the allospecific T-cell response during organ transplantation. Through these studies, they aim to gain new insights into the molecular basis of alloimmunity and immune tolerance in order to reveal novel targets for the prevention and treatment of transplant rejection.

FACULTY

148

Bradley Henry Collins, MDAssociate Professor of Surgery

Title: Medical Director, Animal Research


Residency: General Surgery, Duke University Medical Center, 1989–1997

Fellowship: Transplant Surgery, University of Wisconsin at Madison, 1997–1999

Clinical Interests: Liver, pancreas, and kidney transplantation; general surgery in transplant patients, dialysis access surgery

Research Interests: The laboratory’s primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, they have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Their goal is to demonstrate the utility of this system as a pre-clinical model. The laboratory is also collaborating with hepatologist Dr. Don Rockey to study senes-cence of the liver.

Abdominal Transplant Surgery (continued)

FACULTY

149

Allan Douglas Kirk, MD, PhDProfessor of Surgery

Title: Chair, Department of Surgery


Residency: Surgery, Duke University, 1995

Fellowship: Multi-organ Transplantation Fellowship, University of Wisconsin, 1997

Other Training: PhD, Immunology, Duke University, 1992

Research Interests: Dr. Kirk’s primary research interests lie in the development and implementation of novel immunomodulatory strategies for transplantation and other surgically relevant conditions. He is principal investigator on numerous projects funded by the NIH, FDA, and Department of Defense.

Stuart Johnston Knechtle, MDProfessor of Surgery

Training: MD, Weill Cornell Medical College, 1982

Residency: Surgery, Duke University, 1989

Fellowship: Multi-organ transplantation, University of Wisconsin, 1991

Research Interests: Dr. Knechtle’s research interests lie in the development and implementation of novel strategies for preventing organ trans-plant rejection, preventing antibody-mediated injury, and pre-venting recurrence of autoimmune disease. His lab has been continually funded by the NIH for 24 years.


FACULTY

150

Jean Kwun, PhDAssistant Professor of Surgery

Training: PhD, University of Wisconsin at Madison, 2007

Kadiyala Venkata Ravindra, MBBSAssociate Professor of Surgery

Title: Director, Abdominal Transplant Surgical Fellowship

Training: MBBS, Jawaharlal Institute of Postgraduate Medical Education and Research, India, 1987

Residency: General Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, India, 1988–1992

Surgical Gastroenterology, Sanjay Gandhi Post-Graduate Insti-tute of Medical Sciences, India, 1992–1994

Fellowship: Hepatobiliary and Pancreatic Surgery, St. James University Hos-pital, United Kingdom, 2000–2003

Transplant Surgery, University of Nebraska Medical Center, 2003–2005

Clinical Interests: Hepatobiliary and pancreatic surgery, laparoscopic liver resec-tions, cholangiocarcinoma, surgery for chronic pancreatitis, abdominal organ transplantation (liver, kidney, pancreas)


FACULTY

151

Debra Sudan, MDProfessor of Surgery

Title: Chief, Division of Abdominal Transplant Surgery

Training: MD, Wright State University, Boonshoft School of Medicine, Ohio, 1989

Residency: General Surgery, Wright State University, Ohio, 1994

Fellowship: Solid Organ Transplantation, University of Nebraska, 1996

Clinical Interests: Abdominal organ transplantation, including liver, intestine, kid-ney, and pancreas; pediatric transplantation; intestinal failure; intestine-lengthening surgery (STEP and Bianchi) for patients with short-bowel syndrome; hepatobiliary surgery; laparoscopic liver resection

Deepak Vikraman Sushama, MDAssistant Professor of Surgery

Training: MD, Trivandrum Medical College (India), 1996


FACULTY

152

Cardiovascular and Thoracic Surgery

Albert Chang, MDAssistant Professor of Surgery

Training: MD, Duke University, 1996

Thomas Anthony D’Amico, MDProfessor of Surgery

Title: Director, Integrated Thoracic Surgery Residency Program and Joint General Surgery and Thoracic Surgery Residency Program

Director, Advanced Training in Cardiothoracic Surgery


Residency: Thoracic Surgery, Duke University Medical Center, 1987–1996

Fellowship: Thoracic Oncology, Memorial Sloan-Kettering Cancer Center, 1996

Clinical Interests: Lung and esophageal cancer; general thoracic and thoroco-scopic surgery; minimally invasive thoracic surgery; thoracic oncology; lung volume reduction; photodynamic therapy (PDT); laser bronchoscopy; bronchial and esophageal stents; molecu-lar biology of lung and esophageal cancer

Research Interests: Lung cancer: (1) the role of molecular markers in the prognosis and therapy of lung cancer; (2) genomic analysis lung cancer mutations. Esophageal cancer: (1) the role of molecular mark-ers in the prognosis and therapy of esophageal cancer; (2) genomic analysis esophageal cancer mutations.

