For Your PhysicianBioniCare Hand System

© 2018 VisionQuest Industries, Inc. VQO511999REVA

18011 Mitchell South, Suite A • Irvine, CA • 92614800.266.6969 • www.vqorthocare.com

Review the clinical evidence and benefits in the MD Brochure and Clinical Summary and see how the BioniCare System fits into your current treatment protocol to enhance the patient’s outcome.

Fill out a prescription.

• Example: “BioniCare Hand System for hand RA” or “BioniCare Hand System for hand OA”

• Make sure to include “left” or “right” and diagnosis or use the complete ICD-10 code if you prefer

Fax the prescription along with patient demographics to VQ OrthoCare at 866.439.8063.

STEP 1:

STEP 1 STEP 2 STEP 3

Review and discuss with patient

Fill out a prescription

Fax prescription to 866.439.8063

Bion iCare Hand SystemHand RA

Jamie Jones

Dr. Vicki DoeX

00/00/0000

456 1st St, Anytown, USA 00000

Dr. Vicki Doe & Associates123 Main Steet

Anytown, USA 00000000-555-1234 • 000-555-4567

Dr. Vicki DoeDEA# AB0000000NPI# 0000000000

Dr. Mary SmithDEA# AB0000000NPI# 0000000000

Dr. John DoeDEA# AB0000000NPI# 0000000000

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PROVEN NON-INVASIVE TREATMENT FOR ARTHRITIS OF THE HAND AND WRIST

WHY BIONICARE?

BioniCare is a pulsed electrical signal delivered via a conductive glove and electrodes specifically designed for the treatment of osteoarthritis and rheumatoid arthritis of the hand, thumb and wrist.

• Non-invasive

• Non-drug

• Conservative treatment

UNLIKE ALL OTHERS STIMULATORS:

The unique BioniCare signal should not be confused withother types of stimulators that only block the body’s painsignals and do not improve function or reduce stiffness.

Finite Element Analysis of the electricalsignal distributed to the hand and wristjoint by theBioniCare generator (courtesyof the University of Auckland)

BIONICARE SCIENCE

• Arthritis is characterized by the degradation of the joint by inflammatory cytokines.

• Scientific research supports the hypothesis that electrical signals can increase aggrecan and Type II collagen synthesis and decrease inflammatory cytokines involved in the inflammation of arthritis.1,2

• The BioniCare signal has been proven to reduce pain and medications, increase function, defer surgery and improve the overall condition of synovial joints.5

• The BioniCare Hand System signal has been proven to decrease the pain and symptoms of osteoarthritis and rheumatoid arthritis of the hand.3,4

FEATURES: • Compact, touch-screen device

• Easy to apply, reusable electrodes

• Comfortable glove

• Rechargeable battery

• Can be worn while sleeping or during the day

• Bluetooth enabled compliance reporting

A Significant REDUCTION of:Hand Pain

Thumb Pain

Subject Global Assessment

A Significant IMPROVEMENT in:Function (DASH)

Pinch Force

Grip Strength

Physician’s Global Assessment (Disease Severity)

80% GREATER IMPROVEMENT IN FUNCTIONIn a double-blind, placebo controlled study, of rheumatoid arthritis patients, patients with BioniCare achieved an 80% greater improvement in function and 73% improvement in

pain and symptoms versus a placebo.

CLINICAL STUDIES

EFFECT SIZE OF BIONICARE TREATMENT

Improvement from the Baseline at 4 months in OA Patients

OA Pain in Thumb

EFFE

CT SI

ZE

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

Subject GlobalAssessment

Physician’s GlobalAssessment

OA Pain in Hand

SMALL EFFECT SIZE

MEDIUM EFFECT SIZE

LARGE EFFECT SIZE

EFFECT SIZE OF BIONICARE TREATMENTEFFECT SIZE OF BIONICARE TREATMENT

Improvement from the Baseline at 4 months in OA Patients

EFFE

CT SI

ZE

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

Pinch ForceDASH Score Grip Strength

SMALL EFFECT SIZE

MEDIUM EFFECT SIZE

LARGE EFFECT SIZE

IMPR

OVEM

ENT

(VAS

)

0.0

0.5

1.0

1.5

2.0

Week 4Week 3Week 2Week 1

0.9

0.6

1.01.1

1.0

1.5 1.5

1.8

Placebo (N=44)Active (N=45)

PATIENT EVALUATION OF FUNCTION

Improvement from the Baseline for Rheumatoid Arthritis Patients

© 2018 VisionQuest Industries, Inc. VQO511992REVA

18011 Mitchell South, Suite A • Irvine, CA • 92614www.vqorthocare.com • 800.266.6969

Indications• The BioniCare Hand System, Model BIO-2000, is indicated for use

as an adjunctive therapy in osteoarthritis of the hand to reduce the level of pain and stiffness and to improve the function of the hand.

• The BioniCare Hand System, Model BIO-2000, is indicated for use as an adjunctive therapy in reducing the level of pain and stiffness associated with pain from rheumatoid arthritis of the hand.

Contraindications• Do not use the BioniCare Hand System for any electrode

placement that applies current to the carotid sinus (neck) region.• Do not use the BioniCare Hand System for any electrode

placement that causes current to flow transcerebrally (through the head).

• Patients with demand type cardiac pacemakers should consult with their physician prior to use of this system.

• Do not use the BioniCare Hand System whenever pain syndromes are undiagnosed, until etiology is established.

Warnings• The BioniCare Hand System must be used only as prescribed and

applied only to the hand.• The safety of the BioniCare Hand System for use during pregnancy

has not been established.

• The BioniCare Hand System is not effective for pain of central origin (including headache).

• Use only under the continued supervision of a physician.• Keep out of reach of children.• Electronic monitoring equipment (such as ECG monitors and

ECG alarms) may not operate properly when the BioniCare Hand Device is in use.

PRECAUTIONS• Isolated cases of skin irritation may occur at the site of electrodes

and conductive glove placement following long-term application.• Effectiveness is highly dependent upon patient selection by a

physician qualified in the management of arthritis.REFERENCE1. Peter A. Holt, MD; Tuna Ozyurekoglu, MD; Shaili Deveshwar, MD;

Edmund J. Maclaughlin, MD; Anton Khlopas, MD; Michael A. Mont, MD; Shirley W. Pang, MD; Jack S. Tuber, DO; Joy Schechtman, DO; Thomas M. Zizic, MD. "A Pulsed Electrical Joint Stimulator for The Treatment of Osteoarthritis of the Hand and Wrist. Orthopedics." 2018 Vol XX(X).

Trademark Information:BioniCare and VQ OrthoCare are registered trademarks of VisionQuest Industries, Inc.