FACULTY

153

Cardiovascular and Thoracic Surgery (continued)

Mani Ali Daneshmand, MDAssistant Professor of Surgery

Training: MD, Albany Medical College, 2004


Fellowship: Cardiothoracic Surgical Research, Duke University Medical Center, 2006–2008

Cardiothoracic Surgery, Duke University Medical Center, 2011–2013

Clinical Interests: Cardiac and lung transplantation, left ventricular assist devices, adult cardiac surgery, mitral valve surgery, surgical treatments for end-stage congestive heart failure, aortic valve surgery

Jeffrey Giles Gaca, MDAssociate Professor of Surgery



Fellowship: Cardiothoracic Surgery, Duke University Medical Center, 2005–2008

Clinical Interests: Adult cardiac surgery, thoracic aortic surgery, minimally inva-sive approaches to valvular heart disease.

FACULTY

154

Donald D. Glower, MDProfessor of Surgery

Training: MD, Johns Hopkins University, 1980

Residency: Surgery, Duke University Medical Center, 1980–1987

Fellowship: Thoracic Surgery, Duke University Medical Center, 1987–1989

Clinical Interests: Minimally invasive valve and coronary surgery; valve repair and replacement; robotic heart surgery; septal myectomy for hyper-trophic obstructive cardiomyopathy; minimally invasive maze procedure for atrial fibrillation

Research Interests: Current clinical research projects examine the effects of patient characteristics and surgical technique in outcomes after mini-mally invasive cardiac surgery, valve repair and replacement, and coronary artery bypass grafting. Prior work has examined the role of surgical therapy versus medical therapy in aortic dissec-tion, load-independent means to quantify left and right ventricu-lar function, and management of complex coronary disease.

John Carroll Haney, MD, AB, MPHAssistant Professor of Surgery


Residency: General Surgery, Duke University, 2004–2011

Fellowship: Cardiothoracic Surgery Resident, Duke University, 2011–2014

Other Training: MPH, Boston University, 2000

Clinical Interests: Adult cardiac surgery including coronary artery revasculariza-tion and valve surgery; lung transplantation; extracorporeal life support therapies for cardiac and respiratory failure; ex-vivo lung perfusion; and surgical treatment of chronic thromboem-bolic pulmonary hypertension


FACULTY

155

David Harold Harpole, MDProfessor of Surgery

Title: Resident Research Director




Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School, 1993–1995

Clinical Interests: Thoracic oncology; general thoracic surgery; benign and malignant disease of the lung, esophagus, and mediastinum; advanced airway and thoracoscopic surgery; hyperhidrosis palmaris; mesothelioma

Research Interests: Non-small cell lung cancer: (1) evaluation of serum and tis-sue molecular biologic markers of recurrence in patients with a localized non-small cell lung cancer; (2) molecular biologic staging of lymph nodes in patients with non-small cell lung cancer; (3) the evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer


FACULTY

156

Matthew Hartwig, MDAssociate Professor of Surgery


Residency: Surgery, Duke University Medical Center, 2001–2007 (Chief Resident, 2007–2008)

Thoracic Surgery, Duke University Medical Center, 2008–2010 (Chief Resident, 2010–2011)

Fellowship: Thoracic Surgery Research Fellow, Duke University Medical Center, 2003–2005

Clinical Interests: Thoracic oncology with an emphasis on minimally invasive approaches to lung and esophageal cancer; video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS); benign and malignant diseases of the lung, esophagus, mediastinum, and chest wall; surgical treatment of end-stage lung disease, including lung-volume reduction and lung trans-plantation; ex-vivo lung perfusion; donation after cardiac death; extracorporeal life support for respiratory failure

George Charles Hughes, MDAssociate Professor of Surgery

Title: Director, Aortic Surgery Program




Fellowship: Thoracic Aortic Surgery, Hospital of the University of Pennsylvania, 2005

Clinical Interests: Adult cardiac surgery; surgery of the thoracic aorta, including disorders of the aortic root, ascending aorta, aortic arch, and descending and thoracoabdominal aorta; thoracic endovascular aortic repair (TEVAR); transcatheter aortic valve implantation (TAVI); aortic valve repair


FACULTY

157

Jacob Klapper, MDAssistant Professor of Surgery


Residency: General Surgery Resident, General Surgery, Indiana University at Indianapolis, 2003–2011

Fellowship: Cardiothoracic Surgery Fellow, Surgery, Duke University, 2011–2014

Other Training: BA, Colgate University, 1998

Masters in Clinical Research, Clinical Research, Medical University of South Carolina School of Medicine, 2014–2016

Shu Shiuh-Shi Lin, MD, PhDAssociate Professor of Surgery


Residency: General Surgery, Duke University Medical Center, 1992–2001 Thoracic Surgery, Duke University Medical Center, 2001–2004

Other Training: PhD, Immunology, Duke University Medical Center, 2000

Clinical Interests: Cardiopulmonary transplantation (heart, lung and heart-lung transplantation), transplant immunology, adult cardiac surgery including CABG and valvular surgery

Research Interests: Two challenges of cardiopulmonary transplantation are the lack of consistent long-term graft survival and the shortage of donor organs. In searching for solutions to these problems, Dr. Lin’s laboratory studies: (1) mechanisms underlying the chronic rejection, especially that of lung and heart-lung allografts; (2) induction of immunologic tolerance to reduce the morbidity and improve the long-term survival of heart and lung trans-plantation; (3) xenotransplantation, with the ultimate goal of alleviating the problem of donor organ shortage but the more immediate goal of gaining general knowledge about transplan-tation immunobiology.


FACULTY

158

Andrew James Lodge, MDAssociate Professor of Surgery


Residency: General Surgery, Duke University Medical Center, 1993–2000 Thoracic Surgery, Duke University Medical Center, 2000–2002

Fellowship: Pediatric Cardiac Surgery, Children’s Hospital of Philadelphia, 2002–2003

Clinical Interests: Pediatric cardiac surgery, adult congenital heart disease, heart transplantation, ventricular assist devices

Research Interests: Extracorporeal circulation, ventricular assist, clinical outcomes after congenital heart surgery

Terry Stephen Lowry, MDAssistant Professor of Surgery

Training: MD, University of North Carolina at Chapel Hill, 1996


FACULTY

159

Carmelo Alessio Milano, MDProfessor of Surgery

Title: Surgical Director, Cardiac Transplantation and Left Ventricular Assist Device (LVAD) Programs

Director, Advanced Scholars in Contemporary Medicine Program


Residency: General Surgery, Duke University Medical Center, 1990–1992, 1994–1997

Fellowship: Molecular Cardiology, Howard Medical Institute, Duke University, 1992–1994


Cardiac Transplant, Papworth Hospital, England, 1999

Clinical Interests: Cardiac transplantation, left ventricular assist devices, adult cardiac surgery, mitral valve surgery, surgical treatments for end-stage congestive heart failure, aortic valve surgery

Ryan P. Plichta, MDAssistant Professor of Surgery

Training: MD, Loyola University Chicago Stritch School of Medicine, 2008

Residency: General Surgery Residency, Surgery, Loyola University Chicago Stritch School of Medicine, 2008–2013

Cardiothoracic Surgery Residency, Surgery, Loyola University Chicago Stritch School of Medicine, 2013–2015

Fellowship: Advanced Aortic and Endovascular Surgery Fellowship, Cleve-land Clinic, 2015–2016

Other Training: BSE, Tufts University, 2002


FACULTY

160

Jacob Niall Schroder, MDAssistant Professor of Surgery

Training: MD, Georgetown University School of Medicine, 2001

Residency: Internship, General Surgery, Duke University Medical Center, 2001–2002

Junior Assistant Resident, General Surgery, Duke University Medical Center, 2002–2003

Senior Assistant Resident, General Surgery, Duke University Medical Center, 2006–2008

Chief Resident, General Surgery, Duke University Medical Center, 2008–2009

Thoracic and Cardiovascular Surgery, Duke University Medical Center, 2009–2012

Fellowship: Cardiothoracic Surgery Research Fellow, Duke University Medi-cal Center, 2003–2006

Clinical Interests: Cardiac transplantation, mechanical circulatory support devices and heart failure surgery, adult cardiac surgery, cardiothoracic surgical education


FACULTY

161

Peter Kent Smith, MDProfessor of Surgery

Title: Chief, Division of Cardiovascular and Thoracic Surgery


Residency: Cardiovascular Research, Duke University Medical Center, 1987

Teaching Scholar, AHA Clinician Scientist Awardee, Duke University Medical Center, 1980–1983

Clinical Interests: Adult cardiac surgery with emphasis on coronary artery disease and valvular heart surgery

Research Interests: Dr. Smith is the principal investigator for the Duke site in the Cardiothoracic Surgery Clinical Trials Network (CTSN) and in recent years has focused on clinical research. Topics include comparing CABG alone to CABG with mitral repair for moder-ate ischemic mitral regurgitation, as well as FFR and angio-graphically guided CABG. An integration of clinical research, publications, and scholarship with the advancement of clinically effective thoracic surgery is the goal of his research activities.

Betty Caroline Tong, MD, MS, MHSAssociate Professor of Surgery


Residency: General Surgery, Johns Hopkins Hospital, 1999–2005


Other Training: MS, Mechanical Engineering, Georgia Institute of Technology, 1995

MHS, Graduate Training Program in Clinical Investigation, Johns Hopkins Bloomberg School of Public Health, 2009

Clinical Interests: Thoracic oncology including lung cancer and mesothelioma, esophageal cancer, and chest wall tumors; diseases of the medi-astinum; pulmonary metastases; minimally invasive/videoas-sisted thoracic surgery; benign lung and chest conditions


FACULTY

162

David Cloid White, MDAssociate Professor of Surgery


Walter George Wolfe, MDProfessor of Surgery

Training: MD, Temple University, 1963

Residency: Intern, Surgery, Philadelphia Naval Hospital, 1963–1964 Assistant Resident, Surgery, Duke University, 1964–1965 Senior Assistant Resident, Surgery, Duke University, 1966–1967 Senior Assistant Resident, Surgery, Duke University, 1968–1970 Chief Resident, Surgery, Duke University, 1970–1971

Fellowship: Fellow in Research, Surgery, Duke University, 1965–1966

Other Training: Teaching Scholar, Cardiothoracic Surgery, Duke University, 1971–1972


FACULTY

163

Metabolic and Weight Loss Surgery

A. Daniel Guerron, MDAssistant Professor of Surgery

Training: MD, Pontificia Universidad Catolica, Ecuador, 2004

Residency: General Surgery Residency, General Surgery, Cleveland Clinic, 2010–2015

Fellowship: Minimally Invasive & Bariatric Surgery Fellowship, Surgery, Duke University, 2015–2016

Chan Woo Park, MDAssistant Professor of Surgery

Title: Co-Director, Minimally Invasive and Bariatric Surgery Fellowship

Training: MD, Jefferson Medical College of Thomas Jefferson University, Pennsylvania, 2005

Residency: General Surgery, University of Hawaii Affiliated Program, 2005–2010

Fellowship: Bariatric and Minimally Invasive Surgery, Duke University Medi-cal Center, 2010–2012

Clinical Interests: Minimally invasive and advanced laparoscopic, robotic, single incision, and endoscopic approaches to diseases of the esopha-gus, stomach, small bowel, colon, solid organs, hiatal and abdominal wall hernias; benign and malignant gastrointestinal tumors; metabolic and weight loss surgery, sleeve gastrectomy, adjustable gastric banding, Roux-en-Y gastric bypass, and revi-sional bariatric surgery

FACULTY

164

Dana Dale Portenier, MDAssistant Professor of Surgery

Title: Chief, Division of Metabolic and Weight Loss Surgery Co-Director, Minimally Invasive and Bariatric Surgery Fellowship

Training: MD, Medical University of South Carolina, 1999

Residency: General Surgery, Providence Hospital, Michigan, 1999–2004

Fellowship: Traveling Hepato-Pancreatico-Biliary Fellow, Mayo Clinic, Minne-sota; Memorial Sloan-Kettering Cancer Center, New York; Saint James University Hospital, Leeds, England, 2004–2005

Other Training: Minimally Invasive and Bariatric Surgery, Duke University Medi-cal Center, 2005–2006

Clinical Interests: Minimally invasive approach to upper-GI surgery for diseases of the esophagus, stomach, liver, pancreas, adrenal glands, spleen, small bowel, and colon; complicated revisional foregut and bariatric surgery; developing new techniques in the field of single-incision surgery; weight loss surgery

Keri Anne Seymour, DOAssistant Professor of Surgery

Training: DO, Midwestern University, IL, 2007

Metabolic and Weight Loss Surgery (continued)

FACULTY

165

Ranjan Sudan, MDAssociate Professor of Surgery

Title: Vice Chair of Education

Training: MD, Armed Forces Medical College, India, 1981

Residency: Surgery, Wright State University, Ohio, 1999

Fellowship: Child and Adolescent Psychiatry, Columbia University, 1993

Clinical Interests: Laparoscopic, bariatric, GI, robotic surgery, weight loss surgery

Jin Soo Yoo, MDAssistant Professor of Surgery


Residency: General Surgery, Duke University Medical Center, 2002–2004, 2006–2009

Fellowship: Minimally Invasive Surgery/Bariatric Surgery, Duke University Medical Center, 2009–2010

Clinical Interests: Advanced laparoscopic and bariatric surgery, including surgical management of GERD, achalasia, benign and malignant gastric tumors, pancreatic and adrenal disease, splenectomy, Roux-en-Y gastric bypass, and adjustable gastric

Metabolic and Weight Loss Surgery (continued)

FACULTY

166

Alexander C. Allori, MDAssistant Professor of Surgery

Training: MD, University of Texas Medical School at Houston, 2003

Residency: General Surgery, Beth Israel Medical Center (New York), 2003–2010

Plastic Surgery, Duke University Medical Center, 2010–2013

Fellowship: Pediatric Plastic and Craniofacial Surgery, Harvard-Boston Children’s Hospital, 2013–2014

Patient-Centered Outcomes, International Consortium for Health Outcomes Measurement, 2013–2014

Bioengineering and Reparative Biology Research, Institute for Reconstructive Plastic Surgery, New York University-Langone Medical Center, 2006–2008

Other Training: MPH, University of Texas School of Public Health, 1999

Linda Carime Cendales, MDAssociate Professor of Surgery

Title: Director, Duke Vascularized Composite Allotransplantation Program

Training: MD, Universidad Autonoma Metropolitana, Mexico, 1992

Residency: Internship/Junior Resident, Surgery, Hospital General Dr. Manuel Gea Gonzalez, Mexico, 1993–1995

Chief Resident, Surgery, Hospital General Dr. Manuel Gea Gonzalez, Mexico, 1995–1996

Fellowship: Clinical Fellow & Senior Fellow, Hand & Microsurgery, Christine M. Kleinert Institute, 1997–2001

Fellow, Transplantation Surgery, National Institutes of Health, 2001–2004

Senior Clinical Fellow, National Institutes of Health, 2004–2006

Fellow, Translational Research, Emory University School of Medicine, 2009–2011

Plastic, Macillofacial, and Oral Surgery

FACULTY

167

Detlev Erdmann, MD, MHSProfessor of Surgery

Training: MD, Technical University of Munich School of Medicine, 1990

Residency: Resident, Surgery, Ruprecht Karl University (Germany), 1996–2000

Fellowship: Research Fellow, Institute Of Plastic Surgery, Southern Illinois University, 1994–1995

Other Training: MHS, Duke University School of Medicine, 2007

Gregory S. Georgiade, MDProfessor of Surgery

Title: Vice Chair of Clinical Practice and Chief, Division of Plastic, Max-illofacial, and Oral Surgery

Training: MD, Duke University, 1973

Scott Thomas Hollenbeck, MDAssociate Professor of Surgery

Training: MD, Ohio State University, 2000

Residency: Resident in Plastic Surgery, Surgery, Duke University, 2007–2010

Fellowship: Research Fellow, Surgery, Weill Cornell Medical College, 2002–2004

Plastic, Macillofacial, and Oral Surgery (continued)

FACULTY

168

Bruce Klitzman, PhDAssociate Professor of Surgery

Training: PhD, University of Virginia, 1979

Howard Levinson, MDAssociate Professor of Surgery

Training: MD, University of Texas, Medical Branch at Galveston, 1997


FACULTY

169

Jeffrey Robert Marcus, MDAssociate Professor of Surgery

Training: MD, University of Michigan at Ann Arbor, 1994

Residency: Intern General Surgery, Surgery, Northwestern Memorial Hospital, 1994–1995

Resident General Surgery, Surgery, Northwestern Memorial Hospital, 1995–1997

Resident, Plastic Surgery, Northwestern Memorial Hospital, 1998–2000

Chief Resident, Plastic Surgery, Northwestern Memorial Hospital, 2000–2001

Fellowship: Research Fellow, Plastic Surgery, Northwestern Memorial Hos-pital, 1997–1998

Suhail Kamrudin Mithani, MDAssistant Professor of Surgery

Title: Director, Plastic and Reconstructive Surgery Residency Program

Training: MD, Vanderbilt University School of Medicine, 2003

Residency: Resident, The Medical Scholars Program, Vanderbilt University, 2001–2002

Resident, General Surgery, Johns Hopkins University, 2003–2006

Resident, Plastic Surgery, Johns Hopkins University, 2006–2011

Fellowship: Fellow, Hand Surgery, Department of Orthopaedics, Duke University, 2011–2012


FACULTY

170

David Bryan Powers, MDAssociate Professor of Surgery

Training: MD, University of Texas Health Science Center San Antonio, 2000

Residency: General Surgery Intern, Wilford Hall Medical Center, 2000–2001

Oral & Maxiollofacial Surgery Resident, Wilford Hall Medical Center, 1996–2002

Pedro E Santiago, DMDAssociate Consulting Professor in the Department of Surgery

Training: DMD, University of Puerto Rico (Puerto Rico), 1989

Michael Robert Zenn, MDProfessor of Surgery

Training: MD, Cornell University, 1988

Residency: Resident, General Surgery, New York Hospital Cornell Medical Center, 1988–1992

Chief Resident, Surgery, New York Hospital Cornell Medical Center, 1992–1993

Resident, Plastic Surgery, Massachusetts General Hospital, 1993–1995

Fellowship: Microsurgery Fellow, Surgery, Memorial Sloan Kettrng Rad Te, 1995–1995


FACULTY

171

Obinna Ogochukwu Adibe, MDAssistant Professor of Surgery

Training: MD, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 2001

Residency: General Surgery, University of Connecticut School of Medicine, 2001–2004, 2006–2008

Fellowship: Fetal Surgery Research, Children’s Hospital of Philadelphia, Pennsylvania, 2004–2006

Pediatric Endosurgery, Children’s Hospital of Alabama, 2008–2009

Pediatric Surgery, Children’s Mercy Hospital and Clinics, Mis-souri, 2010–2012

Clinical Interests: Advanced pediatric minimally invasive surgery, neonatal sur-gery, anorectal malformations, inflammatory bowel disease, prenatal counseling, fetal therapy, pediatric outcomes research disease, prenatal counseling

Henry Elliot Rice, MDProfessor of Surgery

Title: Chief, Division of Pediatric General Surgery

Training: MD, Yale University School of Medicine, 1988

Residency: General Surgery, University of Washington Medical Center, 1996

Fellowship: Pediatric Surgery, Children’s Hospital of Buffalo, 1998

Clinical Interests: Neonatal surgery, prenatal counseling, general pediatric tho-racic and abdominal surgery

Pediatric General

FACULTY

172

Elisabeth Tomlinson Tracy, MDAssistant Professor of Surgery

Training: MD, Harvard Medical School, 2005


Fellowship: Pediatric Surgery, Boston Children’s Hospital, 2012–2014

Pediatric General (continued)

FACULTY

173

Amy Rezak Alger, MDAssistant Professor of Surgery

Training: MD, Ross University School of Medicine (West Indies), 2001

Residency: General Surgery Resident, Surgery, Waterbury Hospital, 2002–2007

Fellowship: Surgical Critical Care Fellow, Surgery, Brigham and Women’s Hospital, 2007–2008

Acute Care Surgery Fellow, Surgery, Brigham and Women’s Hospital, 2008–2009

Other Training: BS, State University of New York, Albany, 1996

Noran Maged Barry, MDAssistant Professor of Surgery

Training: MD, Saint James School of Medicine (Netherlands), 2010

Residency: General Surgery Residency, Surgery, St Lukes Hospital Pa, 2010–2015

Fellowship: Surgical Critical Care Fellowship, Surgery, University of North Carolina at Chapel Hill, 2015–2016

Other Training: BS, University of California at Irvine, 2004

Kelli Rachel Brooks, MDAssistant Professor of Surgery


Residency: General Surgery, Duke University Medical Center, 2006

Fellowship: Surgical Critical Care, Duke University Medical Center, 2007

Clinical Interests: Trauma surgery, care of the multisystem trauma patient, surgi-cal critical care, gastrointestinal and general surgery

Trauma and Critical Care Surgery

FACULTY

174

Alison Suzanne Clay, MDAssistant Professor of Surgery


Lisa Clark Pickett, MDAssistant Professor of Surgery

Training: MD, Harvard Medical School, 1994

Residency: Critical Care, Duke University Medical Center, 1998 General Surgery, Duke University Medical Center, 2001

Clinical Interests: Laparoscopic hernia repair; routine and complex ventral and inguinal hernias; hernias in women; abdominal-wall reconstruc-tion; critical care; quality and care redesign.

Research Interests: (1) Hernias database: Dr. Pickett is reviewing all the hernias performed at Duke in the last seven years to create a resource for retrospective and prospective study of patients coming to the Duke Hernia Center; (2) Surgisis mesh: Cook Surgical has provided a $5,000 unrestricted grant for preparing a video of Surgisis mesh placement in a patient with infected ventral hernia mesh. Drs. Pickett and Pappas continue to use this mesh in patients with infected hernias and plan to publish a case series; (3) Enterra device: Drs. Pickett and Pappas continue to work with Medtronic to place Enterra gastric pacing devices in patients with severe gastroparesis.

Trauma and Critical Care Surgery (continued)

FACULTY

175

Vanessa Teaberry Schroder, MDAssistant Professor of Surgery


Residency: General Surgery Resident, Duke University School of Medicine, 2013

Fellowship: Surgical Critical Care, Surgery, Duke University School of Medicine, 2014

Clinical Interests: Acute care and elective general surgery, surgical critical care, and surgical nutrition

Research Interests: Surgical nutrition

Mark Louis Shapiro, MDAssociate Professor of Surgery

Title: Associate Director, Trauma Services Chief, Acute Care Surgery

Training: MD, Ross University, Dominica, 1997

Residency: The Jewish Hospital of Cincinnati, 1997–2002

Fellowship: Trauma and Critical Care, University of Cincinnati, 2002–2003

Clinical Interests: Ventilator-associated pneumonia, shock, and resuscitation; blunt cerebrovascular injuries; thoracic trauma; hypertonic saline in sepsis and trauma; surgical education; evidence-based outcomes; acute care surgery; surgical infection.


FACULTY

176

Courtney Anne Sommer, MD, MPHAssistant Professor of Surgery

Training: MD, University of North Carolina at Chapel Hill School of Medicine, 2006

MPH, University of North Carolina at Chapel Hill Gillings School of Public Health, 2010

Residency: General Surgery, University of North Carolina Hospitals, 2013

Fellowship: Surgical Critical Care and Trauma, Harborview Medical Center - University of Washington, 2014

Clinical Interests: Care of the multiply injured trauma patient, surgical infections, trauma surgery, general and emergency general surgery, surgi-cal critical care, and surgical nutrition

Research Interests: Surgical education, trauma systems development, education and prevention of trauma, care of the elderly trauma patient, implementation of protocols, and surgical nutrition


FACULTY

177

Steven Nicholas Vaslef, MD, PhDAssociate Professor of Surgery

Title: Chief, Division of Trauma and Critical Care Surgery Director, Surgical Critical Care Fellowship


Residency: General Surgery, Cook County Hospital, University of Illinois at Chicago, 1984–1986, 1989–1992 (Chief Resident, 1991–1992)

Fellowship: Surgery (Research), Northwestern University, 1986–1989

Other Training: PhD, Biomedical Engineering, Northwestern University, 1990

Clinical Interests: Trauma, surgical critical care, gastrointestinal surgery, general surgery, surgical infections

Research Interests: Current research interests include: the development of an implantable artificial lung; design and evaluation of membrane oxygenators; evaluation of blood substitutes; treatment and physiology of shock; and gastrointestinal tonometry.

Cory Joseph Vatsaas, MDAssistant Professor of Surgery

Training: MD, University of Minnesota, Twin Cities, 2008

Residency: General Surgery Resident, Mayo School of Health Sciences, 2008–2014

Fellowship: Surgical Critical Care Fellow, University of Michigan at Ann Arbor, 2011–2012


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